| 1970-04-06 | vs DET | 1 | L 0-5 | 0-1 | 6 | 45,015 | Dick Bosman | Mickey Lolich | Mickey Lolich | Dick Bosman | | 0 | 5 | -5 |
| 1970-04-07 | vs DET | 2 | W 14-4 | 1-1 | 4 | 3,372 | Casey Cox | Earl Wilson | Casey Cox | Earl Wilson | Joe Grzenda | 14 | 9 | 5 |
| 1970-04-08 | vs DET | 3 | L 0-3 | 1-2 | 4 | 5,097 | George Brunet | Joe Niekro | Joe Niekro | George Brunet | | 14 | 12 | 2 |
| 1970-04-10 | vs BOS | 4 | L 1-4 | 1-3 | 5 | 12,026 | Joe Coleman | Jim Lonborg | Jim Lonborg | Joe Coleman | Sparky Lyle | 15 | 16 | -1 |
| 1970-04-11 | vs BOS | 5 | W 4-3 | 2-3 | 4 | 9,669 | Dick Bosman | Sonny Siebert | Dick Bosman | Sonny Siebert | Darold Knowles | 19 | 19 | 0 |
| 1970-04-12 | vs BOS | 6 | W 6-5 | 3-3 | 3 | 20,133 | Casey Cox | Gary Peters | Casey Cox | Gary Peters | Horacio Pina | 25 | 24 | 1 |
| 1970-04-16 | @ BAL | 7 | W 4-2 | 4-3 | 4 | 4,674 | Joe Coleman | Jim Palmer | Joe Coleman | Jim Palmer | | 29 | 26 | 3 |
| 1970-04-18 | @ CLE | 8 | L 4-9 | 4-4 | 4 | 4,370 | Dick Bosman | Sam McDowell | Sam McDowell | Dick Bosman | | 33 | 35 | -2 |
| 1970-04-20 | vs NYA | 9 | L 2-11 | 4-5 | 4 | 4,626 | George Brunet | Stan Bahnsen | Stan Bahnsen | George Brunet | Steve Hamilton | 35 | 46 | -11 |
| 1970-04-21 | vs NYA | 10 | W 7-5 | 5-5 | 3 | 5,981 | Casey Cox | Mel Stottlemyre | Casey Cox | Mel Stottlemyre | Darold Knowles | 42 | 51 | -9 |
| 1970-04-22 | vs NYA | 11 | W 2-1 | 6-5 | 3 | 6,316 | Joe Coleman | Fritz Peterson | Joe Grzenda | Ron Klimkowski | | 44 | 52 | -8 |
| 1970-04-23 | vs NYA | 12 | L 6-11 | 6-6 | 4 | 1,807 | Jim Shellenback | Bill Burbach | John Cumberland | Dick Such | | 50 | 63 | -13 |
| 1970-04-24 | vs CAL | 13 | W 5-3 | 7-6 | 3 | 6,364 | Dick Bosman | Andy Messersmith | Dick Bosman | Andy Messersmith | Horacio Pina | 55 | 66 | -11 |
| 1970-04-25 | vs CAL | 14 | L 3-5 | 7-7 | 4 | 11,288 | George Brunet | Rudy May | Rudy May | George Brunet | Paul Doyle | 58 | 71 | -13 |
| 1970-04-26 | vs CAL | 15 | L 2-3 | 7-8 | 4 | 11,346 | Casey Cox | Tom Murphy | Tom Murphy | Casey Cox | Paul Doyle | 60 | 74 | -14 |
| 1970-04-27 | vs MIL | 16 | W 6-5 | 8-8 | 4 | 3,291 | Joe Coleman | Marty Pattin | Horacio Pina | Bob Locker | | 66 | 79 | -13 |
| 1970-04-28 | vs MIL | 17 | W 9-6 | 9-8 | 4 | 4,415 | Jim Shellenback | George Lauzerique | Dick Such | George Lauzerique | Horacio Pina | 75 | 85 | -10 |
| 1970-04-29 | vs MIL | 18 | W 4-0 | 10-8 | 4 | 4,452 | Dick Bosman | Lew Krausse | Dick Bosman | Lew Krausse | | 79 | 85 | -6 |
| 1970-04-30 | vs MIL | 19 | W 12-2 | 11-8 | 4 | 7,575 | George Brunet | Bobby Bolin | George Brunet | Bobby Bolin | | 91 | 87 | 4 |
| 1970-05-01 | vs OAK | 20 | L 5-12 | 11-9 | 4 | 11,014 | Casey Cox | Catfish Hunter | Catfish Hunter | Casey Cox | Mudcat Grant | 96 | 99 | -3 |
| 1970-05-02 | vs OAK | 21 | L 3-6 | 11-10 | 4 | 5,977 | Joe Coleman | Al Downing | Al Downing | Joe Coleman | Diego Segui | 99 | 105 | -6 |
| 1970-05-03 | vs OAK | 22 | L 1-3 | 12-11 | 4 | 0 | Dick Bosman | Blue Moon Odom | Rollie Fingers | Dick Bosman | | 100 | 108 | -8 |
| 1970-05-03 | vs OAK | 23 | W 6-4 | 12-11 | 4 | 21,617 | Jim Shellenback | Chuck Dobson | Horacio Pina | Diego Segui | Darold Knowles | 106 | 112 | -6 |
| 1970-05-05 | @ CAL | 24 | W 6-1 | 13-11 | 4 | 8,079 | George Brunet | Andy Messersmith | George Brunet | Andy Messersmith | Horacio Pina | 112 | 113 | -1 |
| 1970-05-06 | @ CAL | 25 | L 2-4 | 13-12 | 4 | 5,541 | Casey Cox | Rudy May | Eddie Fisher | Darold Knowles | | 114 | 117 | -3 |
| 1970-05-07 | @ CAL | 26 | L 0-8 | 13-13 | 5 | 6,301 | Joe Coleman | Tom Murphy | Tom Murphy | Joe Coleman | | 114 | 125 | -11 |
| 1970-05-09 | @ MIL | 27 | L 2-3 | 13-14 | 5 | 8,935 | Dick Bosman | John Morris | John Gelnar | Joe Grzenda | | 116 | 128 | -12 |
| 1970-05-10 | @ MIL | 28 | L 5-6 | 13-16 | 5 | 0 | George Brunet | Gene Brabender | Marty Pattin | Darold Knowles | | 121 | 134 | -13 |
| 1970-05-10 | @ MIL | 29 | L 6-7 | 13-16 | 5 | 13,941 | Casey Cox | Skip Lockwood | John O'Donoghue | Joe Grzenda | | 127 | 141 | -14 |
| 1970-05-12 | @ OAK | 30 | L 3-5 | 13-17 | 5 | 3,230 | Joe Coleman | Chuck Dobson | Diego Segui | George Brunet | | 130 | 146 | -16 |
| 1970-05-13 | @ OAK | 31 | L 1-8 | 13-18 | 5 | 4,487 | Jim Shellenback | Blue Moon Odom | Blue Moon Odom | Jim Shellenback | Rollie Fingers | 131 | 154 | -23 |
| 1970-05-15 | vs BAL | 32 | L 3-4 | 13-19 | 5 | 11,968 | Dick Bosman | Tom Phoebus | Pete Richert | Darold Knowles | Jim Hardin | 134 | 158 | -24 |
| 1970-05-16 | vs BAL | 33 | L 3-4 | 13-20 | 5 | 8,917 | Casey Cox | Dave McNally | Dave McNally | Casey Cox | Eddie Watt | 137 | 162 | -25 |
| 1970-05-18 | vs CLE | 34 | W 7-3 | 14-20 | 5 | 4,362 | George Brunet | Rich Hand | George Brunet | Rich Hand | Darold Knowles | 144 | 165 | -21 |
| 1970-05-19 | vs CLE | 35 | W 3-1 | 15-20 | 5 | 6,614 | Joe Coleman | Barry Moore | Joe Coleman | Barry Moore | | 147 | 166 | -19 |
| 1970-05-20 | @ NYA | 36 | W 2-0 | 16-20 | 5 | 7,649 | Dick Bosman | Stan Bahnsen | Dick Bosman | Stan Bahnsen | Darold Knowles | 149 | 166 | -17 |
| 1970-05-21 | @ NYA | 37 | L 0-2 | 16-21 | 5 | 9,254 | Dick Such | Mel Stottlemyre | Mel Stottlemyre | Dick Such | Steve Hamilton | 149 | 168 | -19 |
| 1970-05-22 | @ DET | 38 | L 2-3 | 16-22 | 5 | 17,572 | Jim Hannan | Joe Niekro | Joe Niekro | Jim Hannan | Fred Scherman | 151 | 171 | -20 |
| 1970-05-23 | @ DET | 39 | W 6-5 | 17-22 | 4 | 18,756 | George Brunet | Mike Kilkenny | Jim Shellenback | Daryl Patterson | Darold Knowles | 157 | 176 | -19 |
| 1970-05-24 | @ DET | 40 | W 6-4 | 18-22 | 4 | 15,049 | Joe Coleman | Mickey Lolich | Joe Coleman | Mickey Lolich | Darold Knowles | 163 | 180 | -17 |
| 1970-05-25 | @ BOS | 41 | L 3-5 | 18-23 | 5 | 14,825 | Dick Bosman | Bill Lee | Bill Lee | Dick Bosman | Lee Stange | 166 | 185 | -19 |
| 1970-05-26 | @ BOS | 42 | W 7-5 | 19-23 | 4 | 12,647 | Joe Grzenda | Gary Peters | Joe Grzenda | Gary Peters | Casey Cox | 173 | 190 | -17 |
| 1970-05-27 | @ BOS | 43 | W 7-5 | 20-23 | 4 | 16,867 | Jim Hannan | Ray Culp | Darold Knowles | Ray Culp | | 180 | 195 | -15 |
| 1970-05-29 | vs KCA | 44 | W 5-4 | 21-23 | 4 | 19,214 | Joe Coleman | Jim Rooker | Jim Shellenback | Wally Bunker | | 185 | 199 | -14 |
| 1970-05-30 | vs KCA | 45 | W 3-2 | 22-23 | 3 | 11,982 | Dick Bosman | Bill Butler | Dick Bosman | Bill Butler | Darold Knowles | 188 | 201 | -13 |
| 1970-05-31 | vs KCA | 46 | L 5-6 | 22-24 | 3 | 23,889 | Casey Cox | Dave Morehead | Tom Burgmeier | Darold Knowles | Ken Wright | 193 | 207 | -14 |
| 1970-06-02 | vs CHA | 47 | W 4-3 | 23-24 | 3 | 7,815 | George Brunet | Joe Horlen | Horacio Pina | Wilbur Wood | Joe Grzenda | 197 | 210 | -13 |
| 1970-06-03 | vs CHA | 48 | W 5-4 | 24-24 | 3 | 4,678 | Joe Coleman | Tommy John | Joe Coleman | Tommy John | Darold Knowles | 202 | 214 | -12 |
| 1970-06-04 | vs CHA | 49 | L 3-7 | 24-25 | 3 | 6,270 | Dick Bosman | Jerry Crider | Jerry Crider | Dick Bosman | Danny Murphy | 205 | 221 | -16 |
| 1970-06-05 | vs MIN | 50 | L 1-2 | 24-26 | 3 | 12,818 | Casey Cox | Bert Blyleven | Bert Blyleven | Casey Cox | Ron Perranoski | 206 | 223 | -17 |
| 1970-06-06 | vs MIN | 51 | L 2-4 | 24-27 | 5 | 8,836 | Jim Hannan | Jim Perry | Jim Perry | Jim Hannan | | 208 | 227 | -19 |
| 1970-06-07 | vs MIN | 52 | L 9-10 | 24-28 | 5 | 35,040 | George Brunet | Dave Boswell | Bill Zepp | Joe Grzenda | Steve Barber | 217 | 237 | -20 |
| 1970-06-09 | @ KCA | 53 | L 1-8 | 24-29 | 5 | 7,404 | Casey Cox | Dick Drago | Dick Drago | Casey Cox | | 218 | 245 | -27 |
| 1970-06-10 | @ KCA | 54 | W 8-1 | 25-29 | 5 | 7,258 | Joe Coleman | Jim Rooker | Joe Coleman | Jim Rooker | | 226 | 246 | -20 |
| 1970-06-12 | @ CHA | 55 | L 0-6 | 25-30 | 5 | 7,928 | George Brunet | Tommy John | Tommy John | George Brunet | | 226 | 252 | -26 |
| 1970-06-13 | @ CHA | 56 | W 12-7 | 26-30 | 5 | 8,281 | Joe Grzenda | Gerry Janeski | Jim Hannan | Gerry Janeski | Darold Knowles | 238 | 259 | -21 |
| 1970-06-14 | @ CHA | 57 | W 8-4 | 28-30 | 5 | 0 | Dick Bosman | Joe Horlen | Dick Bosman | Joe Horlen | Darold Knowles | 246 | 263 | -17 |
| 1970-06-14 | @ CHA | 58 | W 5-3 | 28-30 | 5 | 10,049 | Casey Cox | Jerry Crider | Casey Cox | Jerry Crider | Darold Knowles | 251 | 266 | -15 |
| 1970-06-15 | @ MIN | 59 | L 3-5 | 28-31 | 5 | 12,807 | Joe Coleman | Dave Boswell | Bill Zepp | Joe Coleman | Ron Perranoski | 254 | 271 | -17 |
| 1970-06-16 | @ MIN | 60 | L 3-7 | 28-32 | 5 | 17,108 | Joe Grzenda | Jim Perry | Jim Perry | Joe Grzenda | | 257 | 278 | -21 |
| 1970-06-17 | @ MIN | 61 | W 3-1 | 29-32 | 5 | 17,476 | George Brunet | Jim Kaat | George Brunet | Jim Kaat | Darold Knowles | 260 | 279 | -19 |
| 1970-06-18 | @ CLE | 62 | L 3-6 | 29-33 | 5 | 7,634 | Jim Hannan | Mike Paul | Fred Lasher | Jim Shellenback | Dean Chance | 263 | 285 | -22 |
| 1970-06-19 | @ BAL | 63 | L 10-12 | 29-35 | 6 | 0 | Dick Bosman | Jim Palmer | Jim Palmer | Dick Bosman | Dick Hall | 273 | 297 | -24 |
| 1970-06-19 | @ BAL | 64 | L 2-3 | 29-35 | 6 | 18,298 | Casey Cox | Jim Hardin | Pete Richert | Darold Knowles | | 275 | 300 | -25 |
| 1970-06-20 | @ BAL | 65 | L 4-5 | 29-36 | 6 | 19,876 | Joe Coleman | Mike Cuellar | Mike Cuellar | Joe Coleman | Pete Richert | 279 | 305 | -26 |
| 1970-06-21 | @ BAL | 66 | L 2-4 | 29-37 | 6 | 10,634 | Dick Such | Dave McNally | Dave McNally | Dick Such | Pete Richert | 281 | 309 | -28 |
| 1970-06-23 | vs DET | 67 | W 6-2 | 30-37 | 6 | 14,935 | George Brunet | Mickey Lolich | George Brunet | Mickey Lolich | Darold Knowles | 287 | 311 | -24 |
| 1970-06-24 | vs DET | 68 | L 2-3 | 30-38 | 6 | 12,240 | Casey Cox | Earl Wilson | Fred Scherman | Darold Knowles | Tom Timmermann | 289 | 314 | -25 |
| 1970-06-25 | vs DET | 69 | L 1-2 | 30-39 | 6 | 5,404 | Dick Bosman | Les Cain | Les Cain | Dick Bosman | Tom Timmermann | 290 | 316 | -26 |
| 1970-06-26 | vs BAL | 70 | L 2-12 | 30-40 | 6 | 13,194 | Joe Coleman | Dave McNally | Dave McNally | Joe Coleman | | 292 | 328 | -36 |
| 1970-06-27 | vs BAL | 71 | W 5-3 | 31-40 | 6 | 12,220 | Dick Such | Jim Palmer | Jim Hannan | Jim Palmer | Horacio Pina | 297 | 331 | -34 |
| 1970-06-28 | vs BAL | 72 | W 4-3 | 32-40 | 6 | 19,043 | George Brunet | Jim Hardin | Jim Hannan | Eddie Watt | | 301 | 334 | -33 |
| 1970-06-29 | vs BAL | 73 | W 5-3 | 33-40 | 6 | 10,069 | Casey Cox | Mike Cuellar | Jim Shellenback | Mike Cuellar | | 306 | 337 | -31 |
| 1970-06-30 | @ BOS | 74 | W 3-1 | 34-40 | 5 | 19,797 | Dick Bosman | Sonny Siebert | Dick Bosman | Sonny Siebert | Darold Knowles | 309 | 338 | -29 |
| 1970-07-01 | @ BOS | 75 | L 5-6 | 34-41 | 5 | 22,218 | Joe Coleman | Mike Nagy | Mike Nagy | Joe Coleman | Sparky Lyle | 314 | 344 | -30 |
| 1970-07-02 | @ BOS | 76 | L 0-5 | 34-42 | 6 | 15,593 | Dick Such | Gary Peters | Gary Peters | Dick Such | | 314 | 349 | -35 |
| 1970-07-03 | @ NYA | 77 | W 4-3 | 35-42 | 5 | 14,795 | George Brunet | Stan Bahnsen | George Brunet | Stan Bahnsen | Darold Knowles | 318 | 352 | -34 |
| 1970-07-04 | @ NYA | 78 | L 2-4 | 35-43 | 5 | 22,994 | Casey Cox | John Cumberland | Ron Klimkowski | Casey Cox | Jack Aker | 320 | 356 | -36 |
| 1970-07-05 | @ NYA | 79 | W 7-3 | 37-43 | 5 | 0 | Dick Bosman | Fritz Peterson | Dick Bosman | Fritz Peterson | Darold Knowles | 327 | 359 | -32 |
| 1970-07-05 | @ NYA | 80 | W 7-3 | 37-43 | 5 | 23,243 | Jim Shellenback | Gary Waslewski | Jim Shellenback | Gary Waslewski | Darold Knowles | 334 | 362 | -28 |
| 1970-07-06 | @ CLE | 81 | L 4-6 | 37-44 | 5 | 11,950 | Joe Coleman | Sam McDowell | Sam McDowell | Joe Coleman | | 338 | 368 | -30 |
| 1970-07-07 | @ CLE | 82 | L 3-7 | 37-46 | 6 | 0 | Jim Hannan | Dick Ellsworth | Dick Ellsworth | Jim Hannan | Fred Lasher | 341 | 375 | -34 |
| 1970-07-07 | @ CLE | 83 | L 5-7 | 37-46 | 6 | 9,433 | Dick Such | Mike Paul | Phil Hennigan | Dick Such | Dennis Higgins | 346 | 382 | -36 |
| 1970-07-08 | @ CLE | 84 | L 5-6 | 37-47 | 6 | 6,322 | George Brunet | Steve Dunning | Phil Hennigan | Darold Knowles | Dennis Higgins | 351 | 388 | -37 |
| 1970-07-09 | @ CLE | 85 | W 9-3 | 38-47 | 6 | 11,152 | Casey Cox | Rick Austin | Casey Cox | Rick Austin | | 360 | 391 | -31 |
| 1970-07-10 | vs NYA | 86 | W 2-1 | 39-47 | 5 | 16,225 | Dick Bosman | Steve Kline | Dick Bosman | Steve Kline | | 362 | 392 | -30 |
| 1970-07-11 | vs NYA | 87 | L 1-3 | 39-48 | 6 | 21,836 | Jim Shellenback | Stan Bahnsen | Stan Bahnsen | Jim Shellenback | Lindy McDaniel | 363 | 395 | -32 |
| 1970-07-12 | vs NYA | 88 | W 7-3 | 40-48 | 5 | 30,155 | Jim Hannan | Mel Stottlemyre | Jim Hannan | Mel Stottlemyre | Darold Knowles | 370 | 398 | -28 |
| 1970-07-16 | vs CAL | 89 | L 2-3 | 40-49 | 5 | 9,292 | Dick Bosman | Andy Messersmith | Dave LaRoche | Joe Grzenda | Paul Doyle | 372 | 401 | -29 |
| 1970-07-17 | vs CAL | 90 | L 0-10 | 40-50 | 6 | 7,859 | Casey Cox | Clyde Wright | Clyde Wright | Casey Cox | | 372 | 411 | -39 |
| 1970-07-18 | vs CAL | 91 | W 4-0 | 41-50 | 6 | 8,551 | George Brunet | Tom Bradley | George Brunet | Tom Bradley | | 376 | 411 | -35 |
| 1970-07-19 | vs MIL | 92 | W 4-3 | 42-50 | 6 | 10,023 | Jim Shellenback | Marty Pattin | Jim Shellenback | Bob Humphreys | | 380 | 414 | -34 |
| 1970-07-20 | vs MIL | 93 | W 2-0 | 43-50 | 5 | 4,897 | Jim Hannan | Al Downing | Jim Hannan | Al Downing | Darold Knowles | 382 | 414 | -32 |
| 1970-07-21 | vs OAK | 94 | L 0-4 | 43-51 | 5 | 8,179 | Dick Bosman | Diego Segui | Diego Segui | Dick Bosman | Paul Lindblad | 382 | 418 | -36 |
| 1970-07-22 | vs OAK | 95 | L 3-4 | 43-52 | 6 | 9,072 | Casey Cox | Catfish Hunter | Marcel Lachemann | Darold Knowles | Mudcat Grant | 385 | 422 | -37 |
| 1970-07-24 | @ CAL | 96 | W 9-8 | 44-52 | 6 | 15,486 | George Brunet | Andy Messersmith | Jim Hannan | Ken Tatum | | 394 | 430 | -36 |
| 1970-07-25 | @ CAL | 97 | W 5-0 | 45-52 | 6 | 14,891 | Jim Shellenback | Clyde Wright | Jim Shellenback | Clyde Wright | | 399 | 430 | -31 |
| 1970-07-26 | @ CAL | 98 | L 10-11 | 45-53 | 6 | 11,775 | Casey Cox | Tom Murphy | Greg Garrett | Darold Knowles | | 409 | 441 | -32 |
| 1970-07-28 | @ MIL | 99 | L 1-5 | 45-54 | 6 | 12,773 | Jim Hannan | Al Downing | Al Downing | Jim Hannan | | 410 | 446 | -36 |
| 1970-07-29 | @ MIL | 100 | W 4-2 | 46-54 | 6 | 13,237 | Dick Bosman | Lew Krausse | Dick Bosman | Lew Krausse | Joe Grzenda | 414 | 448 | -34 |
| 1970-07-30 | @ MIL | 101 | L 2-6 | 46-55 | 6 | 10,938 | George Brunet | Marty Pattin | Marty Pattin | George Brunet | Ken Sanders | 416 | 454 | -38 |
| 1970-07-31 | @ OAK | 102 | L 4-5 | 46-56 | 6 | 4,382 | Jim Shellenback | Rollie Fingers | Paul Lindblad | Darold Knowles | | 420 | 459 | -39 |
| 1970-08-01 | @ OAK | 103 | L 0-5 | 46-57 | 6 | 14,568 | Casey Cox | Chuck Dobson | Chuck Dobson | Casey Cox | | 420 | 464 | -44 |
| 1970-08-02 | @ OAK | 104 | W 6-2 | 47-58 | 6 | 0 | Jim Hannan | Diego Segui | Jim Hannan | Diego Segui | Darold Knowles | 426 | 466 | -40 |
| 1970-08-02 | @ OAK | 105 | L 0-1 | 47-58 | 6 | 18,997 | Joe Coleman | Rollie Fingers | Mudcat Grant | Horacio Pina | | 426 | 467 | -41 |
| 1970-08-03 | @ DET | 106 | W 4-0 | 48-58 | 6 | 26,253 | Dick Bosman | Mike Kilkenny | Dick Bosman | Mike Kilkenny | Joe Grzenda | 430 | 467 | -37 |
| 1970-08-04 | @ DET | 107 | W 4-1 | 49-58 | 6 | 19,016 | George Brunet | Denny McLain | Jackie Brown | Denny McLain | Darold Knowles | 434 | 468 | -34 |
| 1970-08-05 | @ DET | 108 | L 1-3 | 49-59 | 6 | 16,387 | Jim Shellenback | Mickey Lolich | Mickey Lolich | Jim Shellenback | | 435 | 471 | -36 |
| 1970-08-06 | vs BOS | 109 | W 5-2 | 50-59 | 6 | 12,558 | Casey Cox | Gary Peters | Casey Cox | Gary Peters | Darold Knowles | 440 | 473 | -33 |
| 1970-08-07 | vs BOS | 110 | L 1-3 | 50-60 | 6 | 14,905 | Jim Hannan | Cal Koonce | Cal Koonce | Jim Hannan | Ken Brett | 441 | 476 | -35 |
| 1970-08-08 | vs CLE | 111 | L 2-4 | 50-61 | 6 | 8,614 | Dick Bosman | Steve Hargan | Vince Colbert | Darold Knowles | | 443 | 480 | -37 |
| 1970-08-09 | vs CLE | 112 | W 7-3 | 51-62 | 6 | 0 | Joe Coleman | Sam McDowell | Joe Coleman | Sam McDowell | | 450 | 483 | -33 |
| 1970-08-09 | vs CLE | 113 | L 3-6 | 51-62 | 6 | 18,497 | Jackie Brown | Rick Austin | Dennis Higgins | Jackie Brown | Steve Mingori | 453 | 489 | -36 |
| 1970-08-11 | vs MIN | 114 | W 3-2 | 52-62 | 6 | 9,372 | Casey Cox | Jim Perry | Darold Knowles | Bert Blyleven | | 456 | 491 | -35 |
| 1970-08-12 | vs MIN | 115 | W 5-3 | 53-62 | 6 | 8,811 | Jim Hannan | Luis Tiant | Jim Hannan | Luis Tiant | Joe Grzenda | 461 | 494 | -33 |
| 1970-08-13 | vs MIN | 116 | W 1-0 | 54-62 | 6 | 10,724 | Dick Bosman | Jim Kaat | Dick Bosman | Jim Kaat | | 462 | 494 | -32 |
| 1970-08-14 | vs CHA | 117 | W 6-5 | 55-62 | 6 | 5,140 | Joe Coleman | Tommy John | Joe Grzenda | Wilbur Wood | | 468 | 499 | -31 |
| 1970-08-15 | vs CHA | 118 | W 4-2 | 56-62 | 6 | 8,610 | Jackie Brown | Barry Moore | Jackie Brown | Jerry Crider | | 472 | 501 | -29 |
| 1970-08-16 | vs CHA | 119 | W 2-1 | 57-62 | 6 | 8,457 | Casey Cox | Gerry Janeski | Casey Cox | Gerry Janeski | Darold Knowles | 474 | 502 | -28 |
| 1970-08-17 | vs KCA | 120 | W 7-0 | 58-62 | 5 | 5,722 | Jim Hannan | Bob Johnson | Jim Hannan | Bob Johnson | | 481 | 502 | -21 |
| 1970-08-18 | vs KCA | 121 | L 8-12 | 58-63 | 5 | 11,576 | Dick Bosman | Al Fitzmorris | Al Fitzmorris | Dick Bosman | Ted Abernathy | 489 | 514 | -25 |
| 1970-08-19 | vs KCA | 122 | L 1-2 | 58-64 | 6 | 5,868 | Joe Coleman | Dick Drago | Dick Drago | Joe Coleman | | 490 | 516 | -26 |
| 1970-08-21 | @ MIN | 123 | L 3-4 | 58-65 | 6 | 23,101 | Casey Cox | Bert Blyleven | Stan Williams | Casey Cox | | 493 | 520 | -27 |
| 1970-08-22 | @ MIN | 124 | W 5-4 | 59-65 | 6 | 25,556 | Jim Hannan | Jim Kaat | Horacio Pina | Tom Hall | | 498 | 524 | -26 |
| 1970-08-23 | @ MIN | 125 | W 11-1 | 60-65 | 6 | 23,922 | Dick Bosman | Jim Perry | Dick Bosman | Jim Perry | | 509 | 525 | -16 |
| 1970-08-25 | @ CHA | 126 | L 3-4 | 60-66 | 6 | 6,774 | Joe Coleman | Barry Moore | Wilbur Wood | Darold Knowles | | 512 | 529 | -17 |
| 1970-08-26 | @ CHA | 127 | L 1-3 | 60-67 | 6 | 3,742 | Casey Cox | Gerry Janeski | Gerry Janeski | Casey Cox | Wilbur Wood | 513 | 532 | -19 |
| 1970-08-28 | @ KCA | 128 | W 2-1 | 61-68 | 6 | 0 | Dick Bosman | Bob Johnson | Dick Bosman | Bob Johnson | | 515 | 533 | -18 |
| 1970-08-28 | @ KCA | 129 | L 1-3 | 61-68 | 6 | 9,317 | Jim Hannan | Jim Rooker | Jim Rooker | Jim Hannan | Tom Burgmeier | 516 | 536 | -20 |
| 1970-08-29 | @ KCA | 130 | W 11-4 | 62-68 | 6 | 7,064 | Jim Shellenback | Al Fitzmorris | George Brunet | Al Fitzmorris | Darold Knowles | 527 | 540 | -13 |
| 1970-08-30 | @ KCA | 131 | L 3-4 | 62-69 | 6 | 9,049 | Joe Coleman | Dick Drago | Tom Burgmeier | Horacio Pina | | 530 | 544 | -14 |
| 1970-08-31 | vs CLE | 132 | W 5-4 | 63-69 | 6 | 7,379 | Casey Cox | Steve Dunning | Casey Cox | Steve Dunning | Darold Knowles | 535 | 548 | -13 |
| 1970-09-01 | vs CLE | 133 | L 3-4 | 63-70 | 6 | 7,567 | Jackie Brown | Mike Paul | Mike Paul | Jackie Brown | Rick Austin | 538 | 552 | -14 |
| 1970-09-02 | vs CLE | 134 | W 4-1 | 64-70 | 6 | 10,509 | Dick Bosman | Sam McDowell | Dick Bosman | Sam McDowell | | 542 | 553 | -11 |
| 1970-09-03 | vs CLE | 135 | L 2-4 | 64-71 | 6 | 5,550 | Jim Hannan | Steve Hargan | Steve Hargan | Jim Hannan | Dennis Higgins | 544 | 557 | -13 |
| 1970-09-04 | vs DET | 136 | L 3-6 | 64-72 | 6 | 8,726 | Joe Coleman | Mickey Lolich | Daryl Patterson | Darold Knowles | Tom Timmermann | 547 | 563 | -16 |
| 1970-09-05 | vs DET | 137 | W 3-2 | 65-72 | 6 | 6,953 | Casey Cox | Mike Kilkenny | Horacio Pina | Bob Reed | | 550 | 565 | -15 |
| 1970-09-06 | vs DET | 138 | L 7-8 | 65-73 | 6 | 11,580 | Jackie Brown | Les Cain | Fred Scherman | Jim Hannan | | 557 | 573 | -16 |
| 1970-09-07 | vs NYA | 139 | L 3-4 | 65-74 | 6 | 13,632 | Dick Bosman | Mike Kekich | Mike Kekich | Dick Bosman | Lindy McDaniel | 560 | 577 | -17 |
| 1970-09-08 | vs NYA | 140 | L 3-7 | 65-75 | 6 | 4,628 | Jim Shellenback | Mel Stottlemyre | Mel Stottlemyre | Jim Shellenback | | 563 | 584 | -21 |
| 1970-09-09 | @ CLE | 141 | W 5-4 | 66-75 | 6 | 3,138 | Joe Coleman | Rich Hand | Joe Coleman | Rich Hand | Joe Grzenda | 568 | 588 | -20 |
| 1970-09-10 | @ CLE | 142 | L 4-13 | 66-76 | 6 | 2,746 | Casey Cox | Steve Dunning | Steve Dunning | Casey Cox | Dennis Higgins | 572 | 601 | -29 |
| 1970-09-11 | @ DET | 143 | W 4-2 | 67-76 | 6 | 8,506 | Bill Gogolewski | Joe Niekro | Bill Gogolewski | Joe Niekro | Horacio Pina | 576 | 603 | -27 |
| 1970-09-12 | @ DET | 144 | L 4-6 | 67-77 | 6 | 14,258 | Dick Bosman | Mickey Lolich | Tom Timmermann | Joe Grzenda | Bob Reed | 580 | 609 | -29 |
| 1970-09-13 | @ DET | 145 | W 10-0 | 68-77 | 6 | 7,168 | Joe Coleman | Mike Kilkenny | Joe Coleman | Mike Kilkenny | | 590 | 609 | -19 |
| 1970-09-15 | vs BAL | 146 | L 2-6 | 68-78 | 6 | 7,942 | Casey Cox | Dave McNally | Dave McNally | Casey Cox | | 592 | 615 | -23 |
| 1970-09-16 | vs BAL | 147 | W 2-0 | 69-78 | 6 | 6,196 | Bill Gogolewski | Jim Palmer | Bill Gogolewski | Jim Palmer | Darold Knowles | 594 | 615 | -21 |
| 1970-09-17 | vs BAL | 148 | W 2-0 | 70-78 | 6 | 7,393 | Dick Bosman | Mike Cuellar | Dick Bosman | Mike Cuellar | | 596 | 615 | -19 |
| 1970-09-19 | @ BOS | 149 | L 3-7 | 70-80 | 6 | 17,285 | Joe Coleman | Ken Brett | Ken Brett | Joe Coleman | Gary Wagner | 599 | 622 | -23 |
| 1970-09-19 | @ BOS | 150 | L 3-11 | 70-80 | 6 | 14,858 | Jim Hannan | Mike Nagy | Mike Nagy | Jim Hannan | | 602 | 633 | -31 |
| 1970-09-20 | @ BOS | 151 | L 1-3 | 70-81 | 6 | 21,275 | Jim Shellenback | Ray Culp | Ray Culp | Jim Shellenback | | 603 | 636 | -33 |
| 1970-09-21 | @ NYA | 152 | L 2-5 | 70-82 | 6 | 4,749 | Bill Gogolewski | Fritz Peterson | Fritz Peterson | Bill Gogolewski | | 605 | 641 | -36 |
| 1970-09-22 | @ NYA | 153 | L 1-2 | 70-83 | 6 | 5,631 | Dick Bosman | Mel Stottlemyre | Mel Stottlemyre | Dick Bosman | Lindy McDaniel | 606 | 643 | -37 |
| 1970-09-23 | @ NYA | 154 | L 4-6 | 70-84 | 6 | 5,082 | Joe Coleman | Rob Gardner | Rob Gardner | Joe Coleman | Jack Aker | 610 | 649 | -39 |
| 1970-09-24 | vs BOS | 155 | L 3-4 | 70-85 | 6 | 3,660 | Jim Hannan | Roger Moret | Vicente Romo | Jim Hannan | Bobby Bolin | 613 | 653 | -40 |
| 1970-09-25 | vs BOS | 156 | L 1-5 | 70-86 | 6 | 5,354 | Jim Shellenback | Ray Culp | Ray Culp | Jim Shellenback | | 614 | 658 | -44 |
| 1970-09-26 | vs BOS | 157 | L 3-6 | 70-87 | 6 | 6,871 | Bill Gogolewski | Sonny Siebert | Sonny Siebert | Bill Gogolewski | Gary Wagner | 617 | 664 | -47 |
| 1970-09-27 | vs BOS | 158 | L 1-10 | 70-88 | 6 | 4,978 | Dick Bosman | Gary Peters | Gary Peters | Dick Bosman | | 618 | 674 | -56 |
| 1970-09-29 | @ BAL | 159 | L 2-3 | 70-90 | 6 | 0 | Joe Coleman | Mike Cuellar | Moe Drabowsky | Joe Coleman | | 620 | 677 | -57 |
| 1970-09-29 | @ BAL | 160 | L 2-3 | 70-90 | 6 | 5,616 | Jackie Brown | Tom Phoebus | Eddie Watt | Darold Knowles | | 622 | 680 | -58 |
| 1970-09-30 | @ BAL | 161 | L 2-6 | 70-91 | 6 | 5,202 | Bill Gogolewski | Dave McNally | Dave McNally | Jim Hannan | | 624 | 686 | -62 |
| 1970-10-01 | @ BAL | 162 | L 2-3 | 70-92 | 6 | 4,358 | Dick Bosman | Jim Palmer | Jim Hardin | Horacio Pina | | 626 | 689 | -63 |