| 1971-04-06 | @ PIT | 1 | L 2-4 | 0-1 | 5 | 39,712 | Chris Short | Dock Ellis | Dock Ellis | Chris Short | | 2 | 4 | -2 |
| 1971-04-08 | @ PIT | 2 | L 0-2 | 0-2 | 6 | 12,289 | Woodie Fryman | Luke Walker | Luke Walker | Woodie Fryman | | 2 | 6 | -4 |
| 1971-04-10 | vs MON | 3 | W 4-1 | 1-2 | 5 | 55,352 | Jim Bunning | Bill Stoneman | Jim Bunning | Bill Stoneman | Joe Hoerner | 6 | 7 | -1 |
| 1971-04-11 | vs MON | 4 | W 11-4 | 2-2 | 3 | 12,431 | Barry Lersch | Carl Morton | Barry Lersch | Carl Morton | Bucky Brandon | 17 | 11 | 6 |
| 1971-04-12 | vs PIT | 5 | L 3-4 | 2-3 | 4 | 19,469 | Rick Wise | Bob Johnson | Dave Giusti | Dick Selma | | 20 | 15 | 5 |
| 1971-04-13 | vs PIT | 6 | L 3-9 | 2-4 | 6 | 14,934 | Chris Short | Luke Walker | Nelson Briles | Chris Short | | 23 | 24 | -1 |
| 1971-04-14 | vs PIT | 7 | W 6-5 | 3-4 | 4 | 8,379 | Woodie Fryman | Bob Moose | Joe Hoerner | Mudcat Grant | Dick Selma | 29 | 29 | 0 |
| 1971-04-16 | vs ATL | 8 | L 7-8 | 3-5 | 6 | 15,099 | Jim Bunning | Jim Nash | Cecil Upshaw | Jim Bunning | | 36 | 37 | -1 |
| 1971-04-17 | vs ATL | 9 | L 2-6 | 3-6 | 6 | 10,686 | Barry Lersch | Ron Reed | Ron Reed | Barry Lersch | | 38 | 43 | -5 |
| 1971-04-18 | vs ATL | 10 | L 4-5 | 3-7 | 6 | 29,583 | Rick Wise | Pat Jarvis | Cecil Upshaw | Woodie Fryman | | 42 | 48 | -6 |
| 1971-04-20 | @ MON | 11 | W 1-0 | 4-7 | 5 | 11,634 | Chris Short | Ernie McAnally | Chris Short | Ernie McAnally | | 43 | 48 | -5 |
| 1971-04-22 | @ SLN | 12 | L 2-5 | 4-8 | 6 | 8,411 | Jim Bunning | Steve Carlton | Steve Carlton | Jim Bunning | | 45 | 53 | -8 |
| 1971-04-23 | @ SLN | 13 | W 8-6 | 5-8 | 5 | 29,290 | Barry Lersch | Mike Torrez | Bucky Brandon | George Brunet | | 53 | 59 | -6 |
| 1971-04-24 | @ SLN | 14 | L 0-5 | 5-9 | 5 | 17,733 | Bill Champion | Jerry Reuss | Jerry Reuss | Bill Champion | | 53 | 64 | -11 |
| 1971-04-25 | @ SLN | 15 | L 4-5 | 5-10 | 6 | 13,122 | Chris Short | Reggie Cleveland | Frank Linzy | Woodie Fryman | | 57 | 69 | -12 |
| 1971-04-26 | @ HOU | 16 | W 2-1 | 6-10 | 6 | 7,227 | Rick Wise | Tom Griffin | Rick Wise | Tom Griffin | | 59 | 70 | -11 |
| 1971-04-27 | @ HOU | 17 | L 0-1 | 6-11 | 6 | 8,152 | Jim Bunning | Larry Dierker | Larry Dierker | Jim Bunning | | 59 | 71 | -12 |
| 1971-04-28 | @ HOU | 18 | L 3-4 | 6-12 | 6 | 8,576 | Barry Lersch | Don Wilson | Jim Ray | Bucky Brandon | | 62 | 75 | -13 |
| 1971-04-30 | @ CHN | 19 | W 1-0 | 7-12 | 6 | 9,110 | Chris Short | Milt Pappas | Chris Short | Milt Pappas | | 63 | 75 | -12 |
| 1971-05-01 | @ CHN | 20 | L 4-7 | 7-13 | 6 | 16,618 | Rick Wise | Fergie Jenkins | Fergie Jenkins | Rick Wise | | 67 | 82 | -15 |
| 1971-05-02 | @ CHN | 21 | L 1-7 | 7-14 | 6 | 9,585 | Jim Bunning | Bill Hands | Bill Hands | Jim Bunning | | 68 | 89 | -21 |
| 1971-05-03 | vs SLN | 22 | W 3-2 | 8-14 | 6 | 9,102 | Barry Lersch | Chris Zachary | Barry Lersch | Chris Zachary | Joe Hoerner | 71 | 91 | -20 |
| 1971-05-04 | vs SLN | 23 | L 3-7 | 8-15 | 6 | 9,339 | Chris Short | Jerry Reuss | Jerry Reuss | Chris Short | | 74 | 98 | -24 |
| 1971-05-05 | vs SLN | 24 | L 1-5 | 8-16 | 6 | 10,184 | Rick Wise | Reggie Cleveland | Reggie Cleveland | Joe Hoerner | | 75 | 103 | -28 |
| 1971-05-07 | vs HOU | 25 | L 1-8 | 8-17 | 6 | 15,728 | Jim Bunning | Don Wilson | Don Wilson | Jim Bunning | | 76 | 111 | -35 |
| 1971-05-09 | vs HOU | 26 | W 2-1 | 9-17 | 6 | 36,145 | Barry Lersch | Jack Billingham | Barry Lersch | Jack Billingham | | 78 | 112 | -34 |
| 1971-05-10 | vs CHN | 27 | L 0-3 | 9-18 | 6 | 8,606 | Chris Short | Fergie Jenkins | Fergie Jenkins | Chris Short | | 78 | 115 | -37 |
| 1971-05-11 | vs CHN | 28 | L 2-6 | 9-19 | 6 | 9,873 | Rick Wise | Bill Hands | Bill Hands | Rick Wise | | 80 | 121 | -41 |
| 1971-05-12 | vs CHN | 29 | L 4-9 | 9-20 | 6 | 8,518 | Jim Bunning | Ken Holtzman | Ken Holtzman | Jim Bunning | | 84 | 130 | -46 |
| 1971-05-14 | @ ATL | 30 | L 2-3 | 9-21 | 6 | 10,164 | Barry Lersch | Ron Reed | Ron Reed | Barry Lersch | Cecil Upshaw | 86 | 133 | -47 |
| 1971-05-15 | @ ATL | 31 | L 2-6 | 9-22 | 6 | 4,976 | Chris Short | Phil Niekro | Phil Niekro | Chris Short | | 88 | 139 | -51 |
| 1971-05-16 | @ ATL | 32 | W 4-3 | 10-22 | 6 | 16,990 | Rick Wise | Pat Jarvis | Rick Wise | Pat Jarvis | Woodie Fryman | 92 | 142 | -50 |
| 1971-05-17 | @ CIN | 33 | W 3-2 | 11-22 | 6 | 7,089 | Jim Bunning | Jim Merritt | Jim Bunning | Jim Merritt | Bucky Brandon | 95 | 144 | -49 |
| 1971-05-18 | @ CIN | 34 | L 3-4 | 11-23 | 6 | 7,399 | Barry Lersch | Don Gullett | Don Gullett | Barry Lersch | Joe Gibbon | 98 | 148 | -50 |
| 1971-05-19 | vs NYN | 35 | W 4-1 | 12-23 | 6 | 19,159 | Chris Short | Jerry Koosman | Chris Short | Jerry Koosman | | 102 | 149 | -47 |
| 1971-05-20 | vs NYN | 36 | W 1-0 | 13-23 | 6 | 14,619 | Rick Wise | Gary Gentry | Rick Wise | Gary Gentry | | 103 | 149 | -46 |
| 1971-05-21 | vs CIN | 37 | L 3-7 | 13-24 | 6 | 26,159 | Jim Bunning | Tony Cloninger | Tony Cloninger | Jim Bunning | Wayne Granger | 106 | 156 | -50 |
| 1971-05-22 | vs CIN | 38 | W 5-3 | 14-24 | 6 | 31,628 | Barry Lersch | Jim Merritt | Barry Lersch | Jim Merritt | | 111 | 159 | -48 |
| 1971-05-23 | vs CIN | 39 | L 3-4 | 14-25 | 6 | 40,455 | Chris Short | Don Gullett | Don Gullett | Chris Short | Clay Carroll | 114 | 163 | -49 |
| 1971-05-24 | vs CIN | 40 | W 2-1 | 15-25 | 6 | 13,614 | Rick Wise | Gary Nolan | Rick Wise | Gary Nolan | | 116 | 164 | -48 |
| 1971-05-25 | @ NYN | 41 | L 4-5 | 15-26 | 6 | 18,853 | Ken Reynolds | Jerry Koosman | Danny Frisella | Jim Bunning | | 120 | 169 | -49 |
| 1971-05-26 | @ NYN | 42 | W 3-2 | 16-26 | 6 | 22,409 | Barry Lersch | Gary Gentry | Bucky Brandon | Tug McGraw | | 123 | 171 | -48 |
| 1971-05-28 | @ LAN | 43 | L 2-6 | 16-27 | 6 | 27,309 | Chris Short | Al Downing | Al Downing | Chris Short | | 125 | 177 | -52 |
| 1971-05-29 | @ LAN | 44 | L 3-9 | 16-28 | 6 | 35,843 | Rick Wise | Bill Singer | Bill Singer | Rick Wise | | 128 | 186 | -58 |
| 1971-05-30 | @ LAN | 45 | L 1-2 | 16-29 | 6 | 36,385 | Ken Reynolds | Claude Osteen | Jim Brewer | Bucky Brandon | | 129 | 188 | -59 |
| 1971-05-31 | @ SDN | 46 | W 3-1 | 17-30 | 6 | 0 | Jim Bunning | Dave Roberts | Jim Bunning | Al Severinsen | Bucky Brandon | 132 | 189 | -57 |
| 1971-05-31 | @ SDN | 47 | L 3-6 | 17-30 | 6 | 7,458 | Barry Lersch | Al Santorini | Bob Miller | Barry Lersch | | 135 | 195 | -60 |
| 1971-06-02 | @ SDN | 48 | L 0-6 | 17-31 | 6 | 2,425 | Rick Wise | Steve Arlin | Steve Arlin | Rick Wise | | 135 | 201 | -66 |
| 1971-06-04 | @ SFN | 49 | W 5-3 | 18-31 | 6 | 9,403 | Chris Short | Gaylord Perry | Chris Short | Gaylord Perry | Jim Bunning | 140 | 204 | -64 |
| 1971-06-05 | @ SFN | 50 | W 5-3 | 19-31 | 6 | 10,945 | Ken Reynolds | Ron Bryant | Joe Hoerner | Jerry Johnson | | 145 | 207 | -62 |
| 1971-06-06 | @ SFN | 51 | W 1-0 | 20-32 | 6 | 0 | Rick Wise | Steve Stone | Rick Wise | Steve Stone | | 146 | 207 | -61 |
| 1971-06-06 | @ SFN | 52 | L 3-4 | 20-32 | 6 | 33,516 | Barry Lersch | Frank Reberger | Rich Robertson | Joe Hoerner | | 149 | 211 | -62 |
| 1971-06-08 | vs LAN | 53 | L 2-4 | 20-33 | 6 | 21,388 | Chris Short | Bill Singer | Bill Singer | Chris Short | Jim Brewer | 151 | 215 | -64 |
| 1971-06-09 | vs LAN | 54 | W 9-4 | 21-33 | 6 | 19,004 | Ken Reynolds | Claude Osteen | Ken Reynolds | Claude Osteen | Woodie Fryman | 160 | 219 | -59 |
| 1971-06-10 | vs LAN | 55 | W 4-2 | 22-33 | 6 | 19,493 | Rick Wise | Don Sutton | Rick Wise | Don Sutton | | 164 | 221 | -57 |
| 1971-06-11 | vs SDN | 56 | L 1-2 | 22-34 | 6 | 19,260 | Barry Lersch | Dave Roberts | Dave Roberts | Barry Lersch | | 165 | 223 | -58 |
| 1971-06-12 | vs SDN | 57 | W 3-0 | 23-34 | 6 | 17,039 | Jim Bunning | Steve Arlin | Jim Bunning | Steve Arlin | Bucky Brandon | 168 | 223 | -55 |
| 1971-06-13 | vs SDN | 58 | L 8-9 | 23-35 | 6 | 35,343 | Ken Reynolds | Tom Phoebus | Bob Miller | Bill Wilson | Dick Kelley | 176 | 232 | -56 |
| 1971-06-14 | vs SFN | 59 | W 9-4 | 24-35 | 6 | 16,118 | Rick Wise | Gaylord Perry | Rick Wise | Gaylord Perry | | 185 | 236 | -51 |
| 1971-06-15 | vs SFN | 60 | L 0-6 | 24-36 | 6 | 21,588 | Barry Lersch | Ron Bryant | Ron Bryant | Barry Lersch | | 185 | 242 | -57 |
| 1971-06-16 | vs SFN | 61 | W 6-3 | 25-36 | 6 | 27,212 | Jim Bunning | Steve Stone | Jim Bunning | Steve Stone | Joe Hoerner | 191 | 245 | -54 |
| 1971-06-18 | @ NYN | 62 | L 0-2 | 25-37 | 6 | 45,428 | Ken Reynolds | Gary Gentry | Gary Gentry | Ken Reynolds | | 191 | 247 | -56 |
| 1971-06-19 | @ NYN | 63 | L 5-6 | 25-38 | 6 | 52,171 | Rick Wise | Tom Seaver | Danny Frisella | Bill Wilson | | 196 | 253 | -57 |
| 1971-06-20 | @ NYN | 64 | L 6-7 | 26-39 | 6 | 0 | Barry Lersch | Nolan Ryan | Tug McGraw | Bucky Brandon | | 202 | 260 | -58 |
| 1971-06-20 | @ NYN | 65 | W 9-7 | 26-39 | 6 | 51,134 | Jim Bunning | Ray Sadecki | Woodie Fryman | Jim McAndrew | | 211 | 267 | -56 |
| 1971-06-21 | @ CIN | 66 | W 5-3 | 27-39 | 6 | 11,683 | Lowell Palmer | Jim McGlothlin | Bucky Brandon | Jim Merritt | | 216 | 270 | -54 |
| 1971-06-22 | @ CIN | 67 | L 1-6 | 27-40 | 6 | 13,226 | Ken Reynolds | Gary Nolan | Gary Nolan | Ken Reynolds | | 217 | 276 | -59 |
| 1971-06-23 | @ CIN | 68 | W 4-0 | 28-40 | 6 | 13,329 | Rick Wise | Ross Grimsley | Rick Wise | Ross Grimsley | | 221 | 276 | -55 |
| 1971-06-24 | @ CIN | 69 | W 3-1 | 29-40 | 5 | 16,215 | Barry Lersch | Don Gullett | Joe Hoerner | Joe Gibbon | | 224 | 277 | -53 |
| 1971-06-25 | vs PIT | 70 | L 4-14 | 29-41 | 5 | 38,736 | Jim Bunning | Steve Blass | Steve Blass | Jim Bunning | | 228 | 291 | -63 |
| 1971-06-26 | vs PIT | 71 | L 9-11 | 29-42 | 5 | 24,965 | Chris Short | Dock Ellis | Dock Ellis | Chris Short | Dave Giusti | 237 | 302 | -65 |
| 1971-06-27 | vs PIT | 72 | W 8-4 | 30-43 | 5 | 0 | Woodie Fryman | Bob Johnson | Woodie Fryman | Bob Johnson | Joe Hoerner | 245 | 306 | -61 |
| 1971-06-27 | vs PIT | 73 | L 9-10 | 30-43 | 5 | 37,062 | Ken Reynolds | Nelson Briles | Bob Veale | Joe Hoerner | Dave Giusti | 254 | 316 | -62 |
| 1971-06-28 | vs NYN | 74 | L 1-3 | 30-44 | 5 | 24,151 | Rick Wise | Gary Gentry | Gary Gentry | Rick Wise | | 255 | 319 | -64 |
| 1971-06-29 | vs NYN | 75 | L 0-3 | 30-45 | 5 | 22,017 | Barry Lersch | Tom Seaver | Tom Seaver | Barry Lersch | | 255 | 322 | -67 |
| 1971-06-30 | vs CIN | 76 | W 7-4 | 31-45 | 5 | 17,578 | Chris Short | Wayne Simpson | Bucky Brandon | Joe Gibbon | | 262 | 326 | -64 |
| 1971-07-01 | vs CIN | 77 | L 1-5 | 31-46 | 5 | 15,586 | Jim Bunning | Jim McGlothlin | Jim McGlothlin | Jim Bunning | | 263 | 331 | -68 |
| 1971-07-02 | @ MON | 78 | L 2-4 | 32-47 | 5 | 0 | Rick Wise | Dan McGinn | Dan McGinn | Rick Wise | | 265 | 335 | -70 |
| 1971-07-02 | @ MON | 79 | W 8-4 | 32-47 | 5 | 22,210 | Ken Reynolds | Bill Stoneman | Woodie Fryman | Bill Stoneman | | 273 | 339 | -66 |
| 1971-07-03 | @ MON | 80 | W 6-3 | 33-47 | 5 | 17,074 | Barry Lersch | Carl Morton | Joe Hoerner | Carl Morton | | 279 | 342 | -63 |
| 1971-07-04 | @ MON | 81 | W 10-6 | 34-47 | 5 | 16,422 | Chris Short | Ernie McAnally | Chris Short | Claude Raymond | Bill Wilson | 289 | 348 | -59 |
| 1971-07-05 | @ ATL | 82 | W 6-5 | 35-47 | 5 | 33,353 | Bill Champion | Tom Kelley | Woodie Fryman | Bob Priddy | Joe Hoerner | 295 | 353 | -58 |
| 1971-07-06 | @ ATL | 83 | L 2-5 | 35-48 | 5 | 7,950 | Rick Wise | George Stone | George Stone | Rick Wise | Cecil Upshaw | 297 | 358 | -61 |
| 1971-07-07 | @ ATL | 84 | L 2-4 | 35-49 | 5 | 12,268 | Barry Lersch | Ron Reed | Ron Reed | Barry Lersch | | 299 | 362 | -63 |
| 1971-07-08 | vs MON | 85 | W 7-5 | 36-49 | 5 | 12,586 | Ken Reynolds | Dan McGinn | Bill Wilson | Howie Reed | | 306 | 367 | -61 |
| 1971-07-09 | vs MON | 86 | L 0-3 | 36-50 | 5 | 14,847 | Chris Short | Steve Renko | Steve Renko | Chris Short | | 306 | 370 | -64 |
| 1971-07-10 | vs MON | 87 | W 2-0 | 38-50 | 5 | 0 | Woodie Fryman | John Strohmayer | Woodie Fryman | John Strohmayer | | 308 | 370 | -62 |
| 1971-07-10 | vs MON | 88 | W 3-2 | 38-50 | 5 | 37,014 | Rick Wise | Bill Stoneman | Rick Wise | Bill Stoneman | | 311 | 372 | -61 |
| 1971-07-11 | vs MON | 89 | W 11-5 | 39-50 | 5 | 10,321 | Barry Lersch | Carl Morton | Bill Champion | Dan McGinn | Joe Hoerner | 322 | 377 | -55 |
| 1971-07-15 | @ CHN | 90 | L 6-7 | 39-51 | 5 | 26,346 | Rick Wise | Ken Holtzman | Joe Decker | Jim Bunning | | 328 | 384 | -56 |
| 1971-07-16 | @ CHN | 91 | L 2-11 | 39-52 | 5 | 23,212 | Chris Short | Fergie Jenkins | Fergie Jenkins | Chris Short | | 330 | 395 | -65 |
| 1971-07-17 | @ CHN | 92 | W 5-2 | 40-52 | 5 | 30,352 | Woodie Fryman | Bill Hands | Woodie Fryman | Bill Hands | Joe Hoerner | 335 | 397 | -62 |
| 1971-07-18 | @ HOU | 93 | W 1-0 | 41-53 | 5 | 0 | Ken Reynolds | Don Wilson | Ken Reynolds | Don Wilson | | 336 | 397 | -61 |
| 1971-07-18 | @ HOU | 94 | L 7-10 | 41-53 | 5 | 32,181 | Jim Bunning | Wade Blasingame | George Culver | Jim Bunning | | 343 | 407 | -64 |
| 1971-07-19 | @ HOU | 95 | L 2-3 | 41-54 | 5 | 13,693 | Rick Wise | Bill Greif | Buddy Harris | Bill Wilson | | 345 | 410 | -65 |
| 1971-07-20 | @ SLN | 96 | W 5-1 | 42-54 | 5 | 14,650 | Chris Short | Jerry Reuss | Chris Short | Jerry Reuss | | 350 | 411 | -61 |
| 1971-07-21 | @ SLN | 97 | L 1-6 | 42-55 | 5 | 16,200 | Barry Lersch | Reggie Cleveland | Reggie Cleveland | Barry Lersch | | 351 | 417 | -66 |
| 1971-07-22 | @ SLN | 98 | L 0-8 | 42-56 | 5 | 20,547 | Woodie Fryman | Bob Gibson | Bob Gibson | Woodie Fryman | | 351 | 425 | -74 |
| 1971-07-23 | vs CHN | 99 | W 4-3 | 43-56 | 5 | 48,543 | Ken Reynolds | Ken Holtzman | Ken Reynolds | Ken Holtzman | Bill Wilson | 355 | 428 | -73 |
| 1971-07-24 | vs CHN | 100 | L 1-2 | 43-57 | 5 | 30,240 | Rick Wise | Fergie Jenkins | Fergie Jenkins | Rick Wise | | 356 | 430 | -74 |
| 1971-07-25 | vs CHN | 101 | W 2-1 | 44-57 | 5 | 19,572 | Chris Short | Bill Hands | Bill Wilson | Bill Hands | | 358 | 431 | -73 |
| 1971-07-26 | vs HOU | 102 | L 4-7 | 44-58 | 5 | 10,848 | Barry Lersch | Jack Billingham | Jim Ray | Bucky Brandon | | 362 | 438 | -76 |
| 1971-07-27 | vs HOU | 103 | W 8-3 | 45-59 | 5 | 0 | Woodie Fryman | Larry Dierker | Woodie Fryman | Larry Dierker | | 370 | 441 | -71 |
| 1971-07-27 | vs HOU | 104 | L 1-5 | 45-59 | 5 | 20,779 | Ken Reynolds | Wade Blasingame | Wade Blasingame | Ken Reynolds | | 371 | 446 | -75 |
| 1971-07-28 | vs HOU | 105 | L 3-6 | 45-60 | 5 | 15,802 | Rick Wise | Don Wilson | Don Wilson | Rick Wise | | 374 | 452 | -78 |
| 1971-07-30 | vs SLN | 106 | L 3-4 | 45-61 | 5 | 26,461 | Chris Short | Bob Gibson | Bob Gibson | Chris Short | | 377 | 456 | -79 |
| 1971-07-31 | vs SLN | 107 | W 5-4 | 46-61 | 5 | 19,269 | Ken Reynolds | Reggie Cleveland | Bucky Brandon | Moe Drabowsky | | 382 | 460 | -78 |
| 1971-08-01 | vs SLN | 108 | L 6-9 | 46-62 | 5 | 22,432 | Woodie Fryman | Chris Zachary | Stan Williams | Manny Muniz | | 388 | 469 | -81 |
| 1971-08-02 | vs ATL | 109 | W 4-0 | 47-62 | 5 | 12,104 | Rick Wise | George Stone | Rick Wise | George Stone | | 392 | 469 | -77 |
| 1971-08-03 | vs ATL | 110 | W 3-2 | 48-62 | 5 | 17,703 | Chris Short | Ron Reed | Chris Short | Bob Priddy | | 395 | 471 | -76 |
| 1971-08-04 | vs ATL | 111 | L 3-5 | 48-63 | 5 | 19,086 | Barry Lersch | Phil Niekro | Mike McQueen | Bucky Brandon | | 398 | 476 | -78 |
| 1971-08-06 | @ PIT | 112 | W 3-2 | 49-63 | 5 | 21,323 | Ken Reynolds | Dock Ellis | Bill Wilson | Dock Ellis | | 401 | 478 | -77 |
| 1971-08-07 | @ PIT | 113 | W 5-3 | 50-63 | 5 | 29,565 | Rick Wise | Bob Moose | Rick Wise | Bob Moose | Bill Wilson | 406 | 481 | -75 |
| 1971-08-08 | @ PIT | 114 | W 3-2 | 51-64 | 5 | 0 | Woodie Fryman | Steve Blass | Woodie Fryman | Steve Blass | Joe Hoerner | 409 | 483 | -74 |
| 1971-08-08 | @ PIT | 115 | L 0-4 | 51-64 | 5 | 31,448 | Chris Short | Bob Johnson | Bob Johnson | Chris Short | | 409 | 487 | -78 |
| 1971-08-10 | @ LAN | 116 | L 1-6 | 51-65 | 5 | 26,508 | Barry Lersch | Bill Singer | Bill Singer | Barry Lersch | | 410 | 493 | -83 |
| 1971-08-11 | @ LAN | 117 | L 1-4 | 51-66 | 5 | 20,135 | Ken Reynolds | Doyle Alexander | Doyle Alexander | Ken Reynolds | | 411 | 497 | -86 |
| 1971-08-12 | @ LAN | 118 | W 3-1 | 52-66 | 5 | 19,755 | Chris Short | Claude Osteen | Bucky Brandon | Pete Mikkelsen | | 414 | 498 | -84 |
| 1971-08-13 | @ SDN | 119 | W 5-2 | 53-66 | 5 | 4,006 | Rick Wise | Fred Norman | Rick Wise | Fred Norman | | 419 | 500 | -81 |
| 1971-08-15 | @ SDN | 120 | L 4-5 | 53-68 | 5 | 0 | Woodie Fryman | Clay Kirby | Dick Kelley | Bill Wilson | | 423 | 505 | -82 |
| 1971-08-15 | @ SDN | 121 | L 2-3 | 53-68 | 5 | 8,108 | Barry Lersch | Dave Roberts | Dave Roberts | Barry Lersch | | 425 | 508 | -83 |
| 1971-08-17 | @ SFN | 122 | L 1-5 | 53-69 | 5 | 8,973 | Ken Reynolds | Gaylord Perry | Gaylord Perry | Ken Reynolds | | 426 | 513 | -87 |
| 1971-08-18 | @ SFN | 123 | L 0-7 | 53-70 | 5 | 10,663 | Rick Wise | John Cumberland | John Cumberland | Rick Wise | | 426 | 520 | -94 |
| 1971-08-20 | vs LAN | 124 | L 5-9 | 53-71 | 5 | 30,006 | Chris Short | Al Downing | Pete Mikkelsen | Chris Short | Jim Brewer | 431 | 529 | -98 |
| 1971-08-21 | vs LAN | 125 | W 3-0 | 54-71 | 5 | 46,633 | Woodie Fryman | Bill Singer | Woodie Fryman | Bill Singer | | 434 | 529 | -95 |
| 1971-08-22 | vs LAN | 126 | W 3-2 | 55-71 | 5 | 26,403 | Ken Reynolds | Claude Osteen | Ken Reynolds | Claude Osteen | Bill Wilson | 437 | 531 | -94 |
| 1971-08-23 | vs SDN | 127 | W 3-1 | 56-71 | 5 | 10,655 | Rick Wise | Fred Norman | Rick Wise | Fred Norman | | 440 | 532 | -92 |
| 1971-08-24 | vs SDN | 128 | L 0-2 | 56-72 | 5 | 10,688 | Barry Lersch | Ed Acosta | Ed Acosta | Barry Lersch | | 440 | 534 | -94 |
| 1971-08-25 | vs SDN | 129 | L 0-7 | 56-73 | 5 | 10,696 | Bill Champion | Clay Kirby | Clay Kirby | Bill Champion | | 440 | 541 | -101 |
| 1971-08-28 | vs SFN | 130 | L 2-5 | 57-74 | 5 | 0 | Woodie Fryman | Don Carrithers | Steve Hamilton | Woodie Fryman | Jerry Johnson | 442 | 546 | -104 |
| 1971-08-28 | vs SFN | 131 | W 7-3 | 57-74 | 5 | 33,012 | Rick Wise | John Cumberland | Rick Wise | John Cumberland | | 449 | 549 | -100 |
| 1971-08-29 | vs SFN | 132 | L 3-8 | 57-75 | 5 | 26,825 | Ken Reynolds | Juan Marichal | Juan Marichal | Ken Reynolds | | 452 | 557 | -105 |
| 1971-08-30 | @ PIT | 133 | L 4-6 | 57-76 | 5 | 13,399 | Chris Short | Nelson Briles | Luke Walker | Bill Wilson | Dave Giusti | 456 | 563 | -107 |
| 1971-08-31 | @ PIT | 134 | L 5-7 | 57-77 | 5 | 16,179 | Barry Lersch | Bob Moose | Bruce Kison | Joe Hoerner | Bob Miller | 461 | 570 | -109 |
| 1971-09-01 | @ PIT | 135 | L 7-10 | 57-78 | 5 | 11,278 | Woodie Fryman | Dock Ellis | Luke Walker | Bucky Brandon | | 468 | 580 | -112 |
| 1971-09-02 | vs NYN | 136 | L 1-3 | 57-79 | 6 | 17,110 | Rick Wise | Gary Gentry | Gary Gentry | Rick Wise | | 469 | 583 | -114 |
| 1971-09-03 | vs NYN | 137 | L 1-7 | 57-80 | 6 | 16,293 | Ken Reynolds | Ray Sadecki | Ray Sadecki | Ken Reynolds | | 470 | 590 | -120 |
| 1971-09-04 | vs NYN | 138 | L 5-6 | 57-82 | 6 | 0 | Wayne Twitchell | Jerry Koosman | Tug McGraw | Dick Selma | | 475 | 596 | -121 |
| 1971-09-04 | vs NYN | 139 | L 0-3 | 57-82 | 6 | 25,560 | Barry Lersch | Jim McAndrew | Jim McAndrew | Barry Lersch | Danny Frisella | 475 | 599 | -124 |
| 1971-09-05 | vs NYN | 140 | W 7-3 | 58-82 | 6 | 16,886 | Woodie Fryman | Nolan Ryan | Woodie Fryman | Nolan Ryan | Bill Wilson | 482 | 602 | -120 |
| 1971-09-06 | vs SLN | 141 | L 3-6 | 59-83 | 6 | 0 | Rick Wise | Bob Gibson | Bob Gibson | Rick Wise | | 485 | 608 | -123 |
| 1971-09-06 | vs SLN | 142 | W 2-1 | 59-83 | 6 | 13,193 | Bill Champion | Chris Zachary | Bill Champion | Chris Zachary | Joe Hoerner | 487 | 609 | -122 |
| 1971-09-07 | vs SLN | 143 | L 5-7 | 59-84 | 6 | 9,339 | Ken Reynolds | Reggie Cleveland | Don Shaw | Bill Wilson | Al Santorini | 492 | 616 | -124 |
| 1971-09-10 | @ NYN | 144 | L 3-4 | 59-85 | 6 | 25,437 | Rick Wise | Jerry Koosman | Jerry Koosman | Rick Wise | Danny Frisella | 495 | 620 | -125 |
| 1971-09-11 | @ NYN | 145 | L 2-9 | 59-86 | 6 | 19,508 | Woodie Fryman | Tom Seaver | Tom Seaver | Woodie Fryman | | 497 | 629 | -132 |
| 1971-09-12 | @ NYN | 146 | L 2-3 | 59-87 | 6 | 16,704 | Bill Champion | Gary Gentry | Danny Frisella | Joe Hoerner | | 499 | 632 | -133 |
| 1971-09-13 | @ SLN | 147 | W 6-5 | 60-87 | 6 | 13,863 | Ken Reynolds | Reggie Cleveland | Bill Wilson | Don Shaw | | 505 | 637 | -132 |
| 1971-09-14 | @ SLN | 148 | W 5-4 | 61-87 | 6 | 10,640 | Rick Wise | Chris Zachary | Rick Wise | Chris Zachary | Chris Short | 510 | 641 | -131 |
| 1971-09-15 | vs MON | 149 | L 0-1 | 61-88 | 6 | 7,734 | Woodie Fryman | Ernie McAnally | Ernie McAnally | Woodie Fryman | | 510 | 642 | -132 |
| 1971-09-16 | vs MON | 150 | L 2-6 | 61-89 | 6 | 5,893 | Bill Champion | Steve Renko | Steve Renko | Bill Champion | | 512 | 648 | -136 |
| 1971-09-17 | vs CHN | 151 | L 3-4 | 61-90 | 6 | 13,644 | Ken Reynolds | Joe Decker | Joe Decker | Ken Reynolds | Larry Gura | 515 | 652 | -137 |
| 1971-09-18 | vs CHN | 152 | W 4-3 | 62-90 | 6 | 7,740 | Rick Wise | Milt Pappas | Rick Wise | Phil Regan | | 519 | 655 | -136 |
| 1971-09-19 | vs CHN | 153 | L 3-6 | 62-91 | 6 | 20,815 | Barry Lersch | Fergie Jenkins | Fergie Jenkins | Barry Lersch | | 522 | 661 | -139 |
| 1971-09-21 | @ MON | 154 | W 5-4 | 63-92 | 6 | 0 | Bill Champion | Carl Morton | Bill Champion | Carl Morton | Bill Wilson | 527 | 665 | -138 |
| 1971-09-21 | @ MON | 155 | L 3-4 | 63-92 | 6 | 14,963 | Ken Reynolds | Jim Britton | Jim Britton | Ken Reynolds | Mike Marshall | 530 | 669 | -139 |
| 1971-09-22 | @ MON | 156 | L 0-2 | 63-93 | 6 | 8,798 | Rick Wise | Bill Stoneman | Bill Stoneman | Rick Wise | | 530 | 671 | -141 |
| 1971-09-23 | @ MON | 157 | W 6-4 | 64-93 | 6 | 6,786 | Woodie Fryman | Ernie McAnally | Wayne Twitchell | Ernie McAnally | Bill Wilson | 536 | 675 | -139 |
| 1971-09-24 | @ CHN | 158 | W 6-1 | 65-93 | 6 | 2,183 | Barry Lersch | Milt Pappas | Barry Lersch | Milt Pappas | | 542 | 676 | -134 |
| 1971-09-25 | @ CHN | 159 | L 2-4 | 65-94 | 6 | 8,891 | Bill Champion | Fergie Jenkins | Fergie Jenkins | Bill Champion | | 544 | 680 | -136 |
| 1971-09-26 | @ CHN | 160 | W 5-1 | 66-94 | 6 | 18,505 | Ken Reynolds | Joe Decker | Ken Reynolds | Joe Decker | | 549 | 681 | -132 |
| 1971-09-28 | vs PIT | 161 | W 6-3 | 67-94 | 6 | 14,582 | Rick Wise | Dock Ellis | Rick Wise | Dock Ellis | | 555 | 684 | -129 |
| 1971-09-30 | vs PIT | 162 | L 3-4 | 67-95 | 6 | 14,157 | Bill Champion | Nelson Briles | Bob Moose | Bill Champion | Dave Giusti | 558 | 688 | -130 |