| 1971-04-06 | @ BOS | 1 | L 1-3 | 0-1 | 6 | 34,517 | Stan Bahnsen | Ray Culp | Ray Culp | Stan Bahnsen | | 1 | 3 | -2 |
| 1971-04-09 | @ WS2 | 2 | L 4-5 | 0-2 | 6 | 25,079 | Fritz Peterson | Denny McLain | Denny McLain | Lindy McDaniel | | 5 | 8 | -3 |
| 1971-04-10 | @ WS2 | 3 | W 6-0 | 1-2 | 6 | 6,412 | Mel Stottlemyre | Jim Shellenback | Mel Stottlemyre | Jim Shellenback | | 11 | 8 | 3 |
| 1971-04-11 | @ WS2 | 4 | W 1-0 | 2-3 | 5 | 0 | Steve Kline | Dick Bosman | Steve Kline | Dick Bosman | | 12 | 8 | 4 |
| 1971-04-11 | @ WS2 | 5 | L 3-4 | 2-3 | 5 | 24,358 | Mike Kekich | Casey Cox | Darold Knowles | Jack Aker | | 15 | 12 | 3 |
| 1971-04-13 | vs DET | 6 | W 5-2 | 3-3 | 4 | 34,745 | Stan Bahnsen | Joe Niekro | Stan Bahnsen | Joe Niekro | | 20 | 14 | 6 |
| 1971-04-14 | vs DET | 7 | W 8-4 | 4-3 | 3 | 11,745 | Fritz Peterson | Mickey Lolich | Fritz Peterson | Mickey Lolich | Jack Aker | 28 | 18 | 10 |
| 1971-04-15 | vs DET | 8 | L 2-3 | 4-4 | 3 | 10,425 | Mel Stottlemyre | Dean Chance | Jim Hannan | Lindy McDaniel | | 30 | 21 | 9 |
| 1971-04-16 | @ BAL | 9 | L 1-6 | 4-5 | 4 | 7,465 | Steve Kline | Pat Dobson | Pat Dobson | Steve Kline | | 31 | 27 | 4 |
| 1971-04-17 | @ BAL | 10 | W 5-3 | 5-5 | 2 | 6,555 | Mike Kekich | Dave McNally | Fritz Peterson | Pete Richert | | 36 | 30 | 6 |
| 1971-04-18 | @ BAL | 11 | L 6-11 | 5-6 | 4 | 30,427 | Stan Bahnsen | Mike Cuellar | Dick Hall | Stan Bahnsen | | 42 | 41 | 1 |
| 1971-04-20 | vs WS2 | 12 | L 2-7 | 5-7 | 6 | 6,851 | Fritz Peterson | Jim Shellenback | Jim Shellenback | Fritz Peterson | | 44 | 48 | -4 |
| 1971-04-21 | vs WS2 | 13 | L 6-9 | 5-8 | 6 | 5,415 | Mel Stottlemyre | Dick Bosman | Gerry Janeski | Jack Aker | | 50 | 57 | -7 |
| 1971-04-23 | vs MIN | 14 | W 7-3 | 6-8 | 5 | 11,704 | Steve Kline | Bert Blyleven | Steve Kline | Bert Blyleven | | 57 | 60 | -3 |
| 1971-04-24 | vs MIN | 15 | L 8-11 | 6-9 | 5 | 10,204 | Stan Bahnsen | Tom Hall | Ray Corbin | Bill Burbach | | 65 | 71 | -6 |
| 1971-04-25 | vs MIN | 16 | L 0-8 | 6-10 | 5 | 29,474 | Fritz Peterson | Jim Kaat | Jim Kaat | Fritz Peterson | | 65 | 79 | -14 |
| 1971-04-27 | vs CHA | 17 | W 6-5 | 7-10 | 5 | 7,009 | Mel Stottlemyre | Tommy John | Lindy McDaniel | Terry Forster | | 71 | 84 | -13 |
| 1971-04-30 | vs MIL | 18 | W 5-1 | 8-10 | 5 | 7,023 | Steve Kline | Skip Lockwood | Steve Kline | Skip Lockwood | | 76 | 85 | -9 |
| 1971-05-01 | vs MIL | 19 | L 0-1 | 8-11 | 5 | 7,384 | Stan Bahnsen | Lew Krausse | Lew Krausse | Stan Bahnsen | Ken Sanders | 76 | 86 | -10 |
| 1971-05-02 | vs MIL | 20 | W 2-1 | 10-11 | 4 | 0 | Mel Stottlemyre | Marty Pattin | Mel Stottlemyre | Marty Pattin | | 78 | 87 | -9 |
| 1971-05-02 | vs MIL | 21 | W 5-4 | 10-11 | 4 | 21,461 | Fritz Peterson | Jim Slaton | Jack Aker | Marcelino Lopez | | 83 | 91 | -8 |
| 1971-05-04 | @ MIN | 22 | L 5-6 | 10-12 | 5 | 8,571 | Steve Kline | Jim Kaat | Ray Corbin | Lindy McDaniel | | 88 | 97 | -9 |
| 1971-05-05 | @ MIN | 23 | L 3-5 | 10-13 | 5 | 7,059 | Stan Bahnsen | Jim Perry | Jim Perry | Stan Bahnsen | Ray Corbin | 91 | 102 | -11 |
| 1971-05-06 | @ MIN | 24 | L 3-5 | 10-14 | 5 | 7,494 | Mel Stottlemyre | Tom Hall | Tom Hall | Mel Stottlemyre | Ron Perranoski | 94 | 107 | -13 |
| 1971-05-07 | @ CHA | 25 | W 4-3 | 11-14 | 5 | 12,101 | Fritz Peterson | Tommy John | Fritz Peterson | Tommy John | Lindy McDaniel | 98 | 110 | -12 |
| 1971-05-08 | @ CHA | 26 | W 2-1 | 12-14 | 5 | 10,477 | Steve Kline | Tom Bradley | Steve Kline | Joe Horlen | | 100 | 111 | -11 |
| 1971-05-09 | @ CHA | 27 | W 6-1 | 13-14 | 4 | 10,401 | Mike Kekich | Wilbur Wood | Mike Kekich | Wilbur Wood | Jack Aker | 106 | 112 | -6 |
| 1971-05-12 | @ MIL | 28 | W 3-0 | 14-14 | 4 | 4,010 | Mel Stottlemyre | Skip Lockwood | Mel Stottlemyre | Skip Lockwood | | 109 | 112 | -3 |
| 1971-05-13 | @ MIL | 29 | W 4-3 | 15-14 | 3 | 3,809 | Fritz Peterson | Marty Pattin | Lindy McDaniel | Ken Sanders | | 113 | 115 | -2 |
| 1971-05-14 | vs CLE | 30 | L 1-2 | 15-15 | 3 | 10,541 | Steve Kline | Ray Lamb | Ray Lamb | Steve Kline | | 114 | 117 | -3 |
| 1971-05-15 | vs CLE | 31 | L 2-4 | 15-16 | 3 | 9,459 | Stan Bahnsen | Alan Foster | Alan Foster | Stan Bahnsen | Phil Hennigan | 116 | 121 | -5 |
| 1971-05-17 | vs BAL | 32 | W 6-3 | 16-16 | 3 | 15,378 | Mel Stottlemyre | Pat Dobson | Mel Stottlemyre | Pat Dobson | Jack Aker | 122 | 124 | -2 |
| 1971-05-18 | vs BAL | 33 | L 2-6 | 16-17 | 3 | 14,700 | Fritz Peterson | Mike Cuellar | Mike Cuellar | Fritz Peterson | | 124 | 130 | -6 |
| 1971-05-19 | @ BOS | 34 | L 2-7 | 16-18 | 4 | 21,077 | Steve Kline | Sonny Siebert | Sonny Siebert | Lindy McDaniel | Sparky Lyle | 126 | 137 | -11 |
| 1971-05-20 | @ BOS | 35 | L 2-5 | 16-19 | 4 | 20,334 | Stan Bahnsen | Bill Lee | Bill Lee | Stan Bahnsen | Bobby Bolin | 128 | 142 | -14 |
| 1971-05-21 | @ CLE | 36 | L 7-8 | 16-20 | 4 | 6,981 | Mike Kekich | Rich Hand | Phil Hennigan | Lindy McDaniel | | 135 | 150 | -15 |
| 1971-05-22 | @ CLE | 37 | L 1-2 | 16-21 | 4 | 10,351 | Mel Stottlemyre | Steve Dunning | Steve Dunning | Mel Stottlemyre | | 136 | 152 | -16 |
| 1971-05-23 | @ CLE | 38 | W 6-3 | 17-22 | 4 | 0 | Fritz Peterson | Ray Lamb | Fritz Peterson | Ray Lamb | | 142 | 155 | -13 |
| 1971-05-23 | @ CLE | 39 | L 1-2 | 17-22 | 4 | 19,014 | Steve Kline | Sam McDowell | Sam McDowell | Steve Kline | | 143 | 157 | -14 |
| 1971-05-25 | @ DET | 40 | L 4-7 | 17-23 | 5 | 10,842 | Stan Bahnsen | Joe Coleman | Fred Scherman | Lindy McDaniel | | 147 | 164 | -17 |
| 1971-05-26 | @ DET | 41 | W 2-1 | 18-23 | 4 | 11,565 | Mel Stottlemyre | Mike Kilkenny | Mel Stottlemyre | Mike Kilkenny | | 149 | 165 | -16 |
| 1971-05-27 | @ DET | 42 | L 3-4 | 18-24 | 5 | 14,518 | Fritz Peterson | Mickey Lolich | Mickey Lolich | Fritz Peterson | | 152 | 169 | -17 |
| 1971-05-28 | vs CAL | 43 | L 6-9 | 18-25 | 5 | 9,508 | Steve Kline | Andy Messersmith | Andy Messersmith | Steve Kline | Dave LaRoche | 158 | 178 | -20 |
| 1971-05-29 | vs CAL | 44 | W 6-1 | 19-25 | 5 | 8,894 | Stan Bahnsen | Clyde Wright | Stan Bahnsen | Clyde Wright | | 164 | 179 | -15 |
| 1971-05-30 | vs CAL | 45 | W 7-4 | 20-25 | 5 | 8,105 | Mel Stottlemyre | Andy Hassler | Mel Stottlemyre | Archie Reynolds | | 171 | 183 | -12 |
| 1971-05-31 | vs OAK | 46 | W 5-3 | 21-26 | 4 | 0 | Fritz Peterson | Catfish Hunter | Fritz Peterson | Catfish Hunter | | 176 | 186 | -10 |
| 1971-05-31 | vs OAK | 47 | L 3-6 | 21-26 | 4 | 20,167 | Mike Kekich | Blue Moon Odom | Blue Moon Odom | Mike Kekich | Rollie Fingers | 179 | 192 | -13 |
| 1971-06-01 | vs OAK | 48 | L 2-5 | 21-27 | 4 | 30,052 | Steve Kline | Vida Blue | Vida Blue | Steve Kline | | 181 | 197 | -16 |
| 1971-06-02 | vs BOS | 49 | W 6-1 | 22-27 | 4 | 9,306 | Stan Bahnsen | Sonny Siebert | Stan Bahnsen | Sonny Siebert | | 187 | 198 | -11 |
| 1971-06-03 | vs BOS | 50 | L 2-3 | 22-28 | 4 | 15,010 | Mel Stottlemyre | Ray Culp | Ray Culp | Mel Stottlemyre | Bobby Bolin | 189 | 201 | -12 |
| 1971-06-04 | vs KCA | 51 | L 2-6 | 22-29 | 5 | 10,803 | Fritz Peterson | Ken Wright | Ken Wright | Fritz Peterson | Tom Burgmeier | 191 | 207 | -16 |
| 1971-06-05 | vs KCA | 52 | L 7-11 | 22-30 | 5 | 10,874 | Steve Kline | Bruce Dal Canton | Ted Abernathy | Gary Waslewski | | 198 | 218 | -20 |
| 1971-06-06 | vs KCA | 53 | W 5-2 | 23-30 | 5 | 59,348 | Stan Bahnsen | Dick Drago | Stan Bahnsen | Dick Drago | | 203 | 220 | -17 |
| 1971-06-08 | @ CAL | 54 | W 3-0 | 24-30 | 5 | 9,783 | Mel Stottlemyre | Andy Hassler | Mel Stottlemyre | Andy Hassler | | 206 | 220 | -14 |
| 1971-06-09 | @ CAL | 55 | L 3-4 | 24-31 | 5 | 7,802 | Fritz Peterson | Andy Messersmith | Dave LaRoche | Jim Hardin | | 209 | 224 | -15 |
| 1971-06-10 | @ CAL | 56 | W 3-2 | 25-31 | 5 | 8,557 | Stan Bahnsen | Tom Murphy | Stan Bahnsen | Tom Murphy | | 212 | 226 | -14 |
| 1971-06-11 | @ OAK | 57 | W 6-4 | 26-31 | 5 | 13,468 | Steve Kline | Catfish Hunter | Jack Aker | Catfish Hunter | | 218 | 230 | -12 |
| 1971-06-12 | @ OAK | 58 | L 3-13 | 26-32 | 5 | 23,985 | Mel Stottlemyre | Vida Blue | Vida Blue | Mel Stottlemyre | | 221 | 243 | -22 |
| 1971-06-13 | @ OAK | 59 | W 5-1 | 27-32 | 5 | 38,916 | Fritz Peterson | Blue Moon Odom | Fritz Peterson | Blue Moon Odom | | 226 | 244 | -18 |
| 1971-06-14 | @ KCA | 60 | L 1-4 | 27-33 | 5 | 11,870 | Mike Kekich | Mike Hedlund | Mike Hedlund | Mike Kekich | | 227 | 248 | -21 |
| 1971-06-15 | @ KCA | 61 | W 2-1 | 28-33 | 5 | 15,348 | Steve Kline | Ken Wright | Steve Kline | Ken Wright | | 229 | 249 | -20 |
| 1971-06-16 | @ KCA | 62 | W 3-2 | 29-33 | 4 | 25,496 | Stan Bahnsen | Bruce Dal Canton | Stan Bahnsen | Tom Burgmeier | | 232 | 251 | -19 |
| 1971-06-17 | @ BAL | 63 | L 1-3 | 29-34 | 4 | 15,528 | Mel Stottlemyre | Pat Dobson | Pat Dobson | Mel Stottlemyre | | 233 | 254 | -21 |
| 1971-06-18 | @ BAL | 64 | L 4-6 | 29-35 | 5 | 39,619 | Fritz Peterson | Mike Cuellar | Mike Cuellar | Fritz Peterson | | 237 | 260 | -23 |
| 1971-06-19 | @ BAL | 65 | W 6-4 | 30-35 | 4 | 26,175 | Mike Kekich | Jim Palmer | Jack Aker | Dick Hall | Gary Waslewski | 243 | 264 | -21 |
| 1971-06-20 | @ BAL | 66 | L 4-10 | 30-36 | 5 | 31,359 | Steve Kline | Dave McNally | Dave McNally | Steve Kline | Eddie Watt | 247 | 274 | -27 |
| 1971-06-22 | vs DET | 67 | L 4-7 | 31-37 | 5 | 0 | Mel Stottlemyre | Les Cain | Dean Chance | Mel Stottlemyre | Fred Scherman | 251 | 281 | -30 |
| 1971-06-22 | vs DET | 68 | W 2-1 | 31-37 | 5 | 14,902 | Stan Bahnsen | Joe Coleman | Stan Bahnsen | Joe Coleman | | 253 | 282 | -29 |
| 1971-06-23 | vs DET | 69 | W 6-5 | 32-37 | 5 | 11,949 | Fritz Peterson | Mike Kilkenny | Lindy McDaniel | Fred Scherman | | 259 | 287 | -28 |
| 1971-06-25 | vs WS2 | 70 | W 12-2 | 33-37 | 4 | 13,261 | Steve Kline | Pete Broberg | Steve Kline | Pete Broberg | | 271 | 289 | -18 |
| 1971-06-26 | vs WS2 | 71 | W 4-0 | 34-37 | 4 | 11,221 | Mel Stottlemyre | Denny McLain | Mel Stottlemyre | Denny McLain | | 275 | 289 | -14 |
| 1971-06-27 | vs WS2 | 72 | L 1-2 | 34-39 | 4 | 0 | Stan Bahnsen | Gerry Janeski | Joe Grzenda | Stan Bahnsen | Horacio Pina | 276 | 291 | -15 |
| 1971-06-27 | vs WS2 | 73 | L 0-8 | 34-39 | 4 | 41,173 | Mike Kekich | Jim Shellenback | Jim Shellenback | Mike Kekich | | 276 | 299 | -23 |
| 1971-06-28 | vs CLE | 74 | L 0-3 | 34-41 | 5 | 0 | Fritz Peterson | Ray Lamb | Ray Lamb | Fritz Peterson | Steve Mingori | 276 | 302 | -26 |
| 1971-06-28 | vs CLE | 75 | L 2-5 | 34-41 | 5 | 11,690 | Jim Hardin | Rich Hand | Phil Hennigan | Lindy McDaniel | Steve Mingori | 278 | 307 | -29 |
| 1971-06-29 | vs CLE | 76 | W 9-2 | 35-41 | 5 | 7,192 | Steve Kline | Alan Foster | Steve Kline | Alan Foster | | 287 | 309 | -22 |
| 1971-06-30 | @ WS2 | 77 | L 1-2 | 35-42 | 5 | 8,747 | Mel Stottlemyre | Denny McLain | Denny McLain | Mel Stottlemyre | | 288 | 311 | -23 |
| 1971-07-01 | @ WS2 | 78 | L 1-3 | 35-43 | 5 | 3,775 | Mike Kekich | Jim Shellenback | Jim Shellenback | Mike Kekich | | 289 | 314 | -25 |
| 1971-07-02 | @ BOS | 79 | W 6-0 | 36-43 | 5 | 29,309 | Stan Bahnsen | Ray Culp | Stan Bahnsen | Ray Culp | | 295 | 314 | -19 |
| 1971-07-03 | @ BOS | 80 | W 2-1 | 37-43 | 5 | 28,878 | Fritz Peterson | Luis Tiant | Fritz Peterson | Luis Tiant | | 297 | 315 | -18 |
| 1971-07-04 | @ BOS | 81 | L 4-7 | 37-44 | 5 | 23,108 | Steve Kline | Jim Lonborg | Bill Lee | Steve Kline | Sparky Lyle | 301 | 322 | -21 |
| 1971-07-05 | @ BOS | 82 | L 7-12 | 37-45 | 5 | 23,364 | Mel Stottlemyre | Gary Peters | Bobby Bolin | Lindy McDaniel | Ken Tatum | 308 | 334 | -26 |
| 1971-07-06 | @ DET | 83 | L 7-12 | 37-46 | 5 | 16,382 | Stan Bahnsen | Mickey Lolich | Mickey Lolich | Stan Bahnsen | | 315 | 346 | -31 |
| 1971-07-07 | @ DET | 84 | W 5-3 | 38-46 | 4 | 18,204 | Fritz Peterson | Mike Kilkenny | Mike Kekich | Bill Denehy | | 320 | 349 | -29 |
| 1971-07-08 | @ DET | 85 | L 1-3 | 38-47 | 4 | 27,859 | Steve Kline | Bill Gilbreth | Bill Gilbreth | Steve Kline | | 321 | 352 | -31 |
| 1971-07-09 | vs BOS | 86 | W 5-2 | 39-47 | 4 | 19,016 | Mel Stottlemyre | Gary Peters | Mel Stottlemyre | Gary Peters | | 326 | 354 | -28 |
| 1971-07-10 | vs BOS | 87 | W 5-3 | 40-47 | 4 | 43,433 | Stan Bahnsen | Sonny Siebert | Mike Kekich | Sparky Lyle | | 331 | 357 | -26 |
| 1971-07-11 | vs BOS | 88 | W 3-2 | 41-47 | 4 | 23,104 | Fritz Peterson | Ray Culp | Lindy McDaniel | Ray Culp | | 334 | 359 | -25 |
| 1971-07-15 | vs MIL | 89 | L 0-1 | 41-48 | 4 | 9,649 | Mel Stottlemyre | Marcelino Lopez | Ken Sanders | Mel Stottlemyre | | 334 | 360 | -26 |
| 1971-07-16 | vs MIL | 90 | W 7-4 | 42-48 | 4 | 10,171 | Stan Bahnsen | Marty Pattin | Stan Bahnsen | Marty Pattin | Lindy McDaniel | 341 | 364 | -23 |
| 1971-07-17 | vs CHA | 91 | W 4-2 | 43-48 | 4 | 8,614 | Steve Kline | Joe Horlen | Steve Kline | Joe Horlen | | 345 | 366 | -21 |
| 1971-07-18 | vs CHA | 92 | W 3-2 | 45-48 | 4 | 0 | Fritz Peterson | Wilbur Wood | Fritz Peterson | Wilbur Wood | | 348 | 368 | -20 |
| 1971-07-18 | vs CHA | 93 | W 6-1 | 45-48 | 4 | 35,004 | Mike Kekich | Tom Bradley | Mike Kekich | Tom Bradley | | 354 | 369 | -15 |
| 1971-07-19 | vs CHA | 94 | L 3-8 | 45-50 | 4 | 0 | Mel Stottlemyre | Jim Magnuson | Rich Hinton | Mel Stottlemyre | Bart Johnson | 357 | 377 | -20 |
| 1971-07-19 | vs CHA | 95 | L 1-3 | 45-50 | 4 | 10,231 | Jim Hardin | Tommy John | Tommy John | Jim Hardin | | 358 | 380 | -22 |
| 1971-07-20 | vs MIN | 96 | W 6-5 | 46-50 | 4 | 13,038 | Stan Bahnsen | Bert Blyleven | Roger Hambright | Stan Williams | | 364 | 385 | -21 |
| 1971-07-21 | vs MIN | 97 | L 1-2 | 46-51 | 4 | 10,793 | Steve Kline | Jim Kaat | Jim Kaat | Steve Kline | | 365 | 387 | -22 |
| 1971-07-22 | vs MIN | 98 | W 13-4 | 47-51 | 4 | 9,268 | Fritz Peterson | Ray Corbin | Fritz Peterson | Ray Corbin | | 378 | 391 | -13 |
| 1971-07-23 | @ MIL | 99 | W 6-2 | 48-51 | 4 | 28,958 | Mel Stottlemyre | Bill Parsons | Mel Stottlemyre | Bill Parsons | | 384 | 393 | -9 |
| 1971-07-24 | @ MIL | 100 | W 4-3 | 49-51 | 4 | 16,688 | Mike Kekich | Jim Slaton | Mike Kekich | Jim Slaton | Lindy McDaniel | 388 | 396 | -8 |
| 1971-07-25 | @ MIL | 101 | W 6-2 | 51-51 | 4 | 0 | Stan Bahnsen | Marty Pattin | Lindy McDaniel | Ken Sanders | | 394 | 398 | -4 |
| 1971-07-25 | @ MIL | 102 | W 11-9 | 51-51 | 4 | 15,006 | Jim Hardin | Marcelino Lopez | Al Closter | Marcelino Lopez | Fritz Peterson | 405 | 407 | -2 |
| 1971-07-27 | @ CHA | 103 | L 6-9 | 51-52 | 4 | 13,346 | Mel Stottlemyre | Tommy John | Rich Hinton | Roger Hambright | | 411 | 416 | -5 |
| 1971-07-28 | @ CHA | 104 | L 4-5 | 51-53 | 4 | 10,217 | Fritz Peterson | Wilbur Wood | Wilbur Wood | Lindy McDaniel | | 415 | 421 | -6 |
| 1971-07-29 | @ CHA | 105 | L 0-4 | 51-54 | 4 | 10,124 | Mike Kekich | Tom Bradley | Tom Bradley | Mike Kekich | | 415 | 425 | -10 |
| 1971-07-30 | @ MIN | 106 | W 11-9 | 52-54 | 4 | 19,233 | Stan Bahnsen | Jim Kaat | Jack Aker | Tom Hall | | 426 | 434 | -8 |
| 1971-07-31 | @ MIN | 107 | L 4-5 | 52-55 | 4 | 25,650 | Steve Kline | Bert Blyleven | Bert Blyleven | Steve Kline | | 430 | 439 | -9 |
| 1971-08-01 | @ MIN | 108 | L 7-10 | 52-56 | 4 | 24,056 | Mel Stottlemyre | Steve Luebber | Tom Hall | Mel Stottlemyre | | 437 | 449 | -12 |
| 1971-08-02 | @ CLE | 109 | W 7-0 | 53-56 | 4 | 8,025 | Fritz Peterson | Mike Paul | Fritz Peterson | Mike Paul | | 444 | 449 | -5 |
| 1971-08-03 | @ CLE | 110 | W 8-1 | 54-56 | 4 | 5,084 | Mike Kekich | Alan Foster | Mike Kekich | Alan Foster | | 452 | 450 | 2 |
| 1971-08-04 | @ CLE | 111 | W 7-3 | 55-56 | 4 | 4,721 | Stan Bahnsen | Ray Lamb | Stan Bahnsen | Ray Lamb | Lindy McDaniel | 459 | 453 | 6 |
| 1971-08-05 | vs BAL | 112 | W 5-0 | 56-56 | 4 | 18,509 | Mel Stottlemyre | Mike Cuellar | Mel Stottlemyre | Mike Cuellar | | 464 | 453 | 11 |
| 1971-08-06 | vs BAL | 113 | W 12-3 | 57-56 | 4 | 24,681 | Fritz Peterson | Pat Dobson | Fritz Peterson | Pat Dobson | | 476 | 456 | 20 |
| 1971-08-07 | vs BAL | 114 | L 1-3 | 57-57 | 4 | 21,813 | Mike Kekich | Jim Palmer | Jim Palmer | Mike Kekich | | 477 | 459 | 18 |
| 1971-08-08 | vs BAL | 115 | W 2-1 | 58-57 | 4 | 26,319 | Steve Kline | Grant Jackson | Steve Kline | Grant Jackson | | 479 | 460 | 19 |
| 1971-08-10 | vs CAL | 116 | L 6-7 | 58-58 | 4 | 14,496 | Stan Bahnsen | Clyde Wright | Clyde Wright | Stan Bahnsen | Lloyd Allen | 485 | 467 | 18 |
| 1971-08-12 | vs CAL | 117 | W 3-0 | 60-58 | 4 | 0 | Fritz Peterson | Rudy May | Fritz Peterson | Rudy May | | 488 | 467 | 21 |
| 1971-08-12 | vs CAL | 118 | W 2-1 | 60-58 | 4 | 13,072 | Mike Kekich | Tom Murphy | Mike Kekich | Lloyd Allen | | 490 | 468 | 22 |
| 1971-08-13 | vs OAK | 119 | L 2-5 | 60-59 | 4 | 15,628 | Mel Stottlemyre | Chuck Dobson | Chuck Dobson | Mel Stottlemyre | Rollie Fingers | 492 | 473 | 19 |
| 1971-08-14 | vs OAK | 120 | L 0-1 | 60-60 | 4 | 16,318 | Steve Kline | Catfish Hunter | Catfish Hunter | Steve Kline | | 492 | 474 | 18 |
| 1971-08-15 | vs OAK | 121 | L 4-6 | 60-61 | 4 | 45,343 | Stan Bahnsen | Vida Blue | Vida Blue | Jack Aker | | 496 | 480 | 16 |
| 1971-08-17 | vs KCA | 122 | W 2-0 | 62-61 | 4 | 0 | Fritz Peterson | Paul Splittorff | Fritz Peterson | Paul Splittorff | | 498 | 480 | 18 |
| 1971-08-17 | vs KCA | 123 | W 8-5 | 62-61 | 4 | 17,223 | Mike Kekich | Lance Clemons | Mike Kekich | Ted Abernathy | Roger Hambright | 506 | 485 | 21 |
| 1971-08-18 | vs KCA | 124 | W 3-1 | 63-61 | 4 | 11,829 | Mel Stottlemyre | Dick Drago | Mel Stottlemyre | Dick Drago | | 509 | 486 | 23 |
| 1971-08-20 | @ CAL | 125 | L 0-6 | 63-62 | 4 | 8,655 | Steve Kline | Rudy May | Rudy May | Steve Kline | | 509 | 492 | 17 |
| 1971-08-21 | @ CAL | 126 | L 1-2 | 63-63 | 4 | 25,474 | Stan Bahnsen | Tom Murphy | Dave LaRoche | Al Closter | | 510 | 494 | 16 |
| 1971-08-22 | @ CAL | 127 | L 0-3 | 63-64 | 4 | 8,957 | Fritz Peterson | Andy Messersmith | Andy Messersmith | Fritz Peterson | | 510 | 497 | 13 |
| 1971-08-23 | @ OAK | 128 | L 2-8 | 63-65 | 4 | 4,972 | Mike Kekich | Chuck Dobson | Chuck Dobson | Mike Kekich | Rollie Fingers | 512 | 505 | 7 |
| 1971-08-24 | @ OAK | 129 | W 1-0 | 64-65 | 4 | 18,288 | Mel Stottlemyre | Vida Blue | Mel Stottlemyre | Vida Blue | | 513 | 505 | 8 |
| 1971-08-25 | @ OAK | 130 | W 4-2 | 65-65 | 4 | 5,950 | Steve Kline | Catfish Hunter | Steve Kline | Catfish Hunter | | 517 | 507 | 10 |
| 1971-08-27 | @ KCA | 131 | L 0-4 | 65-66 | 4 | 10,425 | Stan Bahnsen | Paul Splittorff | Paul Splittorff | Stan Bahnsen | | 517 | 511 | 6 |
| 1971-08-28 | @ KCA | 132 | L 3-4 | 65-67 | 4 | 15,845 | Fritz Peterson | Mike Hedlund | Mike Hedlund | Fritz Peterson | | 520 | 515 | 5 |
| 1971-08-29 | @ KCA | 133 | W 10-3 | 66-67 | 4 | 13,229 | Mel Stottlemyre | Dick Drago | Al Closter | Dick Drago | | 530 | 518 | 12 |
| 1971-08-31 | vs WS2 | 134 | L 5-6 | 66-68 | 4 | 8,950 | Mike Kekich | Dick Bosman | Paul Lindblad | Lindy McDaniel | | 535 | 524 | 11 |
| 1971-09-01 | vs WS2 | 135 | L 0-2 | 66-69 | 4 | 8,467 | Steve Kline | Bill Gogolewski | Bill Gogolewski | Steve Kline | | 535 | 526 | 9 |
| 1971-09-02 | vs WS2 | 136 | W 11-1 | 67-69 | 4 | 7,461 | Stan Bahnsen | Jim Shellenback | Stan Bahnsen | Jim Shellenback | | 546 | 527 | 19 |
| 1971-09-03 | vs DET | 137 | L 1-3 | 67-70 | 4 | 11,353 | Fritz Peterson | Mike Kilkenny | Mike Kilkenny | Fritz Peterson | | 547 | 530 | 17 |
| 1971-09-04 | vs DET | 138 | L 1-9 | 67-71 | 4 | 9,315 | Al Closter | Joe Coleman | Joe Coleman | Al Closter | | 548 | 539 | 9 |
| 1971-09-05 | vs DET | 139 | W 6-5 | 68-71 | 4 | 12,366 | Mike Kekich | Les Cain | Mike Kekich | Les Cain | Jack Aker | 554 | 544 | 10 |
| 1971-09-06 | vs BOS | 140 | W 5-3 | 70-71 | 4 | 0 | Steve Kline | Ray Culp | Roger Hambright | Ray Culp | | 559 | 547 | 12 |
| 1971-09-06 | vs BOS | 141 | W 3-0 | 70-71 | 4 | 21,490 | Stan Bahnsen | John Curtis | Stan Bahnsen | John Curtis | | 562 | 547 | 15 |
| 1971-09-07 | vs BOS | 142 | L 3-9 | 70-72 | 4 | 14,527 | Fritz Peterson | Sonny Siebert | Sonny Siebert | Fritz Peterson | | 565 | 556 | 9 |
| 1971-09-08 | vs BOS | 143 | W 2-1 | 71-72 | 4 | 6,154 | Mel Stottlemyre | Roger Moret | Roger Hambright | Bobby Bolin | | 567 | 557 | 10 |
| 1971-09-11 | @ CLE | 144 | W 10-8 | 72-72 | 4 | 4,925 | Mike Kekich | Rich Hand | Mike Kekich | Rich Hand | Roger Hambright | 577 | 565 | 12 |
| 1971-09-12 | @ CLE | 145 | L 2-5 | 72-73 | 4 | 7,556 | Fritz Peterson | Sam McDowell | Sam McDowell | Fritz Peterson | Phil Hennigan | 579 | 570 | 9 |
| 1971-09-13 | @ BOS | 146 | W 4-0 | 73-73 | 4 | 12,272 | Stan Bahnsen | Sonny Siebert | Stan Bahnsen | Sonny Siebert | | 583 | 570 | 13 |
| 1971-09-14 | @ BOS | 147 | W 6-3 | 74-73 | 4 | 12,492 | Mel Stottlemyre | Roger Moret | Mel Stottlemyre | Roger Moret | | 589 | 573 | 16 |
| 1971-09-15 | @ BAL | 148 | W 4-2 | 75-73 | 4 | 9,921 | Steve Kline | Mike Cuellar | Steve Kline | Mike Cuellar | | 593 | 575 | 18 |
| 1971-09-16 | @ BAL | 149 | L 2-6 | 75-74 | 4 | 11,602 | Mike Kekich | Pat Dobson | Pat Dobson | Mike Kekich | | 595 | 581 | 14 |
| 1971-09-17 | vs CLE | 150 | W 1-0 | 77-74 | 4 | 0 | Fritz Peterson | Sam McDowell | Fritz Peterson | Sam McDowell | | 596 | 581 | 15 |
| 1971-09-17 | vs CLE | 151 | W 7-1 | 77-74 | 4 | 7,527 | Stan Bahnsen | Mike Paul | Stan Bahnsen | Mike Paul | | 603 | 582 | 21 |
| 1971-09-18 | vs CLE | 152 | W 9-0 | 78-74 | 4 | 9,105 | Mel Stottlemyre | Vince Colbert | Mel Stottlemyre | Vince Colbert | | 612 | 582 | 30 |
| 1971-09-19 | vs CLE | 153 | W 3-2 | 79-74 | 4 | 9,177 | Steve Kline | Steve Dunning | Steve Kline | Steve Dunning | | 615 | 584 | 31 |
| 1971-09-20 | vs BAL | 154 | L 4-8 | 79-75 | 4 | 7,120 | Mike Kekich | Pat Dobson | Pat Dobson | Jack Aker | Eddie Watt | 619 | 592 | 27 |
| 1971-09-21 | vs BAL | 155 | L 0-5 | 79-76 | 4 | 8,136 | Fritz Peterson | Dave McNally | Dave McNally | Fritz Peterson | | 619 | 597 | 22 |
| 1971-09-22 | vs BAL | 156 | L 1-10 | 79-77 | 4 | 8,845 | Stan Bahnsen | Jim Palmer | Jim Palmer | Stan Bahnsen | | 620 | 607 | 13 |
| 1971-09-24 | @ DET | 157 | L 5-8 | 79-78 | 4 | 11,037 | Mel Stottlemyre | Joe Coleman | Joe Coleman | Mel Stottlemyre | Fred Scherman | 625 | 615 | 10 |
| 1971-09-25 | @ DET | 158 | L 7-10 | 79-79 | 4 | 12,164 | Mike Kekich | Les Cain | Les Cain | Mike Kekich | Tom Timmermann | 632 | 625 | 7 |
| 1971-09-26 | @ DET | 159 | W 3-2 | 80-79 | 4 | 9,514 | Fritz Peterson | Mickey Lolich | Fritz Peterson | Mickey Lolich | | 635 | 627 | 8 |
| 1971-09-28 | @ WS2 | 160 | L 2-4 | 80-80 | 4 | 3,242 | Stan Bahnsen | Bill Gogolewski | Joe Grzenda | Stan Bahnsen | | 637 | 631 | 6 |
| 1971-09-29 | @ WS2 | 161 | W 6-3 | 81-80 | 4 | 4,003 | Mel Stottlemyre | Jim Shellenback | Mel Stottlemyre | Jim Shellenback | | 643 | 634 | 9 |
| 1971-09-30 | @ WS2 | 162 | L 5-7 | 81-81 | 4 | 14,460 | Mike Kekich | Dick Bosman | | | | 648 | 641 | 7 |