| 1971-04-05 | vs LAN | 1 | W 5-2 | - | | 22,421 | Larry Dierker | Bill Singer | Larry Dierker | Bill Singer | | 5 | 2 | 3 |
| 1971-04-06 | vs LAN | 2 | L 0-2 | - | | 11,883 | Don Wilson | Claude Osteen | Claude Osteen | Don Wilson | | 5 | 4 | 1 |
| 1971-04-07 | vs LAN | 3 | W 2-1 | - | | 11,009 | Wade Blasingame | Don Sutton | Wade Blasingame | Don Sutton | George Culver | 7 | 5 | 2 |
| 1971-04-08 | vs CHN | 4 | W 7-3 | - | | 11,375 | Jack Billingham | Ken Holtzman | Jack Billingham | Ken Holtzman | | 14 | 8 | 6 |
| 1971-04-09 | vs CHN | 5 | L 0-6 | - | | 17,359 | Tom Griffin | Milt Pappas | Milt Pappas | Tom Griffin | | 14 | 14 | 0 |
| 1971-04-10 | vs CHN | 6 | W 2-1 | - | | 22,341 | Larry Dierker | Fergie Jenkins | George Culver | Fergie Jenkins | | 16 | 15 | 1 |
| 1971-04-11 | vs CHN | 7 | W 7-4 | - | | 12,978 | Don Wilson | Bill Hands | Don Wilson | Bill Hands | | 23 | 19 | 4 |
| 1971-04-12 | @ SLN | 8 | L 4-5 | - | | 11,270 | Wade Blasingame | Steve Carlton | Steve Carlton | Wade Blasingame | Frank Linzy | 27 | 24 | 3 |
| 1971-04-13 | @ SLN | 9 | W 8-4 | - | | 5,105 | Jack Billingham | Mike Torrez | George Culver | Mike Torrez | Denny Lemaster | 35 | 28 | 7 |
| 1971-04-14 | @ SFN | 10 | L 1-2 | - | | 3,588 | Tom Griffin | Steve Stone | Don McMahon | George Culver | | 36 | 30 | 6 |
| 1971-04-15 | @ SFN | 11 | L 3-4 | - | | 3,557 | Larry Dierker | Frank Reberger | Jerry Johnson | Jim Ray | | 39 | 34 | 5 |
| 1971-04-16 | @ LAN | 12 | L 5-6 | - | | 18,492 | Don Wilson | Sandy Vance | Pete Mikkelsen | George Culver | | 44 | 40 | 4 |
| 1971-04-17 | @ LAN | 13 | W 5-3 | - | | 16,172 | Wade Blasingame | Bill Singer | Wade Blasingame | Bill Singer | Denny Lemaster | 49 | 43 | 6 |
| 1971-04-18 | @ LAN | 14 | W 8-6 | - | | 19,097 | Jack Billingham | Claude Osteen | Jack Billingham | Claude Osteen | George Culver | 57 | 49 | 8 |
| 1971-04-20 | @ CHN | 15 | L 1-3 | - | | 6,199 | Tom Griffin | Fergie Jenkins | Fergie Jenkins | Tom Griffin | | 58 | 52 | 6 |
| 1971-04-22 | @ CHN | 16 | W 6-1 | - | | 4,100 | Larry Dierker | Bill Hands | Larry Dierker | Bill Hands | | 64 | 53 | 11 |
| 1971-04-23 | vs MON | 17 | L 2-3 | - | | 25,430 | Don Wilson | Carl Morton | Carl Morton | Don Wilson | Mike Marshall | 66 | 56 | 10 |
| 1971-04-24 | vs MON | 18 | L 2-3 | - | | 17,252 | Wade Blasingame | Steve Renko | Steve Renko | Wade Blasingame | Mike Marshall | 68 | 59 | 9 |
| 1971-04-25 | vs MON | 19 | L 1-2 | - | | 12,122 | Jack Billingham | Bill Stoneman | Bill Stoneman | Jack Billingham | | 69 | 61 | 8 |
| 1971-04-26 | vs PHI | 20 | L 1-2 | - | | 7,227 | Tom Griffin | Rick Wise | Rick Wise | Tom Griffin | | 70 | 63 | 7 |
| 1971-04-27 | vs PHI | 21 | W 1-0 | - | | 8,152 | Larry Dierker | Jim Bunning | Larry Dierker | Jim Bunning | | 71 | 63 | 8 |
| 1971-04-28 | vs PHI | 22 | W 4-3 | - | | 8,576 | Don Wilson | Barry Lersch | Jim Ray | Bucky Brandon | | 75 | 66 | 9 |
| 1971-04-30 | vs NYN | 23 | L 3-4 | - | | 13,860 | Tom Griffin | Jim McAndrew | Tug McGraw | George Culver | | 78 | 70 | 8 |
| 1971-05-01 | vs NYN | 24 | W 3-1 | - | | 23,571 | Larry Dierker | Tom Seaver | Larry Dierker | Tom Seaver | | 81 | 71 | 10 |
| 1971-05-02 | vs NYN | 25 | L 5-6 | - | | 15,616 | Don Wilson | Jerry Koosman | Ron Taylor | George Culver | | 86 | 77 | 9 |
| 1971-05-05 | @ MON | 26 | L 1-5 | - | | 8,282 | Wade Blasingame | Bill Stoneman | Bill Stoneman | Wade Blasingame | | 87 | 82 | 5 |
| 1971-05-06 | @ MON | 27 | W 5-2 | - | | 7,403 | Larry Dierker | Steve Renko | Larry Dierker | Steve Renko | Fred Gladding | 92 | 84 | 8 |
| 1971-05-07 | @ PHI | 28 | W 8-1 | - | | 15,728 | Don Wilson | Jim Bunning | Don Wilson | Jim Bunning | | 100 | 85 | 15 |
| 1971-05-09 | @ PHI | 29 | L 1-2 | - | | 36,145 | Jack Billingham | Barry Lersch | Barry Lersch | Jack Billingham | | 101 | 87 | 14 |
| 1971-05-10 | @ NYN | 30 | L 1-2 | - | | 16,056 | Wade Blasingame | Gary Gentry | Gary Gentry | Wade Blasingame | Tug McGraw | 102 | 89 | 13 |
| 1971-05-11 | @ NYN | 31 | L 1-8 | - | | 20,612 | Larry Dierker | Nolan Ryan | Nolan Ryan | Larry Dierker | | 103 | 97 | 6 |
| 1971-05-12 | @ NYN | 32 | W 5-4 | - | | 20,547 | Don Wilson | Tom Seaver | Don Wilson | Tom Seaver | Fred Gladding | 108 | 101 | 7 |
| 1971-05-14 | vs SLN | 33 | L 2-4 | - | | 16,437 | Jack Billingham | Bob Gibson | Bob Gibson | Jack Billingham | | 110 | 105 | 5 |
| 1971-05-15 | vs SLN | 34 | L 5-6 | - | | 19,285 | Wade Blasingame | Steve Carlton | Steve Carlton | Tom Griffin | Chuck Taylor | 115 | 111 | 4 |
| 1971-05-16 | vs SLN | 35 | W 12-4 | - | | 14,983 | Larry Dierker | Jerry Reuss | Larry Dierker | Jerry Reuss | Jim Ray | 127 | 115 | 12 |
| 1971-05-17 | vs SDN | 36 | W 2-0 | - | | 7,457 | Don Wilson | Dave Roberts | Don Wilson | Dave Roberts | | 129 | 115 | 14 |
| 1971-05-18 | vs SDN | 37 | W 3-2 | - | | 8,015 | Ken Forsch | Steve Arlin | Fred Gladding | Bob Miller | | 132 | 117 | 15 |
| 1971-05-19 | vs SDN | 38 | L 1-2 | - | | 8,816 | Jack Billingham | Tom Phoebus | Bob Miller | Fred Gladding | | 133 | 119 | 14 |
| 1971-05-20 | vs SDN | 39 | L 2-4 | - | | 7,162 | Wade Blasingame | Clay Kirby | Clay Kirby | Wade Blasingame | Al Severinsen | 135 | 123 | 12 |
| 1971-05-21 | vs SFN | 40 | W 4-1 | - | | 18,555 | Larry Dierker | Gaylord Perry | Larry Dierker | Gaylord Perry | Fred Gladding | 139 | 124 | 15 |
| 1971-05-22 | vs SFN | 41 | W 2-1 | - | | 25,893 | Don Wilson | Rich Robertson | George Culver | Don McMahon | | 141 | 125 | 16 |
| 1971-05-23 | vs SFN | 42 | L 4-7 | - | | 23,692 | Tom Griffin | Ron Bryant | Ron Bryant | Tom Griffin | Jerry Johnson | 145 | 132 | 13 |
| 1971-05-25 | @ SDN | 43 | W 3-2 | - | | 2,863 | Jack Billingham | Clay Kirby | Jack Billingham | Clay Kirby | Fred Gladding | 148 | 134 | 14 |
| 1971-05-26 | @ SDN | 44 | W 2-1 | - | | 0 | Wade Blasingame | Al Santorini | Wade Blasingame | Dave Roberts | George Culver | 150 | 135 | 15 |
| 1971-05-26 | @ SDN | 45 | W 8-0 | - | | 4,221 | Larry Dierker | Al Santorini | Larry Dierker | Al Santorini | | 158 | 135 | 23 |
| 1971-05-28 | @ CIN | 46 | L 0-1 | - | | 11,471 | Don Wilson | Don Gullett | Clay Carroll | George Culver | | 158 | 136 | 22 |
| 1971-05-29 | @ CIN | 47 | W 2-1 | - | | 15,285 | Ken Forsch | Gary Nolan | Ken Forsch | Gary Nolan | | 160 | 137 | 23 |
| 1971-05-30 | @ CIN | 48 | L 1-2 | - | | 23,111 | Jack Billingham | Ross Grimsley | Ross Grimsley | Jack Billingham | | 161 | 139 | 22 |
| 1971-05-31 | @ CIN | 49 | W 4-1 | - | | 12,186 | Larry Dierker | Tony Cloninger | Larry Dierker | Tony Cloninger | | 165 | 140 | 25 |
| 1971-06-01 | @ ATL | 50 | W 7-6 | - | | 6,754 | Wade Blasingame | Tom Kelley | Wade Blasingame | Tom Kelley | Fred Gladding | 172 | 146 | 26 |
| 1971-06-02 | @ ATL | 51 | L 1-3 | - | | 4,586 | Don Wilson | Ron Reed | Ron Reed | Don Wilson | Cecil Upshaw | 173 | 149 | 24 |
| 1971-06-03 | @ ATL | 52 | L 2-5 | - | | 5,425 | Ken Forsch | Jim Nash | Pat Jarvis | Ken Forsch | Bob Priddy | 175 | 154 | 21 |
| 1971-06-04 | @ PIT | 53 | L 2-3 | - | | 14,025 | Jack Billingham | Bob Moose | Bob Moose | Jack Billingham | Dave Giusti | 177 | 157 | 20 |
| 1971-06-05 | @ PIT | 54 | W 4-1 | - | | 23,793 | Larry Dierker | Steve Blass | Larry Dierker | Steve Blass | Fred Gladding | 181 | 158 | 23 |
| 1971-06-06 | @ PIT | 55 | L 8-9 | - | | 23,051 | Wade Blasingame | Dock Ellis | Dock Ellis | Wade Blasingame | Bob Veale | 189 | 167 | 22 |
| 1971-06-08 | vs CIN | 56 | W 2-0 | - | | 1,740 | Don Wilson | Gary Nolan | Don Wilson | Gary Nolan | | 191 | 167 | 24 |
| 1971-06-09 | vs CIN | 57 | L 1-2 | - | | 16,354 | Jack Billingham | Ross Grimsley | Clay Carroll | Jack Billingham | | 192 | 169 | 23 |
| 1971-06-10 | vs ATL | 58 | L 1-2 | - | | 14,591 | Larry Dierker | Tom Kelley | Tom Kelley | Larry Dierker | Cecil Upshaw | 193 | 171 | 22 |
| 1971-06-11 | vs ATL | 59 | W 5-4 | - | | 14,885 | Wade Blasingame | Jim Nash | Fred Gladding | Bob Priddy | | 198 | 175 | 23 |
| 1971-06-12 | vs ATL | 60 | W 3-2 | - | | 23,876 | Ken Forsch | Ron Reed | Ken Forsch | Ron Reed | | 201 | 177 | 24 |
| 1971-06-13 | vs ATL | 61 | L 0-9 | - | | 19,646 | Don Wilson | Pat Jarvis | Pat Jarvis | Don Wilson | | 201 | 186 | 15 |
| 1971-06-14 | vs PIT | 62 | W 5-4 | - | | 11,655 | Jack Billingham | Bob Moose | Fred Gladding | Jim Nelson | | 206 | 190 | 16 |
| 1971-06-15 | vs PIT | 63 | L 0-3 | - | | 16,307 | Larry Dierker | Steve Blass | Steve Blass | Larry Dierker | | 206 | 193 | 13 |
| 1971-06-16 | vs PIT | 64 | L 4-6 | - | | 16,098 | Wade Blasingame | Dock Ellis | Dock Ellis | Wade Blasingame | | 210 | 199 | 11 |
| 1971-06-18 | @ LAN | 65 | L 4-5 | - | | 20,756 | Don Wilson | Claude Osteen | Claude Osteen | Don Wilson | Jim Brewer | 214 | 204 | 10 |
| 1971-06-19 | @ LAN | 66 | L 0-4 | - | | 24,677 | Jack Billingham | Don Sutton | Don Sutton | Jack Billingham | | 214 | 208 | 6 |
| 1971-06-20 | @ LAN | 67 | W 9-7 | - | | 24,277 | Larry Dierker | Al Downing | Jim Ray | Al Downing | Fred Gladding | 223 | 215 | 8 |
| 1971-06-22 | @ SDN | 68 | W 4-2 | - | | 4,300 | Ken Forsch | Steve Arlin | Ken Forsch | Steve Arlin | Fred Gladding | 227 | 217 | 10 |
| 1971-06-23 | @ SDN | 69 | L 2-3 | - | | 0 | Don Wilson | Clay Kirby | Bob Miller | Fred Gladding | | 229 | 220 | 9 |
| 1971-06-23 | @ SDN | 70 | L 3-4 | - | | 5,936 | Wade Blasingame | Tom Phoebus | Bob Miller | George Culver | | 232 | 224 | 8 |
| 1971-06-25 | vs SFN | 71 | W 5-4 | - | | 24,713 | Jack Billingham | Gaylord Perry | Jim Ray | Gaylord Perry | | 237 | 228 | 9 |
| 1971-06-26 | vs SFN | 72 | L 1-3 | - | | 32,025 | Larry Dierker | Ron Bryant | Ron Bryant | Larry Dierker | Steve Hamilton | 238 | 231 | 7 |
| 1971-06-27 | vs SFN | 73 | W 5-2 | - | | 24,908 | Ken Forsch | Steve Stone | Ken Forsch | Steve Stone | | 243 | 233 | 10 |
| 1971-06-28 | vs ATL | 74 | W 6-5 | - | | 0 | Don Wilson | Steve Barber | Don Wilson | Steve Barber | | 249 | 238 | 11 |
| 1971-06-28 | vs ATL | 75 | W 6-4 | - | | 18,908 | Wade Blasingame | Jim Nash | Jim Ray | Jim Nash | George Culver | 255 | 242 | 13 |
| 1971-06-29 | vs ATL | 76 | L 4-5 | - | | 14,855 | Jack Billingham | Phil Niekro | Phil Niekro | Jack Billingham | Cecil Upshaw | 259 | 247 | 12 |
| 1971-07-02 | vs CIN | 77 | W 3-2 | - | | 17,996 | Larry Dierker | Gary Nolan | Larry Dierker | Gary Nolan | Fred Gladding | 262 | 249 | 13 |
| 1971-07-03 | vs CIN | 78 | W 4-3 | - | | 26,217 | Don Wilson | Don Gullett | Jim Ray | Joe Gibbon | | 266 | 252 | 14 |
| 1971-07-04 | vs CIN | 79 | W 6-1 | - | | 25,768 | Ken Forsch | Ross Grimsley | Ken Forsch | Ross Grimsley | | 272 | 253 | 19 |
| 1971-07-05 | vs CIN | 80 | W 4-3 | - | | 19,854 | Wade Blasingame | Wayne Simpson | Wade Blasingame | Wayne Simpson | Fred Gladding | 276 | 256 | 20 |
| 1971-07-06 | @ SFN | 81 | W 5-2 | - | | 5,765 | Jack Billingham | Ron Bryant | Jack Billingham | Ron Bryant | George Culver | 281 | 258 | 23 |
| 1971-07-07 | @ SFN | 82 | W 18-4 | - | | 5,791 | Larry Dierker | Steve Stone | Larry Dierker | Steve Stone | Jim Ray | 299 | 262 | 37 |
| 1971-07-08 | @ SFN | 83 | L 2-4 | - | | 6,849 | Don Wilson | John Cumberland | John Cumberland | Don Wilson | | 301 | 266 | 35 |
| 1971-07-09 | @ SLN | 84 | L 2-5 | - | | 0 | Ken Forsch | Steve Carlton | Steve Carlton | Ken Forsch | | 303 | 271 | 32 |
| 1971-07-09 | @ SLN | 85 | L 5-9 | - | | 24,748 | Wade Blasingame | Jerry Reuss | Jerry Reuss | Wade Blasingame | Moe Drabowsky | 308 | 280 | 28 |
| 1971-07-10 | @ SLN | 86 | L 5-6 | - | | 32,895 | Jack Billingham | Reggie Cleveland | Frank Linzy | Fred Gladding | | 313 | 286 | 27 |
| 1971-07-11 | @ SLN | 87 | L 3-7 | - | | 15,252 | Jim Ray | Bob Gibson | Bob Gibson | Jim Ray | | 316 | 293 | 23 |
| 1971-07-15 | vs NYN | 88 | L 4-9 | - | | 20,412 | Ken Forsch | Gary Gentry | Tug McGraw | Ken Forsch | | 320 | 302 | 18 |
| 1971-07-16 | vs NYN | 89 | W 9-4 | - | | 20,621 | Jack Billingham | Nolan Ryan | Jack Billingham | Nolan Ryan | Fred Gladding | 329 | 306 | 23 |
| 1971-07-17 | vs NYN | 90 | W 2-1 | - | | 32,852 | Larry Dierker | Tom Seaver | Jim Ray | Tom Seaver | | 331 | 307 | 24 |
| 1971-07-18 | vs PHI | 91 | L 0-1 | - | | 0 | Don Wilson | Ken Reynolds | Ken Reynolds | Don Wilson | | 331 | 308 | 23 |
| 1971-07-18 | vs PHI | 92 | W 10-7 | - | | 32,181 | Wade Blasingame | Jim Bunning | George Culver | Jim Bunning | | 341 | 315 | 26 |
| 1971-07-19 | vs PHI | 93 | W 3-2 | - | | 13,693 | Bill Greif | Rick Wise | Buddy Harris | Bill Wilson | | 344 | 317 | 27 |
| 1971-07-20 | vs MON | 94 | L 3-4 | - | | 12,397 | Ken Forsch | Bill Stoneman | Mike Marshall | Buddy Harris | | 347 | 321 | 26 |
| 1971-07-21 | vs MON | 95 | L 3-5 | - | | 13,780 | Jack Billingham | Steve Renko | Steve Renko | Fred Gladding | | 350 | 326 | 24 |
| 1971-07-22 | vs MON | 96 | W 8-2 | - | | 15,058 | Wade Blasingame | Ernie McAnally | Wade Blasingame | Ernie McAnally | George Culver | 358 | 328 | 30 |
| 1971-07-23 | @ NYN | 97 | W 5-1 | - | | 37,227 | Don Wilson | Nolan Ryan | Don Wilson | Nolan Ryan | | 363 | 329 | 34 |
| 1971-07-24 | @ NYN | 98 | L 3-9 | - | | 24,368 | Bill Greif | Jon Matlack | Tug McGraw | Bill Greif | | 366 | 338 | 28 |
| 1971-07-25 | @ NYN | 99 | L 6-7 | - | | 28,776 | Ken Forsch | Gary Gentry | Gary Gentry | Ken Forsch | Ron Taylor | 372 | 345 | 27 |
| 1971-07-26 | @ PHI | 100 | W 7-4 | - | | 10,848 | Jack Billingham | Barry Lersch | Jim Ray | Bucky Brandon | | 379 | 349 | 30 |
| 1971-07-27 | @ PHI | 101 | L 3-8 | - | | 0 | Larry Dierker | Woodie Fryman | Woodie Fryman | Larry Dierker | | 382 | 357 | 25 |
| 1971-07-27 | @ PHI | 102 | W 5-1 | - | | 20,779 | Wade Blasingame | Ken Reynolds | Wade Blasingame | Ken Reynolds | | 387 | 358 | 29 |
| 1971-07-28 | @ PHI | 103 | W 6-3 | - | | 15,802 | Don Wilson | Rick Wise | Don Wilson | Rick Wise | | 393 | 361 | 32 |
| 1971-07-30 | @ MON | 104 | L 4-7 | - | | 0 | Ken Forsch | John Strohmayer | John Strohmayer | Ken Forsch | Mike Marshall | 397 | 368 | 29 |
| 1971-07-30 | @ MON | 105 | W 6-5 | - | | 23,654 | Bill Greif | Bill Stoneman | Jim Ray | Mike Marshall | | 403 | 373 | 30 |
| 1971-07-31 | @ MON | 106 | L 4-6 | - | | 14,306 | Jack Billingham | Steve Renko | Steve Renko | Jack Billingham | Mike Marshall | 407 | 379 | 28 |
| 1971-08-01 | @ MON | 107 | W 8-1 | - | | 17,605 | Wade Blasingame | Ernie McAnally | Wade Blasingame | Ernie McAnally | | 415 | 380 | 35 |
| 1971-08-02 | vs CHN | 108 | W 2-1 | - | | 20,020 | Don Wilson | Fergie Jenkins | Don Wilson | Fergie Jenkins | | 417 | 381 | 36 |
| 1971-08-03 | vs CHN | 109 | L 0-5 | - | | 14,622 | Larry Dierker | Bill Hands | Bill Hands | Larry Dierker | | 417 | 386 | 31 |
| 1971-08-04 | vs LAN | 110 | W 2-0 | - | | 23,338 | Ken Forsch | Al Downing | Ken Forsch | Al Downing | | 419 | 386 | 33 |
| 1971-08-05 | vs LAN | 111 | L 0-3 | - | | 17,893 | Jack Billingham | Bill Singer | Bill Singer | Jack Billingham | | 419 | 389 | 30 |
| 1971-08-06 | vs SDN | 112 | L 3-4 | - | | 21,915 | Wade Blasingame | Dave Roberts | Dave Roberts | Jim Ray | Bob Miller | 422 | 393 | 29 |
| 1971-08-07 | vs SDN | 113 | W 5-3 | - | | 23,334 | Don Wilson | Steve Arlin | Don Wilson | Steve Arlin | George Culver | 427 | 396 | 31 |
| 1971-08-08 | vs SDN | 114 | L 2-3 | - | | 19,757 | Larry Dierker | Fred Norman | Fred Norman | Denny Lemaster | Bob Miller | 429 | 399 | 30 |
| 1971-08-10 | @ CIN | 115 | W 3-2 | - | | 15,083 | Ken Forsch | Wayne Simpson | Ken Forsch | Wayne Simpson | | 432 | 401 | 31 |
| 1971-08-11 | @ CIN | 116 | L 1-5 | - | | 15,053 | Jack Billingham | Gary Nolan | Gary Nolan | Jack Billingham | | 433 | 406 | 27 |
| 1971-08-12 | @ ATL | 117 | L 5-10 | - | | 10,430 | Wade Blasingame | Ron Reed | Ron Reed | Wade Blasingame | | 438 | 416 | 22 |
| 1971-08-13 | @ ATL | 118 | W 8-2 | - | | 11,568 | Don Wilson | Phil Niekro | Don Wilson | Phil Niekro | | 446 | 418 | 28 |
| 1971-08-14 | @ ATL | 119 | L 0-7 | - | | 25,188 | Ron Cook | Pat Jarvis | Pat Jarvis | Ron Cook | | 446 | 425 | 21 |
| 1971-08-15 | @ ATL | 120 | W 5-4 | - | | 12,895 | Ken Forsch | George Stone | George Culver | Cecil Upshaw | | 451 | 429 | 22 |
| 1971-08-16 | @ PIT | 121 | L 3-8 | - | | 12,664 | Jack Billingham | Dock Ellis | Dock Ellis | Jack Billingham | Dave Giusti | 454 | 437 | 17 |
| 1971-08-17 | @ PIT | 122 | W 6-5 | - | | 16,694 | Wade Blasingame | Luke Walker | Wade Blasingame | Bob Miller | Jim Ray | 460 | 442 | 18 |
| 1971-08-18 | @ PIT | 123 | L 2-3 | - | | 29,670 | Don Wilson | Steve Blass | Bob Miller | Denny Lemaster | | 462 | 445 | 17 |
| 1971-08-20 | @ CHN | 124 | L 2-3 | - | | 0 | Ron Cook | Fergie Jenkins | Fergie Jenkins | Ron Cook | | 464 | 448 | 16 |
| 1971-08-20 | @ CHN | 125 | L 4-5 | - | | 30,711 | Ken Forsch | Ken Holtzman | Phil Regan | George Culver | | 468 | 453 | 15 |
| 1971-08-21 | @ CHN | 126 | W 3-0 | - | | 26,386 | Jack Billingham | Bill Hands | Jack Billingham | Bill Hands | | 471 | 453 | 18 |
| 1971-08-22 | @ CHN | 127 | W 4-3 | - | | 28,933 | Wade Blasingame | Milt Pappas | Jim Ray | Milt Pappas | | 475 | 456 | 19 |
| 1971-08-23 | vs SLN | 128 | L 2-3 | - | | 19,167 | Don Wilson | Bob Gibson | Bob Gibson | Don Wilson | | 477 | 459 | 18 |
| 1971-08-24 | vs SLN | 129 | L 1-2 | - | | 13,860 | Ken Forsch | Reggie Cleveland | Reggie Cleveland | Ken Forsch | Al Santorini | 478 | 461 | 17 |
| 1971-08-25 | vs SLN | 130 | L 1-4 | - | | 11,025 | Ron Cook | Steve Carlton | Steve Carlton | Ron Cook | | 479 | 465 | 14 |
| 1971-08-27 | vs PIT | 131 | L 3-7 | - | | 14,933 | Jack Billingham | Dock Ellis | Dock Ellis | Jack Billingham | Dave Giusti | 482 | 472 | 10 |
| 1971-08-28 | vs PIT | 132 | W 4-0 | - | | 25,619 | Don Wilson | Steve Blass | Don Wilson | Steve Blass | | 486 | 472 | 14 |
| 1971-08-29 | vs PIT | 133 | L 2-5 | - | | 15,723 | Wade Blasingame | Bob Johnson | Bob Johnson | Wade Blasingame | Dave Giusti | 488 | 477 | 11 |
| 1971-08-30 | vs LAN | 134 | L 2-3 | - | | 6,410 | Ken Forsch | Al Downing | Al Downing | Ken Forsch | Jim Brewer | 490 | 480 | 10 |
| 1971-08-31 | vs LAN | 135 | L 1-6 | - | | 7,340 | Ron Cook | Doyle Alexander | Doyle Alexander | Ron Cook | | 491 | 486 | 5 |
| 1971-09-01 | vs LAN | 136 | L 2-9 | - | | 6,474 | Jack Billingham | Don Sutton | Don Sutton | Jack Billingham | | 493 | 495 | -2 |
| 1971-09-02 | vs LAN | 137 | W 9-3 | - | | 7,508 | Don Wilson | Claude Osteen | Don Wilson | Claude Osteen | | 502 | 498 | 4 |
| 1971-09-03 | @ SFN | 138 | L 6-16 | - | | 9,120 | Wade Blasingame | Juan Marichal | Jim Barr | Jim Ray | Jerry Johnson | 508 | 514 | -6 |
| 1971-09-04 | @ SFN | 139 | L 0-1 | - | | 10,698 | Ken Forsch | Don Carrithers | Don Carrithers | Ken Forsch | | 508 | 515 | -7 |
| 1971-09-05 | @ SFN | 140 | W 1-0 | - | | 0 | Jack Billingham | Gaylord Perry | Jack Billingham | Gaylord Perry | | 509 | 515 | -6 |
| 1971-09-05 | @ SFN | 141 | W 5-3 | - | | 25,527 | J.R. Richard | Jim Willoughby | J.R. Richard | Jim Willoughby | | 514 | 518 | -4 |
| 1971-09-06 | @ ATL | 142 | W 6-4 | - | | 7,978 | Scipio Spinks | George Stone | Scipio Spinks | George Stone | | 520 | 522 | -2 |
| 1971-09-07 | @ ATL | 143 | W 5-1 | - | | 5,753 | Don Wilson | Ron Reed | Don Wilson | Ron Reed | | 525 | 523 | 2 |
| 1971-09-10 | @ CIN | 144 | W 1-0 | - | | 12,002 | Jack Billingham | Jim McGlothlin | Jack Billingham | Jim McGlothlin | | 526 | 523 | 3 |
| 1971-09-11 | @ CIN | 145 | W 5-2 | - | | 17,092 | J.R. Richard | Ross Grimsley | J.R. Richard | Ross Grimsley | Fred Gladding | 531 | 525 | 6 |
| 1971-09-12 | @ CIN | 146 | W 4-2 | - | | 12,529 | Don Wilson | Wayne Simpson | Don Wilson | Wayne Simpson | | 535 | 527 | 8 |
| 1971-09-13 | vs SDN | 147 | W 3-2 | - | | 7,476 | Ken Forsch | Clay Kirby | Jim Ray | Clay Kirby | | 538 | 529 | 9 |
| 1971-09-14 | vs SDN | 148 | L 2-5 | - | | 5,986 | Wade Blasingame | Ed Acosta | Ed Acosta | Wade Blasingame | | 540 | 534 | 6 |
| 1971-09-15 | vs ATL | 149 | L 2-4 | - | | 6,513 | Jack Billingham | Phil Niekro | Phil Niekro | Jack Billingham | | 542 | 538 | 4 |
| 1971-09-16 | vs ATL | 150 | L 3-4 | - | | 7,906 | J.R. Richard | Tom Kelley | Pat Jarvis | J.R. Richard | | 545 | 542 | 3 |
| 1971-09-17 | vs CIN | 151 | W 4-1 | - | | 8,070 | Don Wilson | Wayne Simpson | Don Wilson | Wayne Simpson | | 549 | 543 | 6 |
| 1971-09-18 | vs CIN | 152 | L 2-3 | - | | 6,963 | Ken Forsch | Gary Nolan | Clay Carroll | George Culver | Milt Wilcox | 551 | 546 | 5 |
| 1971-09-19 | vs CIN | 153 | W 5-4 | - | | 9,260 | Scipio Spinks | Jim Merritt | Fred Gladding | Clay Carroll | | 556 | 550 | 6 |
| 1971-09-21 | vs SFN | 154 | W 3-1 | - | | 7,777 | Jack Billingham | John Cumberland | Jack Billingham | John Cumberland | | 559 | 551 | 8 |
| 1971-09-22 | vs SFN | 155 | L 1-3 | - | | 11,208 | J.R. Richard | Juan Marichal | Juan Marichal | Tom Griffin | | 560 | 554 | 6 |
| 1971-09-23 | vs SFN | 156 | L 1-2 | - | | 12,281 | Don Wilson | Gaylord Perry | Gaylord Perry | Don Wilson | | 561 | 556 | 5 |
| 1971-09-24 | @ SDN | 157 | W 2-1 | - | | 0 | Ken Forsch | Clay Kirby | Bill Greif | Gary Ross | Skip Guinn | 563 | 557 | 6 |
| 1971-09-24 | @ SDN | 158 | L 4-5 | - | | 6,339 | Scipio Spinks | Dave Roberts | Dave Roberts | Fred Gladding | | 567 | 562 | 5 |
| 1971-09-25 | @ SDN | 159 | W 5-1 | - | | 2,718 | Jack Billingham | Steve Arlin | Jack Billingham | Steve Arlin | | 572 | 563 | 9 |
| 1971-09-28 | @ LAN | 160 | L 1-2 | - | | 29,628 | Don Wilson | Bill Singer | Bill Singer | Don Wilson | | 573 | 565 | 8 |
| 1971-09-29 | @ LAN | 161 | W 11-0 | - | | 34,802 | Ken Forsch | Al Downing | Ken Forsch | Al Downing | | 584 | 565 | 19 |
| 1971-09-30 | @ LAN | 162 | L 1-2 | - | | 52,684 | Jack Billingham | Don Sutton | Don Sutton | Jack Billingham | | 585 | 567 | 18 |