| 1971-04-07 | vs WS2 | 1 | W 3-2 | 1-0 | 1 | 36,423 | Dave McNally | Casey Cox | Dave McNally | Casey Cox | | 3 | 2 | 1 |
| 1971-04-09 | vs DET | 2 | W 6-5 | 2-0 | 1 | 9,442 | Mike Cuellar | Joe Niekro | Dick Hall | Joe Niekro | | 9 | 7 | 2 |
| 1971-04-10 | vs DET | 3 | W 2-1 | 3-0 | 1 | 5,274 | Jim Palmer | Mickey Lolich | Jim Palmer | Mickey Lolich | | 11 | 8 | 3 |
| 1971-04-11 | vs DET | 4 | L 4-5 | 4-1 | 1 | 0 | Pat Dobson | Dean Chance | Tom Timmermann | Pete Richert | Fred Scherman | 15 | 13 | 2 |
| 1971-04-11 | vs DET | 5 | W 9-3 | 4-1 | 1 | 18,624 | Dave McNally | Mike Kilkenny | Dave McNally | Mike Kilkenny | | 24 | 16 | 8 |
| 1971-04-14 | @ CLE | 6 | W 3-0 | 5-1 | 1 | 4,676 | Mike Cuellar | Sam McDowell | Mike Cuellar | Sam McDowell | | 27 | 16 | 11 |
| 1971-04-15 | @ CLE | 7 | W 6-4 | 6-1 | 1 | 4,461 | Jim Palmer | Alan Foster | Jim Palmer | Chuck Machemehl | Eddie Watt | 33 | 20 | 13 |
| 1971-04-16 | vs NYA | 8 | W 6-1 | 7-1 | 1 | 7,465 | Pat Dobson | Steve Kline | Pat Dobson | Steve Kline | | 39 | 21 | 18 |
| 1971-04-17 | vs NYA | 9 | L 3-5 | 7-2 | 1 | 6,555 | Dave McNally | Mike Kekich | Fritz Peterson | Pete Richert | | 42 | 26 | 16 |
| 1971-04-18 | vs NYA | 10 | W 11-6 | 8-2 | 1 | 30,427 | Mike Cuellar | Stan Bahnsen | Dick Hall | Stan Bahnsen | | 53 | 32 | 21 |
| 1971-04-20 | @ DET | 11 | L 6-7 | 8-3 | 1 | 18,509 | Jim Palmer | Joe Niekro | Tom Timmermann | Tom Dukes | | 59 | 39 | 20 |
| 1971-04-21 | @ DET | 12 | L 1-5 | 8-4 | 1 | 14,800 | Pat Dobson | Mickey Lolich | Mickey Lolich | Pat Dobson | | 60 | 44 | 16 |
| 1971-04-23 | @ CAL | 13 | W 8-2 | 9-4 | 1 | 13,644 | Dave McNally | Clyde Wright | Dave McNally | Clyde Wright | | 68 | 46 | 22 |
| 1971-04-24 | @ CAL | 14 | L 4-7 | 9-5 | 1 | 12,590 | Mike Cuellar | Tom Murphy | Lloyd Allen | Dick Hall | | 72 | 53 | 19 |
| 1971-04-25 | @ CAL | 15 | W 7-1 | 10-5 | 1 | 28,328 | Jim Palmer | Jim Maloney | Jim Palmer | Jim Maloney | | 79 | 54 | 25 |
| 1971-04-26 | @ OAK | 16 | L 0-1 | 10-6 | 1 | 6,998 | Pat Dobson | Vida Blue | Vida Blue | Pat Dobson | | 79 | 55 | 24 |
| 1971-04-27 | @ OAK | 17 | W 6-2 | 11-6 | 1 | 5,502 | Dave McNally | Diego Segui | Dave McNally | Diego Segui | | 85 | 57 | 28 |
| 1971-04-28 | @ OAK | 18 | L 4-5 | 11-7 | 1 | 4,109 | Mike Cuellar | Catfish Hunter | Catfish Hunter | Dick Hall | | 89 | 62 | 27 |
| 1971-04-29 | @ OAK | 19 | W 3-2 | 12-7 | 1 | 3,320 | Jim Palmer | Rollie Fingers | Jim Palmer | Rollie Fingers | | 92 | 64 | 28 |
| 1971-04-30 | @ KCA | 20 | L 4-5 | 12-8 | 2 | 9,432 | Pat Dobson | Mike Hedlund | Ted Abernathy | Tom Dukes | | 96 | 69 | 27 |
| 1971-05-01 | @ KCA | 21 | L 2-5 | 12-9 | 2 | 8,151 | Dave McNally | Wally Bunker | Wally Bunker | Dave McNally | Ted Abernathy | 98 | 74 | 24 |
| 1971-05-02 | @ KCA | 22 | W 5-3 | 13-9 | 2 | 29,120 | Mike Cuellar | Ken Wright | Mike Cuellar | Ken Wright | | 103 | 77 | 26 |
| 1971-05-04 | vs CAL | 23 | W 4-1 | 14-9 | 2 | 6,415 | Jim Palmer | Tom Murphy | Jim Palmer | Tom Murphy | | 107 | 78 | 29 |
| 1971-05-06 | vs CAL | 24 | W 3-1 | 16-9 | 2 | 0 | Dave McNally | Andy Messersmith | Dave McNally | Andy Messersmith | | 110 | 79 | 31 |
| 1971-05-06 | vs CAL | 25 | W 3-1 | 16-9 | 2 | 5,786 | Pat Dobson | Jim Maloney | Pat Dobson | Lloyd Allen | | 113 | 80 | 33 |
| 1971-05-09 | vs OAK | 26 | L 2-6 | 16-11 | 2 | 0 | Mike Cuellar | Catfish Hunter | Catfish Hunter | Mike Cuellar | | 115 | 86 | 29 |
| 1971-05-09 | vs OAK | 27 | L 1-2 | 16-11 | 2 | 43,307 | Jim Palmer | Vida Blue | Vida Blue | Jim Palmer | | 116 | 88 | 28 |
| 1971-05-10 | vs KCA | 28 | L 1-4 | 16-12 | 2 | 5,577 | Dave McNally | Bruce Dal Canton | Bruce Dal Canton | Dave McNally | | 117 | 92 | 25 |
| 1971-05-11 | vs KCA | 29 | W 5-4 | 17-12 | 2 | 4,979 | Pat Dobson | Dick Drago | Eddie Watt | Ted Abernathy | | 122 | 96 | 26 |
| 1971-05-12 | vs KCA | 30 | W 6-0 | 18-12 | 2 | 5,900 | Mike Cuellar | Mike Hedlund | Mike Cuellar | Mike Hedlund | | 128 | 96 | 32 |
| 1971-05-14 | @ BOS | 31 | L 0-2 | 18-13 | 2 | 33,941 | Jim Palmer | Sonny Siebert | Sonny Siebert | Jim Palmer | | 128 | 98 | 30 |
| 1971-05-15 | @ BOS | 32 | W 7-4 | 19-13 | 2 | 28,480 | Dave McNally | Mike Nagy | Dave McNally | Mike Nagy | Pete Richert | 135 | 102 | 33 |
| 1971-05-17 | @ NYA | 33 | L 3-6 | 19-14 | 2 | 15,378 | Pat Dobson | Mel Stottlemyre | Mel Stottlemyre | Pat Dobson | Jack Aker | 138 | 108 | 30 |
| 1971-05-18 | @ NYA | 34 | W 6-2 | 20-14 | 2 | 14,700 | Mike Cuellar | Fritz Peterson | Mike Cuellar | Fritz Peterson | | 144 | 110 | 34 |
| 1971-05-19 | @ WS2 | 35 | W 4-1 | 21-14 | 2 | 6,833 | Jim Palmer | Mike Thompson | Jim Palmer | Mike Thompson | | 148 | 111 | 37 |
| 1971-05-21 | vs BOS | 36 | L 4-8 | 21-15 | 2 | 17,528 | Pat Dobson | Jim Lonborg | Ken Tatum | Dick Hall | | 152 | 119 | 33 |
| 1971-05-22 | vs BOS | 37 | W 5-2 | 22-15 | 2 | 9,855 | Mike Cuellar | Ray Culp | Mike Cuellar | Ray Culp | | 157 | 121 | 36 |
| 1971-05-23 | vs BOS | 38 | W 12-3 | 23-16 | 2 | 0 | Jim Palmer | Gary Peters | Jim Palmer | Gary Peters | | 169 | 124 | 45 |
| 1971-05-23 | vs BOS | 39 | L 1-2 | 23-16 | 2 | 40,267 | Dave McNally | Sonny Siebert | Sonny Siebert | Dave McNally | Sparky Lyle | 170 | 126 | 44 |
| 1971-05-26 | vs CLE | 40 | W 3-2 | 24-16 | 2 | 8,865 | Mike Cuellar | Rich Hand | Mike Cuellar | Rich Hand | | 173 | 128 | 45 |
| 1971-05-27 | vs CLE | 41 | L 5-10 | 24-17 | 2 | 6,054 | Jim Palmer | Steve Dunning | Steve Dunning | Tom Dukes | Phil Hennigan | 178 | 138 | 40 |
| 1971-05-28 | @ MIN | 42 | L 6-7 | 24-18 | 2 | 13,737 | Dave McNally | Jim Perry | Jim Perry | Dave McNally | Tom Hall | 184 | 145 | 39 |
| 1971-05-29 | @ MIN | 43 | W 11-8 | 25-18 | 2 | 12,796 | Pat Dobson | Pete Hamm | Dave Boswell | Ray Corbin | Eddie Watt | 195 | 153 | 42 |
| 1971-05-30 | @ MIN | 44 | W 6-5 | 26-18 | 2 | 17,594 | Mike Cuellar | Bert Blyleven | Mike Cuellar | Bert Blyleven | Eddie Watt | 201 | 158 | 43 |
| 1971-05-31 | @ CHA | 45 | L 0-1 | 27-19 | 2 | 0 | Jim Palmer | Tommy John | Tommy John | Jim Palmer | | 201 | 159 | 42 |
| 1971-05-31 | @ CHA | 46 | W 11-3 | 27-19 | 2 | 19,588 | Dave McNally | Joe Horlen | Dave McNally | Joe Horlen | Tom Dukes | 212 | 162 | 50 |
| 1971-06-02 | @ CHA | 47 | W 3-2 | 28-19 | 1 | 9,547 | Pat Dobson | Tom Bradley | Dick Hall | Vicente Romo | Tom Dukes | 215 | 164 | 51 |
| 1971-06-04 | @ MIL | 48 | W 2-0 | 29-19 | 2 | 11,633 | Mike Cuellar | Lew Krausse | Mike Cuellar | Lew Krausse | | 217 | 164 | 53 |
| 1971-06-05 | @ MIL | 49 | W 12-4 | 30-19 | 1 | 14,117 | Jim Palmer | Skip Lockwood | Jim Palmer | Jim Hannan | | 229 | 168 | 61 |
| 1971-06-06 | @ MIL | 50 | W 4-3 | 31-19 | 1 | 11,605 | Dave McNally | Marty Pattin | Dave McNally | Marty Pattin | Eddie Watt | 233 | 171 | 62 |
| 1971-06-08 | vs MIN | 51 | W 8-2 | 32-19 | 1 | 12,255 | Pat Dobson | Bert Blyleven | Pat Dobson | Bert Blyleven | | 241 | 173 | 68 |
| 1971-06-09 | vs MIN | 52 | W 2-1 | 33-19 | 1 | 11,216 | Mike Cuellar | Jim Kaat | Mike Cuellar | Jim Kaat | | 243 | 174 | 69 |
| 1971-06-10 | vs MIN | 53 | W 12-0 | 34-19 | 1 | 10,952 | Jim Palmer | Jim Perry | Jim Palmer | Jim Perry | | 255 | 174 | 81 |
| 1971-06-11 | vs CHA | 54 | W 8-5 | 35-19 | 1 | 15,959 | Dave McNally | Joe Horlen | Dave McNally | Joe Horlen | Pete Richert | 263 | 179 | 84 |
| 1971-06-12 | vs CHA | 55 | L 3-7 | 35-20 | 1 | 21,586 | Pat Dobson | Wilbur Wood | Wilbur Wood | Pat Dobson | Vicente Romo | 266 | 186 | 80 |
| 1971-06-13 | vs CHA | 56 | W 2-1 | 36-20 | 1 | 14,418 | Mike Cuellar | Tommy John | Mike Cuellar | Tommy John | | 268 | 187 | 81 |
| 1971-06-15 | vs MIL | 57 | L 5-6 | 36-21 | 1 | 6,499 | Jim Palmer | Lew Krausse | Ken Sanders | Pete Richert | | 273 | 193 | 80 |
| 1971-06-16 | vs MIL | 58 | W 8-3 | 37-21 | 1 | 6,302 | Dave McNally | Marty Pattin | Dave McNally | Marty Pattin | | 281 | 196 | 85 |
| 1971-06-17 | vs NYA | 59 | W 3-1 | 38-21 | 1 | 15,528 | Pat Dobson | Mel Stottlemyre | Pat Dobson | Mel Stottlemyre | | 284 | 197 | 87 |
| 1971-06-18 | vs NYA | 60 | W 6-4 | 39-21 | 1 | 39,619 | Mike Cuellar | Fritz Peterson | Mike Cuellar | Fritz Peterson | | 290 | 201 | 89 |
| 1971-06-19 | vs NYA | 61 | L 4-6 | 39-22 | 1 | 26,175 | Jim Palmer | Mike Kekich | Jack Aker | Dick Hall | Gary Waslewski | 294 | 207 | 87 |
| 1971-06-20 | vs NYA | 62 | W 10-4 | 40-22 | 1 | 31,359 | Dave McNally | Steve Kline | Dave McNally | Steve Kline | Eddie Watt | 304 | 211 | 93 |
| 1971-06-21 | @ WS2 | 63 | W 7-2 | 41-22 | 1 | 5,106 | Pat Dobson | Denny McLain | Pat Dobson | Denny McLain | | 311 | 213 | 98 |
| 1971-06-22 | @ WS2 | 64 | L 6-8 | 42-23 | 1 | 0 | Mike Cuellar | Gerry Janeski | Paul Lindblad | Dave Boswell | Casey Cox | 317 | 221 | 96 |
| 1971-06-22 | @ WS2 | 65 | W 2-0 | 42-23 | 1 | 11,072 | Grant Jackson | Jim Shellenback | Grant Jackson | Jim Shellenback | Tom Dukes | 319 | 221 | 98 |
| 1971-06-23 | @ WS2 | 66 | W 7-5 | 43-23 | 1 | 7,867 | Jim Palmer | Dick Bosman | Jim Palmer | Dick Bosman | Pete Richert | 326 | 226 | 100 |
| 1971-06-24 | @ WS2 | 67 | W 6-1 | 44-23 | 1 | 5,765 | Dave McNally | Jackie Brown | Dave McNally | Jackie Brown | | 332 | 227 | 105 |
| 1971-06-25 | @ BOS | 68 | W 7-3 | 45-23 | 1 | 31,505 | Pat Dobson | Jim Lonborg | Pat Dobson | Sparky Lyle | Tom Dukes | 339 | 230 | 109 |
| 1971-06-26 | @ BOS | 69 | L 2-3 | 45-25 | 1 | 27,298 | Mike Cuellar | Gary Peters | Gary Peters | Dick Hall | | 341 | 233 | 108 |
| 1971-06-26 | @ BOS | 70 | L 2-10 | 45-25 | 1 | 24,531 | Grant Jackson | Sonny Siebert | Sonny Siebert | Grant Jackson | | 343 | 243 | 100 |
| 1971-06-27 | @ BOS | 71 | L 1-3 | 45-26 | 1 | 29,362 | Jim Palmer | Ray Culp | Ray Culp | Jim Palmer | | 344 | 246 | 98 |
| 1971-06-28 | vs DET | 72 | L 4-9 | 45-27 | 1 | 17,034 | Dave McNally | Mickey Lolich | Fred Scherman | Pete Richert | | 348 | 255 | 93 |
| 1971-06-29 | vs DET | 73 | W 15-6 | 46-27 | 1 | 21,299 | Pat Dobson | Les Cain | Pat Dobson | Les Cain | | 363 | 261 | 102 |
| 1971-06-30 | @ CLE | 74 | L 4-5 | 47-28 | 1 | 0 | Mike Cuellar | Steve Dunning | Phil Hennigan | Pete Richert | | 367 | 266 | 101 |
| 1971-06-30 | @ CLE | 75 | W 4-3 | 47-28 | 1 | 13,945 | Grant Jackson | Steve Hargan | Grant Jackson | Steve Hargan | Dick Hall | 371 | 269 | 102 |
| 1971-07-01 | @ CLE | 76 | L 2-3 | 47-29 | 1 | 7,862 | Jim Palmer | Sam McDowell | Ed Farmer | Eddie Watt | | 373 | 272 | 101 |
| 1971-07-02 | @ DET | 77 | L 1-3 | 47-30 | 1 | 37,829 | Dave McNally | Mickey Lolich | Mickey Lolich | Tom Dukes | | 374 | 275 | 99 |
| 1971-07-03 | @ DET | 78 | W 8-1 | 48-30 | 1 | 18,091 | Pat Dobson | Les Cain | Pat Dobson | Les Cain | | 382 | 276 | 106 |
| 1971-07-04 | @ DET | 79 | W 3-2 | 49-30 | 1 | 23,410 | Mike Cuellar | Joe Coleman | Mike Cuellar | Joe Coleman | | 385 | 278 | 107 |
| 1971-07-06 | vs WS2 | 80 | W 6-2 | 50-31 | 1 | 0 | Dave McNally | Jim Shellenback | Dave McNally | Jim Shellenback | | 391 | 280 | 111 |
| 1971-07-06 | vs WS2 | 81 | L 2-3 | 50-31 | 1 | 11,349 | Grant Jackson | Bill Gogolewski | Casey Cox | Grant Jackson | | 393 | 283 | 110 |
| 1971-07-07 | vs WS2 | 82 | W 4-0 | 51-31 | 1 | 10,685 | Pat Dobson | Dick Bosman | Pat Dobson | Dick Bosman | | 397 | 283 | 114 |
| 1971-07-08 | vs WS2 | 83 | W 7-3 | 52-31 | 1 | 8,093 | Mike Cuellar | Jackie Brown | Mike Cuellar | Jackie Brown | | 404 | 286 | 118 |
| 1971-07-09 | vs CLE | 84 | W 4-1 | 53-31 | 1 | 34,374 | Jim Palmer | Steve Dunning | Jim Palmer | Steve Dunning | | 408 | 287 | 121 |
| 1971-07-10 | vs CLE | 85 | W 11-3 | 54-32 | 1 | 0 | Grant Jackson | Sam McDowell | Dave Leonhard | Sam McDowell | | 419 | 290 | 129 |
| 1971-07-10 | vs CLE | 86 | L 2-3 | 54-32 | 1 | 21,464 | Dave Boswell | Mike Paul | Mike Paul | Dave Boswell | Phil Hennigan | 421 | 293 | 128 |
| 1971-07-11 | vs CLE | 87 | W 7-1 | 55-32 | 1 | 16,071 | Pat Dobson | Ed Farmer | Pat Dobson | Steve Hargan | | 428 | 294 | 134 |
| 1971-07-15 | @ CAL | 88 | W 4-3 | 56-32 | 1 | 9,846 | Pat Dobson | Andy Messersmith | Pat Dobson | Andy Messersmith | | 432 | 297 | 135 |
| 1971-07-16 | @ CAL | 89 | L 4-5 | 56-33 | 1 | 25,047 | Mike Cuellar | Clyde Wright | Clyde Wright | Mike Cuellar | Lloyd Allen | 436 | 302 | 134 |
| 1971-07-17 | @ CAL | 90 | L 3-10 | 56-34 | 1 | 14,819 | Jim Palmer | Tom Murphy | Tom Murphy | Jim Palmer | Mel Queen | 439 | 312 | 127 |
| 1971-07-18 | @ OAK | 91 | W 7-3 | 57-34 | 1 | 18,140 | Grant Jackson | Blue Moon Odom | Grant Jackson | Blue Moon Odom | Pete Richert | 446 | 315 | 131 |
| 1971-07-19 | @ OAK | 92 | W 4-2 | 58-34 | 1 | 7,685 | Pat Dobson | Diego Segui | Pat Dobson | Diego Segui | | 450 | 317 | 133 |
| 1971-07-20 | @ KCA | 93 | L 1-7 | 58-35 | 1 | 13,165 | Mike Cuellar | Dick Drago | Dick Drago | Mike Cuellar | | 451 | 324 | 127 |
| 1971-07-21 | @ KCA | 94 | L 2-7 | 58-36 | 1 | 13,239 | Jim Palmer | Al Fitzmorris | Al Fitzmorris | Jim Palmer | Tom Burgmeier | 453 | 331 | 122 |
| 1971-07-22 | @ KCA | 95 | W 4-0 | 59-36 | 1 | 15,615 | Dave Leonhard | Mike Hedlund | Dave Leonhard | Mike Hedlund | | 457 | 331 | 126 |
| 1971-07-23 | vs CAL | 96 | W 4-3 | 60-36 | 1 | 14,957 | Pat Dobson | Rudy May | Pat Dobson | Rudy May | | 461 | 334 | 127 |
| 1971-07-25 | vs CAL | 97 | L 2-6 | 60-38 | 1 | 0 | Mike Cuellar | Andy Messersmith | Andy Messersmith | Mike Cuellar | | 463 | 340 | 123 |
| 1971-07-25 | vs CAL | 98 | L 6-9 | 60-38 | 1 | 19,096 | Jim Palmer | Rickey Clark | Lloyd Allen | Orlando Pena | | 469 | 349 | 120 |
| 1971-07-27 | vs OAK | 99 | W 1-0 | 62-38 | 1 | 0 | Pat Dobson | Catfish Hunter | Pat Dobson | Catfish Hunter | | 470 | 349 | 121 |
| 1971-07-27 | vs OAK | 100 | W 6-4 | 62-38 | 1 | 20,465 | Grant Jackson | Diego Segui | Dick Hall | Rollie Fingers | | 476 | 353 | 123 |
| 1971-07-28 | vs OAK | 101 | W 3-2 | 63-38 | 1 | 22,169 | Mike Cuellar | Blue Moon Odom | Tom Dukes | Rollie Fingers | | 479 | 355 | 124 |
| 1971-07-30 | vs KCA | 102 | W 1-0 | 64-38 | 1 | 6,828 | Jim Palmer | Dick Drago | Jim Palmer | Dick Drago | | 480 | 355 | 125 |
| 1971-07-31 | vs KCA | 103 | W 4-0 | 65-38 | 1 | 13,222 | Pat Dobson | Bruce Dal Canton | Pat Dobson | Bruce Dal Canton | | 484 | 355 | 129 |
| 1971-08-02 | vs BOS | 104 | L 4-7 | 65-39 | 1 | 11,709 | Dave Leonhard | Luis Tiant | Bill Lee | Tom Dukes | | 488 | 362 | 126 |
| 1971-08-04 | vs BOS | 105 | W 5-4 | 66-39 | 1 | 26,849 | Jim Palmer | Jim Lonborg | Pete Richert | Ken Tatum | | 493 | 366 | 127 |
| 1971-08-05 | @ NYA | 106 | L 0-5 | 66-40 | 1 | 18,509 | Mike Cuellar | Mel Stottlemyre | Mel Stottlemyre | Mike Cuellar | | 493 | 371 | 122 |
| 1971-08-06 | @ NYA | 107 | L 3-12 | 66-41 | 1 | 24,681 | Pat Dobson | Fritz Peterson | Fritz Peterson | Pat Dobson | | 496 | 383 | 113 |
| 1971-08-07 | @ NYA | 108 | W 3-1 | 67-41 | 1 | 21,813 | Jim Palmer | Mike Kekich | Jim Palmer | Mike Kekich | | 499 | 384 | 115 |
| 1971-08-08 | @ NYA | 109 | L 1-2 | 67-42 | 1 | 26,319 | Grant Jackson | Steve Kline | Steve Kline | Grant Jackson | | 500 | 386 | 114 |
| 1971-08-10 | @ MIN | 110 | W 4-3 | 68-42 | 1 | 15,881 | Mike Cuellar | Tom Hall | Mike Cuellar | Ray Corbin | | 504 | 389 | 115 |
| 1971-08-11 | @ MIN | 111 | W 9-6 | 69-42 | 1 | 17,028 | Pat Dobson | Jim Perry | Dick Hall | Bob Gebhard | | 513 | 395 | 118 |
| 1971-08-12 | @ MIN | 112 | W 8-2 | 70-42 | 1 | 17,745 | Jim Palmer | Jim Kaat | Jim Palmer | Jim Kaat | | 521 | 397 | 124 |
| 1971-08-13 | @ CHA | 113 | W 12-1 | 71-42 | 1 | 28,977 | Dave McNally | Tommy John | Dave McNally | Tommy John | Dave Leonhard | 533 | 398 | 135 |
| 1971-08-14 | @ CHA | 114 | L 0-2 | 71-43 | 1 | 10,148 | Mike Cuellar | Tom Bradley | Tom Bradley | Mike Cuellar | Bart Johnson | 533 | 400 | 133 |
| 1971-08-15 | @ CHA | 115 | L 1-2 | 71-44 | 1 | 18,246 | Pat Dobson | Wilbur Wood | Wilbur Wood | Pat Dobson | | 534 | 402 | 132 |
| 1971-08-16 | @ MIL | 116 | W 3-2 | 72-44 | 1 | 8,346 | Jim Palmer | Skip Lockwood | Jim Palmer | Skip Lockwood | | 537 | 404 | 133 |
| 1971-08-17 | @ MIL | 117 | W 3-2 | 73-44 | 1 | 10,079 | Dave McNally | Marty Pattin | Eddie Watt | Ken Sanders | | 540 | 406 | 134 |
| 1971-08-18 | @ MIL | 118 | W 6-4 | 74-44 | 1 | 11,628 | Mike Cuellar | Jim Slaton | Mike Cuellar | Jim Slaton | | 546 | 410 | 136 |
| 1971-08-20 | vs MIN | 119 | L 5-8 | 74-45 | 1 | 29,616 | Pat Dobson | Jim Perry | Jim Perry | Dick Hall | Stan Williams | 551 | 418 | 133 |
| 1971-08-21 | vs MIN | 120 | W 4-1 | 75-45 | 1 | 22,107 | Jim Palmer | Jim Kaat | Jim Palmer | Jim Kaat | | 555 | 419 | 136 |
| 1971-08-22 | vs MIN | 121 | W 6-3 | 76-45 | 1 | 20,632 | Dave McNally | Bert Blyleven | Dave McNally | Bert Blyleven | Eddie Watt | 561 | 422 | 139 |
| 1971-08-24 | vs CHA | 122 | W 1-0 | 77-45 | 1 | 13,164 | Mike Cuellar | Tom Bradley | Mike Cuellar | Tom Bradley | | 562 | 422 | 140 |
| 1971-08-25 | vs CHA | 123 | W 6-3 | 78-45 | 1 | 13,797 | Pat Dobson | Wilbur Wood | Pat Dobson | Wilbur Wood | | 568 | 425 | 143 |
| 1971-08-26 | vs CHA | 124 | W 8-7 | 79-45 | 1 | 13,600 | Jim Palmer | Joe Horlen | Dick Hall | Bart Johnson | | 576 | 432 | 144 |
| 1971-08-28 | vs MIL | 125 | W 9-4 | 80-46 | 1 | 0 | Dave McNally | Marty Pattin | Dave McNally | Marty Pattin | Eddie Watt | 585 | 436 | 149 |
| 1971-08-28 | vs MIL | 126 | L 0-3 | 80-46 | 1 | 16,996 | Mike Cuellar | Lew Krausse | Lew Krausse | Mike Cuellar | Ken Sanders | 585 | 439 | 146 |
| 1971-08-29 | vs MIL | 127 | W 3-2 | 81-47 | 1 | 0 | Pat Dobson | Bill Parsons | Pat Dobson | John Morris | | 588 | 441 | 147 |
| 1971-08-29 | vs MIL | 128 | L 1-4 | 81-47 | 1 | 18,877 | Dave Leonhard | Jim Slaton | Jim Slaton | Dave Leonhard | Ken Sanders | 589 | 445 | 144 |
| 1971-08-31 | @ BOS | 129 | L 3-4 | 81-48 | 1 | 26,040 | Jim Palmer | Gary Peters | Luis Tiant | Jim Palmer | | 592 | 449 | 143 |
| 1971-09-01 | @ BOS | 130 | W 8-2 | 82-48 | 1 | 23,676 | Mike Cuellar | Ray Culp | Mike Cuellar | Ray Culp | | 600 | 451 | 149 |
| 1971-09-02 | @ BOS | 131 | L 0-3 | 82-49 | 1 | 19,676 | Pat Dobson | Sonny Siebert | Sonny Siebert | Pat Dobson | | 600 | 454 | 146 |
| 1971-09-03 | @ WS2 | 132 | W 4-2 | 83-49 | 1 | 7,761 | Dave McNally | Pete Broberg | Dave McNally | Pete Broberg | Eddie Watt | 604 | 456 | 148 |
| 1971-09-04 | @ WS2 | 133 | W 6-2 | 84-49 | 1 | 7,909 | Jim Palmer | Denny McLain | Jim Palmer | Denny McLain | | 610 | 458 | 152 |
| 1971-09-05 | @ WS2 | 134 | L 3-5 | 84-50 | 1 | 9,623 | Mike Cuellar | Dick Bosman | Dick Bosman | Mike Cuellar | | 613 | 463 | 150 |
| 1971-09-06 | vs CLE | 135 | W 10-5 | 85-51 | 1 | 0 | Pat Dobson | Mike Paul | Eddie Watt | Mark Ballinger | | 623 | 468 | 155 |
| 1971-09-06 | vs CLE | 136 | L 0-1 | 85-51 | 1 | 16,088 | Dave Leonhard | Vince Colbert | Vince Colbert | Dave Leonhard | Steve Dunning | 623 | 469 | 154 |
| 1971-09-07 | vs CLE | 137 | W 3-1 | 86-51 | 1 | 7,196 | Dave McNally | Sam McDowell | Dave McNally | Sam McDowell | | 626 | 470 | 156 |
| 1971-09-09 | vs WS2 | 138 | W 4-2 | 87-51 | 1 | 5,601 | Jim Palmer | Denny McLain | Jim Palmer | Denny McLain | | 630 | 472 | 158 |
| 1971-09-10 | vs WS2 | 139 | W 7-1 | 88-51 | 1 | 13,443 | Mike Cuellar | Dick Bosman | Mike Cuellar | Dick Bosman | | 637 | 473 | 164 |
| 1971-09-13 | vs DET | 140 | W 9-1 | 89-52 | 1 | 0 | Dave McNally | Mike Kilkenny | Dave McNally | Mike Kilkenny | | 646 | 474 | 172 |
| 1971-09-13 | vs DET | 141 | L 5-10 | 89-52 | 1 | 13,292 | Pat Dobson | Joe Niekro | Fred Scherman | Pat Dobson | | 651 | 484 | 167 |
| 1971-09-14 | vs DET | 142 | L 1-6 | 89-53 | 1 | 11,605 | Jim Palmer | Mickey Lolich | Mickey Lolich | Jim Palmer | | 652 | 490 | 162 |
| 1971-09-15 | vs NYA | 143 | L 2-4 | 89-54 | 1 | 9,921 | Mike Cuellar | Steve Kline | Steve Kline | Mike Cuellar | | 654 | 494 | 160 |
| 1971-09-16 | vs NYA | 144 | W 6-2 | 90-54 | 1 | 11,602 | Pat Dobson | Mike Kekich | Pat Dobson | Mike Kekich | | 660 | 496 | 164 |
| 1971-09-17 | @ DET | 145 | L 4-9 | 90-56 | 1 | 0 | Dave McNally | Tom Timmermann | Tom Timmermann | Dave McNally | Ron Perranoski | 664 | 505 | 159 |
| 1971-09-17 | @ DET | 146 | L 3-5 | 90-56 | 1 | 29,458 | Dave Leonhard | Fred Scherman | Fred Scherman | Dave Leonhard | | 667 | 510 | 157 |
| 1971-09-18 | @ DET | 147 | L 1-2 | 90-57 | 1 | 17,237 | Jim Palmer | Mickey Lolich | Mickey Lolich | Jim Palmer | | 668 | 512 | 156 |
| 1971-09-19 | @ DET | 148 | W 8-1 | 91-57 | 1 | 26,099 | Mike Cuellar | Joe Coleman | Mike Cuellar | Joe Coleman | | 676 | 513 | 163 |
| 1971-09-20 | @ NYA | 149 | W 8-4 | 92-57 | 1 | 7,120 | Pat Dobson | Mike Kekich | Pat Dobson | Jack Aker | Eddie Watt | 684 | 517 | 167 |
| 1971-09-21 | @ NYA | 150 | W 5-0 | 93-57 | 1 | 8,136 | Dave McNally | Fritz Peterson | Dave McNally | Fritz Peterson | | 689 | 517 | 172 |
| 1971-09-22 | @ NYA | 151 | W 10-1 | 94-57 | 1 | 8,845 | Jim Palmer | Stan Bahnsen | Jim Palmer | Stan Bahnsen | | 699 | 518 | 181 |
| 1971-09-24 | @ CLE | 152 | W 9-2 | 96-57 | 1 | 0 | Mike Cuellar | Sam McDowell | Mike Cuellar | Sam McDowell | | 708 | 520 | 188 |
| 1971-09-24 | @ CLE | 153 | W 7-0 | 96-57 | 1 | 3,511 | Pat Dobson | Mike Paul | Pat Dobson | Mike Paul | | 715 | 520 | 195 |
| 1971-09-25 | @ CLE | 154 | W 6-4 | 97-57 | 1 | 3,307 | Dave Leonhard | Steve Dunning | Pete Richert | Mark Ballinger | Eddie Watt | 721 | 524 | 197 |
| 1971-09-26 | @ CLE | 155 | W 5-0 | 98-57 | 1 | 2,967 | Jim Palmer | Alan Foster | Jim Palmer | Alan Foster | | 726 | 524 | 202 |
| 1971-09-28 | vs BOS | 156 | W 10-2 | 100-57 | 1 | 0 | Dave McNally | Ray Culp | Dave McNally | Ray Culp | Pat Dobson | 736 | 526 | 210 |
| 1971-09-28 | vs BOS | 157 | W 5-4 | 100-57 | 1 | 18,195 | Mike Cuellar | Gary Peters | Pete Richert | Gary Peters | | 741 | 530 | 211 |
| 1971-09-29 | vs BOS | 158 | W 1-0 | 101-57 | 1 | 21,028 | Grant Jackson | Mike Garman | Grant Jackson | Mike Garman | Eddie Watt | 742 | 530 | 212 |