| 1970-04-07 | vs OAK | 1 | L 4-6 | 0-1 | 5 | 18,127 | Wally Bunker | Blue Moon Odom | Blue Moon Odom | Wally Bunker | Rollie Fingers | 4 | 6 | -2 |
| 1970-04-08 | vs OAK | 2 | W 2-0 | 1-1 | 3 | 8,668 | Dick Drago | Catfish Hunter | Dick Drago | Catfish Hunter | | 6 | 6 | 0 |
| 1970-04-09 | vs OAK | 3 | W 3-1 | 2-1 | 3 | 7,529 | Bill Butler | Chuck Dobson | Bill Butler | Chuck Dobson | Dave Morehead | 9 | 7 | 2 |
| 1970-04-10 | vs CAL | 4 | L 7-11 | 2-2 | 3 | 8,379 | Roger Nelson | Clyde Wright | Clyde Wright | Roger Nelson | Mel Queen | 16 | 18 | -2 |
| 1970-04-11 | vs CAL | 5 | L 3-6 | 2-3 | 3 | 9,434 | Wally Bunker | Andy Messersmith | Andy Messersmith | Wally Bunker | Paul Doyle | 19 | 24 | -5 |
| 1970-04-12 | vs CAL | 6 | L 5-7 | 2-4 | 4 | 13,078 | Dick Drago | Tom Murphy | Eddie Fisher | Dick Drago | | 24 | 31 | -7 |
| 1970-04-16 | @ MIL | 7 | W 8-6 | 3-4 | 4 | 7,110 | Bill Butler | Lew Krausse | Bill Butler | Lew Krausse | Moe Drabowsky | 32 | 37 | -5 |
| 1970-04-17 | @ CAL | 8 | W 7-5 | 4-4 | 4 | 24,154 | Dave Morehead | Tom Murphy | Dave Morehead | Tom Murphy | Jim Rooker | 39 | 42 | -3 |
| 1970-04-18 | @ CAL | 9 | L 1-7 | 4-5 | 4 | 10,094 | Wally Bunker | Clyde Wright | Clyde Wright | Wally Bunker | | 40 | 49 | -9 |
| 1970-04-19 | @ CAL | 10 | W 4-1 | 5-5 | 3 | 11,643 | Dick Drago | Andy Messersmith | Jim Rooker | Mel Queen | | 44 | 50 | -6 |
| 1970-04-20 | @ OAK | 11 | W 4-2 | 6-5 | 3 | 2,631 | Bill Butler | Blue Moon Odom | Mike Hedlund | Diego Segui | | 48 | 52 | -4 |
| 1970-04-21 | @ OAK | 12 | L 3-4 | 6-6 | 3 | 2,635 | Dave Morehead | Catfish Hunter | Catfish Hunter | Jim Rooker | | 51 | 56 | -5 |
| 1970-04-22 | @ OAK | 13 | L 1-2 | 6-7 | 4 | 5,277 | Wally Bunker | Al Downing | Al Downing | Wally Bunker | | 52 | 58 | -6 |
| 1970-04-24 | vs BAL | 14 | L 5-7 | 6-8 | 4 | 9,011 | Dick Drago | Mike Cuellar | Jim Hardin | Mike Hedlund | Pete Richert | 57 | 65 | -8 |
| 1970-04-25 | vs BAL | 15 | L 3-9 | 6-9 | 4 | 10,311 | Bill Butler | Jim Palmer | Jim Palmer | Bill Butler | Eddie Watt | 60 | 74 | -14 |
| 1970-04-26 | vs BAL | 16 | L 9-10 | 6-10 | 5 | 17,695 | Dave Morehead | Dave McNally | Dick Hall | Al Fitzmorris | Pete Richert | 69 | 84 | -15 |
| 1970-04-28 | vs DET | 17 | L 3-8 | 6-11 | 5 | 7,237 | Wally Bunker | Joe Niekro | Joe Niekro | Wally Bunker | | 72 | 92 | -20 |
| 1970-04-29 | vs DET | 18 | L 2-8 | 6-12 | 5 | 6,165 | Dick Drago | Mike Kilkenny | Mike Kilkenny | Dick Drago | Fred Lasher | 74 | 100 | -26 |
| 1970-04-30 | vs DET | 19 | W 3-2 | 7-12 | 5 | 6,237 | Bill Butler | Mickey Lolich | Ken Wright | Fred Lasher | | 77 | 102 | -25 |
| 1970-05-01 | vs CLE | 20 | L 5-7 | 7-13 | 5 | 6,365 | Dave Morehead | Dean Chance | Phil Hennigan | Moe Drabowsky | Dennis Higgins | 82 | 109 | -27 |
| 1970-05-02 | vs CLE | 21 | W 4-3 | 8-13 | 5 | 8,016 | Bob Johnson | Sam McDowell | Mike Hedlund | Bob Miller | | 86 | 112 | -26 |
| 1970-05-03 | vs CLE | 22 | L 3-6 | 8-14 | 5 | 8,808 | Jim Rooker | Barry Moore | Barry Moore | Jim Rooker | Rich Hand | 89 | 118 | -29 |
| 1970-05-05 | @ BAL | 23 | L 3-7 | 8-15 | 5 | 4,614 | Dick Drago | Tom Phoebus | Tom Phoebus | Dick Drago | | 92 | 125 | -33 |
| 1970-05-06 | @ BAL | 24 | L 1-3 | 8-16 | 5 | 5,080 | Bill Butler | Dave McNally | Dave McNally | Bill Butler | Pete Richert | 93 | 128 | -35 |
| 1970-05-07 | @ BAL | 25 | L 6-7 | 8-17 | 5 | 5,063 | Dave Morehead | Mike Cuellar | Eddie Watt | Moe Drabowsky | | 99 | 135 | -36 |
| 1970-05-08 | @ DET | 26 | W 9-3 | 9-17 | 5 | 18,266 | Bob Johnson | Mike Kilkenny | Bob Johnson | Mike Kilkenny | | 108 | 138 | -30 |
| 1970-05-09 | @ DET | 27 | L 4-7 | 9-18 | 5 | 11,274 | Jim Rooker | Mickey Lolich | John Hiller | Mike Hedlund | | 112 | 145 | -33 |
| 1970-05-10 | @ DET | 28 | W 9-7 | 10-18 | 5 | 31,546 | Dick Drago | Earl Wilson | Al Fitzmorris | Fred Lasher | | 121 | 152 | -31 |
| 1970-05-13 | @ CLE | 29 | W 1-0 | 11-18 | 5 | 3,028 | Bill Butler | Barry Moore | Al Fitzmorris | Phil Hennigan | Ken Wright | 122 | 152 | -30 |
| 1970-05-14 | @ MIN | 30 | L 2-5 | 11-19 | 5 | 2,121 | Dave Morehead | Luis Tiant | Tom Hall | Dave Morehead | | 124 | 157 | -33 |
| 1970-05-15 | @ CHA | 31 | L 3-9 | 11-20 | 6 | 5,196 | Roger Nelson | Joe Horlen | Joe Horlen | Roger Nelson | | 127 | 166 | -39 |
| 1970-05-16 | @ CHA | 32 | L 1-6 | 11-21 | 6 | 3,655 | Bob Johnson | Tommy John | Tommy John | Bob Johnson | | 128 | 172 | -44 |
| 1970-05-17 | @ CHA | 33 | W 3-2 | 13-21 | 5 | 0 | Dick Drago | Gerry Janeski | Al Fitzmorris | Wilbur Wood | | 131 | 174 | -43 |
| 1970-05-17 | @ CHA | 34 | W 8-4 | 13-21 | 5 | 18,145 | Jim Rooker | Bart Johnson | Jim Rooker | Wilbur Wood | | 139 | 178 | -39 |
| 1970-05-18 | vs MIN | 35 | L 5-7 | 13-22 | 5 | 8,560 | Bill Butler | Jim Kaat | Bill Zepp | Mike Hedlund | Ron Perranoski | 144 | 185 | -41 |
| 1970-05-19 | vs MIN | 36 | L 4-5 | 13-23 | 5 | 7,766 | Dave Morehead | Luis Tiant | Ron Perranoski | Tom Burgmeier | | 148 | 190 | -42 |
| 1970-05-20 | vs MIN | 37 | L 5-10 | 13-24 | 6 | 7,710 | Bob Johnson | Dave Boswell | Dave Boswell | Bob Johnson | Tom Hall | 153 | 200 | -47 |
| 1970-05-22 | vs MIL | 38 | W 6-3 | 14-24 | 5 | 8,201 | Dick Drago | Bobby Bolin | Dick Drago | Bobby Bolin | Al Fitzmorris | 159 | 203 | -44 |
| 1970-05-23 | vs MIL | 39 | W 3-1 | 15-24 | 5 | 9,001 | Jim Rooker | Lew Krausse | Jim Rooker | Lew Krausse | | 162 | 204 | -42 |
| 1970-05-24 | vs MIL | 40 | W 6-5 | 16-24 | 4 | 30,035 | Bill Butler | John Morris | Moe Drabowsky | Gene Brabender | | 168 | 209 | -41 |
| 1970-05-25 | vs CHA | 41 | W 7-1 | 17-24 | 4 | 6,643 | Dave Morehead | Jerry Crider | Dave Morehead | Jerry Crider | | 175 | 210 | -35 |
| 1970-05-26 | vs CHA | 42 | L 1-3 | 17-25 | 4 | 7,270 | Bob Johnson | Gerry Janeski | Gerry Janeski | Bob Johnson | Wilbur Wood | 176 | 213 | -37 |
| 1970-05-27 | vs CHA | 43 | W 4-3 | 18-25 | 4 | 11,054 | Dick Drago | Joe Horlen | Dick Drago | Joe Horlen | Moe Drabowsky | 180 | 216 | -36 |
| 1970-05-29 | @ WS2 | 44 | L 4-5 | 18-26 | 4 | 19,214 | Jim Rooker | Joe Coleman | Jim Shellenback | Wally Bunker | | 184 | 221 | -37 |
| 1970-05-30 | @ WS2 | 45 | L 2-3 | 18-27 | 4 | 11,982 | Bill Butler | Dick Bosman | Dick Bosman | Bill Butler | Darold Knowles | 186 | 224 | -38 |
| 1970-05-31 | @ WS2 | 46 | W 6-5 | 19-27 | 4 | 23,889 | Dave Morehead | Casey Cox | Tom Burgmeier | Darold Knowles | Ken Wright | 192 | 229 | -37 |
| 1970-06-02 | @ NYA | 47 | L 2-3 | 19-28 | 4 | 9,181 | Bob Johnson | Fritz Peterson | Fritz Peterson | Bob Johnson | Lindy McDaniel | 194 | 232 | -38 |
| 1970-06-03 | @ NYA | 48 | L 3-5 | 19-29 | 4 | 6,891 | Dick Drago | Mike Kekich | Mike Kekich | Dick Drago | Jack Aker | 197 | 237 | -40 |
| 1970-06-04 | @ NYA | 49 | L 1-2 | 19-30 | 4 | 6,510 | Jim Rooker | Stan Bahnsen | Lindy McDaniel | Jim Rooker | | 198 | 239 | -41 |
| 1970-06-05 | @ BOS | 50 | L 2-4 | 19-31 | 4 | 19,412 | Bill Butler | Mike Nagy | Mike Nagy | Bill Butler | Vicente Romo | 200 | 243 | -43 |
| 1970-06-07 | @ BOS | 51 | L 4-7 | 19-33 | 5 | 0 | Dave Morehead | Ray Culp | Lee Stange | Tom Burgmeier | Ken Brett | 204 | 250 | -46 |
| 1970-06-07 | @ BOS | 52 | L 2-5 | 19-33 | 5 | 30,434 | Bob Johnson | Gary Peters | Vicente Romo | Al Fitzmorris | Sparky Lyle | 206 | 255 | -49 |
| 1970-06-09 | vs WS2 | 53 | W 8-1 | 20-33 | 5 | 7,404 | Dick Drago | Casey Cox | Dick Drago | Casey Cox | | 214 | 256 | -42 |
| 1970-06-10 | vs WS2 | 54 | L 1-8 | 20-34 | 5 | 7,258 | Jim Rooker | Joe Coleman | Joe Coleman | Jim Rooker | | 215 | 264 | -49 |
| 1970-06-12 | vs NYA | 55 | L 0-5 | 20-35 | 5 | 9,272 | Dave Morehead | Fritz Peterson | Fritz Peterson | Dave Morehead | | 215 | 269 | -54 |
| 1970-06-13 | vs NYA | 56 | L 4-9 | 20-36 | 5 | 16,406 | Bob Johnson | Mike Kekich | Lindy McDaniel | Ken Wright | | 219 | 278 | -59 |
| 1970-06-14 | vs NYA | 57 | L 2-3 | 20-37 | 5 | 12,332 | Dick Drago | Stan Bahnsen | Steve Hamilton | Tom Burgmeier | | 221 | 281 | -60 |
| 1970-06-15 | vs BOS | 58 | W 7-6 | 21-37 | 5 | 7,324 | Jim Rooker | Mike Nagy | Aurelio Monteagudo | Cal Koonce | | 228 | 287 | -59 |
| 1970-06-16 | vs BOS | 59 | L 5-7 | 21-38 | 5 | 7,666 | Bill Butler | Gary Peters | Gary Peters | Bill Butler | Jose Santiago | 233 | 294 | -61 |
| 1970-06-17 | vs BOS | 60 | L 1-3 | 21-39 | 5 | 9,493 | Dave Morehead | Ken Brett | Ken Brett | Dave Morehead | | 234 | 297 | -63 |
| 1970-06-19 | vs MIN | 61 | W 5-1 | 22-39 | 5 | 8,571 | Dick Drago | Bert Blyleven | Dick Drago | Bert Blyleven | | 239 | 298 | -59 |
| 1970-06-20 | vs MIN | 62 | W 5-3 | 23-39 | 5 | 10,016 | Jim Rooker | Dave Boswell | Jim Rooker | Dave Boswell | Bob Johnson | 244 | 301 | -57 |
| 1970-06-21 | vs MIN | 63 | L 2-11 | 23-40 | 4 | 10,864 | Bill Butler | Jim Perry | Jim Perry | Bill Butler | Ron Perranoski | 246 | 312 | -66 |
| 1970-06-22 | @ OAK | 64 | L 1-2 | 23-41 | 5 | 3,815 | Dave Morehead | Diego Segui | Bob Locker | Tom Burgmeier | | 247 | 314 | -67 |
| 1970-06-23 | @ OAK | 65 | W 7-5 | 24-41 | 5 | 5,273 | Dick Drago | Chuck Dobson | Dick Drago | Chuck Dobson | Bob Johnson | 254 | 319 | -65 |
| 1970-06-24 | @ OAK | 66 | L 1-5 | 24-42 | 4 | 5,737 | Jim Rooker | Darrell Osteen | Darrell Osteen | Jim Rooker | Marcel Lachemann | 255 | 324 | -69 |
| 1970-06-26 | vs CAL | 67 | L 4-5 | 24-43 | 5 | 9,677 | Bill Butler | Rudy May | Steve Kealey | Bill Butler | Eddie Fisher | 259 | 329 | -70 |
| 1970-06-27 | vs CAL | 68 | W 2-0 | 25-43 | 4 | 7,677 | Dave Morehead | Andy Messersmith | Tom Burgmeier | Andy Messersmith | Bob Johnson | 261 | 329 | -68 |
| 1970-06-28 | vs CAL | 69 | L 1-2 | 26-44 | 4 | 0 | Jim Rooker | Tom Murphy | Tom Murphy | Jim Rooker | Ken Tatum | 262 | 331 | -69 |
| 1970-06-28 | vs CAL | 70 | W 13-1 | 26-44 | 4 | 13,386 | Al Fitzmorris | Mel Queen | Al Fitzmorris | Greg Garrett | Ken Wright | 275 | 332 | -57 |
| 1970-06-29 | @ MIN | 71 | L 4-5 | 26-45 | 4 | 14,600 | Dick Drago | Jim Perry | Jim Perry | Dick Drago | Ron Perranoski | 279 | 337 | -58 |
| 1970-06-30 | @ MIN | 72 | L 5-8 | 26-46 | 4 | 11,809 | Don O'Riley | Jim Kaat | Dick Woodson | Bob Johnson | Stan Williams | 284 | 345 | -61 |
| 1970-07-01 | @ MIN | 73 | L 1-2 | 26-47 | 4 | 15,674 | Jim Rooker | Bert Blyleven | Ron Perranoski | Jim Rooker | | 285 | 347 | -62 |
| 1970-07-02 | @ MIN | 74 | L 2-5 | 26-48 | 4 | 20,044 | Al Fitzmorris | Tom Hall | Tom Hall | Al Fitzmorris | Stan Williams | 287 | 352 | -65 |
| 1970-07-03 | @ MIL | 75 | W 5-3 | 28-48 | 4 | 0 | Dick Drago | Marty Pattin | Ted Abernathy | Bob Humphreys | | 292 | 355 | -63 |
| 1970-07-03 | @ MIL | 76 | W 4-3 | 28-48 | 4 | 29,661 | Bob Johnson | Al Downing | Bob Johnson | Al Downing | Ted Abernathy | 296 | 358 | -62 |
| 1970-07-04 | @ MIL | 77 | W 8-6 | 29-48 | 4 | 9,665 | Don O'Riley | Lew Krausse | Ted Abernathy | Dave Baldwin | | 304 | 364 | -60 |
| 1970-07-05 | @ MIL | 78 | L 1-2 | 29-49 | 4 | 10,323 | Bill Butler | Skip Lockwood | Skip Lockwood | Bill Butler | | 305 | 366 | -61 |
| 1970-07-06 | @ CAL | 79 | L 2-6 | 29-50 | 4 | 7,476 | Jim Rooker | Tom Murphy | Tom Murphy | Jim Rooker | Eddie Fisher | 307 | 372 | -65 |
| 1970-07-07 | @ CAL | 80 | W 4-3 | 30-50 | 4 | 8,481 | Al Fitzmorris | Clyde Wright | Ted Abernathy | Eddie Fisher | Bob Johnson | 311 | 375 | -64 |
| 1970-07-08 | @ CAL | 81 | L 2-3 | 30-51 | 4 | 7,733 | Dick Drago | Tom Bradley | Ken Tatum | Ted Abernathy | | 313 | 378 | -65 |
| 1970-07-10 | vs CHA | 82 | W 8-6 | 32-51 | 4 | 0 | Bob Johnson | Gerry Janeski | Bob Johnson | Gerry Janeski | Ted Abernathy | 321 | 384 | -63 |
| 1970-07-10 | vs CHA | 83 | W 2-0 | 32-51 | 4 | 12,463 | Jim Rooker | Bob Miller | Jim Rooker | Bob Miller | | 323 | 384 | -61 |
| 1970-07-11 | vs CHA | 84 | W 4-0 | 33-51 | 4 | 10,494 | Bill Butler | Joe Horlen | Bill Butler | Joe Horlen | | 327 | 384 | -57 |
| 1970-07-12 | vs CHA | 85 | L 5-10 | 33-52 | 4 | 10,565 | Dick Drago | Tommy John | Tommy John | Dick Drago | Jerry Crider | 332 | 394 | -62 |
| 1970-07-16 | vs CLE | 86 | L 0-6 | 33-53 | 4 | 8,046 | Jim Rooker | Rich Hand | Rich Hand | Jim Rooker | | 332 | 400 | -68 |
| 1970-07-17 | vs CLE | 87 | L 0-6 | 33-54 | 4 | 12,063 | Bob Johnson | Steve Dunning | Steve Dunning | Bob Johnson | Phil Hennigan | 332 | 406 | -74 |
| 1970-07-18 | vs CLE | 88 | L 1-4 | 33-55 | 4 | 7,334 | Bill Butler | Steve Hargan | Steve Hargan | Bill Butler | | 333 | 410 | -77 |
| 1970-07-19 | vs DET | 89 | L 0-2 | 33-57 | 4 | 0 | Dick Drago | Joe Niekro | Joe Niekro | Dick Drago | Tom Timmermann | 333 | 412 | -79 |
| 1970-07-19 | vs DET | 90 | L 4-6 | 33-57 | 4 | 14,377 | Dave Morehead | Mike Kilkenny | Bob Reed | Ted Abernathy | Tom Timmermann | 337 | 418 | -81 |
| 1970-07-20 | vs DET | 91 | W 3-0 | 34-57 | 4 | 7,412 | Jim Rooker | Les Cain | Jim Rooker | Les Cain | | 340 | 418 | -78 |
| 1970-07-21 | vs BAL | 92 | L 1-2 | 34-58 | 4 | 9,334 | Bob Johnson | Jim Hardin | Eddie Watt | Bob Johnson | | 341 | 420 | -79 |
| 1970-07-22 | vs BAL | 93 | L 3-4 | 34-59 | 4 | 9,130 | Bill Butler | Dave McNally | Pete Richert | Ted Abernathy | Moe Drabowsky | 344 | 424 | -80 |
| 1970-07-23 | vs BAL | 94 | L 4-5 | 34-60 | 4 | 11,222 | Dick Drago | Jim Palmer | Jim Palmer | Dick Drago | Eddie Watt | 348 | 429 | -81 |
| 1970-07-24 | @ CLE | 95 | W 5-2 | 35-61 | 5 | 0 | Jim Rooker | Rich Hand | Jim Rooker | Rich Hand | Ted Abernathy | 353 | 431 | -78 |
| 1970-07-24 | @ CLE | 96 | L 6-9 | 35-61 | 5 | 12,076 | Wally Bunker | Dean Chance | Dean Chance | Wally Bunker | Fred Lasher | 359 | 440 | -81 |
| 1970-07-25 | @ CLE | 97 | W 8-4 | 36-61 | 5 | 18,853 | Bob Johnson | Rick Austin | Tom Burgmeier | Fred Lasher | Ted Abernathy | 367 | 444 | -77 |
| 1970-07-26 | @ CLE | 98 | L 5-6 | 36-63 | 5 | 0 | Bill Butler | Steve Dunning | Steve Dunning | Ken Wright | Rick Austin | 372 | 450 | -78 |
| 1970-07-26 | @ CLE | 99 | L 0-3 | 36-63 | 5 | 21,237 | Dave Morehead | Steve Hargan | Steve Hargan | Dave Morehead | | 372 | 453 | -81 |
| 1970-07-28 | @ DET | 100 | W 7-6 | 37-63 | 5 | 15,226 | Dick Drago | Joe Niekro | Ted Abernathy | Fred Scherman | | 379 | 459 | -80 |
| 1970-07-29 | @ DET | 101 | L 3-10 | 37-64 | 5 | 13,886 | Jim Rooker | Les Cain | Les Cain | Jim Rooker | Tom Timmermann | 382 | 469 | -87 |
| 1970-07-30 | @ DET | 102 | W 3-2 | 38-64 | 5 | 13,888 | Bob Johnson | Mike Kilkenny | Ted Abernathy | Tom Timmermann | | 385 | 471 | -86 |
| 1970-07-31 | @ BAL | 103 | L 1-3 | 38-65 | 5 | 10,159 | Bill Butler | Dave McNally | Dave McNally | Dave Morehead | | 386 | 474 | -88 |
| 1970-08-01 | @ BAL | 104 | L 1-9 | 38-66 | 5 | 13,640 | Dick Drago | Jim Palmer | Jim Palmer | Dick Drago | | 387 | 483 | -96 |
| 1970-08-02 | @ BAL | 105 | L 8-10 | 38-67 | 5 | 12,108 | Jim Rooker | Mike Cuellar | Mike Cuellar | Jim Rooker | Eddie Watt | 395 | 493 | -98 |
| 1970-08-03 | @ CHA | 106 | W 7-2 | 39-67 | 5 | 3,587 | Bob Johnson | Bob Miller | Bob Johnson | Bob Miller | | 402 | 495 | -93 |
| 1970-08-04 | @ CHA | 107 | L 1-2 | 39-68 | 5 | 4,533 | Bill Butler | Tommy John | Tommy John | Bill Butler | | 403 | 497 | -94 |
| 1970-08-05 | vs OAK | 108 | L 1-4 | 39-69 | 5 | 9,274 | Dick Drago | Chuck Dobson | Chuck Dobson | Dick Drago | | 404 | 501 | -97 |
| 1970-08-06 | vs OAK | 109 | W 5-3 | 40-69 | 4 | 9,833 | Jim Rooker | Diego Segui | Al Fitzmorris | Bob Locker | Ted Abernathy | 409 | 504 | -95 |
| 1970-08-07 | vs MIL | 110 | W 4-0 | 42-69 | 4 | 0 | Bob Johnson | Skip Lockwood | Bob Johnson | Skip Lockwood | Ted Abernathy | 413 | 504 | -91 |
| 1970-08-07 | vs MIL | 111 | W 10-2 | 42-69 | 4 | 11,363 | Dave Morehead | Lew Krausse | Dave Morehead | Lew Krausse | Ted Abernathy | 423 | 506 | -83 |
| 1970-08-08 | vs MIL | 112 | L 3-5 | 42-70 | 4 | 8,383 | Bill Butler | Marty Pattin | Marty Pattin | Bill Butler | Ken Sanders | 426 | 511 | -85 |
| 1970-08-09 | vs MIL | 113 | L 2-4 | 42-71 | 4 | 9,492 | Dick Drago | Bobby Bolin | Bobby Bolin | Dick Drago | Ken Sanders | 428 | 515 | -87 |
| 1970-08-12 | @ BOS | 114 | L 4-7 | 43-72 | 4 | 0 | Jim Rooker | Gary Peters | Gary Peters | Jim Rooker | | 432 | 522 | -90 |
| 1970-08-12 | @ BOS | 115 | W 4-3 | 43-72 | 4 | 23,450 | Bob Johnson | Cal Koonce | Ted Abernathy | Ken Brett | | 436 | 525 | -89 |
| 1970-08-13 | @ BOS | 116 | W 11-3 | 44-72 | 4 | 17,252 | Al Fitzmorris | Vicente Romo | Al Fitzmorris | Vicente Romo | | 447 | 528 | -81 |
| 1970-08-14 | @ NYA | 117 | L 2-3 | 44-73 | 5 | 10,350 | Dick Drago | Fritz Peterson | Lindy McDaniel | Dick Drago | | 449 | 531 | -82 |
| 1970-08-15 | @ NYA | 118 | L 4-5 | 44-74 | 5 | 10,098 | Wally Bunker | Mel Stottlemyre | Ron Klimkowski | Tom Burgmeier | Lindy McDaniel | 453 | 536 | -83 |
| 1970-08-16 | @ NYA | 119 | L 1-5 | 44-75 | 5 | 13,200 | Jim Rooker | Stan Bahnsen | Stan Bahnsen | Jim Rooker | | 454 | 541 | -87 |
| 1970-08-17 | @ WS2 | 120 | L 0-7 | 44-76 | 5 | 5,722 | Bob Johnson | Jim Hannan | Jim Hannan | Bob Johnson | | 454 | 548 | -94 |
| 1970-08-18 | @ WS2 | 121 | W 12-8 | 45-76 | 5 | 11,576 | Al Fitzmorris | Dick Bosman | Al Fitzmorris | Dick Bosman | Ted Abernathy | 466 | 556 | -90 |
| 1970-08-19 | @ WS2 | 122 | W 2-1 | 46-76 | 5 | 5,868 | Dick Drago | Joe Coleman | Dick Drago | Joe Coleman | | 468 | 557 | -89 |
| 1970-08-21 | vs BOS | 123 | W 2-1 | 47-76 | 4 | 12,050 | Wally Bunker | Sonny Siebert | Ted Abernathy | Ken Brett | | 470 | 558 | -88 |
| 1970-08-22 | vs BOS | 124 | L 1-8 | 47-77 | 4 | 9,884 | Jim Rooker | Gary Peters | Gary Peters | Jim Rooker | | 471 | 566 | -95 |
| 1970-08-23 | vs BOS | 125 | W 4-3 | 48-77 | 4 | 11,992 | Bob Johnson | Cal Koonce | Bob Johnson | Sparky Lyle | | 475 | 569 | -94 |
| 1970-08-24 | vs NYA | 126 | W 8-7 | 49-77 | 4 | 8,622 | Al Fitzmorris | Mel Stottlemyre | Tom Burgmeier | Ron Klimkowski | | 483 | 576 | -93 |
| 1970-08-25 | vs NYA | 127 | L 1-2 | 49-78 | 4 | 9,353 | Dick Drago | Steve Kline | Fritz Peterson | Dick Drago | Lindy McDaniel | 484 | 578 | -94 |
| 1970-08-26 | vs NYA | 128 | L 0-3 | 49-79 | 4 | 8,826 | Wally Bunker | Stan Bahnsen | Stan Bahnsen | Wally Bunker | | 484 | 581 | -97 |
| 1970-08-28 | vs WS2 | 129 | L 1-2 | 50-80 | 4 | 0 | Bob Johnson | Dick Bosman | Dick Bosman | Bob Johnson | | 485 | 583 | -98 |
| 1970-08-28 | vs WS2 | 130 | W 3-1 | 50-80 | 4 | 9,317 | Jim Rooker | Jim Hannan | Jim Rooker | Jim Hannan | Tom Burgmeier | 488 | 584 | -96 |
| 1970-08-29 | vs WS2 | 131 | L 4-11 | 50-81 | 4 | 7,064 | Al Fitzmorris | Jim Shellenback | George Brunet | Al Fitzmorris | Darold Knowles | 492 | 595 | -103 |
| 1970-08-30 | vs WS2 | 132 | W 4-3 | 51-81 | 4 | 9,049 | Dick Drago | Joe Coleman | Tom Burgmeier | Horacio Pina | | 496 | 598 | -102 |
| 1970-09-01 | @ CAL | 133 | W 4-0 | 52-81 | 4 | 9,219 | Wally Bunker | Tom Murphy | Wally Bunker | Tom Murphy | | 500 | 598 | -98 |
| 1970-09-02 | @ CAL | 134 | L 1-3 | 52-82 | 4 | 9,212 | Bob Johnson | Clyde Wright | Clyde Wright | Bob Johnson | Andy Messersmith | 501 | 601 | -100 |
| 1970-09-03 | @ CAL | 135 | L 0-1 | 52-83 | 4 | 6,960 | Jim Rooker | Tom Bradley | Tom Bradley | Jim Rooker | | 501 | 602 | -101 |
| 1970-09-04 | @ OAK | 136 | L 0-5 | 52-84 | 5 | 3,720 | Al Fitzmorris | Catfish Hunter | Catfish Hunter | Al Fitzmorris | | 501 | 607 | -106 |
| 1970-09-05 | @ OAK | 137 | L 3-8 | 52-85 | 5 | 9,824 | Dick Drago | Chuck Dobson | Paul Lindblad | Dick Drago | Bob Locker | 504 | 615 | -111 |
| 1970-09-06 | @ OAK | 138 | L 1-7 | 52-86 | 5 | 8,245 | Wally Bunker | Blue Moon Odom | Blue Moon Odom | Wally Bunker | | 505 | 622 | -117 |
| 1970-09-07 | vs CAL | 139 | W 4-1 | 53-86 | 4 | 6,626 | Bob Johnson | Tom Bradley | Bob Johnson | Tom Bradley | | 509 | 623 | -114 |
| 1970-09-08 | vs CAL | 140 | W 12-0 | 54-86 | 4 | 6,244 | Jim Rooker | Rudy May | Jim Rooker | Rudy May | | 521 | 623 | -102 |
| 1970-09-10 | vs MIL | 141 | W 2-0 | 56-86 | 4 | 0 | Bill Butler | Skip Lockwood | Bill Butler | Skip Lockwood | Ted Abernathy | 523 | 623 | -100 |
| 1970-09-10 | vs MIL | 142 | W 10-2 | 56-86 | 4 | 7,369 | Dick Drago | John Morris | Dick Drago | John Morris | | 533 | 625 | -92 |
| 1970-09-11 | vs OAK | 143 | L 0-3 | 56-87 | 4 | 6,993 | Wally Bunker | Vida Blue | Vida Blue | Wally Bunker | | 533 | 628 | -95 |
| 1970-09-12 | vs OAK | 144 | L 2-3 | 56-88 | 4 | 6,579 | Bob Johnson | Diego Segui | Mudcat Grant | Bob Johnson | | 535 | 631 | -96 |
| 1970-09-13 | vs OAK | 145 | W 8-7 | 58-88 | 4 | 0 | Jim Rooker | Chuck Dobson | Tom Burgmeier | Mudcat Grant | | 543 | 638 | -95 |
| 1970-09-13 | vs OAK | 146 | W 8-7 | 58-88 | 4 | 9,824 | Al Fitzmorris | Catfish Hunter | Ted Abernathy | Marcel Lachemann | | 551 | 645 | -94 |
| 1970-09-17 | @ MIL | 147 | L 3-4 | 58-89 | 4 | 7,116 | Dick Drago | Marty Pattin | Ken Sanders | Tom Burgmeier | | 554 | 649 | -95 |
| 1970-09-18 | @ MIL | 148 | L 3-4 | 58-90 | 4 | 10,424 | Bill Butler | Al Downing | Al Downing | Bill Butler | Ken Sanders | 557 | 653 | -96 |
| 1970-09-19 | @ MIL | 149 | W 4-1 | 59-90 | 4 | 12,562 | Wally Bunker | John Morris | Wally Bunker | John Morris | Ted Abernathy | 561 | 654 | -93 |
| 1970-09-20 | @ MIL | 150 | L 3-4 | 59-91 | 4 | 12,841 | Bob Johnson | Skip Lockwood | Skip Lockwood | Bob Johnson | Ken Sanders | 564 | 658 | -94 |
| 1970-09-21 | @ CHA | 151 | L 4-8 | 60-92 | 4 | 0 | Jim Rooker | Joe Horlen | Wilbur Wood | Aurelio Monteagudo | | 568 | 666 | -98 |
| 1970-09-21 | @ CHA | 152 | W 8-2 | 60-92 | 4 | 672 | Bill Butler | Floyd Weaver | Jim York | Floyd Weaver | | 576 | 668 | -92 |
| 1970-09-22 | @ CHA | 153 | W 2-1 | 62-92 | 4 | 0 | Dick Drago | Billy Wynne | Dick Drago | Billy Wynne | Ted Abernathy | 578 | 669 | -91 |
| 1970-09-22 | @ CHA | 154 | W 6-2 | 62-92 | 4 | 2,369 | Al Fitzmorris | Jim Magnuson | Al Fitzmorris | Jim Magnuson | | 584 | 671 | -87 |
| 1970-09-23 | @ CHA | 155 | L 0-6 | 62-93 | 4 | 693 | Paul Splittorff | Bart Johnson | Bart Johnson | Paul Splittorff | | 584 | 677 | -93 |
| 1970-09-25 | vs MIN | 156 | L 0-1 | 62-94 | 5 | 6,663 | Wally Bunker | Jim Perry | Jim Perry | Wally Bunker | | 584 | 678 | -94 |
| 1970-09-26 | vs MIN | 157 | W 5-0 | 63-94 | 5 | 7,710 | Bob Johnson | Bert Blyleven | Bob Johnson | Bert Blyleven | | 589 | 678 | -89 |
| 1970-09-27 | vs MIN | 158 | W 4-3 | 64-94 | 5 | 9,390 | Jim Rooker | Luis Tiant | Jim Rooker | Luis Tiant | Ted Abernathy | 593 | 681 | -88 |
| 1970-09-28 | @ MIN | 159 | L 0-1 | 64-95 | 5 | 1,100 | Dick Drago | Tom Hall | Tom Hall | Dick Drago | Ron Perranoski | 593 | 682 | -89 |
| 1970-09-29 | @ MIN | 160 | W 14-13 | 65-95 | 4 | 5,473 | Al Fitzmorris | Jim Perry | Ted Abernathy | Pete Hamm | | 607 | 695 | -88 |
| 1970-09-30 | @ MIN | 161 | L 4-6 | 65-96 | 5 | 5,219 | Wally Bunker | Bert Blyleven | Hal Haydel | Jim York | | 611 | 701 | -90 |
| 1970-10-01 | @ MIN | 162 | L 0-4 | 65-97 | 5 | 6,008 | Bob Johnson | Jim Kaat | Jim Kaat | Bob Johnson | Ron Perranoski | 611 | 705 | -94 |