| 1971-04-06 | vs KCA | 1 | L 1-4 | 0-1 | 6 | 24,434 | Clyde Wright | Dick Drago | Dick Drago | Clyde Wright | | 1 | 4 | -3 |
| 1971-04-07 | vs KCA | 2 | W 7-3 | 1-1 | 5 | 8,042 | Tom Murphy | Wally Bunker | Tom Murphy | Wally Bunker | | 8 | 7 | 1 |
| 1971-04-08 | vs KCA | 3 | L 2-3 | 1-2 | 5 | 8,754 | Andy Messersmith | Mike Hedlund | Mike Hedlund | Andy Messersmith | Jim York | 10 | 10 | 0 |
| 1971-04-10 | @ MIL | 4 | L 3-4 | 1-3 | 6 | 40,566 | Clyde Wright | Skip Lockwood | Marcelino Lopez | Clyde Wright | | 13 | 14 | -1 |
| 1971-04-11 | @ MIL | 5 | L 0-3 | 1-4 | 6 | 8,720 | Tom Murphy | Marty Pattin | Marty Pattin | Tom Murphy | | 13 | 17 | -4 |
| 1971-04-12 | @ CHA | 6 | W 3-2 | 2-4 | 6 | 8,356 | Rudy May | Wilbur Wood | Eddie Fisher | Wilbur Wood | Mel Queen | 16 | 19 | -3 |
| 1971-04-13 | @ CHA | 7 | W 3-1 | 3-4 | 6 | 2,693 | Andy Messersmith | Tom Bradley | Dave LaRoche | Vicente Romo | | 19 | 20 | -1 |
| 1971-04-14 | @ KCA | 8 | W 4-1 | 4-4 | 4 | 6,885 | Clyde Wright | Jim Rooker | Clyde Wright | Jim Rooker | Mel Queen | 23 | 21 | 2 |
| 1971-04-15 | @ KCA | 9 | W 5-2 | 5-4 | 3 | 7,510 | Tom Murphy | Bruce Dal Canton | Eddie Fisher | Jim York | Lloyd Allen | 28 | 23 | 5 |
| 1971-04-16 | @ MIN | 10 | W 4-1 | 6-4 | 3 | 4,429 | Rudy May | Jim Perry | Rudy May | Jim Perry | Dave LaRoche | 32 | 24 | 8 |
| 1971-04-17 | @ MIN | 11 | W 4-3 | 7-4 | 1 | 12,968 | Andy Messersmith | Bert Blyleven | Andy Messersmith | Bert Blyleven | | 36 | 27 | 9 |
| 1971-04-18 | @ MIN | 12 | W 5-4 | 8-4 | 1 | 6,566 | Clyde Wright | Tom Hall | Clyde Wright | Tom Hall | Mel Queen | 41 | 31 | 10 |
| 1971-04-20 | vs OAK | 13 | L 0-4 | 8-5 | 2 | 8,088 | Tom Murphy | Catfish Hunter | Catfish Hunter | Tom Murphy | | 41 | 35 | 6 |
| 1971-04-21 | vs OAK | 14 | L 2-4 | 8-6 | 2 | 6,432 | Rudy May | Rollie Fingers | Ron Klimkowski | Eddie Fisher | | 43 | 39 | 4 |
| 1971-04-22 | vs OAK | 15 | L 3-7 | 8-7 | 2 | 7,186 | Andy Messersmith | Vida Blue | Vida Blue | Andy Messersmith | | 46 | 46 | 0 |
| 1971-04-23 | vs BAL | 16 | L 2-8 | 8-8 | 3 | 13,644 | Clyde Wright | Dave McNally | Dave McNally | Clyde Wright | | 48 | 54 | -6 |
| 1971-04-24 | vs BAL | 17 | W 7-4 | 9-8 | 2 | 12,590 | Tom Murphy | Mike Cuellar | Lloyd Allen | Dick Hall | | 55 | 58 | -3 |
| 1971-04-25 | vs BAL | 18 | L 1-7 | 9-9 | 3 | 28,328 | Jim Maloney | Jim Palmer | Jim Palmer | Jim Maloney | | 56 | 65 | -9 |
| 1971-04-26 | vs CLE | 19 | W 8-0 | 10-9 | 2 | 5,153 | Rudy May | Steve Dunning | Rudy May | Steve Dunning | | 64 | 65 | -1 |
| 1971-04-27 | vs CLE | 20 | W 2-1 | 11-9 | 2 | 6,692 | Andy Messersmith | Ray Lamb | Lloyd Allen | Camilo Pascual | | 66 | 66 | 0 |
| 1971-04-28 | vs CLE | 21 | L 2-3 | 11-10 | 2 | 6,096 | Clyde Wright | Sam McDowell | Camilo Pascual | Mel Queen | Steve Mingori | 68 | 69 | -1 |
| 1971-04-29 | vs CLE | 22 | W 8-4 | 12-10 | 2 | 6,205 | Tom Murphy | Alan Foster | Eddie Fisher | Alan Foster | | 76 | 73 | 3 |
| 1971-04-30 | vs DET | 23 | L 4-7 | 12-11 | 2 | 42,651 | Rudy May | Joe Coleman | Joe Coleman | Rudy May | Bill Zepp | 80 | 80 | 0 |
| 1971-05-01 | vs DET | 24 | W 9-1 | 13-11 | 2 | 12,838 | Andy Messersmith | Dean Chance | Andy Messersmith | Dean Chance | | 89 | 81 | 8 |
| 1971-05-02 | vs DET | 25 | W 4-3 | 14-11 | 2 | 11,815 | Clyde Wright | Mickey Lolich | Eddie Fisher | Bill Zepp | Lloyd Allen | 93 | 84 | 9 |
| 1971-05-04 | @ BAL | 26 | L 1-4 | 14-12 | 2 | 6,415 | Tom Murphy | Jim Palmer | Jim Palmer | Tom Murphy | | 94 | 88 | 6 |
| 1971-05-06 | @ BAL | 27 | L 1-3 | 14-14 | 3 | 0 | Andy Messersmith | Dave McNally | Dave McNally | Andy Messersmith | | 95 | 91 | 4 |
| 1971-05-06 | @ BAL | 28 | L 1-3 | 14-14 | 3 | 5,786 | Jim Maloney | Pat Dobson | Pat Dobson | Lloyd Allen | | 96 | 94 | 2 |
| 1971-05-07 | @ CLE | 29 | W 4-2 | 15-14 | 3 | 4,602 | Clyde Wright | Sam McDowell | Mel Queen | Chuck Machemehl | Eddie Fisher | 100 | 96 | 4 |
| 1971-05-08 | @ CLE | 30 | W 5-2 | 16-14 | 2 | 4,295 | Rudy May | Ray Lamb | Rudy May | Rich Hand | Dave LaRoche | 105 | 98 | 7 |
| 1971-05-09 | @ CLE | 31 | L 1-4 | 16-15 | 3 | 4,288 | Tom Murphy | Alan Foster | Alan Foster | Tom Murphy | | 106 | 102 | 4 |
| 1971-05-10 | @ DET | 32 | L 2-5 | 16-16 | 4 | 15,215 | Andy Messersmith | Dean Chance | Fred Scherman | Andy Messersmith | Tom Timmermann | 108 | 107 | 1 |
| 1971-05-11 | @ DET | 33 | W 5-0 | 17-16 | 3 | 8,275 | Clyde Wright | Mickey Lolich | Clyde Wright | Mickey Lolich | | 113 | 107 | 6 |
| 1971-05-12 | @ DET | 34 | L 1-8 | 17-17 | 4 | 7,908 | Rudy May | Joe Coleman | Joe Coleman | Rudy May | | 114 | 115 | -1 |
| 1971-05-14 | vs MIL | 35 | L 1-4 | 17-18 | 3 | 27,420 | Tom Murphy | Bill Parsons | Bill Parsons | Tom Murphy | Ken Sanders | 115 | 119 | -4 |
| 1971-05-15 | vs MIL | 36 | W 4-1 | 18-18 | 3 | 24,969 | Andy Messersmith | Lew Krausse | Andy Messersmith | Lew Krausse | | 119 | 120 | -1 |
| 1971-05-16 | vs MIL | 37 | L 2-6 | 18-19 | 4 | 8,951 | Lloyd Allen | Skip Lockwood | Skip Lockwood | Archie Reynolds | Ken Sanders | 121 | 126 | -5 |
| 1971-05-17 | vs MIN | 38 | L 2-3 | 18-20 | 4 | 6,903 | Rudy May | Bert Blyleven | Bert Blyleven | Rudy May | Tom Hall | 123 | 129 | -6 |
| 1971-05-18 | vs MIN | 39 | W 3-1 | 19-20 | 3 | 7,095 | Tom Murphy | Jim Kaat | Tom Murphy | Jim Kaat | | 126 | 130 | -4 |
| 1971-05-19 | vs MIN | 40 | L 6-12 | 19-21 | 4 | 9,319 | Andy Messersmith | Jim Perry | Jim Strickland | Andy Messersmith | Tom Hall | 132 | 142 | -10 |
| 1971-05-20 | vs MIN | 41 | W 1-0 | 20-21 | 4 | 7,525 | Clyde Wright | Pete Hamm | Clyde Wright | Ray Corbin | | 133 | 142 | -9 |
| 1971-05-21 | vs CHA | 42 | L 0-3 | 20-22 | 4 | 10,018 | Rudy May | Tom Bradley | Tom Bradley | Rudy May | | 133 | 145 | -12 |
| 1971-05-22 | vs CHA | 43 | L 0-13 | 20-23 | 4 | 11,279 | Tom Murphy | Wilbur Wood | Wilbur Wood | Tom Murphy | | 133 | 158 | -25 |
| 1971-05-23 | vs CHA | 44 | W 10-5 | 21-23 | 3 | 10,252 | Andy Messersmith | Bart Johnson | Andy Messersmith | Bart Johnson | Eddie Fisher | 143 | 163 | -20 |
| 1971-05-25 | @ OAK | 45 | L 5-7 | 21-24 | 4 | 2,868 | Clyde Wright | Chuck Dobson | Bob Locker | Eddie Fisher | | 148 | 170 | -22 |
| 1971-05-26 | @ OAK | 46 | W 7-5 | 22-24 | 3 | 4,354 | Tom Murphy | Catfish Hunter | Dave LaRoche | Ron Klimkowski | | 155 | 175 | -20 |
| 1971-05-28 | @ NYA | 47 | W 9-6 | 23-24 | 3 | 9,508 | Andy Messersmith | Steve Kline | Andy Messersmith | Steve Kline | Dave LaRoche | 164 | 181 | -17 |
| 1971-05-29 | @ NYA | 48 | L 1-6 | 23-25 | 4 | 8,894 | Clyde Wright | Stan Bahnsen | Stan Bahnsen | Clyde Wright | | 165 | 187 | -22 |
| 1971-05-30 | @ NYA | 49 | L 4-7 | 23-26 | 4 | 8,105 | Andy Hassler | Mel Stottlemyre | Mel Stottlemyre | Archie Reynolds | | 169 | 194 | -25 |
| 1971-05-31 | @ WS2 | 50 | L 0-4 | 23-27 | 4 | 13,289 | Tom Murphy | Mike Thompson | Denny Riddleberger | Tom Murphy | Casey Cox | 169 | 198 | -29 |
| 1971-06-01 | @ WS2 | 51 | L 5-6 | 23-28 | 4 | 3,675 | Jim Maloney | Dick Bosman | Dick Bosman | Jim Maloney | Paul Lindblad | 174 | 204 | -30 |
| 1971-06-02 | @ WS2 | 52 | W 2-1 | 24-28 | 4 | 3,606 | Clyde Wright | Denny McLain | Clyde Wright | Denny McLain | | 176 | 205 | -29 |
| 1971-06-04 | @ BOS | 53 | L 1-10 | 24-29 | 4 | 31,375 | Andy Messersmith | Gary Peters | Gary Peters | Andy Messersmith | | 177 | 215 | -38 |
| 1971-06-05 | @ BOS | 54 | W 3-2 | 25-29 | 4 | 25,764 | Tom Murphy | Jim Lonborg | Tom Murphy | Jim Lonborg | | 180 | 217 | -37 |
| 1971-06-06 | @ BOS | 55 | W 5-2 | 26-29 | 4 | 28,853 | Clyde Wright | Sonny Siebert | Clyde Wright | Sonny Siebert | Dave LaRoche | 185 | 219 | -34 |
| 1971-06-08 | vs NYA | 56 | L 0-3 | 26-30 | 4 | 9,783 | Andy Hassler | Mel Stottlemyre | Mel Stottlemyre | Andy Hassler | | 185 | 222 | -37 |
| 1971-06-09 | vs NYA | 57 | W 4-3 | 27-30 | 4 | 7,802 | Andy Messersmith | Fritz Peterson | Dave LaRoche | Jim Hardin | | 189 | 225 | -36 |
| 1971-06-10 | vs NYA | 58 | L 2-3 | 27-31 | 4 | 8,557 | Tom Murphy | Stan Bahnsen | Stan Bahnsen | Tom Murphy | | 191 | 228 | -37 |
| 1971-06-11 | vs WS2 | 59 | W 4-2 | 28-31 | 3 | 8,445 | Clyde Wright | Denny McLain | Clyde Wright | Denny McLain | Dave LaRoche | 195 | 230 | -35 |
| 1971-06-12 | vs WS2 | 60 | L 2-3 | 28-32 | 4 | 12,836 | Andy Hassler | Dick Bosman | Dick Bosman | Andy Hassler | Paul Lindblad | 197 | 233 | -36 |
| 1971-06-13 | vs WS2 | 61 | L 2-5 | 28-33 | 4 | 20,051 | Jim Maloney | Jackie Brown | Casey Cox | Jim Maloney | | 199 | 238 | -39 |
| 1971-06-14 | vs BOS | 62 | L 3-4 | 28-34 | 4 | 8,410 | Andy Messersmith | Ray Culp | Sparky Lyle | Eddie Fisher | | 202 | 242 | -40 |
| 1971-06-15 | vs BOS | 63 | W 5-4 | 29-34 | 4 | 12,489 | Tom Murphy | Gary Peters | Eddie Fisher | Sparky Lyle | | 207 | 246 | -39 |
| 1971-06-16 | vs BOS | 64 | L 1-4 | 29-35 | 4 | 10,801 | Clyde Wright | Jim Lonborg | Jim Lonborg | Clyde Wright | | 208 | 250 | -42 |
| 1971-06-17 | @ KCA | 65 | L 0-5 | 29-36 | 4 | 10,509 | Rudy May | Dick Drago | Dick Drago | Rudy May | | 208 | 255 | -47 |
| 1971-06-18 | @ KCA | 66 | L 1-6 | 29-37 | 4 | 14,657 | Andy Hassler | Paul Splittorff | Paul Splittorff | Andy Hassler | | 209 | 261 | -52 |
| 1971-06-19 | @ KCA | 67 | W 7-4 | 30-37 | 4 | 9,800 | Andy Messersmith | Mike Hedlund | Andy Messersmith | Jim York | Dave LaRoche | 216 | 265 | -49 |
| 1971-06-20 | @ KCA | 68 | L 1-5 | 31-38 | 4 | 0 | Clyde Wright | Bruce Dal Canton | Bruce Dal Canton | Clyde Wright | Ted Abernathy | 217 | 270 | -53 |
| 1971-06-20 | @ KCA | 69 | W 8-4 | 31-38 | 4 | 35,295 | Tom Murphy | Al Fitzmorris | Tom Murphy | Al Fitzmorris | Lloyd Allen | 225 | 274 | -49 |
| 1971-06-21 | @ MIL | 70 | L 2-3 | 31-39 | 4 | 5,498 | Rudy May | Marty Pattin | Ken Sanders | Dave LaRoche | | 227 | 277 | -50 |
| 1971-06-23 | @ MIL | 71 | L 0-6 | 32-40 | 4 | 0 | Andy Messersmith | Bill Parsons | Bill Parsons | Andy Messersmith | | 227 | 283 | -56 |
| 1971-06-23 | @ MIL | 72 | W 9-5 | 32-40 | 4 | 12,317 | Eddie Fisher | Lew Krausse | Eddie Fisher | Lew Krausse | Lloyd Allen | 236 | 288 | -52 |
| 1971-06-24 | @ MIL | 73 | L 0-6 | 32-41 | 4 | 9,673 | Clyde Wright | Jim Slaton | Jim Slaton | Clyde Wright | | 236 | 294 | -58 |
| 1971-06-25 | @ CHA | 74 | L 0-2 | 32-42 | 4 | 15,513 | Tom Murphy | Tommy John | Tommy John | Tom Murphy | Bart Johnson | 236 | 296 | -60 |
| 1971-06-26 | @ CHA | 75 | L 3-4 | 32-43 | 4 | 8,001 | Rudy May | Tom Bradley | Terry Forster | Eddie Fisher | | 239 | 300 | -61 |
| 1971-06-27 | @ CHA | 76 | W 2-1 | 34-43 | 4 | 0 | Andy Messersmith | Wilbur Wood | Andy Messersmith | Wilbur Wood | Dave LaRoche | 241 | 301 | -60 |
| 1971-06-27 | @ CHA | 77 | W 12-3 | 34-43 | 4 | 23,190 | Rickey Clark | Joe Horlen | Rickey Clark | Joe Horlen | Eddie Fisher | 253 | 304 | -51 |
| 1971-06-28 | vs KCA | 78 | L 0-3 | 34-44 | 4 | 8,920 | Archie Reynolds | Paul Splittorff | Paul Splittorff | Archie Reynolds | | 253 | 307 | -54 |
| 1971-06-29 | vs KCA | 79 | L 1-2 | 34-45 | 5 | 8,297 | Tom Murphy | Mike Hedlund | Mike Hedlund | Tom Murphy | | 254 | 309 | -55 |
| 1971-06-30 | vs KCA | 80 | W 4-3 | 35-45 | 4 | 20,635 | Rudy May | Bruce Dal Canton | Lloyd Allen | Ted Abernathy | | 258 | 312 | -54 |
| 1971-07-01 | vs KCA | 81 | L 4-9 | 35-46 | 4 | 6,657 | Andy Messersmith | Dick Drago | Dick Drago | Andy Messersmith | | 262 | 321 | -59 |
| 1971-07-02 | vs OAK | 82 | W 1-0 | 36-46 | 4 | 8,488 | Rickey Clark | Blue Moon Odom | Rickey Clark | Blue Moon Odom | | 263 | 321 | -58 |
| 1971-07-03 | vs OAK | 83 | L 3-5 | 36-47 | 5 | 13,154 | Clyde Wright | Chuck Dobson | Chuck Dobson | Clyde Wright | Darold Knowles | 266 | 326 | -60 |
| 1971-07-04 | vs OAK | 84 | L 1-2 | 36-48 | 6 | 44,631 | Tom Murphy | Vida Blue | Vida Blue | Tom Murphy | | 267 | 328 | -61 |
| 1971-07-05 | vs OAK | 85 | W 2-1 | 37-48 | 6 | 8,456 | Rudy May | Catfish Hunter | Rudy May | Catfish Hunter | Lloyd Allen | 269 | 329 | -60 |
| 1971-07-06 | @ MIN | 86 | W 7-5 | 38-48 | 4 | 26,687 | Andy Messersmith | Bert Blyleven | Dave LaRoche | Ray Corbin | Lloyd Allen | 276 | 334 | -58 |
| 1971-07-07 | @ MIN | 87 | W 3-1 | 39-48 | 4 | 8,173 | Rickey Clark | Jim Kaat | Eddie Fisher | Jim Kaat | | 279 | 335 | -56 |
| 1971-07-08 | @ MIN | 88 | W 7-4 | 40-48 | 4 | 21,741 | Tom Murphy | Steve Luebber | Tom Murphy | Steve Luebber | Lloyd Allen | 286 | 339 | -53 |
| 1971-07-09 | @ OAK | 89 | L 0-1 | 40-49 | 4 | 22,938 | Rudy May | Vida Blue | Darold Knowles | Mel Queen | | 286 | 340 | -54 |
| 1971-07-10 | @ OAK | 90 | W 3-0 | 41-49 | 4 | 19,364 | Andy Messersmith | Catfish Hunter | Andy Messersmith | Catfish Hunter | | 289 | 340 | -51 |
| 1971-07-11 | @ OAK | 91 | L 2-3 | 42-50 | 4 | 0 | Rickey Clark | Diego Segui | Diego Segui | Lloyd Allen | Rollie Fingers | 291 | 343 | -52 |
| 1971-07-11 | @ OAK | 92 | W 6-3 | 42-50 | 4 | 11,195 | Clyde Wright | Blue Moon Odom | Clyde Wright | Blue Moon Odom | Dave LaRoche | 297 | 346 | -49 |
| 1971-07-15 | vs BAL | 93 | L 3-4 | 42-51 | 4 | 9,846 | Andy Messersmith | Pat Dobson | Pat Dobson | Andy Messersmith | | 300 | 350 | -50 |
| 1971-07-16 | vs BAL | 94 | W 5-4 | 43-51 | 4 | 25,047 | Clyde Wright | Mike Cuellar | Clyde Wright | Mike Cuellar | Lloyd Allen | 305 | 354 | -49 |
| 1971-07-17 | vs BAL | 95 | W 10-3 | 44-51 | 4 | 14,819 | Tom Murphy | Jim Palmer | Tom Murphy | Jim Palmer | Mel Queen | 315 | 357 | -42 |
| 1971-07-18 | vs CLE | 96 | W 3-1 | 45-51 | 3 | 10,607 | Rudy May | Alan Foster | Rudy May | Alan Foster | | 318 | 358 | -40 |
| 1971-07-19 | vs CLE | 97 | L 1-3 | 45-52 | 3 | 8,100 | Rickey Clark | Sam McDowell | Sam McDowell | Rickey Clark | | 319 | 361 | -42 |
| 1971-07-20 | vs DET | 98 | W 2-0 | 46-52 | 3 | 10,669 | Andy Messersmith | Les Cain | Andy Messersmith | Les Cain | | 321 | 361 | -40 |
| 1971-07-21 | vs DET | 99 | L 3-6 | 47-53 | 3 | 0 | Clyde Wright | Joe Coleman | Joe Coleman | Clyde Wright | Fred Scherman | 324 | 367 | -43 |
| 1971-07-21 | vs DET | 100 | W 7-6 | 47-53 | 3 | 30,054 | Tom Murphy | Dean Chance | Eddie Fisher | Fred Scherman | | 331 | 373 | -42 |
| 1971-07-23 | @ BAL | 101 | L 3-4 | 47-54 | 3 | 14,957 | Rudy May | Pat Dobson | Pat Dobson | Rudy May | | 334 | 377 | -43 |
| 1971-07-25 | @ BAL | 102 | W 6-2 | 49-54 | 3 | 0 | Andy Messersmith | Mike Cuellar | Andy Messersmith | Mike Cuellar | | 340 | 379 | -39 |
| 1971-07-25 | @ BAL | 103 | W 9-6 | 49-54 | 3 | 19,096 | Rickey Clark | Jim Palmer | Lloyd Allen | Orlando Pena | | 349 | 385 | -36 |
| 1971-07-27 | @ CLE | 104 | L 3-4 | 49-55 | 3 | 8,016 | Clyde Wright | Sam McDowell | Sam McDowell | Clyde Wright | | 352 | 389 | -37 |
| 1971-07-28 | @ CLE | 105 | W 5-1 | 50-55 | 3 | 3,512 | Rudy May | Steve Hargan | Rudy May | Steve Hargan | | 357 | 390 | -33 |
| 1971-07-29 | @ CLE | 106 | W 7-2 | 51-55 | 3 | 3,272 | Tom Murphy | Mike Paul | Eddie Fisher | Mike Paul | | 364 | 392 | -28 |
| 1971-07-30 | @ DET | 107 | L 3-4 | 51-56 | 3 | 19,410 | Andy Messersmith | Joe Niekro | Fred Scherman | Andy Messersmith | Tom Timmermann | 367 | 396 | -29 |
| 1971-07-31 | @ DET | 108 | W 3-2 | 52-56 | 3 | 13,853 | Clyde Wright | Mickey Lolich | Clyde Wright | Mickey Lolich | Lloyd Allen | 370 | 398 | -28 |
| 1971-08-01 | @ DET | 109 | L 3-4 | 52-57 | 3 | 37,107 | Rickey Clark | Les Cain | Joe Niekro | Lloyd Allen | | 373 | 402 | -29 |
| 1971-08-02 | vs MIL | 110 | W 3-1 | 53-57 | 3 | 6,289 | Rudy May | Marty Pattin | Rudy May | Marty Pattin | | 376 | 403 | -27 |
| 1971-08-03 | vs MIL | 111 | L 0-2 | 53-58 | 3 | 7,875 | Tom Murphy | Lew Krausse | Lew Krausse | Tom Murphy | Ken Sanders | 376 | 405 | -29 |
| 1971-08-04 | vs CHA | 112 | L 3-10 | 53-59 | 3 | 8,443 | Andy Messersmith | Tommy John | Tommy John | Andy Messersmith | | 379 | 415 | -36 |
| 1971-08-05 | vs CHA | 113 | L 0-1 | 53-60 | 4 | 7,457 | Clyde Wright | Wilbur Wood | Wilbur Wood | Clyde Wright | | 379 | 416 | -37 |
| 1971-08-06 | vs MIN | 114 | W 2-0 | 54-60 | 4 | 30,140 | Andy Messersmith | Jim Perry | Andy Messersmith | Jim Perry | | 381 | 416 | -35 |
| 1971-08-07 | vs MIN | 115 | L 1-7 | 54-61 | 4 | 13,091 | Rudy May | Jim Kaat | Jim Kaat | Rudy May | | 382 | 423 | -41 |
| 1971-08-08 | vs MIN | 116 | L 1-2 | 54-62 | 4 | 7,567 | Tom Murphy | Bert Blyleven | Bert Blyleven | Tom Murphy | | 383 | 425 | -42 |
| 1971-08-10 | @ NYA | 117 | W 7-6 | 55-62 | 4 | 14,496 | Clyde Wright | Stan Bahnsen | Clyde Wright | Stan Bahnsen | Lloyd Allen | 390 | 431 | -41 |
| 1971-08-12 | @ NYA | 118 | L 0-3 | 55-64 | 4 | 0 | Rudy May | Fritz Peterson | Fritz Peterson | Rudy May | | 390 | 434 | -44 |
| 1971-08-12 | @ NYA | 119 | L 1-2 | 55-64 | 4 | 13,072 | Tom Murphy | Mike Kekich | Mike Kekich | Lloyd Allen | | 391 | 436 | -45 |
| 1971-08-13 | @ WS2 | 120 | L 0-4 | 55-65 | 4 | 4,928 | Andy Messersmith | Denny McLain | Denny McLain | Andy Messersmith | | 391 | 440 | -49 |
| 1971-08-14 | @ WS2 | 121 | L 0-2 | 55-66 | 4 | 4,011 | Clyde Wright | Mike Thompson | Mike Thompson | Clyde Wright | Paul Lindblad | 391 | 442 | -51 |
| 1971-08-15 | @ WS2 | 122 | W 4-3 | 56-66 | 4 | 6,895 | Eddie Fisher | Dick Bosman | Mel Queen | Paul Lindblad | Rickey Clark | 395 | 445 | -50 |
| 1971-08-16 | @ BOS | 123 | L 5-6 | 56-67 | 4 | 17,877 | Tom Murphy | Sonny Siebert | Sparky Lyle | Rudy May | | 400 | 451 | -51 |
| 1971-08-17 | @ BOS | 124 | W 4-3 | 57-67 | 4 | 19,953 | Andy Messersmith | Ken Tatum | Andy Messersmith | Ken Tatum | | 404 | 454 | -50 |
| 1971-08-18 | @ BOS | 125 | L 3-4 | 57-68 | 4 | 25,507 | Clyde Wright | Jim Lonborg | Jim Lonborg | Clyde Wright | Bobby Bolin | 407 | 458 | -51 |
| 1971-08-20 | vs NYA | 126 | W 6-0 | 58-68 | 4 | 8,655 | Rudy May | Steve Kline | Rudy May | Steve Kline | | 413 | 458 | -45 |
| 1971-08-21 | vs NYA | 127 | W 2-1 | 59-68 | 4 | 25,474 | Tom Murphy | Stan Bahnsen | Dave LaRoche | Al Closter | | 415 | 459 | -44 |
| 1971-08-22 | vs NYA | 128 | W 3-0 | 60-68 | 4 | 8,957 | Andy Messersmith | Fritz Peterson | Andy Messersmith | Fritz Peterson | | 418 | 459 | -41 |
| 1971-08-24 | vs WS2 | 129 | W 2-1 | 61-68 | 4 | 9,004 | Clyde Wright | Pete Broberg | Clyde Wright | Pete Broberg | | 420 | 460 | -40 |
| 1971-08-25 | vs WS2 | 130 | L 4-5 | 61-69 | 4 | 7,114 | Rudy May | Denny McLain | Denny McLain | Lloyd Allen | Joe Grzenda | 424 | 465 | -41 |
| 1971-08-26 | vs WS2 | 131 | L 3-8 | 61-70 | 4 | 6,221 | Tom Murphy | Dick Bosman | Paul Lindblad | Eddie Fisher | Casey Cox | 427 | 473 | -46 |
| 1971-08-27 | vs BOS | 132 | W 1-0 | 62-70 | 4 | 7,897 | Andy Messersmith | Sonny Siebert | Andy Messersmith | Sonny Siebert | Lloyd Allen | 428 | 473 | -45 |
| 1971-08-28 | vs BOS | 133 | L 2-6 | 62-71 | 4 | 13,042 | Clyde Wright | Roger Moret | Roger Moret | Clyde Wright | | 430 | 479 | -49 |
| 1971-08-29 | vs BOS | 134 | W 2-1 | 63-71 | 4 | 6,539 | Rudy May | Jim Lonborg | Rudy May | Jim Lonborg | Lloyd Allen | 432 | 480 | -48 |
| 1971-08-31 | vs OAK | 135 | L 1-4 | 63-72 | 4 | 8,690 | Tom Murphy | Blue Moon Odom | Blue Moon Odom | Tom Murphy | Darold Knowles | 433 | 484 | -51 |
| 1971-09-01 | vs OAK | 136 | L 0-7 | 63-73 | 4 | 9,120 | Andy Messersmith | Chuck Dobson | Chuck Dobson | Andy Messersmith | | 433 | 491 | -58 |
| 1971-09-03 | @ MIL | 137 | W 6-2 | 64-73 | 4 | 6,175 | Clyde Wright | Jim Slaton | Clyde Wright | Jim Slaton | | 439 | 493 | -54 |
| 1971-09-04 | @ MIL | 138 | L 1-4 | 64-74 | 4 | 4,965 | Rudy May | Bill Parsons | Bill Parsons | Rudy May | | 440 | 497 | -57 |
| 1971-09-05 | @ MIL | 139 | L 4-6 | 64-75 | 5 | 10,697 | Tom Murphy | Skip Lockwood | Skip Lockwood | Eddie Fisher | Ken Sanders | 444 | 503 | -59 |
| 1971-09-06 | @ OAK | 140 | W 4-2 | 65-75 | 4 | 6,392 | Andy Messersmith | Chuck Dobson | Andy Messersmith | Chuck Dobson | | 448 | 505 | -57 |
| 1971-09-07 | @ OAK | 141 | W 6-1 | 66-75 | 4 | 6,878 | Clyde Wright | Vida Blue | Clyde Wright | Vida Blue | | 454 | 506 | -52 |
| 1971-09-08 | @ OAK | 142 | L 0-1 | 66-76 | 4 | 3,264 | Rudy May | Catfish Hunter | Catfish Hunter | Rudy May | | 454 | 507 | -53 |
| 1971-09-09 | vs MIL | 143 | W 3-2 | 67-76 | 4 | 6,098 | Tom Murphy | Bill Parsons | Eddie Fisher | Floyd Weaver | | 457 | 509 | -52 |
| 1971-09-10 | vs MIL | 144 | W 7-3 | 68-76 | 3 | 6,805 | Andy Messersmith | Skip Lockwood | Andy Messersmith | Skip Lockwood | | 464 | 512 | -48 |
| 1971-09-11 | vs MIL | 145 | L 0-3 | 68-77 | 3 | 6,673 | Clyde Wright | Lew Krausse | Lew Krausse | Clyde Wright | Ken Sanders | 464 | 515 | -51 |
| 1971-09-12 | vs MIL | 146 | L 3-4 | 68-78 | 4 | 5,072 | Eddie Fisher | Marty Pattin | Marty Pattin | Eddie Fisher | Ken Sanders | 467 | 519 | -52 |
| 1971-09-13 | vs MIN | 147 | W 3-2 | 69-79 | 4 | 0 | Rudy May | Pete Hamm | Rudy May | Pete Hamm | Lloyd Allen | 470 | 521 | -51 |
| 1971-09-13 | vs MIN | 148 | L 0-1 | 69-79 | 4 | 6,065 | Tom Murphy | Jim Kaat | Jim Kaat | Tom Murphy | | 470 | 522 | -52 |
| 1971-09-15 | @ KCA | 149 | W 6-2 | 70-79 | 4 | 5,370 | Andy Messersmith | Bruce Dal Canton | Andy Messersmith | Bruce Dal Canton | | 476 | 524 | -48 |
| 1971-09-16 | @ KCA | 150 | W 2-1 | 71-79 | 3 | 5,801 | Clyde Wright | Dick Drago | Clyde Wright | Dick Drago | | 478 | 525 | -47 |
| 1971-09-17 | @ CHA | 151 | L 4-9 | 71-80 | 4 | 8,149 | Rudy May | Bart Johnson | Bart Johnson | Rudy May | | 482 | 534 | -52 |
| 1971-09-18 | @ CHA | 152 | L 1-5 | 71-81 | 4 | 4,612 | Tom Murphy | Tom Bradley | Tom Bradley | Tom Murphy | | 483 | 539 | -56 |
| 1971-09-19 | @ CHA | 153 | W 2-0 | 72-81 | 4 | 3,854 | Andy Messersmith | Wilbur Wood | Andy Messersmith | Wilbur Wood | Dave LaRoche | 485 | 539 | -54 |
| 1971-09-21 | vs KCA | 154 | L 2-6 | 72-82 | 4 | 6,084 | Clyde Wright | Dick Drago | Dick Drago | Clyde Wright | | 487 | 545 | -58 |
| 1971-09-22 | vs KCA | 155 | L 3-10 | 72-83 | 4 | 5,030 | Rudy May | Mike Hedlund | Ted Abernathy | Lloyd Allen | Tom Burgmeier | 490 | 555 | -65 |
| 1971-09-23 | vs CHA | 156 | L 0-5 | 72-84 | 4 | 5,234 | Tom Murphy | Wilbur Wood | Wilbur Wood | Tom Murphy | | 490 | 560 | -70 |
| 1971-09-24 | vs CHA | 157 | W 4-3 | 73-84 | 4 | 14,563 | Andy Messersmith | Terry Forster | Andy Messersmith | Stan Perzanowski | | 494 | 563 | -69 |
| 1971-09-25 | vs CHA | 158 | W 3-2 | 74-84 | 4 | 6,502 | Clyde Wright | Tommy John | Clyde Wright | Tommy John | Lloyd Allen | 497 | 565 | -68 |
| 1971-09-26 | vs CHA | 159 | L 5-6 | 74-85 | 4 | 6,319 | Rudy May | Wilbur Wood | Joe Horlen | Eddie Fisher | | 502 | 571 | -69 |
| 1971-09-28 | @ MIN | 160 | W 6-2 | 75-85 | 4 | 3,353 | Andy Messersmith | Tom Hall | Andy Messersmith | Tom Hall | | 508 | 573 | -65 |
| 1971-09-29 | @ MIN | 161 | L 0-1 | 75-86 | 4 | 3,799 | Clyde Wright | Bert Blyleven | Bert Blyleven | Clyde Wright | | 508 | 574 | -66 |
| 1971-09-30 | @ MIN | 162 | W 3-2 | 76-86 | 4 | 4,938 | Rudy May | Jim Kaat | Rudy May | Jim Kaat | Lloyd Allen | 511 | 576 | -65 |