Oldest Player: Howie Reed (34)
Youngest Player: Terry Humphrey (21)
Longest Tenure: Claude Raymond, Ron Fairly, Jim Fairey, Mack Jones, Coco Laboy, Bob Bailey, Dan McGinn, Carl Morton, Howie Reed, Steve Renko, Rusty Staub, Bill Stoneman, Gary Sutherland, Ron Brand, John Boccabella, John Bateman, Bobby Wine (3)
Top Hitter: Rusty Staub (2)
Top Pitcher: Bill Stoneman (5)
Top Draft Pick: Condredge Holloway (#4)
Roster Continuity: 81.35%
| 1971-04-06 | @ NYN | 1 | L 2-4 | 0-1 | 4 | 26,062 | Carl Morton | Tom Seaver | Tom Seaver | Carl Morton | | 2 | 4 | -2 |
| 1971-04-08 | @ NYN | 2 | W 6-2 | 1-1 | 2 | 13,033 | Steve Renko | Gary Gentry | Steve Renko | Gary Gentry | | 8 | 6 | 2 |
| 1971-04-10 | @ PHI | 3 | L 1-4 | 1-2 | 4 | 55,352 | Bill Stoneman | Jim Bunning | Jim Bunning | Bill Stoneman | Joe Hoerner | 9 | 10 | -1 |
| 1971-04-11 | @ PHI | 4 | L 4-11 | 1-3 | 6 | 12,431 | Carl Morton | Barry Lersch | Barry Lersch | Carl Morton | Bucky Brandon | 13 | 21 | -8 |
| 1971-04-13 | vs NYN | 5 | W 4-1 | 2-3 | 4 | 21,996 | Steve Renko | Gary Gentry | Steve Renko | Gary Gentry | | 17 | 22 | -5 |
| 1971-04-17 | vs CIN | 6 | W 3-2 | 3-3 | 4 | 15,931 | Carl Morton | Gary Nolan | Carl Morton | Gary Nolan | Mike Marshall | 20 | 24 | -4 |
| 1971-04-18 | vs CIN | 7 | W 3-2 | 5-3 | 1 | 0 | Steve Renko | Jim Merritt | Howie Reed | Joe Gibbon | Mike Marshall | 23 | 26 | -3 |
| 1971-04-18 | vs CIN | 8 | W 5-3 | 5-3 | 1 | 21,409 | Bill Stoneman | Jim McGlothlin | Bill Stoneman | Greg Garrett | | 28 | 29 | -1 |
| 1971-04-20 | vs PHI | 9 | L 0-1 | 5-4 | 2 | 11,634 | Ernie McAnally | Chris Short | Chris Short | Ernie McAnally | | 28 | 30 | -2 |
| 1971-04-23 | @ HOU | 10 | W 3-2 | 6-4 | 1 | 25,430 | Carl Morton | Don Wilson | Carl Morton | Don Wilson | Mike Marshall | 31 | 32 | -1 |
| 1971-04-24 | @ HOU | 11 | W 3-2 | 7-4 | 1 | 17,252 | Steve Renko | Wade Blasingame | Steve Renko | Wade Blasingame | Mike Marshall | 34 | 34 | 0 |
| 1971-04-25 | @ HOU | 12 | W 2-1 | 8-4 | 1 | 12,122 | Bill Stoneman | Jack Billingham | Bill Stoneman | Jack Billingham | | 36 | 35 | 1 |
| 1971-04-28 | @ CHN | 13 | L 2-3 | 8-5 | 1 | 4,374 | Carl Morton | Bill Hands | Bill Hands | Carl Morton | | 38 | 38 | 0 |
| 1971-04-29 | @ CHN | 14 | W 7-6 | 9-5 | 1 | 7,889 | Ernie McAnally | Ken Holtzman | Claude Raymond | Phil Regan | Mike Marshall | 45 | 44 | 1 |
| 1971-04-30 | @ SLN | 15 | L 2-4 | 9-6 | 2 | 10,766 | Bill Stoneman | Reggie Cleveland | Don Shaw | Claude Raymond | | 47 | 48 | -1 |
| 1971-05-01 | @ SLN | 16 | L 2-2 | 9-7 | 3 | 32,061 | Steve Renko | Bob Gibson | | | | 49 | 50 | -1 |
| 1971-05-02 | @ SLN | 17 | L 0-1 | 9-8 | 4 | 10,320 | Carl Morton | Steve Carlton | Steve Carlton | Carl Morton | | 49 | 51 | -2 |
| 1971-05-05 | vs HOU | 18 | W 5-1 | 10-8 | 4 | 8,282 | Bill Stoneman | Wade Blasingame | Bill Stoneman | Wade Blasingame | | 54 | 52 | 2 |
| 1971-05-06 | vs HOU | 19 | L 2-5 | 10-9 | 4 | 7,403 | Steve Renko | Larry Dierker | Larry Dierker | Steve Renko | Fred Gladding | 56 | 57 | -1 |
| 1971-05-07 | vs CHN | 20 | W 3-1 | 11-9 | 4 | 17,723 | Carl Morton | Bill Hands | Carl Morton | Bill Hands | | 59 | 58 | 1 |
| 1971-05-08 | vs CHN | 21 | L 0-3 | 11-10 | 4 | 20,699 | Ernie McAnally | Ken Holtzman | Ken Holtzman | Ernie McAnally | | 59 | 61 | -2 |
| 1971-05-09 | vs CHN | 22 | W 7-3 | 12-10 | 4 | 16,872 | Bill Stoneman | Milt Pappas | Bill Stoneman | Milt Pappas | | 66 | 64 | 2 |
| 1971-05-10 | vs SLN | 23 | L 5-8 | 12-11 | 4 | 16,703 | Steve Renko | Jerry Reuss | Jerry Reuss | Steve Renko | Frank Linzy | 71 | 72 | -1 |
| 1971-05-11 | vs SLN | 24 | L 4-10 | 12-12 | 4 | 8,862 | Carl Morton | Reggie Cleveland | Reggie Cleveland | Carl Morton | Frank Linzy | 75 | 82 | -7 |
| 1971-05-14 | @ CIN | 25 | L 2-5 | 12-13 | 5 | 24,751 | Bill Stoneman | Gary Nolan | Gary Nolan | Bill Stoneman | | 77 | 87 | -10 |
| 1971-05-15 | @ CIN | 26 | L 1-6 | 12-14 | 5 | 15,550 | Ernie McAnally | Jim McGlothlin | Jim McGlothlin | Ernie McAnally | Joe Gibbon | 78 | 93 | -15 |
| 1971-05-16 | @ CIN | 27 | W 9-3 | 13-14 | 5 | 16,671 | Steve Renko | Ross Grimsley | Steve Renko | Ross Grimsley | Mike Marshall | 87 | 96 | -9 |
| 1971-05-17 | @ PIT | 28 | L 5-6 | 13-15 | 5 | 6,431 | Carl Morton | Luke Walker | Mudcat Grant | Mike Marshall | | 92 | 102 | -10 |
| 1971-05-18 | @ PIT | 29 | L 2-3 | 13-16 | 5 | 10,226 | Bill Stoneman | Bob Johnson | Bob Johnson | Mike Marshall | | 94 | 105 | -11 |
| 1971-05-19 | @ ATL | 30 | L 4-10 | 13-17 | 5 | 4,686 | Ernie McAnally | Jim Nash | Jim Nash | Ernie McAnally | Steve Barber | 98 | 115 | -17 |
| 1971-05-20 | @ ATL | 31 | W 4-3 | 14-17 | 5 | 5,497 | Steve Renko | Phil Niekro | Mike Marshall | Ron Herbel | | 102 | 118 | -16 |
| 1971-05-21 | vs PIT | 32 | L 2-6 | 14-18 | 5 | 17,379 | Carl Morton | Dock Ellis | Mudcat Grant | Howie Reed | | 104 | 124 | -20 |
| 1971-05-22 | vs PIT | 33 | W 5-2 | 15-18 | 5 | 18,814 | Bill Stoneman | Luke Walker | Bill Stoneman | Luke Walker | | 109 | 126 | -17 |
| 1971-05-23 | vs PIT | 34 | W 4-2 | 16-18 | 5 | 27,216 | Ernie McAnally | Bob Johnson | Ernie McAnally | Bob Johnson | Mike Marshall | 113 | 128 | -15 |
| 1971-05-24 | vs ATL | 35 | L 4-9 | 16-19 | 5 | 23,018 | Steve Renko | Jim Nash | Jim Nash | Steve Renko | Bob Priddy | 117 | 137 | -20 |
| 1971-05-25 | vs ATL | 36 | W 3-2 | 17-19 | 5 | 8,426 | Carl Morton | Phil Niekro | Carl Morton | Phil Niekro | | 120 | 139 | -19 |
| 1971-05-26 | vs ATL | 37 | W 11-1 | 18-19 | 4 | 6,263 | Bill Stoneman | Pat Jarvis | Bill Stoneman | Pat Jarvis | | 131 | 140 | -9 |
| 1971-05-27 | vs ATL | 38 | L 1-4 | 18-20 | 4 | 13,156 | Ernie McAnally | Tom Kelley | Tom Kelley | Ernie McAnally | | 132 | 144 | -12 |
| 1971-05-28 | @ SFN | 39 | L 1-3 | 18-21 | 5 | 5,960 | Steve Renko | Steve Stone | Steve Stone | Steve Renko | Jerry Johnson | 133 | 147 | -14 |
| 1971-05-29 | @ SFN | 40 | L 3-8 | 18-22 | 5 | 8,039 | Carl Morton | Juan Marichal | Juan Marichal | Carl Morton | | 136 | 155 | -19 |
| 1971-05-30 | @ SFN | 41 | L 4-5 | 18-24 | 5 | 0 | Bill Stoneman | Gaylord Perry | Gaylord Perry | Bill Stoneman | Jerry Johnson | 140 | 160 | -20 |
| 1971-05-30 | @ SFN | 42 | L 7-8 | 18-24 | 5 | 20,393 | John Strohmayer | Rich Robertson | Steve Hamilton | Mike Marshall | | 147 | 168 | -21 |
| 1971-05-31 | @ LAN | 43 | L 0-4 | 18-25 | 5 | 22,195 | Ernie McAnally | Don Sutton | Don Sutton | Ernie McAnally | Jim Brewer | 147 | 172 | -25 |
| 1971-06-01 | @ LAN | 44 | W 5-2 | 19-25 | 5 | 10,571 | Steve Renko | Al Downing | Steve Renko | Al Downing | Mike Marshall | 152 | 174 | -22 |
| 1971-06-02 | @ LAN | 45 | L 1-7 | 19-26 | 5 | 10,911 | Carl Morton | Bill Singer | Bob O'Brien | Carl Morton | | 153 | 181 | -28 |
| 1971-06-04 | @ SDN | 46 | W 3-1 | 20-26 | 5 | 6,447 | Bill Stoneman | Tom Phoebus | Bill Stoneman | Tom Phoebus | | 156 | 182 | -26 |
| 1971-06-05 | @ SDN | 47 | W 2-1 | 21-26 | 5 | 2,748 | Steve Renko | Clay Kirby | Steve Renko | Clay Kirby | Mike Marshall | 158 | 183 | -25 |
| 1971-06-06 | @ SDN | 48 | L 0-8 | 21-28 | 5 | 0 | Carl Morton | Dave Roberts | Dave Roberts | Carl Morton | | 158 | 191 | -33 |
| 1971-06-06 | @ SDN | 49 | L 4-8 | 21-28 | 5 | 8,781 | John Strohmayer | Dick Kelley | Dick Kelley | John Strohmayer | Al Severinsen | 162 | 199 | -37 |
| 1971-06-08 | vs SFN | 50 | W 10-3 | 22-28 | 5 | 13,861 | Bill Stoneman | Juan Marichal | Bill Stoneman | Juan Marichal | | 172 | 202 | -30 |
| 1971-06-09 | vs SFN | 51 | W 4-0 | 23-28 | 5 | 20,011 | Steve Renko | Gaylord Perry | Steve Renko | Gaylord Perry | | 176 | 202 | -26 |
| 1971-06-10 | vs SFN | 52 | W 3-1 | 24-28 | 5 | 16,582 | Carl Morton | Ron Bryant | Carl Morton | Ron Bryant | | 179 | 203 | -24 |
| 1971-06-11 | vs LAN | 53 | L 1-12 | 24-29 | 5 | 20,929 | Jim Britton | Al Downing | Al Downing | Jim Britton | | 180 | 215 | -35 |
| 1971-06-12 | vs LAN | 54 | L 3-5 | 24-30 | 5 | 21,576 | Bill Stoneman | Bill Singer | Bill Singer | Bill Stoneman | Jim Brewer | 183 | 220 | -37 |
| 1971-06-13 | vs LAN | 55 | L 1-7 | 24-31 | 5 | 28,116 | Steve Renko | Claude Osteen | Claude Osteen | Steve Renko | | 184 | 227 | -43 |
| 1971-06-14 | vs SDN | 56 | L 1-2 | 24-32 | 5 | 10,840 | Carl Morton | Clay Kirby | Clay Kirby | Carl Morton | Bob Miller | 185 | 229 | -44 |
| 1971-06-15 | vs SDN | 57 | L 1-3 | 24-33 | 5 | 13,512 | Jim Britton | Fred Norman | Al Severinsen | Mike Marshall | Bob Miller | 186 | 232 | -46 |
| 1971-06-16 | vs SDN | 58 | W 2-0 | 25-33 | 5 | 23,623 | Bill Stoneman | Dave Roberts | Bill Stoneman | Dave Roberts | | 188 | 232 | -44 |
| 1971-06-18 | @ PIT | 59 | L 8-9 | 25-34 | 5 | 26,644 | Steve Renko | Luke Walker | Dave Giusti | Claude Raymond | | 196 | 241 | -45 |
| 1971-06-19 | @ PIT | 60 | W 10-1 | 26-34 | 5 | 12,091 | Carl Morton | Bob Moose | Carl Morton | Bob Moose | | 206 | 242 | -36 |
| 1971-06-20 | @ PIT | 61 | L 1-7 | 26-36 | 5 | 0 | Bill Stoneman | Steve Blass | Steve Blass | Bill Stoneman | | 207 | 249 | -42 |
| 1971-06-20 | @ PIT | 62 | L 3-7 | 26-36 | 5 | 32,301 | Jim Britton | Nelson Briles | Nelson Briles | Jim Britton | Mudcat Grant | 210 | 256 | -46 |
| 1971-06-21 | @ ATL | 63 | L 4-6 | 27-37 | 5 | 0 | John Strohmayer | Jim Nash | Cecil Upshaw | Claude Raymond | | 214 | 262 | -48 |
| 1971-06-21 | @ ATL | 64 | W 5-3 | 27-37 | 5 | 8,203 | Dan McGinn | Steve Barber | Howie Reed | Cecil Upshaw | Carl Morton | 219 | 265 | -46 |
| 1971-06-22 | @ ATL | 65 | L 0-4 | 27-38 | 5 | 5,567 | Steve Renko | Ron Reed | Ron Reed | Steve Renko | | 219 | 269 | -50 |
| 1971-06-23 | @ ATL | 66 | W 6-3 | 28-38 | 5 | 5,262 | Carl Morton | Pat Jarvis | Carl Morton | Pat Jarvis | John Strohmayer | 225 | 272 | -47 |
| 1971-06-24 | vs NYN | 67 | L 1-2 | 28-39 | 6 | 21,618 | Bill Stoneman | Tom Seaver | Tom Seaver | Bill Stoneman | | 226 | 274 | -48 |
| 1971-06-25 | vs NYN | 68 | L 1-4 | 28-41 | 6 | 0 | Jim Britton | Nolan Ryan | Nolan Ryan | Claude Raymond | | 227 | 278 | -51 |
| 1971-06-25 | vs NYN | 69 | L 2-4 | 28-41 | 6 | 22,751 | Dan McGinn | Ray Sadecki | Danny Frisella | Dan McGinn | | 229 | 282 | -53 |
| 1971-06-26 | vs NYN | 70 | L 1-2 | 28-42 | 6 | 21,289 | Steve Renko | Jerry Koosman | Jerry Koosman | Steve Renko | | 230 | 284 | -54 |
| 1971-06-27 | vs NYN | 71 | W 12-4 | 29-42 | 6 | 23,243 | John Strohmayer | Charlie Williams | John Strohmayer | Charlie Williams | | 242 | 288 | -46 |
| 1971-06-28 | vs CIN | 72 | L 3-4 | 29-44 | 6 | 0 | Bill Stoneman | Don Gullett | Don Gullett | Bill Stoneman | Joe Gibbon | 245 | 292 | -47 |
| 1971-06-28 | vs CIN | 73 | L 4-5 | 29-44 | 6 | 22,970 | Carl Morton | Ross Grimsley | Clay Carroll | Claude Raymond | Joe Gibbon | 249 | 297 | -48 |
| 1971-06-29 | vs CIN | 74 | L 0-14 | 29-45 | 6 | 15,501 | Ernie McAnally | Tony Cloninger | Tony Cloninger | Ernie McAnally | | 249 | 311 | -62 |
| 1971-06-30 | vs ATL | 75 | L 5-6 | 29-46 | 6 | 13,906 | Steve Renko | Tom Kelley | Tom Kelley | Steve Renko | Ron Herbel | 254 | 317 | -63 |
| 1971-07-01 | vs ATL | 76 | L 3-7 | 29-47 | 6 | 11,176 | John Strohmayer | George Stone | Phil Niekro | Mike Marshall | Cecil Upshaw | 257 | 324 | -67 |
| 1971-07-02 | vs PHI | 77 | W 4-2 | 30-48 | 6 | 0 | Dan McGinn | Rick Wise | Dan McGinn | Rick Wise | | 261 | 326 | -65 |
| 1971-07-02 | vs PHI | 78 | L 4-8 | 30-48 | 6 | 22,210 | Bill Stoneman | Ken Reynolds | Woodie Fryman | Bill Stoneman | | 265 | 334 | -69 |
| 1971-07-03 | vs PHI | 79 | L 3-6 | 30-49 | 6 | 17,074 | Carl Morton | Barry Lersch | Joe Hoerner | Carl Morton | | 268 | 340 | -72 |
| 1971-07-04 | vs PHI | 80 | L 6-10 | 30-50 | 6 | 16,422 | Ernie McAnally | Chris Short | Chris Short | Claude Raymond | Bill Wilson | 274 | 350 | -76 |
| 1971-07-05 | @ NYN | 81 | W 2-1 | 31-51 | 6 | 0 | John Strohmayer | Nolan Ryan | John Strohmayer | Nolan Ryan | | 276 | 351 | -75 |
| 1971-07-05 | @ NYN | 82 | L 0-8 | 31-51 | 6 | 39,849 | Steve Renko | Ray Sadecki | Ray Sadecki | Steve Renko | | 276 | 359 | -83 |
| 1971-07-06 | @ NYN | 83 | W 5-1 | 32-51 | 6 | 29,906 | Bill Stoneman | Jerry Koosman | Bill Stoneman | Jerry Koosman | | 281 | 360 | -79 |
| 1971-07-07 | @ NYN | 84 | W 12-7 | 33-51 | 6 | 26,324 | Carl Morton | Charlie Williams | Carl Morton | Charlie Williams | Mike Marshall | 293 | 367 | -74 |
| 1971-07-08 | @ PHI | 85 | L 5-7 | 33-52 | 6 | 12,586 | Dan McGinn | Ken Reynolds | Bill Wilson | Howie Reed | | 298 | 374 | -76 |
| 1971-07-09 | @ PHI | 86 | W 3-0 | 34-52 | 6 | 14,847 | Steve Renko | Chris Short | Steve Renko | Chris Short | | 301 | 374 | -73 |
| 1971-07-10 | @ PHI | 87 | L 0-2 | 34-54 | 6 | 0 | John Strohmayer | Woodie Fryman | Woodie Fryman | John Strohmayer | | 301 | 376 | -75 |
| 1971-07-10 | @ PHI | 88 | L 2-3 | 34-54 | 6 | 37,014 | Bill Stoneman | Rick Wise | Rick Wise | Bill Stoneman | | 303 | 379 | -76 |
| 1971-07-11 | @ PHI | 89 | L 5-11 | 34-55 | 6 | 10,321 | Carl Morton | Barry Lersch | Bill Champion | Dan McGinn | Joe Hoerner | 308 | 390 | -82 |
| 1971-07-15 | @ SLN | 90 | L 3-7 | 35-56 | 6 | 0 | John Strohmayer | Steve Carlton | Steve Carlton | John Strohmayer | | 311 | 397 | -86 |
| 1971-07-15 | @ SLN | 91 | W 6-4 | 35-56 | 6 | 19,409 | Bill Stoneman | Jerry Reuss | Bill Stoneman | Jerry Reuss | | 317 | 401 | -84 |
| 1971-07-16 | @ SLN | 92 | L 0-6 | 35-57 | 6 | 23,765 | Steve Renko | Reggie Cleveland | Reggie Cleveland | Steve Renko | | 317 | 407 | -90 |
| 1971-07-17 | @ SLN | 93 | W 5-3 | 36-57 | 6 | 22,791 | Ernie McAnally | Bob Gibson | Ernie McAnally | Bob Gibson | | 322 | 410 | -88 |
| 1971-07-18 | @ CHN | 94 | L 4-8 | 36-58 | 6 | 31,985 | Dan McGinn | Milt Pappas | Ray Newman | Dan McGinn | | 326 | 418 | -92 |
| 1971-07-19 | @ CHN | 95 | W 5-3 | 37-58 | 6 | 13,514 | John Strohmayer | Ken Holtzman | John Strohmayer | Ken Holtzman | Mike Marshall | 331 | 421 | -90 |
| 1971-07-20 | @ HOU | 96 | W 4-3 | 38-58 | 6 | 12,397 | Bill Stoneman | Ken Forsch | Mike Marshall | Buddy Harris | | 335 | 424 | -89 |
| 1971-07-21 | @ HOU | 97 | W 5-3 | 39-58 | 6 | 13,780 | Steve Renko | Jack Billingham | Steve Renko | Fred Gladding | | 340 | 427 | -87 |
| 1971-07-22 | @ HOU | 98 | L 2-8 | 39-59 | 6 | 15,058 | Ernie McAnally | Wade Blasingame | Wade Blasingame | Ernie McAnally | George Culver | 342 | 435 | -93 |
| 1971-07-23 | vs SLN | 99 | L 2-6 | 39-60 | 6 | 20,480 | Dan McGinn | Chuck Taylor | Chris Zachary | Dan McGinn | | 344 | 441 | -97 |
| 1971-07-24 | vs SLN | 100 | L 7-8 | 39-62 | 6 | 0 | John Strohmayer | Steve Carlton | Don Shaw | Claude Raymond | | 351 | 449 | -98 |
| 1971-07-24 | vs SLN | 101 | L 3-9 | 39-62 | 6 | 24,109 | Carl Morton | Jerry Reuss | Jerry Reuss | Carl Morton | | 354 | 458 | -104 |
| 1971-07-25 | vs SLN | 102 | W 5-4 | 40-62 | 6 | 20,346 | Bill Stoneman | Reggie Cleveland | Bill Stoneman | Reggie Cleveland | | 359 | 462 | -103 |
| 1971-07-26 | vs CHN | 103 | L 2-5 | 40-63 | 6 | 16,037 | Steve Renko | Milt Pappas | Milt Pappas | Steve Renko | | 361 | 467 | -106 |
| 1971-07-27 | vs CHN | 104 | W 6-1 | 41-63 | 6 | 20,401 | Ernie McAnally | Ken Holtzman | Ernie McAnally | Ken Holtzman | | 367 | 468 | -101 |
| 1971-07-28 | vs CHN | 105 | L 2-10 | 41-64 | 6 | 17,063 | Carl Morton | Fergie Jenkins | Fergie Jenkins | Carl Morton | | 369 | 478 | -109 |
| 1971-07-30 | vs HOU | 106 | W 7-4 | 42-65 | 6 | 0 | John Strohmayer | Ken Forsch | John Strohmayer | Ken Forsch | Mike Marshall | 376 | 482 | -106 |
| 1971-07-30 | vs HOU | 107 | L 5-6 | 42-65 | 6 | 23,654 | Bill Stoneman | Bill Greif | Jim Ray | Mike Marshall | | 381 | 488 | -107 |
| 1971-07-31 | vs HOU | 108 | W 6-4 | 42-65 | 6 | 14,306 | Steve Renko | Jack Billingham | Steve Renko | Jack Billingham | Mike Marshall | 387 | 492 | -105 |
| 1971-08-01 | vs HOU | 109 | L 1-8 | 42-66 | 6 | 17,605 | Ernie McAnally | Wade Blasingame | Wade Blasingame | Ernie McAnally | | 388 | 500 | -112 |
| 1971-08-03 | vs PIT | 110 | L 6-10 | 42-67 | 6 | 18,137 | Carl Morton | Steve Blass | Bob Veale | Carl Morton | Dave Giusti | 394 | 510 | -116 |
| 1971-08-04 | vs PIT | 111 | W 4-3 | 43-67 | 6 | 17,481 | Bill Stoneman | Luke Walker | Mike Marshall | Mudcat Grant | | 398 | 513 | -115 |
| 1971-08-05 | vs PIT | 112 | L 2-7 | 43-68 | 6 | 21,233 | John Strohmayer | Bruce Kison | Bruce Kison | John Strohmayer | | 400 | 520 | -120 |
| 1971-08-06 | @ CIN | 113 | L 1-9 | 43-69 | 6 | 18,061 | Steve Renko | Don Gullett | Don Gullett | Steve Renko | | 401 | 529 | -128 |
| 1971-08-07 | @ CIN | 114 | W 4-3 | 44-69 | 6 | 22,861 | Ernie McAnally | Jim McGlothlin | Ernie McAnally | Jim McGlothlin | Mike Marshall | 405 | 532 | -127 |
| 1971-08-08 | @ CIN | 115 | L 3-6 | 44-70 | 6 | 28,158 | Carl Morton | Ross Grimsley | Clay Carroll | John Strohmayer | | 408 | 538 | -130 |
| 1971-08-10 | @ SFN | 116 | L 0-1 | 44-71 | 6 | 6,879 | Bill Stoneman | Juan Marichal | Juan Marichal | Bill Stoneman | | 408 | 539 | -131 |
| 1971-08-11 | @ SFN | 117 | W 5-0 | 45-71 | 6 | 6,697 | Steve Renko | John Cumberland | Steve Renko | John Cumberland | | 413 | 539 | -126 |
| 1971-08-13 | @ LAN | 118 | L 0-2 | 45-72 | 6 | 26,861 | Carl Morton | Don Sutton | Don Sutton | Carl Morton | | 413 | 541 | -128 |
| 1971-08-14 | @ LAN | 119 | W 3-0 | 46-72 | 6 | 26,851 | Bill Stoneman | Al Downing | Bill Stoneman | Al Downing | | 416 | 541 | -125 |
| 1971-08-15 | @ LAN | 120 | W 6-3 | 47-72 | 6 | 18,572 | Steve Renko | Bill Singer | Steve Renko | Bill Singer | | 422 | 544 | -122 |
| 1971-08-17 | @ SDN | 121 | W 11-0 | 48-72 | 6 | 4,248 | Ernie McAnally | Steve Arlin | Ernie McAnally | Steve Arlin | | 433 | 544 | -111 |
| 1971-08-18 | @ SDN | 122 | W 4-3 | 48-72 | 6 | 4,848 | Carl Morton | Fred Norman | Carl Morton | Fred Norman | Mike Marshall | 437 | 547 | -110 |
| 1971-08-20 | vs SFN | 123 | W 4-1 | 49-72 | 6 | 26,122 | Bill Stoneman | Juan Marichal | Bill Stoneman | Juan Marichal | | 441 | 548 | -107 |
| 1971-08-21 | vs SFN | 124 | W 4-3 | 50-72 | 6 | 23,242 | Steve Renko | Gaylord Perry | Mike Marshall | Jerry Johnson | | 445 | 551 | -106 |
| 1971-08-22 | vs SFN | 125 | W 6-3 | 51-72 | 6 | 28,102 | Ernie McAnally | John Cumberland | Ernie McAnally | Jim Barr | | 451 | 554 | -103 |
| 1971-08-23 | vs LAN | 126 | W 12-6 | 52-72 | 6 | 16,291 | John Strohmayer | Don Sutton | John Strohmayer | Don Sutton | Mike Marshall | 463 | 560 | -97 |
| 1971-08-24 | vs LAN | 127 | L 4-6 | 52-73 | 6 | 28,159 | Bill Stoneman | Al Downing | Al Downing | Bill Stoneman | Don Sutton | 467 | 566 | -99 |
| 1971-08-25 | vs LAN | 128 | L 1-4 | 52-74 | 6 | 18,037 | Steve Renko | Doyle Alexander | Doyle Alexander | Steve Renko | Jim Brewer | 468 | 570 | -102 |
| 1971-08-29 | vs SDN | 129 | W 6-1 | 53-75 | 6 | 0 | Ernie McAnally | Dave Roberts | Ernie McAnally | Dave Roberts | | 474 | 571 | -97 |
| 1971-08-29 | vs SDN | 130 | L 3-13 | 53-75 | 6 | 27,383 | Bill Stoneman | Steve Arlin | Steve Arlin | Bill Stoneman | | 477 | 584 | -107 |
| 1971-08-30 | @ CHN | 131 | W 6-2 | 54-75 | 6 | 13,651 | Steve Renko | Bill Hands | Steve Renko | Bill Hands | Mike Marshall | 483 | 586 | -103 |
| 1971-08-31 | @ CHN | 132 | L 6-7 | 55-76 | 6 | 0 | Carl Morton | Milt Pappas | Phil Regan | Howie Reed | | 489 | 593 | -104 |
| 1971-08-31 | @ CHN | 133 | W 11-2 | 55-76 | 6 | 18,699 | John Strohmayer | Ken Holtzman | John Strohmayer | Ken Holtzman | Mike Marshall | 500 | 595 | -95 |
| 1971-09-01 | @ CHN | 134 | L 2-5 | 55-77 | 6 | 11,575 | Bill Stoneman | Fergie Jenkins | Fergie Jenkins | Bill Stoneman | | 502 | 600 | -98 |
| 1971-09-02 | @ CHN | 135 | W 9-5 | 56-77 | 5 | 9,402 | Ernie McAnally | Juan Pizarro | Ernie McAnally | Juan Pizarro | Mike Marshall | 511 | 605 | -94 |
| 1971-09-03 | @ PIT | 136 | W 6-4 | 57-77 | 5 | 17,951 | Steve Renko | Steve Blass | Jim Britton | Dave Giusti | Mike Marshall | 517 | 609 | -92 |
| 1971-09-04 | @ PIT | 137 | L 6-7 | 57-78 | 5 | 11,302 | Carl Morton | Bob Johnson | Dave Giusti | Mike Marshall | | 523 | 616 | -93 |
| 1971-09-05 | @ PIT | 138 | L 2-8 | 57-79 | 5 | 15,897 | Bill Stoneman | Bruce Kison | Bruce Kison | Bill Stoneman | Ramon Hernandez | 525 | 624 | -99 |
| 1971-09-06 | vs NYN | 139 | L 0-7 | 57-80 | 5 | 15,543 | Ernie McAnally | Tom Seaver | Tom Seaver | Ernie McAnally | | 525 | 631 | -106 |
| 1971-09-07 | vs NYN | 140 | W 9-3 | 58-80 | 5 | 13,254 | Steve Renko | Gary Gentry | Steve Renko | Gary Gentry | Mike Marshall | 534 | 634 | -100 |
| 1971-09-08 | vs NYN | 141 | W 10-2 | 59-80 | 5 | 16,639 | Carl Morton | Ray Sadecki | Carl Morton | Ray Sadecki | Mike Marshall | 544 | 636 | -92 |
| 1971-09-10 | vs PIT | 142 | W 3-2 | 60-80 | 5 | 21,529 | Bill Stoneman | Bob Johnson | John Strohmayer | Dave Giusti | | 547 | 638 | -91 |
| 1971-09-11 | vs PIT | 143 | W 4-1 | 61-80 | 5 | 18,376 | Ernie McAnally | Bruce Kison | Ernie McAnally | Bruce Kison | | 551 | 639 | -88 |
| 1971-09-12 | vs PIT | 144 | L 0-4 | 61-81 | 5 | 16,770 | Steve Renko | Nelson Briles | Nelson Briles | Steve Renko | | 551 | 643 | -92 |
| 1971-09-13 | @ NYN | 145 | L 2-4 | 61-82 | 5 | 9,507 | Carl Morton | Ray Sadecki | Ray Sadecki | Carl Morton | | 553 | 647 | -94 |
| 1971-09-14 | @ NYN | 146 | W 12-1 | 62-83 | 5 | 0 | John Strohmayer | Nolan Ryan | Bill Stoneman | Nolan Ryan | | 565 | 648 | -83 |
| 1971-09-14 | @ NYN | 147 | L 3-6 | 62-83 | 5 | 4,038 | Jim Britton | Jim McAndrew | Jim McAndrew | Jim Britton | Danny Frisella | 568 | 654 | -86 |
| 1971-09-15 | @ PHI | 148 | W 1-0 | 63-83 | 5 | 7,734 | Ernie McAnally | Woodie Fryman | Ernie McAnally | Woodie Fryman | | 569 | 654 | -85 |
| 1971-09-16 | @ PHI | 149 | W 6-2 | 64-83 | 5 | 5,893 | Steve Renko | Bill Champion | Steve Renko | Bill Champion | | 575 | 656 | -81 |
| 1971-09-17 | vs SLN | 150 | L 2-7 | 64-84 | 5 | 13,371 | Carl Morton | Bob Gibson | Bob Gibson | Carl Morton | | 577 | 663 | -86 |
| 1971-09-18 | vs SLN | 151 | W 4-2 | 65-84 | 5 | 16,779 | Bill Stoneman | Reggie Cleveland | Bill Stoneman | Reggie Cleveland | | 581 | 665 | -84 |
| 1971-09-19 | vs SLN | 152 | L 0-11 | 65-85 | 5 | 25,769 | Ernie McAnally | Steve Carlton | Steve Carlton | Ernie McAnally | | 581 | 676 | -95 |
| 1971-09-21 | vs PHI | 153 | L 4-5 | 66-86 | 5 | 0 | Carl Morton | Bill Champion | Bill Champion | Carl Morton | Bill Wilson | 585 | 681 | -96 |
| 1971-09-21 | vs PHI | 154 | W 4-3 | 66-86 | 5 | 14,963 | Jim Britton | Ken Reynolds | Jim Britton | Ken Reynolds | Mike Marshall | 589 | 684 | -95 |
| 1971-09-22 | vs PHI | 155 | W 2-0 | 67-86 | 5 | 8,798 | Bill Stoneman | Rick Wise | Bill Stoneman | Rick Wise | | 591 | 684 | -93 |
| 1971-09-23 | vs PHI | 156 | L 4-6 | 67-87 | 5 | 6,786 | Ernie McAnally | Woodie Fryman | Wayne Twitchell | Ernie McAnally | Bill Wilson | 595 | 690 | -95 |
| 1971-09-24 | @ SLN | 157 | L 6-10 | 67-88 | 5 | 8,109 | Steve Renko | Steve Carlton | Chuck Taylor | Mike Marshall | | 601 | 700 | -99 |
| 1971-09-25 | @ SLN | 158 | L 6-8 | 67-89 | 5 | 9,114 | Carl Morton | Jerry Reuss | Don Shaw | Carl Morton | | 607 | 708 | -101 |
| 1971-09-26 | @ SLN | 159 | L 1-7 | 67-90 | 5 | 11,473 | Bill Stoneman | Daryl Patterson | Dennis Higgins | Bill Stoneman | | 608 | 715 | -107 |
| 1971-09-28 | vs CHN | 160 | W 5-4 | 68-90 | 5 | 10,232 | Ernie McAnally | Juan Pizarro | Ernie McAnally | Phil Regan | | 613 | 719 | -106 |
| 1971-09-29 | vs CHN | 161 | W 6-5 | 69-90 | 5 | 9,786 | Steve Renko | Milt Pappas | Mike Marshall | Ray Newman | | 619 | 724 | -105 |
| 1971-09-30 | vs CHN | 162 | L 3-5 | 69-91 | 5 | 27,274 | Bill Stoneman | Fergie Jenkins | Fergie Jenkins | Bill Stoneman | | 622 | 729 | -107 |