| 1970-04-07 | vs BOS | 1 | L 3-4 | 0-1 | 6 | 21,379 | Mel Stottlemyre | Gary Peters | Gary Peters | Mel Stottlemyre | Bill Lee | 3 | 4 | -1 |
| 1970-04-09 | vs BOS | 2 | W 4-3 | 1-1 | 4 | 7,039 | Fritz Peterson | Ray Culp | Fritz Peterson | Ray Culp | Jack Aker | 7 | 7 | 0 |
| 1970-04-11 | vs CLE | 3 | L 0-3 | 1-2 | 5 | 7,889 | Stan Bahnsen | Dean Chance | Dean Chance | Stan Bahnsen | Dennis Higgins | 7 | 10 | -3 |
| 1970-04-12 | vs CLE | 4 | L 1-2 | 2-3 | 5 | 0 | Mel Stottlemyre | Sam McDowell | Sam McDowell | Mel Stottlemyre | | 8 | 12 | -4 |
| 1970-04-12 | vs CLE | 5 | W 5-4 | 2-3 | 5 | 27,308 | Mike Kekich | Barry Moore | Jack Aker | Dennis Higgins | | 13 | 16 | -3 |
| 1970-04-14 | @ BOS | 6 | L 3-8 | 2-4 | 5 | 34,002 | Fritz Peterson | Ray Culp | Ray Culp | Fritz Peterson | | 16 | 24 | -8 |
| 1970-04-15 | @ BOS | 7 | L 2-6 | 2-5 | 6 | 7,906 | Bill Burbach | Jim Lonborg | Jim Lonborg | Bill Burbach | Sparky Lyle | 18 | 30 | -12 |
| 1970-04-16 | @ BOS | 8 | L 5-8 | 2-6 | 6 | 8,217 | Stan Bahnsen | Sonny Siebert | Lee Stange | Jack Aker | Vicente Romo | 23 | 38 | -15 |
| 1970-04-17 | @ BAL | 9 | W 4-1 | 3-6 | 5 | 7,715 | Mel Stottlemyre | Tom Phoebus | Lindy McDaniel | Dick Hall | | 27 | 39 | -12 |
| 1970-04-18 | @ BAL | 10 | L 4-5 | 3-7 | 6 | 5,282 | Fritz Peterson | Dave McNally | Dave McNally | Fritz Peterson | Pete Richert | 31 | 44 | -13 |
| 1970-04-19 | @ BAL | 11 | L 3-4 | 4-8 | 6 | 0 | Bill Burbach | Mike Cuellar | Mike Cuellar | Bill Burbach | | 34 | 48 | -14 |
| 1970-04-19 | @ BAL | 12 | W 8-5 | 4-8 | 6 | 19,213 | Ron Klimkowski | Jim Hardin | Joe Verbanic | Jim Hardin | Jack Aker | 42 | 53 | -11 |
| 1970-04-20 | @ WS2 | 13 | W 11-2 | 5-8 | 5 | 4,626 | Stan Bahnsen | George Brunet | Stan Bahnsen | George Brunet | Steve Hamilton | 53 | 55 | -2 |
| 1970-04-21 | @ WS2 | 14 | L 5-7 | 5-9 | 5 | 5,981 | Mel Stottlemyre | Casey Cox | Casey Cox | Mel Stottlemyre | Darold Knowles | 58 | 62 | -4 |
| 1970-04-22 | @ WS2 | 15 | L 1-2 | 5-10 | 5 | 6,316 | Fritz Peterson | Joe Coleman | Joe Grzenda | Ron Klimkowski | | 59 | 64 | -5 |
| 1970-04-23 | @ WS2 | 16 | W 11-6 | 6-10 | 5 | 1,807 | Bill Burbach | Jim Shellenback | John Cumberland | Dick Such | | 70 | 70 | 0 |
| 1970-04-25 | vs OAK | 17 | L 0-3 | 6-11 | 6 | 10,617 | Stan Bahnsen | Chuck Dobson | Chuck Dobson | Stan Bahnsen | | 70 | 73 | -3 |
| 1970-04-26 | vs OAK | 18 | W 8-3 | 7-11 | 5 | 27,009 | Mel Stottlemyre | Blue Moon Odom | Mel Stottlemyre | Blue Moon Odom | Jack Aker | 78 | 76 | 2 |
| 1970-04-28 | vs CAL | 19 | W 7-5 | 8-11 | 6 | 8,359 | Fritz Peterson | Clyde Wright | Fritz Peterson | Clyde Wright | Steve Hamilton | 85 | 81 | 4 |
| 1970-04-29 | vs CAL | 20 | L 2-3 | 8-12 | 6 | 5,450 | John Cumberland | Andy Messersmith | Andy Messersmith | John Cumberland | Paul Doyle | 87 | 84 | 3 |
| 1970-04-30 | vs CAL | 21 | W 1-0 | 9-12 | 5 | 5,395 | Stan Bahnsen | Rudy May | Stan Bahnsen | Rudy May | | 88 | 84 | 4 |
| 1970-05-01 | vs MIL | 22 | W 6-3 | 10-12 | 5 | 8,476 | Mel Stottlemyre | Gene Brabender | Mel Stottlemyre | Gene Brabender | Jack Aker | 94 | 87 | 7 |
| 1970-05-02 | vs MIL | 23 | W 7-6 | 11-12 | 5 | 7,813 | Fritz Peterson | Marty Pattin | Steve Hamilton | John Gelnar | | 101 | 93 | 8 |
| 1970-05-03 | vs MIL | 24 | W 8-7 | 13-12 | 5 | 0 | Bill Burbach | George Lauzerique | Steve Hamilton | Bob Meyer | | 109 | 100 | 9 |
| 1970-05-03 | vs MIL | 25 | W 4-2 | 13-12 | 5 | 11,490 | John Cumberland | Lew Krausse | Lindy McDaniel | Lew Krausse | | 113 | 102 | 11 |
| 1970-05-05 | @ OAK | 26 | L 3-11 | 13-13 | 5 | 4,737 | Stan Bahnsen | Catfish Hunter | Catfish Hunter | Stan Bahnsen | | 116 | 113 | 3 |
| 1970-05-06 | @ OAK | 27 | W 7-6 | 14-13 | 5 | 3,706 | Mel Stottlemyre | Al Downing | Mel Stottlemyre | Al Downing | Jack Aker | 123 | 119 | 4 |
| 1970-05-07 | @ OAK | 28 | W 7-3 | 15-13 | 4 | 4,272 | Fritz Peterson | Rollie Fingers | Fritz Peterson | Rollie Fingers | Lindy McDaniel | 130 | 122 | 8 |
| 1970-05-08 | @ CAL | 29 | L 3-4 | 15-14 | 4 | 10,647 | Ron Klimkowski | Clyde Wright | Clyde Wright | Ron Klimkowski | Ken Tatum | 133 | 126 | 7 |
| 1970-05-09 | @ CAL | 30 | L 3-11 | 15-15 | 4 | 36,353 | Mike Kekich | Andy Messersmith | Andy Messersmith | Mike Kekich | | 136 | 137 | -1 |
| 1970-05-10 | @ CAL | 31 | W 4-3 | 16-15 | 4 | 15,232 | Stan Bahnsen | Rudy May | Jack Aker | Rudy May | Lindy McDaniel | 140 | 140 | 0 |
| 1970-05-11 | @ MIL | 32 | L 5-5 | 16-16 | 4 | 4,822 | Mel Stottlemyre | Bobby Bolin | | | | 145 | 145 | 0 |
| 1970-05-12 | @ MIL | 33 | W 9-5 | 17-16 | 3 | 5,382 | Fritz Peterson | Lew Krausse | Fritz Peterson | Lew Krausse | Lindy McDaniel | 154 | 150 | 4 |
| 1970-05-13 | @ MIL | 34 | L 1-3 | 17-17 | 3 | 4,719 | John Cumberland | John Morris | John Morris | John Cumberland | | 155 | 153 | 2 |
| 1970-05-15 | vs DET | 35 | W 4-1 | 18-17 | 2 | 13,607 | Stan Bahnsen | Mickey Lolich | Stan Bahnsen | Mickey Lolich | | 159 | 154 | 5 |
| 1970-05-16 | vs DET | 36 | W 7-4 | 19-17 | 2 | 26,178 | Mel Stottlemyre | Mike Kilkenny | Steve Hamilton | Fred Scherman | Jack Aker | 166 | 158 | 8 |
| 1970-05-18 | vs BAL | 37 | W 10-4 | 20-17 | 2 | 10,061 | Fritz Peterson | Mike Cuellar | Fritz Peterson | Mike Cuellar | | 176 | 162 | 14 |
| 1970-05-19 | vs BAL | 38 | L 1-5 | 20-18 | 2 | 14,147 | John Cumberland | Jim Palmer | Jim Palmer | John Cumberland | | 177 | 167 | 10 |
| 1970-05-20 | vs WS2 | 39 | L 0-2 | 20-19 | 2 | 7,649 | Stan Bahnsen | Dick Bosman | Dick Bosman | Stan Bahnsen | Darold Knowles | 177 | 169 | 8 |
| 1970-05-21 | vs WS2 | 40 | W 2-0 | 21-19 | 2 | 9,254 | Mel Stottlemyre | Dick Such | Mel Stottlemyre | Dick Such | Steve Hamilton | 179 | 169 | 10 |
| 1970-05-22 | @ CLE | 41 | W 7-4 | 22-19 | 2 | 12,890 | Fritz Peterson | Dean Chance | Fritz Peterson | Dean Chance | Jack Aker | 186 | 173 | 13 |
| 1970-05-23 | @ CLE | 42 | L 3-4 | 22-20 | 2 | 6,855 | Gary Waslewski | Rich Hand | Phil Hennigan | Steve Hamilton | | 189 | 177 | 12 |
| 1970-05-24 | @ CLE | 43 | W 6-5 | 24-20 | 2 | 0 | Mike Kekich | Sam McDowell | Lindy McDaniel | Fred Lasher | | 195 | 182 | 13 |
| 1970-05-24 | @ CLE | 44 | W 8-7 | 24-20 | 2 | 19,421 | John Cumberland | Barry Moore | Lindy McDaniel | Fred Lasher | Jack Aker | 203 | 189 | 14 |
| 1970-05-25 | @ DET | 45 | L 3-4 | 24-21 | 2 | 12,475 | Stan Bahnsen | Les Cain | Les Cain | Steve Hamilton | | 206 | 193 | 13 |
| 1970-05-26 | @ DET | 46 | L 0-3 | 24-22 | 2 | 10,181 | Mel Stottlemyre | Earl Wilson | Earl Wilson | Mel Stottlemyre | | 206 | 196 | 10 |
| 1970-05-27 | @ DET | 47 | W 4-2 | 25-22 | 2 | 12,161 | Fritz Peterson | Joe Niekro | Fritz Peterson | Joe Niekro | Jack Aker | 210 | 198 | 12 |
| 1970-05-29 | @ MIN | 48 | W 4-2 | 26-22 | 2 | 14,194 | Mike Kekich | Jim Perry | Mike Kekich | Jim Perry | Lindy McDaniel | 214 | 200 | 14 |
| 1970-05-30 | @ MIN | 49 | L 6-10 | 26-23 | 2 | 16,119 | Stan Bahnsen | Bill Zepp | Ron Perranoski | Steve Hamilton | | 220 | 210 | 10 |
| 1970-05-31 | @ MIN | 50 | L 6-7 | 26-24 | 2 | 15,752 | Mel Stottlemyre | Jim Kaat | Stan Williams | Lindy McDaniel | | 226 | 217 | 9 |
| 1970-06-02 | vs KCA | 51 | W 3-2 | 27-24 | 2 | 9,181 | Fritz Peterson | Bob Johnson | Fritz Peterson | Bob Johnson | Lindy McDaniel | 229 | 219 | 10 |
| 1970-06-03 | vs KCA | 52 | W 5-3 | 28-24 | 2 | 6,891 | Mike Kekich | Dick Drago | Mike Kekich | Dick Drago | Jack Aker | 234 | 222 | 12 |
| 1970-06-04 | vs KCA | 53 | W 2-1 | 29-24 | 2 | 6,510 | Stan Bahnsen | Jim Rooker | Lindy McDaniel | Jim Rooker | | 236 | 223 | 13 |
| 1970-06-05 | vs CHA | 54 | W 10-1 | 30-24 | 2 | 11,772 | Mel Stottlemyre | Gerry Janeski | Mel Stottlemyre | Gerry Janeski | | 246 | 224 | 22 |
| 1970-06-06 | vs CHA | 55 | W 3-1 | 31-24 | 2 | 10,384 | John Cumberland | Joe Horlen | John Cumberland | Joe Horlen | | 249 | 225 | 24 |
| 1970-06-07 | vs CHA | 56 | L 3-4 | 31-25 | 2 | 65,880 | Fritz Peterson | Tommy John | Wilbur Wood | Lindy McDaniel | | 252 | 229 | 23 |
| 1970-06-09 | vs MIN | 57 | W 5-2 | 32-25 | 2 | 21,857 | Stan Bahnsen | Jim Kaat | Stan Bahnsen | Jim Kaat | | 257 | 231 | 26 |
| 1970-06-10 | vs MIN | 58 | W 2-1 | 33-25 | 2 | 18,039 | Mel Stottlemyre | Bert Blyleven | Mel Stottlemyre | Bert Blyleven | | 259 | 232 | 27 |
| 1970-06-12 | @ KCA | 59 | W 5-0 | 34-25 | 2 | 9,272 | Fritz Peterson | Dave Morehead | Fritz Peterson | Dave Morehead | | 264 | 232 | 32 |
| 1970-06-13 | @ KCA | 60 | W 9-4 | 35-25 | 2 | 16,406 | Mike Kekich | Bob Johnson | Lindy McDaniel | Ken Wright | | 273 | 236 | 37 |
| 1970-06-14 | @ KCA | 61 | W 3-2 | 36-25 | 2 | 12,332 | Stan Bahnsen | Dick Drago | Steve Hamilton | Tom Burgmeier | | 276 | 238 | 38 |
| 1970-06-16 | @ CHA | 62 | W 6-2 | 37-25 | 2 | 10,189 | Mel Stottlemyre | Tommy John | Mel Stottlemyre | Tommy John | | 282 | 240 | 42 |
| 1970-06-17 | @ CHA | 63 | L 3-6 | 37-26 | 2 | 8,472 | Fritz Peterson | Gerry Janeski | Gerry Janeski | Fritz Peterson | Wilbur Wood | 285 | 246 | 39 |
| 1970-06-18 | @ BOS | 64 | W 3-2 | 38-26 | 2 | 26,305 | Gary Waslewski | Ray Culp | Gary Waslewski | Ray Culp | Lindy McDaniel | 288 | 248 | 40 |
| 1970-06-19 | @ BOS | 65 | L 4-7 | 38-27 | 2 | 32,311 | Stan Bahnsen | Sonny Siebert | Sonny Siebert | Stan Bahnsen | Sparky Lyle | 292 | 255 | 37 |
| 1970-06-20 | @ BOS | 66 | W 8-3 | 39-27 | 2 | 30,789 | Mel Stottlemyre | Mike Nagy | Mel Stottlemyre | Mike Nagy | | 300 | 258 | 42 |
| 1970-06-21 | @ BOS | 67 | W 14-10 | 40-27 | 2 | 31,073 | Fritz Peterson | Gary Peters | Lindy McDaniel | Jose Santiago | | 314 | 268 | 46 |
| 1970-06-24 | vs CLE | 68 | L 2-7 | 41-28 | 2 | 0 | Mel Stottlemyre | Sam McDowell | Sam McDowell | Mel Stottlemyre | | 316 | 275 | 41 |
| 1970-06-24 | vs CLE | 69 | W 5-4 | 41-28 | 2 | 31,925 | Stan Bahnsen | Mike Paul | Stan Bahnsen | Fred Lasher | Lindy McDaniel | 321 | 279 | 42 |
| 1970-06-25 | vs CLE | 70 | W 3-1 | 42-28 | 2 | 17,583 | Fritz Peterson | Steve Dunning | Fritz Peterson | Steve Dunning | | 324 | 280 | 44 |
| 1970-06-27 | vs BOS | 71 | L 0-4 | 42-29 | 2 | 21,801 | Gary Waslewski | Gary Peters | Gary Peters | Gary Waslewski | | 324 | 284 | 40 |
| 1970-06-28 | vs BOS | 72 | L 3-5 | 43-30 | 2 | 0 | Mel Stottlemyre | Ken Brett | Ken Brett | Mel Stottlemyre | Sparky Lyle | 327 | 289 | 38 |
| 1970-06-28 | vs BOS | 73 | W 8-2 | 43-30 | 2 | 56,412 | Stan Bahnsen | Ray Culp | Stan Bahnsen | Ray Culp | | 335 | 291 | 44 |
| 1970-06-30 | @ DET | 74 | L 3-5 | 43-31 | 2 | 21,233 | Fritz Peterson | Les Cain | Les Cain | Fritz Peterson | Tom Timmermann | 338 | 296 | 42 |
| 1970-07-01 | @ DET | 75 | L 5-6 | 43-32 | 2 | 53,863 | Gary Waslewski | Denny McLain | Tom Timmermann | Ron Klimkowski | | 343 | 302 | 41 |
| 1970-07-02 | @ DET | 76 | L 0-5 | 43-33 | 2 | 18,787 | Mel Stottlemyre | Joe Niekro | Joe Niekro | Mel Stottlemyre | | 343 | 307 | 36 |
| 1970-07-03 | vs WS2 | 77 | L 3-4 | 43-34 | 2 | 14,795 | Stan Bahnsen | George Brunet | George Brunet | Stan Bahnsen | Darold Knowles | 346 | 311 | 35 |
| 1970-07-04 | vs WS2 | 78 | W 4-2 | 44-34 | 2 | 22,994 | John Cumberland | Casey Cox | Ron Klimkowski | Casey Cox | Jack Aker | 350 | 313 | 37 |
| 1970-07-05 | vs WS2 | 79 | L 3-7 | 44-36 | 2 | 0 | Fritz Peterson | Dick Bosman | Dick Bosman | Fritz Peterson | Darold Knowles | 353 | 320 | 33 |
| 1970-07-05 | vs WS2 | 80 | L 3-7 | 44-36 | 2 | 23,243 | Gary Waslewski | Jim Shellenback | Jim Shellenback | Gary Waslewski | Darold Knowles | 356 | 327 | 29 |
| 1970-07-07 | @ BAL | 81 | L 2-6 | 44-37 | 3 | 28,906 | Mel Stottlemyre | Mike Cuellar | Mike Cuellar | Lindy McDaniel | | 358 | 333 | 25 |
| 1970-07-08 | @ BAL | 82 | L 8-9 | 44-38 | 3 | 33,749 | Stan Bahnsen | Dave McNally | Moe Drabowsky | Lindy McDaniel | | 366 | 342 | 24 |
| 1970-07-09 | @ BAL | 83 | W 7-5 | 45-38 | 3 | 18,725 | Fritz Peterson | Jim Hardin | John Cumberland | Marcelino Lopez | Jack Aker | 373 | 347 | 26 |
| 1970-07-10 | @ WS2 | 84 | L 1-2 | 45-39 | 3 | 16,225 | Steve Kline | Dick Bosman | Dick Bosman | Steve Kline | | 374 | 349 | 25 |
| 1970-07-11 | @ WS2 | 85 | W 3-1 | 46-39 | 3 | 21,836 | Stan Bahnsen | Jim Shellenback | Stan Bahnsen | Jim Shellenback | Lindy McDaniel | 377 | 350 | 27 |
| 1970-07-12 | @ WS2 | 86 | L 3-7 | 46-40 | 3 | 30,155 | Mel Stottlemyre | Jim Hannan | Jim Hannan | Mel Stottlemyre | Darold Knowles | 380 | 357 | 23 |
| 1970-07-16 | vs OAK | 87 | L 2-8 | 47-41 | 3 | 0 | Fritz Peterson | Chuck Dobson | Chuck Dobson | Fritz Peterson | | 382 | 365 | 17 |
| 1970-07-16 | vs OAK | 88 | W 4-1 | 47-41 | 3 | 17,862 | Stan Bahnsen | Diego Segui | Stan Bahnsen | Diego Segui | Lindy McDaniel | 386 | 366 | 20 |
| 1970-07-17 | vs OAK | 89 | W 7-1 | 48-41 | 3 | 17,821 | Mel Stottlemyre | Catfish Hunter | Mel Stottlemyre | Catfish Hunter | | 393 | 367 | 26 |
| 1970-07-18 | vs OAK | 90 | W 7-2 | 49-41 | 3 | 12,780 | Steve Kline | Jim Roland | Steve Kline | Jim Roland | | 400 | 369 | 31 |
| 1970-07-19 | vs CAL | 91 | L 2-5 | 49-43 | 3 | 0 | John Cumberland | Rudy May | Rudy May | John Cumberland | Dave LaRoche | 402 | 374 | 28 |
| 1970-07-19 | vs CAL | 92 | L 1-3 | 49-43 | 3 | 52,325 | Mike Kekich | Tom Murphy | Tom Murphy | Mike Kekich | Mel Queen | 403 | 377 | 26 |
| 1970-07-20 | vs CAL | 93 | W 6-1 | 50-43 | 3 | 10,435 | Fritz Peterson | Andy Messersmith | Fritz Peterson | Andy Messersmith | | 409 | 378 | 31 |
| 1970-07-21 | vs MIL | 94 | W 4-2 | 51-43 | 3 | 12,315 | Stan Bahnsen | Skip Lockwood | Stan Bahnsen | Skip Lockwood | Lindy McDaniel | 413 | 380 | 33 |
| 1970-07-22 | vs MIL | 95 | L 1-4 | 51-44 | 3 | 11,943 | Mel Stottlemyre | Bobby Bolin | Bobby Bolin | Mel Stottlemyre | | 414 | 384 | 30 |
| 1970-07-24 | @ OAK | 96 | L 0-11 | 51-45 | 3 | 11,991 | Steve Kline | Chuck Dobson | Chuck Dobson | Steve Kline | | 414 | 395 | 19 |
| 1970-07-25 | @ OAK | 97 | L 0-1 | 51-46 | 3 | 15,012 | Fritz Peterson | Diego Segui | Diego Segui | Fritz Peterson | | 414 | 396 | 18 |
| 1970-07-26 | @ OAK | 98 | L 3-4 | 51-47 | 3 | 25,271 | Stan Bahnsen | Catfish Hunter | Catfish Hunter | Stan Bahnsen | Mudcat Grant | 417 | 400 | 17 |
| 1970-07-27 | @ CAL | 99 | W 5-2 | 52-47 | 3 | 9,097 | Mel Stottlemyre | Rudy May | Mel Stottlemyre | Rudy May | | 422 | 402 | 20 |
| 1970-07-28 | @ CAL | 100 | W 6-5 | 53-47 | 3 | 13,170 | Mike McCormick | Greg Garrett | Mike McCormick | Greg Garrett | Lindy McDaniel | 428 | 407 | 21 |
| 1970-07-29 | @ CAL | 101 | W 8-3 | 54-47 | 3 | 13,953 | Steve Kline | Clyde Wright | Ron Klimkowski | Clyde Wright | Jack Aker | 436 | 410 | 26 |
| 1970-07-31 | @ MIL | 102 | W 7-3 | 56-47 | 3 | 0 | Stan Bahnsen | Bobby Bolin | Stan Bahnsen | Bobby Bolin | Lindy McDaniel | 443 | 413 | 30 |
| 1970-07-31 | @ MIL | 103 | W 5-3 | 56-47 | 3 | 18,861 | Fritz Peterson | Gene Brabender | Fritz Peterson | Gene Brabender | Jack Aker | 448 | 416 | 32 |
| 1970-08-01 | @ MIL | 104 | W 4-1 | 57-47 | 3 | 21,773 | Mel Stottlemyre | Al Downing | Ron Klimkowski | Bob Humphreys | Lindy McDaniel | 452 | 417 | 35 |
| 1970-08-02 | @ MIL | 105 | L 5-9 | 57-48 | 3 | 20,365 | Mike McCormick | Skip Lockwood | John Gelnar | Ron Klimkowski | | 457 | 426 | 31 |
| 1970-08-04 | @ CLE | 106 | L 1-6 | 57-49 | 3 | 10,386 | Steve Kline | Steve Hargan | Steve Hargan | Steve Kline | | 458 | 432 | 26 |
| 1970-08-05 | @ CLE | 107 | W 7-3 | 58-49 | 3 | 19,335 | Fritz Peterson | Sam McDowell | Fritz Peterson | Sam McDowell | Lindy McDaniel | 465 | 435 | 30 |
| 1970-08-06 | vs DET | 108 | L 1-2 | 59-50 | 3 | 0 | Mel Stottlemyre | Mike Kilkenny | Mike Kilkenny | Mel Stottlemyre | | 466 | 437 | 29 |
| 1970-08-06 | vs DET | 109 | W 7-5 | 59-50 | 3 | 22,434 | Stan Bahnsen | Joe Niekro | Ron Klimkowski | John Hiller | Lindy McDaniel | 473 | 442 | 31 |
| 1970-08-07 | vs DET | 110 | W 5-1 | 60-50 | 2 | 19,469 | Mike McCormick | Les Cain | Gary Waslewski | Les Cain | Jack Aker | 478 | 443 | 35 |
| 1970-08-08 | vs BAL | 111 | L 2-4 | 60-51 | 3 | 47,194 | Mike Kekich | Dave McNally | Dave McNally | Mike Kekich | | 480 | 447 | 33 |
| 1970-08-09 | vs BAL | 112 | W 6-4 | 61-52 | 2 | 0 | Fritz Peterson | Jim Palmer | Jack Aker | Dick Hall | | 486 | 451 | 35 |
| 1970-08-09 | vs BAL | 113 | L 9-12 | 61-52 | 2 | 41,610 | Steve Kline | Marcelino Lopez | Eddie Watt | Ron Klimkowski | Dave Leonhard | 495 | 463 | 32 |
| 1970-08-11 | vs CHA | 114 | W 7-1 | 62-52 | 2 | 13,454 | Mel Stottlemyre | Gerry Janeski | Mel Stottlemyre | Gerry Janeski | | 502 | 464 | 38 |
| 1970-08-12 | vs CHA | 115 | L 1-5 | 62-53 | 2 | 12,440 | Stan Bahnsen | Bart Johnson | Bart Johnson | Stan Bahnsen | Wilbur Wood | 503 | 469 | 34 |
| 1970-08-13 | vs CHA | 116 | W 4-3 | 63-53 | 2 | 9,902 | Mike McCormick | Bob Miller | Jack Aker | Floyd Weaver | | 507 | 472 | 35 |
| 1970-08-14 | vs KCA | 117 | W 3-2 | 64-53 | 2 | 10,350 | Fritz Peterson | Dick Drago | Lindy McDaniel | Dick Drago | | 510 | 474 | 36 |
| 1970-08-15 | vs KCA | 118 | W 5-4 | 65-53 | 2 | 10,098 | Mel Stottlemyre | Wally Bunker | Ron Klimkowski | Tom Burgmeier | Lindy McDaniel | 515 | 478 | 37 |
| 1970-08-16 | vs KCA | 119 | W 5-1 | 66-53 | 2 | 13,200 | Stan Bahnsen | Jim Rooker | Stan Bahnsen | Jim Rooker | | 520 | 479 | 41 |
| 1970-08-18 | @ MIN | 120 | L 7-8 | 66-54 | 2 | 23,490 | Mike Kekich | Jim Kaat | Tom Hall | Lindy McDaniel | | 527 | 487 | 40 |
| 1970-08-19 | @ MIN | 121 | L 0-3 | 66-55 | 2 | 23,271 | Fritz Peterson | Jim Perry | Jim Perry | Fritz Peterson | | 527 | 490 | 37 |
| 1970-08-20 | @ MIN | 122 | W 4-3 | 67-55 | 2 | 24,794 | Mel Stottlemyre | Bill Zepp | Mel Stottlemyre | Bill Zepp | Lindy McDaniel | 531 | 493 | 38 |
| 1970-08-21 | @ CHA | 123 | W 4-2 | 68-55 | 2 | 12,263 | Steve Kline | Gerry Janeski | Steve Kline | Gerry Janeski | Lindy McDaniel | 535 | 495 | 40 |
| 1970-08-22 | @ CHA | 124 | L 2-3 | 68-56 | 2 | 5,367 | Stan Bahnsen | Bart Johnson | Bart Johnson | Stan Bahnsen | Wilbur Wood | 537 | 498 | 39 |
| 1970-08-23 | @ CHA | 125 | L 0-2 | 69-57 | 2 | 0 | Fritz Peterson | Tommy John | Tommy John | Fritz Peterson | | 537 | 500 | 37 |
| 1970-08-23 | @ CHA | 126 | W 7-5 | 69-57 | 2 | 17,200 | Mike Kekich | Bob Miller | Mike Kekich | Bob Miller | Lindy McDaniel | 544 | 505 | 39 |
| 1970-08-24 | @ KCA | 127 | L 7-8 | 69-58 | 3 | 8,622 | Mel Stottlemyre | Al Fitzmorris | Tom Burgmeier | Ron Klimkowski | | 551 | 513 | 38 |
| 1970-08-25 | @ KCA | 128 | W 2-1 | 70-58 | 2 | 9,353 | Steve Kline | Dick Drago | Fritz Peterson | Dick Drago | Lindy McDaniel | 553 | 514 | 39 |
| 1970-08-26 | @ KCA | 129 | W 3-0 | 71-58 | 2 | 8,826 | Stan Bahnsen | Wally Bunker | Stan Bahnsen | Wally Bunker | | 556 | 514 | 42 |
| 1970-08-28 | vs MIN | 130 | W 6-0 | 73-58 | 2 | 0 | Fritz Peterson | Jim Kaat | Fritz Peterson | Jim Kaat | | 562 | 514 | 48 |
| 1970-08-28 | vs MIN | 131 | W 2-1 | 73-58 | 2 | 25,824 | Mike Kekich | Luis Tiant | Mike Kekich | Ron Perranoski | | 564 | 515 | 49 |
| 1970-08-29 | vs MIN | 132 | L 1-3 | 73-59 | 2 | 17,344 | Mel Stottlemyre | Bill Zepp | Bill Zepp | Mel Stottlemyre | Tom Hall | 565 | 518 | 47 |
| 1970-08-30 | vs MIN | 133 | W 5-2 | 74-59 | 2 | 20,980 | Steve Kline | Bert Blyleven | Steve Kline | Bert Blyleven | Lindy McDaniel | 570 | 520 | 50 |
| 1970-08-31 | vs BAL | 134 | L 2-10 | 74-60 | 2 | 15,301 | Stan Bahnsen | Mike Cuellar | Mike Cuellar | Stan Bahnsen | | 572 | 530 | 42 |
| 1970-09-01 | vs BAL | 135 | W 4-2 | 75-60 | 2 | 14,437 | Fritz Peterson | Jim Hardin | Fritz Peterson | Jim Hardin | Lindy McDaniel | 576 | 532 | 44 |
| 1970-09-02 | vs BAL | 136 | W 3-2 | 76-60 | 2 | 20,008 | Mike Kekich | Dave McNally | Mike Kekich | Dave McNally | Lindy McDaniel | 579 | 534 | 45 |
| 1970-09-03 | vs BAL | 137 | L 4-8 | 76-61 | 2 | 14,898 | Mel Stottlemyre | Jim Palmer | Jim Palmer | Mel Stottlemyre | Pete Richert | 583 | 542 | 41 |
| 1970-09-04 | vs CLE | 138 | W 3-2 | 77-61 | 2 | 9,394 | Steve Kline | Rich Hand | Steve Kline | Rich Hand | | 586 | 544 | 42 |
| 1970-09-05 | vs CLE | 139 | W 3-1 | 78-61 | 2 | 9,232 | Stan Bahnsen | Steve Dunning | Stan Bahnsen | Steve Dunning | Lindy McDaniel | 589 | 545 | 44 |
| 1970-09-06 | vs CLE | 140 | W 4-1 | 79-61 | 2 | 13,127 | Fritz Peterson | Mike Paul | Fritz Peterson | Mike Paul | | 593 | 546 | 47 |
| 1970-09-07 | @ WS2 | 141 | W 4-3 | 80-61 | 2 | 13,632 | Mike Kekich | Dick Bosman | Mike Kekich | Dick Bosman | Lindy McDaniel | 597 | 549 | 48 |
| 1970-09-08 | @ WS2 | 142 | W 7-3 | 81-61 | 2 | 4,628 | Mel Stottlemyre | Jim Shellenback | Mel Stottlemyre | Jim Shellenback | | 604 | 552 | 52 |
| 1970-09-09 | @ BAL | 143 | L 0-1 | 81-62 | 2 | 11,823 | Steve Kline | Mike Cuellar | Mike Cuellar | Steve Kline | | 604 | 553 | 51 |
| 1970-09-10 | @ BAL | 144 | L 1-2 | 81-63 | 2 | 10,049 | Stan Bahnsen | Dave McNally | Dave McNally | Stan Bahnsen | | 605 | 555 | 50 |
| 1970-09-11 | @ CLE | 145 | L 2-3 | 81-64 | 2 | 5,567 | Fritz Peterson | Mike Paul | Mike Paul | Fritz Peterson | Dennis Higgins | 607 | 558 | 49 |
| 1970-09-12 | @ CLE | 146 | L 3-4 | 81-65 | 2 | 5,861 | Mike Kekich | Sam McDowell | Dean Chance | Ron Klimkowski | | 610 | 562 | 48 |
| 1970-09-13 | @ CLE | 147 | L 1-3 | 81-66 | 2 | 6,651 | Mel Stottlemyre | Steve Hargan | Steve Hargan | Mel Stottlemyre | | 611 | 565 | 46 |
| 1970-09-15 | vs BOS | 148 | W 8-6 | 83-66 | 2 | 0 | Stan Bahnsen | Ray Culp | Stan Bahnsen | Ray Culp | Lindy McDaniel | 619 | 571 | 48 |
| 1970-09-15 | vs BOS | 149 | W 3-2 | 83-66 | 2 | 10,134 | Steve Kline | Mike Nagy | Steve Kline | Mike Nagy | | 622 | 573 | 49 |
| 1970-09-16 | vs BOS | 150 | L 1-3 | 83-67 | 2 | 6,966 | Fritz Peterson | Sonny Siebert | Roger Moret | Fritz Peterson | | 623 | 576 | 47 |
| 1970-09-17 | vs BOS | 151 | L 4-5 | 83-68 | 2 | 4,985 | Mel Stottlemyre | Gary Peters | Bobby Bolin | Jack Aker | Vicente Romo | 627 | 581 | 46 |
| 1970-09-18 | @ DET | 152 | W 5-0 | 84-68 | 2 | 11,202 | Ron Klimkowski | Mike Kilkenny | Ron Klimkowski | Mike Kilkenny | | 632 | 581 | 51 |
| 1970-09-19 | @ DET | 153 | W 7-6 | 85-68 | 2 | 8,864 | Stan Bahnsen | John Hiller | Mike McCormick | Tom Timmermann | Lindy McDaniel | 639 | 587 | 52 |
| 1970-09-20 | @ DET | 154 | W 5-1 | 86-68 | 2 | 11,341 | Steve Kline | Mickey Lolich | Steve Kline | Mickey Lolich | | 644 | 588 | 56 |
| 1970-09-21 | vs WS2 | 155 | W 5-2 | 87-68 | 2 | 4,749 | Fritz Peterson | Bill Gogolewski | Fritz Peterson | Bill Gogolewski | | 649 | 590 | 59 |
| 1970-09-22 | vs WS2 | 156 | W 2-1 | 88-68 | 2 | 5,631 | Mel Stottlemyre | Dick Bosman | Mel Stottlemyre | Dick Bosman | Lindy McDaniel | 651 | 591 | 60 |
| 1970-09-23 | vs WS2 | 157 | W 6-4 | 89-68 | 2 | 5,082 | Rob Gardner | Joe Coleman | Rob Gardner | Joe Coleman | Jack Aker | 657 | 595 | 62 |
| 1970-09-25 | vs DET | 158 | L 1-3 | 90-69 | 2 | 0 | Steve Kline | Mickey Lolich | Mickey Lolich | Steve Kline | | 658 | 598 | 60 |
| 1970-09-25 | vs DET | 159 | W 8-3 | 90-69 | 2 | 10,575 | Stan Bahnsen | Joe Niekro | Lindy McDaniel | Fred Scherman | Ron Klimkowski | 666 | 601 | 65 |
| 1970-09-26 | vs DET | 160 | W 2-1 | 91-69 | 2 | 13,366 | Fritz Peterson | Bob Reed | Fritz Peterson | Bob Reed | | 668 | 602 | 66 |
| 1970-09-27 | vs DET | 161 | W 4-2 | 92-69 | 2 | 10,821 | Mel Stottlemyre | John Hiller | Mel Stottlemyre | John Hiller | | 672 | 604 | 68 |
| 1970-09-29 | @ BOS | 162 | L 4-5 | 92-70 | 2 | 14,254 | Steve Kline | Ken Brett | Bobby Bolin | Steve Kline | | 676 | 609 | 67 |
| 1970-09-30 | @ BOS | 163 | W 4-3 | 93-70 | 2 | 16,255 | Fritz Peterson | Mike Nagy | Fritz Peterson | Mike Nagy | Lindy McDaniel | 680 | 612 | 68 |