| 1970-04-07 | vs BAL | 1 | L 2-8 | 0-1 | 5 | 38,180 | Sam McDowell | Dave McNally | Dave McNally | Sam McDowell | | 2 | 8 | -6 |
| 1970-04-08 | vs BAL | 2 | L 2-3 | 0-2 | 5 | 2,811 | Barry Moore | Mike Cuellar | Mike Cuellar | Barry Moore | | 4 | 11 | -7 |
| 1970-04-09 | vs BAL | 3 | L 1-13 | 0-3 | 6 | 2,440 | Rich Hand | Tom Phoebus | Tom Phoebus | Rich Hand | | 5 | 24 | -19 |
| 1970-04-11 | @ NYA | 4 | W 3-0 | 1-3 | 6 | 7,889 | Dean Chance | Stan Bahnsen | Dean Chance | Stan Bahnsen | Dennis Higgins | 8 | 24 | -16 |
| 1970-04-12 | @ NYA | 5 | W 2-1 | 2-4 | 6 | 0 | Sam McDowell | Mel Stottlemyre | Sam McDowell | Mel Stottlemyre | | 10 | 25 | -15 |
| 1970-04-12 | @ NYA | 6 | L 4-5 | 2-4 | 6 | 27,308 | Barry Moore | Mike Kekich | Jack Aker | Dennis Higgins | | 14 | 30 | -16 |
| 1970-04-14 | @ DET | 7 | L 4-12 | 2-5 | 6 | 26,891 | Rich Hand | Mickey Lolich | Mickey Lolich | Rich Hand | | 18 | 42 | -24 |
| 1970-04-16 | @ DET | 8 | L 2-4 | 2-6 | 5 | 6,280 | Dean Chance | Earl Wilson | Earl Wilson | Dean Chance | | 20 | 46 | -26 |
| 1970-04-18 | vs WS2 | 9 | W 9-4 | 3-6 | 5 | 4,370 | Sam McDowell | Dick Bosman | Sam McDowell | Dick Bosman | | 29 | 50 | -21 |
| 1970-04-21 | vs DET | 10 | L 3-5 | 3-7 | 6 | 3,463 | Dean Chance | Earl Wilson | Earl Wilson | Steve Hargan | Fred Lasher | 32 | 55 | -23 |
| 1970-04-22 | vs DET | 11 | L 0-5 | 3-8 | 6 | 4,447 | Sam McDowell | Mickey Lolich | Mickey Lolich | Sam McDowell | | 32 | 60 | -28 |
| 1970-04-24 | vs CHA | 12 | W 4-1 | 4-8 | 6 | 3,871 | Barry Moore | Gerry Arrigo | Barry Moore | Gerry Arrigo | Dennis Higgins | 36 | 61 | -25 |
| 1970-04-25 | vs CHA | 13 | W 6-5 | 5-8 | 5 | 3,981 | Steve Hargan | Tommy John | Steve Hargan | Tommy John | Dennis Higgins | 42 | 66 | -24 |
| 1970-04-26 | vs CHA | 14 | L 0-2 | 5-9 | 6 | 12,009 | Dean Chance | Joe Horlen | Joe Horlen | Dean Chance | Wilbur Wood | 42 | 68 | -26 |
| 1970-04-27 | @ MIN | 15 | W 5-1 | 6-9 | 5 | 4,167 | Sam McDowell | Dave Boswell | Sam McDowell | Dave Boswell | | 47 | 69 | -22 |
| 1970-04-28 | @ MIN | 16 | W 3-1 | 7-9 | 5 | 4,118 | Barry Moore | Jim Perry | Barry Moore | Jim Perry | Phil Hennigan | 50 | 70 | -20 |
| 1970-04-29 | @ MIN | 17 | L 0-1 | 7-10 | 5 | 4,241 | Rich Hand | Jim Kaat | Jim Kaat | Rich Hand | Stan Williams | 50 | 71 | -21 |
| 1970-04-30 | @ MIN | 18 | L 1-4 | 7-11 | 6 | 5,485 | Steve Hargan | Luis Tiant | Luis Tiant | Steve Hargan | Ron Perranoski | 51 | 75 | -24 |
| 1970-05-01 | @ KCA | 19 | W 7-5 | 8-11 | 6 | 6,365 | Dean Chance | Dave Morehead | Phil Hennigan | Moe Drabowsky | Dennis Higgins | 58 | 80 | -22 |
| 1970-05-02 | @ KCA | 20 | L 3-4 | 8-12 | 6 | 8,016 | Sam McDowell | Bob Johnson | Mike Hedlund | Bob Miller | | 61 | 84 | -23 |
| 1970-05-03 | @ KCA | 21 | W 6-3 | 9-12 | 6 | 8,808 | Barry Moore | Jim Rooker | Barry Moore | Jim Rooker | Rich Hand | 67 | 87 | -20 |
| 1970-05-05 | @ CHA | 22 | L 1-2 | 9-13 | 6 | 2,993 | Dean Chance | Tommy John | Tommy John | Dean Chance | | 68 | 89 | -21 |
| 1970-05-06 | @ CHA | 23 | L 1-2 | 9-14 | 6 | 2,983 | Sam McDowell | Joe Horlen | Joe Horlen | Sam McDowell | | 69 | 91 | -22 |
| 1970-05-08 | vs MIN | 24 | L 6-7 | 9-15 | 6 | 6,233 | Barry Moore | Jim Kaat | Stan Williams | Barry Moore | | 75 | 98 | -23 |
| 1970-05-09 | vs MIN | 25 | L 3-5 | 9-16 | 6 | 5,485 | Dean Chance | Luis Tiant | Ron Perranoski | Dennis Higgins | | 78 | 103 | -25 |
| 1970-05-10 | vs MIN | 26 | W 5-4 | 10-16 | 6 | 14,397 | Sam McDowell | Dave Boswell | Sam McDowell | Dave Boswell | Rich Hand | 83 | 107 | -24 |
| 1970-05-13 | vs KCA | 27 | L 0-1 | 10-17 | 6 | 3,028 | Barry Moore | Bill Butler | Al Fitzmorris | Phil Hennigan | Ken Wright | 83 | 108 | -25 |
| 1970-05-15 | @ BOS | 28 | W 3-0 | 11-17 | 6 | 23,102 | Sam McDowell | Gary Peters | Sam McDowell | Gary Peters | | 86 | 108 | -22 |
| 1970-05-16 | @ BOS | 29 | L 2-6 | 11-18 | 6 | 19,485 | Dean Chance | Ray Culp | Ray Culp | Dennis Higgins | | 88 | 114 | -26 |
| 1970-05-18 | @ WS2 | 30 | L 3-7 | 11-19 | 6 | 4,362 | Rich Hand | George Brunet | George Brunet | Rich Hand | Darold Knowles | 91 | 121 | -30 |
| 1970-05-19 | @ WS2 | 31 | L 1-3 | 11-20 | 6 | 6,614 | Barry Moore | Joe Coleman | Joe Coleman | Barry Moore | | 92 | 124 | -32 |
| 1970-05-20 | vs BOS | 32 | W 7-2 | 12-20 | 6 | 4,930 | Sam McDowell | Sonny Siebert | Sam McDowell | Sonny Siebert | | 99 | 126 | -27 |
| 1970-05-21 | vs BOS | 33 | W 10-7 | 13-20 | 6 | 4,073 | Bob Miller | Bill Lee | Bob Miller | Bill Lee | Dick Ellsworth | 109 | 133 | -24 |
| 1970-05-22 | vs NYA | 34 | L 4-7 | 13-21 | 6 | 12,890 | Dean Chance | Fritz Peterson | Fritz Peterson | Dean Chance | Jack Aker | 113 | 140 | -27 |
| 1970-05-23 | vs NYA | 35 | W 4-3 | 14-21 | 6 | 6,855 | Rich Hand | Gary Waslewski | Phil Hennigan | Steve Hamilton | | 117 | 143 | -26 |
| 1970-05-24 | vs NYA | 36 | L 5-6 | 14-23 | 6 | 0 | Sam McDowell | Mike Kekich | Lindy McDaniel | Fred Lasher | | 122 | 149 | -27 |
| 1970-05-24 | vs NYA | 37 | L 7-8 | 14-23 | 6 | 19,421 | Barry Moore | John Cumberland | Lindy McDaniel | Fred Lasher | Jack Aker | 129 | 157 | -28 |
| 1970-05-25 | @ BAL | 38 | L 2-6 | 14-24 | 6 | 5,573 | Bob Miller | Dave McNally | Dave McNally | Bob Miller | | 131 | 163 | -32 |
| 1970-05-26 | @ BAL | 39 | L 0-7 | 14-25 | 6 | 5,744 | Dean Chance | Jim Hardin | Jim Hardin | Dean Chance | | 131 | 170 | -39 |
| 1970-05-27 | @ BAL | 40 | L 4-5 | 14-26 | 6 | 9,445 | Rich Hand | Jim Palmer | Dick Hall | Mike Paul | Pete Richert | 135 | 175 | -40 |
| 1970-05-29 | @ OAK | 41 | W 2-1 | 15-26 | 6 | 7,640 | Sam McDowell | Blue Moon Odom | Sam McDowell | Blue Moon Odom | | 137 | 176 | -39 |
| 1970-05-30 | @ OAK | 42 | L 4-5 | 15-27 | 6 | 9,163 | Barry Moore | Rollie Fingers | Rollie Fingers | Barry Moore | Mudcat Grant | 141 | 181 | -40 |
| 1970-05-31 | @ OAK | 43 | W 3-2 | 16-27 | 6 | 10,223 | Mike Paul | Catfish Hunter | Dick Ellsworth | Catfish Hunter | Rich Hand | 144 | 183 | -39 |
| 1970-06-02 | @ MIL | 44 | W 4-1 | 18-27 | 6 | 0 | Sam McDowell | Gene Brabender | Sam McDowell | Gene Brabender | | 148 | 184 | -36 |
| 1970-06-02 | @ MIL | 45 | W 9-5 | 18-27 | 6 | 7,812 | Dean Chance | Skip Lockwood | Phil Hennigan | Skip Lockwood | | 157 | 189 | -32 |
| 1970-06-03 | @ MIL | 46 | W 7-6 | 19-27 | 6 | 6,719 | Rich Hand | Lew Krausse | Bob Miller | Marty Pattin | Dick Ellsworth | 164 | 195 | -31 |
| 1970-06-04 | @ MIL | 47 | W 8-4 | 20-27 | 6 | 8,625 | Barry Moore | Ray Peters | Phil Hennigan | Ray Peters | Dean Chance | 172 | 199 | -27 |
| 1970-06-05 | @ CAL | 48 | L 1-2 | 20-28 | 6 | 10,894 | Mike Paul | Clyde Wright | Clyde Wright | Mike Paul | Ken Tatum | 173 | 201 | -28 |
| 1970-06-06 | @ CAL | 49 | L 1-2 | 20-29 | 6 | 18,089 | Sam McDowell | Rudy May | Rudy May | Sam McDowell | Mel Queen | 174 | 203 | -29 |
| 1970-06-07 | @ CAL | 50 | W 6-4 | 21-29 | 6 | 17,595 | Rich Hand | Andy Messersmith | Rich Hand | Andy Messersmith | Fred Lasher | 180 | 207 | -27 |
| 1970-06-09 | vs OAK | 51 | L 2-5 | 21-30 | 6 | 6,283 | Barry Moore | Catfish Hunter | Catfish Hunter | Barry Moore | Mudcat Grant | 182 | 212 | -30 |
| 1970-06-10 | vs OAK | 52 | L 4-6 | 21-31 | 6 | 5,629 | Mike Paul | Blue Moon Odom | Paul Lindblad | Mike Paul | Mudcat Grant | 186 | 218 | -32 |
| 1970-06-11 | vs OAK | 53 | W 6-5 | 22-31 | 6 | 5,140 | Sam McDowell | Chuck Dobson | Dick Ellsworth | Paul Lindblad | | 192 | 223 | -31 |
| 1970-06-12 | vs MIL | 54 | L 1-4 | 22-32 | 6 | 8,156 | Rich Hand | Marty Pattin | Marty Pattin | Rich Hand | | 193 | 227 | -34 |
| 1970-06-13 | vs MIL | 55 | W 10-6 | 23-32 | 6 | 8,162 | Phil Hennigan | Lew Krausse | Dean Chance | Lew Krausse | Fred Lasher | 203 | 233 | -30 |
| 1970-06-14 | vs MIL | 56 | W 9-2 | 24-32 | 6 | 25,380 | Steve Dunning | Skip Lockwood | Steve Dunning | Skip Lockwood | Bob Miller | 212 | 235 | -23 |
| 1970-06-15 | vs CAL | 57 | W 3-2 | 25-32 | 6 | 4,681 | Sam McDowell | Rudy May | Dean Chance | Mel Queen | | 215 | 237 | -22 |
| 1970-06-16 | vs CAL | 58 | W 9-2 | 26-32 | 6 | 12,426 | Rich Hand | Andy Messersmith | Rich Hand | Andy Messersmith | | 224 | 239 | -15 |
| 1970-06-18 | vs WS2 | 59 | W 6-3 | 27-32 | 6 | 7,634 | Mike Paul | Jim Hannan | Fred Lasher | Jim Shellenback | Dean Chance | 230 | 242 | -12 |
| 1970-06-19 | vs DET | 60 | W 4-2 | 28-32 | 5 | 17,156 | Sam McDowell | Mickey Lolich | Sam McDowell | Mickey Lolich | | 234 | 244 | -10 |
| 1970-06-20 | vs DET | 61 | W 2-1 | 29-32 | 5 | 12,420 | Steve Dunning | Earl Wilson | Dean Chance | Earl Wilson | | 236 | 245 | -9 |
| 1970-06-21 | vs DET | 62 | L 2-7 | 29-34 | 5 | 0 | Rich Hand | Les Cain | Joe Niekro | Rich Hand | Tom Timmermann | 238 | 252 | -14 |
| 1970-06-21 | vs DET | 63 | L 8-9 | 29-34 | 5 | 23,904 | Rick Austin | Mike Kilkenny | Tom Timmermann | Phil Hennigan | | 246 | 261 | -15 |
| 1970-06-24 | @ NYA | 64 | W 7-2 | 30-35 | 5 | 0 | Sam McDowell | Mel Stottlemyre | Sam McDowell | Mel Stottlemyre | | 253 | 263 | -10 |
| 1970-06-24 | @ NYA | 65 | L 4-5 | 30-35 | 5 | 31,925 | Mike Paul | Stan Bahnsen | Stan Bahnsen | Fred Lasher | Lindy McDaniel | 257 | 268 | -11 |
| 1970-06-25 | @ NYA | 66 | L 1-3 | 30-36 | 5 | 17,583 | Steve Dunning | Fritz Peterson | Fritz Peterson | Steve Dunning | | 258 | 271 | -13 |
| 1970-06-26 | @ DET | 67 | L 1-7 | 30-37 | 5 | 18,627 | Rich Hand | Joe Niekro | Joe Niekro | Rich Hand | | 259 | 278 | -19 |
| 1970-06-27 | @ DET | 68 | W 3-0 | 31-37 | 5 | 20,967 | Rick Austin | Mickey Lolich | Rick Austin | Mickey Lolich | | 262 | 278 | -16 |
| 1970-06-28 | @ DET | 69 | W 8-2 | 32-38 | 5 | 0 | Sam McDowell | Earl Wilson | Sam McDowell | Earl Wilson | | 270 | 280 | -10 |
| 1970-06-28 | @ DET | 70 | L 1-5 | 32-38 | 5 | 33,640 | Mike Paul | Mike Kilkenny | Mike Kilkenny | Mike Paul | | 271 | 285 | -14 |
| 1970-06-30 | @ BAL | 71 | L 2-4 | 32-39 | 6 | 11,346 | Steve Dunning | Dave McNally | Dave McNally | Steve Dunning | | 273 | 289 | -16 |
| 1970-07-01 | @ BAL | 72 | L 0-3 | 32-40 | 6 | 7,489 | Rick Austin | Jim Palmer | Jim Palmer | Rick Austin | | 273 | 292 | -19 |
| 1970-07-02 | @ BAL | 73 | W 10-9 | 33-40 | 5 | 6,135 | Sam McDowell | Jim Hardin | Dennis Higgins | Moe Drabowsky | Dean Chance | 283 | 301 | -18 |
| 1970-07-03 | @ BOS | 74 | L 1-2 | 33-42 | 6 | 0 | Rich Hand | Ray Culp | Ray Culp | Phil Hennigan | | 284 | 303 | -19 |
| 1970-07-03 | @ BOS | 75 | L 4-5 | 33-42 | 6 | 27,395 | Mike Paul | Ken Brett | Gary Wagner | Dick Ellsworth | Sparky Lyle | 288 | 308 | -20 |
| 1970-07-04 | @ BOS | 76 | L 1-5 | 33-43 | 6 | 14,246 | Steve Dunning | Sonny Siebert | Sonny Siebert | Steve Dunning | | 289 | 313 | -24 |
| 1970-07-05 | @ BOS | 77 | L 4-8 | 33-44 | 6 | 21,690 | Rick Austin | Mike Nagy | Mike Nagy | Rick Austin | Vicente Romo | 293 | 321 | -28 |
| 1970-07-06 | vs WS2 | 78 | W 6-4 | 34-44 | 6 | 11,950 | Sam McDowell | Joe Coleman | Sam McDowell | Joe Coleman | | 299 | 325 | -26 |
| 1970-07-07 | vs WS2 | 79 | W 7-3 | 36-44 | 5 | 0 | Dick Ellsworth | Jim Hannan | Dick Ellsworth | Jim Hannan | Fred Lasher | 306 | 328 | -22 |
| 1970-07-07 | vs WS2 | 80 | W 7-5 | 36-44 | 5 | 9,433 | Mike Paul | Dick Such | Phil Hennigan | Dick Such | Dennis Higgins | 313 | 333 | -20 |
| 1970-07-08 | vs WS2 | 81 | W 6-5 | 37-44 | 5 | 6,322 | Steve Dunning | George Brunet | Phil Hennigan | Darold Knowles | Dennis Higgins | 319 | 338 | -19 |
| 1970-07-09 | vs WS2 | 82 | L 3-9 | 37-45 | 5 | 11,152 | Rick Austin | Casey Cox | Casey Cox | Rick Austin | | 322 | 347 | -25 |
| 1970-07-10 | vs BOS | 83 | L 1-7 | 37-46 | 6 | 13,136 | Rich Hand | Gary Peters | Gary Peters | Rich Hand | | 323 | 354 | -31 |
| 1970-07-11 | vs BOS | 84 | W 3-1 | 38-46 | 5 | 13,251 | Sam McDowell | Ken Brett | Sam McDowell | Ken Brett | | 326 | 355 | -29 |
| 1970-07-12 | vs BOS | 85 | L 2-6 | 38-48 | 6 | 0 | Steve Dunning | Ray Culp | Ray Culp | Steve Dunning | | 328 | 361 | -33 |
| 1970-07-12 | vs BOS | 86 | L 2-8 | 38-48 | 6 | 30,821 | Fred Lasher | Sonny Siebert | Sonny Siebert | Fred Lasher | Sparky Lyle | 330 | 369 | -39 |
| 1970-07-16 | @ KCA | 87 | W 6-0 | 39-48 | 6 | 8,046 | Rich Hand | Jim Rooker | Rich Hand | Jim Rooker | | 336 | 369 | -33 |
| 1970-07-17 | @ KCA | 88 | W 6-0 | 40-48 | 5 | 12,063 | Steve Dunning | Bob Johnson | Steve Dunning | Bob Johnson | Phil Hennigan | 342 | 369 | -27 |
| 1970-07-18 | @ KCA | 89 | W 4-1 | 41-48 | 5 | 7,334 | Steve Hargan | Bill Butler | Steve Hargan | Bill Butler | | 346 | 370 | -24 |
| 1970-07-19 | @ MIN | 90 | W 3-1 | 42-48 | 5 | 24,925 | Sam McDowell | Bert Blyleven | Sam McDowell | Bert Blyleven | | 349 | 371 | -22 |
| 1970-07-20 | @ MIN | 91 | L 2-4 | 42-49 | 6 | 15,054 | Rick Austin | Jim Kaat | Jim Kaat | Rick Austin | Ron Perranoski | 351 | 375 | -24 |
| 1970-07-21 | vs CHA | 92 | L 3-5 | 42-50 | 6 | 12,011 | Steve Dunning | Tommy John | Tommy John | Steve Dunning | | 354 | 380 | -26 |
| 1970-07-22 | vs CHA | 93 | W 6-2 | 43-50 | 5 | 5,590 | Steve Hargan | Jim Magnuson | Steve Hargan | Jim Magnuson | Fred Lasher | 360 | 382 | -22 |
| 1970-07-23 | vs CHA | 94 | W 5-2 | 44-50 | 5 | 7,369 | Sam McDowell | Joe Horlen | Sam McDowell | Joe Horlen | | 365 | 384 | -19 |
| 1970-07-24 | vs KCA | 95 | L 2-5 | 45-51 | 5 | 0 | Rich Hand | Jim Rooker | Jim Rooker | Rich Hand | Ted Abernathy | 367 | 389 | -22 |
| 1970-07-24 | vs KCA | 96 | W 9-6 | 45-51 | 5 | 12,076 | Dean Chance | Wally Bunker | Dean Chance | Wally Bunker | Fred Lasher | 376 | 395 | -19 |
| 1970-07-25 | vs KCA | 97 | L 4-8 | 45-52 | 5 | 18,853 | Rick Austin | Bob Johnson | Tom Burgmeier | Fred Lasher | Ted Abernathy | 380 | 403 | -23 |
| 1970-07-26 | vs KCA | 98 | W 6-5 | 47-52 | 5 | 0 | Steve Dunning | Bill Butler | Steve Dunning | Ken Wright | Rick Austin | 386 | 408 | -22 |
| 1970-07-26 | vs KCA | 99 | W 3-0 | 47-52 | 5 | 21,237 | Steve Hargan | Dave Morehead | Steve Hargan | Dave Morehead | | 389 | 408 | -19 |
| 1970-07-28 | vs MIN | 100 | L 2-5 | 47-53 | 5 | 16,202 | Sam McDowell | Jim Kaat | Jim Kaat | Sam McDowell | Tom Hall | 391 | 413 | -22 |
| 1970-07-29 | vs MIN | 101 | W 9-8 | 48-53 | 5 | 6,772 | Dean Chance | Dave Boswell | Dean Chance | Dave Boswell | Phil Hennigan | 400 | 421 | -21 |
| 1970-07-30 | vs MIN | 102 | W 3-2 | 49-53 | 5 | 11,346 | Steve Hargan | Jim Perry | Steve Hargan | Jim Perry | | 403 | 423 | -20 |
| 1970-07-31 | @ CHA | 103 | L 4-5 | 49-54 | 5 | 5,467 | Steve Dunning | Tommy John | Danny Murphy | Dick Ellsworth | | 407 | 428 | -21 |
| 1970-08-01 | @ CHA | 104 | W 3-2 | 50-54 | 5 | 4,945 | Sam McDowell | Gerry Janeski | Sam McDowell | Gerry Janeski | | 410 | 430 | -20 |
| 1970-08-02 | @ CHA | 105 | W 4-2 | 51-55 | 5 | 0 | Rich Hand | Jerry Crider | Rich Hand | Jerry Crider | Dennis Higgins | 414 | 432 | -18 |
| 1970-08-02 | @ CHA | 106 | L 7-8 | 51-55 | 5 | 9,485 | Dean Chance | Floyd Weaver | Wilbur Wood | Dick Ellsworth | | 421 | 440 | -19 |
| 1970-08-04 | vs NYA | 107 | W 6-1 | 52-55 | 5 | 10,386 | Steve Hargan | Steve Kline | Steve Hargan | Steve Kline | | 427 | 441 | -14 |
| 1970-08-05 | vs NYA | 108 | L 3-7 | 52-56 | 5 | 19,335 | Sam McDowell | Fritz Peterson | Fritz Peterson | Sam McDowell | Lindy McDaniel | 430 | 448 | -18 |
| 1970-08-06 | vs BAL | 109 | W 4-0 | 53-57 | 5 | 0 | Dean Chance | Mike Cuellar | Dean Chance | Mike Cuellar | | 434 | 448 | -14 |
| 1970-08-06 | vs BAL | 110 | L 1-7 | 53-57 | 5 | 18,562 | Steve Dunning | Jim Hardin | Jim Hardin | Steve Dunning | | 435 | 455 | -20 |
| 1970-08-07 | vs BAL | 111 | W 10-4 | 54-57 | 5 | 13,462 | Rich Hand | Tom Phoebus | Dennis Higgins | Dick Hall | | 445 | 459 | -14 |
| 1970-08-08 | @ WS2 | 112 | W 4-2 | 55-57 | 5 | 8,614 | Steve Hargan | Dick Bosman | Vince Colbert | Darold Knowles | | 449 | 461 | -12 |
| 1970-08-09 | @ WS2 | 113 | L 3-7 | 56-58 | 5 | 0 | Sam McDowell | Joe Coleman | Joe Coleman | Sam McDowell | | 452 | 468 | -16 |
| 1970-08-09 | @ WS2 | 114 | W 6-3 | 56-58 | 5 | 18,497 | Rick Austin | Jackie Brown | Dennis Higgins | Jackie Brown | Steve Mingori | 458 | 471 | -13 |
| 1970-08-11 | @ OAK | 115 | L 5-6 | 56-59 | 5 | 6,322 | Dean Chance | Catfish Hunter | Jim Roland | Dean Chance | Bob Locker | 463 | 477 | -14 |
| 1970-08-12 | @ OAK | 116 | L 4-11 | 56-60 | 5 | 5,561 | Steve Hargan | Rollie Fingers | Marcel Lachemann | Rick Austin | Bob Locker | 467 | 488 | -21 |
| 1970-08-13 | @ OAK | 117 | W 4-3 | 57-60 | 5 | 7,644 | Sam McDowell | Blue Moon Odom | Sam McDowell | Paul Lindblad | | 471 | 491 | -20 |
| 1970-08-14 | @ MIL | 118 | L 3-4 | 57-61 | 5 | 12,780 | Steve Dunning | Skip Lockwood | Bobby Bolin | Dean Chance | | 474 | 495 | -21 |
| 1970-08-16 | @ MIL | 119 | L 3-4 | 57-62 | 5 | 44,387 | Steve Hargan | Al Downing | Ken Sanders | Dennis Higgins | | 477 | 499 | -22 |
| 1970-08-17 | @ CAL | 120 | L 0-3 | 57-63 | 6 | 8,860 | Sam McDowell | Tom Murphy | Tom Murphy | Sam McDowell | | 477 | 502 | -25 |
| 1970-08-18 | @ CAL | 121 | L 1-12 | 57-64 | 6 | 10,027 | Dean Chance | Clyde Wright | Clyde Wright | Dean Chance | | 478 | 514 | -36 |
| 1970-08-19 | @ CAL | 122 | W 2-0 | 58-64 | 5 | 9,739 | Rich Hand | Rudy May | Rich Hand | Rudy May | Dennis Higgins | 480 | 514 | -34 |
| 1970-08-21 | vs OAK | 123 | W 6-3 | 59-64 | 5 | 20,827 | Sam McDowell | Catfish Hunter | Sam McDowell | Catfish Hunter | Rick Austin | 486 | 517 | -31 |
| 1970-08-22 | vs OAK | 124 | W 6-5 | 60-64 | 5 | 9,615 | Steve Hargan | Chuck Dobson | Dennis Higgins | Marcel Lachemann | | 492 | 522 | -30 |
| 1970-08-23 | vs OAK | 125 | W 8-6 | 61-64 | 5 | 8,585 | Rich Hand | Blue Moon Odom | Rick Austin | Bob Locker | | 500 | 528 | -28 |
| 1970-08-25 | vs MIL | 126 | L 2-4 | 61-65 | 5 | 13,564 | Sam McDowell | Skip Lockwood | Ken Sanders | Dennis Higgins | | 502 | 532 | -30 |
| 1970-08-26 | vs MIL | 127 | W 7-2 | 62-65 | 5 | 5,407 | Steve Hargan | Al Downing | Steve Hargan | Al Downing | Vince Colbert | 509 | 534 | -25 |
| 1970-08-27 | vs MIL | 128 | L 2-14 | 62-66 | 5 | 5,156 | Steve Dunning | Lew Krausse | Lew Krausse | Steve Dunning | | 511 | 548 | -37 |
| 1970-08-28 | vs CAL | 129 | L 2-3 | 63-67 | 5 | 0 | Dean Chance | Rudy May | Ken Tatum | Dennis Higgins | Andy Messersmith | 513 | 551 | -38 |
| 1970-08-28 | vs CAL | 130 | W 5-1 | 63-67 | 5 | 11,160 | Rich Hand | Tom Murphy | Rich Hand | Tom Murphy | | 518 | 552 | -34 |
| 1970-08-29 | vs CAL | 131 | W 14-1 | 64-67 | 5 | 14,304 | Sam McDowell | Greg Garrett | Sam McDowell | Greg Garrett | | 532 | 553 | -21 |
| 1970-08-30 | vs CAL | 132 | L 9-10 | 64-68 | 5 | 7,885 | Steve Hargan | Clyde Wright | Andy Messersmith | Vince Colbert | | 541 | 563 | -22 |
| 1970-08-31 | @ WS2 | 133 | L 4-5 | 64-69 | 5 | 7,379 | Steve Dunning | Casey Cox | Casey Cox | Steve Dunning | Darold Knowles | 545 | 568 | -23 |
| 1970-09-01 | @ WS2 | 134 | W 4-3 | 65-69 | 5 | 7,567 | Mike Paul | Jackie Brown | Mike Paul | Jackie Brown | Rick Austin | 549 | 571 | -22 |
| 1970-09-02 | @ WS2 | 135 | L 1-4 | 65-70 | 5 | 10,509 | Sam McDowell | Dick Bosman | Dick Bosman | Sam McDowell | | 550 | 575 | -25 |
| 1970-09-03 | @ WS2 | 136 | W 4-2 | 66-70 | 5 | 5,550 | Steve Hargan | Jim Hannan | Steve Hargan | Jim Hannan | Dennis Higgins | 554 | 577 | -23 |
| 1970-09-04 | @ NYA | 137 | L 2-3 | 66-71 | 5 | 9,394 | Rich Hand | Steve Kline | Steve Kline | Rich Hand | | 556 | 580 | -24 |
| 1970-09-05 | @ NYA | 138 | L 1-3 | 66-72 | 5 | 9,232 | Steve Dunning | Stan Bahnsen | Stan Bahnsen | Steve Dunning | Lindy McDaniel | 557 | 583 | -26 |
| 1970-09-06 | @ NYA | 139 | L 1-4 | 66-73 | 5 | 13,127 | Mike Paul | Fritz Peterson | Fritz Peterson | Mike Paul | | 558 | 587 | -29 |
| 1970-09-07 | vs BOS | 140 | L 3-4 | 67-74 | 5 | 0 | Sam McDowell | Gary Peters | Gary Peters | Sam McDowell | Sparky Lyle | 561 | 591 | -30 |
| 1970-09-07 | vs BOS | 141 | W 8-2 | 67-74 | 5 | 17,837 | Dean Chance | Cal Koonce | Dean Chance | Cal Koonce | Vince Colbert | 569 | 593 | -24 |
| 1970-09-08 | vs BOS | 142 | L 3-4 | 67-75 | 5 | 3,194 | Steve Hargan | Ken Brett | Ken Brett | Steve Hargan | Gary Wagner | 572 | 597 | -25 |
| 1970-09-09 | vs WS2 | 143 | L 4-5 | 67-76 | 5 | 3,138 | Rich Hand | Joe Coleman | Joe Coleman | Rich Hand | Joe Grzenda | 576 | 602 | -26 |
| 1970-09-10 | vs WS2 | 144 | W 13-4 | 68-76 | 5 | 2,746 | Steve Dunning | Casey Cox | Steve Dunning | Casey Cox | Dennis Higgins | 589 | 606 | -17 |
| 1970-09-11 | vs NYA | 145 | W 3-2 | 69-76 | 5 | 5,567 | Mike Paul | Fritz Peterson | Mike Paul | Fritz Peterson | Dennis Higgins | 592 | 608 | -16 |
| 1970-09-12 | vs NYA | 146 | W 4-3 | 70-76 | 5 | 5,861 | Sam McDowell | Mike Kekich | Dean Chance | Ron Klimkowski | | 596 | 611 | -15 |
| 1970-09-13 | vs NYA | 147 | W 3-1 | 71-76 | 5 | 6,651 | Steve Hargan | Mel Stottlemyre | Steve Hargan | Mel Stottlemyre | | 599 | 612 | -13 |
| 1970-09-15 | vs DET | 148 | W 4-3 | 72-76 | 5 | 3,404 | Rich Hand | Les Cain | Steve Mingori | Bob Reed | Dean Chance | 603 | 615 | -12 |
| 1970-09-16 | vs DET | 149 | L 3-6 | 72-77 | 5 | 3,681 | Mike Paul | Mickey Lolich | Mickey Lolich | Mike Paul | Tom Timmermann | 606 | 621 | -15 |
| 1970-09-17 | vs DET | 150 | W 6-2 | 73-77 | 5 | 4,005 | Sam McDowell | Joe Niekro | Sam McDowell | Joe Niekro | | 612 | 623 | -11 |
| 1970-09-18 | @ BAL | 151 | L 3-4 | 73-78 | 5 | 5,752 | Steve Hargan | Tom Phoebus | Pete Richert | Fred Lasher | | 615 | 627 | -12 |
| 1970-09-19 | @ BAL | 152 | W 4-2 | 74-78 | 5 | 7,857 | Jim Rittwage | Dave McNally | Jim Rittwage | Dave McNally | | 619 | 629 | -10 |
| 1970-09-20 | @ BAL | 153 | L 0-7 | 74-79 | 5 | 9,085 | Mike Paul | Jim Palmer | Jim Palmer | Mike Paul | | 619 | 636 | -17 |
| 1970-09-21 | @ BOS | 154 | L 1-2 | 74-80 | 5 | 10,010 | Rich Hand | Sonny Siebert | Sonny Siebert | Rich Hand | Bobby Bolin | 620 | 638 | -18 |
| 1970-09-22 | @ BOS | 155 | L 2-8 | 74-81 | 5 | 11,959 | Sam McDowell | Gary Peters | Gary Peters | Sam McDowell | | 622 | 646 | -24 |
| 1970-09-23 | @ BOS | 156 | W 5-2 | 75-81 | 5 | 3,334 | Steve Hargan | Ken Brett | Steve Hargan | Ken Brett | | 627 | 648 | -21 |
| 1970-09-25 | vs BAL | 157 | L 7-9 | 75-82 | 5 | 4,386 | Jim Rittwage | Dave McNally | Pete Richert | Rich Hand | | 634 | 657 | -23 |
| 1970-09-26 | vs BAL | 158 | L 4-7 | 75-83 | 5 | 5,397 | Mike Paul | Jim Palmer | Eddie Watt | Fred Lasher | Pete Richert | 638 | 664 | -26 |
| 1970-09-27 | vs BAL | 159 | L 3-4 | 75-84 | 5 | 6,718 | Sam McDowell | Jim Hardin | Dick Hall | Sam McDowell | | 641 | 668 | -27 |
| 1970-09-29 | @ DET | 160 | W 5-2 | 76-84 | 5 | 6,334 | Steve Hargan | Mickey Lolich | Steve Hargan | Mickey Lolich | | 646 | 670 | -24 |
| 1970-09-30 | @ DET | 161 | L 3-4 | 76-85 | 5 | 3,420 | Jim Rittwage | Bob Reed | Bob Reed | Jim Rittwage | Tom Timmermann | 649 | 674 | -25 |
| 1970-10-01 | @ DET | 162 | L 0-1 | 76-86 | 5 | 3,875 | Mike Paul | John Hiller | John Hiller | Mike Paul | | 649 | 675 | -26 |