| 1969-04-08 | vs PHI | 1 | W 7-6 | 1-0 | 1 | 40,796 | Fergie Jenkins | Chris Short | Phil Regan | Barry Lersch | | 7 | 6 | 1 |
| 1969-04-09 | vs PHI | 2 | W 11-3 | 2-0 | 1 | 6,297 | Bill Hands | Rick Wise | Bill Hands | Rick Wise | | 18 | 9 | 9 |
| 1969-04-10 | vs PHI | 3 | W 6-2 | 3-0 | 1 | 5,422 | Ken Holtzman | Woodie Fryman | Ken Holtzman | Woodie Fryman | | 24 | 11 | 13 |
| 1969-04-11 | vs MON | 4 | W 1-0 | 4-0 | 1 | 7,281 | Joe Niekro | Carl Morton | Ted Abernathy | Carroll Sembera | | 25 | 11 | 14 |
| 1969-04-12 | vs MON | 5 | L 3-7 | 4-1 | 1 | 28,599 | Fergie Jenkins | Mudcat Grant | Mudcat Grant | Fergie Jenkins | Carroll Sembera | 28 | 18 | 10 |
| 1969-04-13 | vs MON | 6 | W 7-6 | 5-1 | 1 | 27,664 | Bill Hands | Bill Stoneman | Phil Regan | Bill Stoneman | | 35 | 24 | 11 |
| 1969-04-14 | vs PIT | 7 | W 4-0 | 6-1 | 1 | 3,114 | Ken Holtzman | Bob Veale | Ken Holtzman | Bob Veale | | 39 | 24 | 15 |
| 1969-04-15 | vs PIT | 8 | W 7-4 | 7-1 | 1 | 4,362 | Joe Niekro | Dock Ellis | Hank Aguirre | Dock Ellis | Ted Abernathy | 46 | 28 | 18 |
| 1969-04-16 | @ SLN | 9 | W 1-0 | 8-1 | 1 | 16,418 | Fergie Jenkins | Steve Carlton | Fergie Jenkins | Steve Carlton | | 47 | 28 | 19 |
| 1969-04-17 | @ SLN | 10 | W 3-0 | 9-1 | 1 | 11,350 | Bill Hands | Dave Giusti | Bill Hands | Dave Giusti | Phil Regan | 50 | 28 | 22 |
| 1969-04-19 | @ MON | 11 | W 6-5 | 10-1 | 1 | 16,005 | Ken Holtzman | Mudcat Grant | Phil Regan | Don Shaw | | 56 | 33 | 23 |
| 1969-04-20 | @ MON | 12 | W 6-3 | 11-2 | 1 | 0 | Fergie Jenkins | Carl Morton | Fergie Jenkins | Carl Morton | | 62 | 36 | 26 |
| 1969-04-20 | @ MON | 13 | L 2-4 | 11-2 | 1 | 28,025 | Joe Niekro | Mike Wegener | Mike Wegener | Joe Niekro | Dan McGinn | 64 | 40 | 24 |
| 1969-04-22 | @ PIT | 14 | L 5-7 | 11-4 | 1 | 0 | Bill Hands | Dock Ellis | Chuck Hartenstein | Bill Hands | | 69 | 47 | 22 |
| 1969-04-22 | @ PIT | 15 | L 5-6 | 11-4 | 1 | 7,906 | Gary Ross | Bob Moose | Bruce Dal Canton | Rich Nye | Ron Kline | 74 | 53 | 21 |
| 1969-04-24 | vs SLN | 16 | L 2-3 | 11-5 | 1 | 11,656 | Ken Holtzman | Dave Giusti | Dave Giusti | Ken Holtzman | | 76 | 56 | 20 |
| 1969-04-25 | @ NYN | 17 | W 3-1 | 12-5 | 1 | 18,548 | Fergie Jenkins | Tom Seaver | Fergie Jenkins | Tom Seaver | | 79 | 57 | 22 |
| 1969-04-26 | @ NYN | 18 | W 9-3 | 13-5 | 1 | 16,252 | Bill Hands | Don Cardwell | Bill Hands | Don Cardwell | | 88 | 60 | 28 |
| 1969-04-27 | @ NYN | 19 | W 8-6 | 14-6 | 1 | 0 | Dick Selma | Gary Gentry | Phil Regan | Cal Koonce | | 96 | 66 | 30 |
| 1969-04-27 | @ NYN | 20 | L 0-3 | 14-6 | 1 | 37,437 | Rich Nye | Jim McAndrew | Tug McGraw | Rich Nye | | 96 | 69 | 27 |
| 1969-04-28 | @ PHI | 21 | W 2-1 | 15-6 | 1 | 4,438 | Ken Holtzman | Rick Wise | Ted Abernathy | Rick Wise | | 98 | 70 | 28 |
| 1969-04-29 | @ PHI | 22 | W 10-0 | 16-6 | 1 | 3,811 | Fergie Jenkins | Grant Jackson | Fergie Jenkins | Grant Jackson | | 108 | 70 | 38 |
| 1969-04-30 | @ PHI | 23 | L 1-3 | 16-7 | 1 | 2,930 | Bill Hands | Woodie Fryman | Woodie Fryman | Bill Hands | | 109 | 73 | 36 |
| 1969-05-02 | vs NYN | 24 | W 6-4 | 17-7 | 1 | 14,702 | Ken Holtzman | Gary Gentry | Ken Holtzman | Gary Gentry | Phil Regan | 115 | 77 | 38 |
| 1969-05-03 | vs NYN | 25 | W 3-2 | 18-7 | 1 | 23,228 | Fergie Jenkins | Nolan Ryan | Phil Regan | Cal Koonce | Ted Abernathy | 118 | 79 | 39 |
| 1969-05-04 | vs NYN | 26 | L 2-3 | 18-9 | 1 | 0 | Bill Hands | Tom Seaver | Tom Seaver | Bill Hands | | 120 | 82 | 38 |
| 1969-05-04 | vs NYN | 27 | L 2-3 | 18-9 | 1 | 40,484 | Dick Selma | Tug McGraw | Tug McGraw | Dick Selma | | 122 | 85 | 37 |
| 1969-05-06 | vs LAN | 28 | W 7-1 | 19-9 | 1 | 7,253 | Ken Holtzman | Don Sutton | Ken Holtzman | Don Sutton | | 129 | 86 | 43 |
| 1969-05-07 | vs LAN | 29 | L 2-4 | 19-10 | 1 | 9,747 | Fergie Jenkins | Claude Osteen | Jim Brewer | Fergie Jenkins | Al McBean | 131 | 90 | 41 |
| 1969-05-09 | vs SFN | 30 | L 1-11 | 19-11 | 1 | 5,189 | Bill Hands | Bobby Bolin | Bobby Bolin | Bill Hands | Joe Gibbon | 132 | 101 | 31 |
| 1969-05-11 | vs SFN | 31 | W 8-0 | 20-11 | 1 | 18,572 | Ken Holtzman | Ray Sadecki | Ken Holtzman | Ray Sadecki | | 140 | 101 | 39 |
| 1969-05-12 | vs SDN | 32 | W 2-0 | 21-11 | 1 | 3,887 | Fergie Jenkins | Gary Ross | Fergie Jenkins | Gary Ross | | 142 | 101 | 41 |
| 1969-05-13 | vs SDN | 33 | W 19-0 | 22-11 | 1 | 5,080 | Dick Selma | Dick Kelley | Dick Selma | Dick Kelley | | 161 | 101 | 60 |
| 1969-05-14 | vs SDN | 34 | W 3-2 | 23-11 | 1 | 9,622 | Bill Hands | Tommie Sisk | Don Nottebart | Johnny Podres | | 164 | 103 | 61 |
| 1969-05-16 | @ HOU | 35 | W 11-0 | 24-11 | 1 | 17,053 | Ken Holtzman | Larry Dierker | Ken Holtzman | Larry Dierker | | 175 | 103 | 72 |
| 1969-05-17 | @ HOU | 36 | L 4-5 | 24-12 | 1 | 18,307 | Fergie Jenkins | Don Wilson | Don Wilson | Don Nottebart | Fred Gladding | 179 | 108 | 71 |
| 1969-05-18 | @ HOU | 37 | L 5-6 | 24-13 | 1 | 13,126 | Dick Selma | Tom Griffin | Jim Ray | Phil Regan | Fred Gladding | 184 | 114 | 70 |
| 1969-05-20 | @ LAN | 38 | W 7-0 | 25-13 | 1 | 21,266 | Ken Holtzman | Don Sutton | Ken Holtzman | Don Sutton | | 191 | 114 | 77 |
| 1969-05-21 | @ LAN | 39 | L 1-3 | 25-14 | 1 | 16,688 | Bill Hands | Claude Osteen | Claude Osteen | Bill Hands | | 192 | 117 | 75 |
| 1969-05-22 | @ LAN | 40 | W 3-0 | 26-14 | 1 | 17,974 | Fergie Jenkins | Bill Singer | Fergie Jenkins | Bill Singer | | 195 | 117 | 78 |
| 1969-05-23 | @ SDN | 41 | W 6-0 | 27-14 | 1 | 7,936 | Dick Selma | Gary Ross | Dick Selma | Gary Ross | | 201 | 117 | 84 |
| 1969-05-24 | @ SDN | 42 | W 7-5 | 28-14 | 1 | 4,432 | Ken Holtzman | Dick Kelley | Ted Abernathy | Dick Kelley | Phil Regan | 208 | 122 | 86 |
| 1969-05-25 | @ SDN | 43 | L 2-10 | 29-15 | 1 | 0 | Rich Nye | Johnny Podres | Johnny Podres | Rich Nye | | 210 | 132 | 78 |
| 1969-05-25 | @ SDN | 44 | W 1-0 | 29-15 | 1 | 13,115 | Bill Hands | Joe Niekro | Ted Abernathy | Joe Niekro | | 211 | 132 | 79 |
| 1969-05-27 | @ SFN | 45 | L 4-5 | 29-16 | 1 | 6,608 | Fergie Jenkins | Bobby Bolin | Frank Linzy | Phil Regan | Ron Herbel | 215 | 137 | 78 |
| 1969-05-28 | @ SFN | 46 | W 9-8 | 30-16 | 1 | 4,447 | Ken Holtzman | Rich Robertson | Ken Holtzman | Rich Robertson | Phil Regan | 224 | 145 | 79 |
| 1969-05-30 | vs ATL | 47 | W 2-0 | 31-16 | 1 | 36,075 | Bill Hands | Ron Reed | Bill Hands | Ron Reed | | 226 | 145 | 81 |
| 1969-05-31 | vs ATL | 48 | W 3-2 | 32-16 | 1 | 29,778 | Fergie Jenkins | Phil Niekro | Fergie Jenkins | Phil Niekro | | 229 | 147 | 82 |
| 1969-06-01 | vs ATL | 49 | W 13-4 | 33-16 | 1 | 24,349 | Ken Holtzman | Pat Jarvis | Dick Selma | Pat Jarvis | | 242 | 151 | 91 |
| 1969-06-03 | vs HOU | 50 | W 4-2 | 34-16 | 1 | 8,320 | Bill Hands | Denny Lemaster | Bill Hands | Denny Lemaster | | 246 | 153 | 93 |
| 1969-06-04 | vs HOU | 51 | W 5-4 | 35-16 | 1 | 13,360 | Fergie Jenkins | Tom Griffin | Fergie Jenkins | Tom Griffin | | 251 | 157 | 94 |
| 1969-06-06 | vs CIN | 52 | W 14-8 | 36-16 | 1 | 22,185 | Ken Holtzman | Tony Cloninger | Ken Holtzman | Tony Cloninger | Phil Regan | 265 | 165 | 100 |
| 1969-06-07 | vs CIN | 53 | W 5-5 | 37-16 | 1 | 25,514 | Bill Hands | Jim Merritt | | | | 270 | 170 | 100 |
| 1969-06-09 | vs CIN | 54 | L 1-4 | 37-17 | 1 | 14,879 | Fergie Jenkins | George Culver | George Culver | Fergie Jenkins | Wayne Granger | 271 | 174 | 97 |
| 1969-06-10 | @ ATL | 55 | W 3-1 | 38-17 | 1 | 27,007 | Ken Holtzman | Ron Reed | Ken Holtzman | Ron Reed | Phil Regan | 274 | 175 | 99 |
| 1969-06-11 | @ ATL | 56 | L 1-5 | 38-18 | 1 | 28,707 | Bill Hands | Phil Niekro | Phil Niekro | Bill Hands | | 275 | 180 | 95 |
| 1969-06-12 | @ ATL | 57 | W 12-6 | 39-18 | 1 | 27,671 | Dick Selma | Garry Hill | Dick Selma | Garry Hill | Ted Abernathy | 287 | 186 | 101 |
| 1969-06-13 | @ CIN | 58 | W 14-8 | 40-18 | 1 | 17,134 | Fergie Jenkins | George Culver | Phil Regan | Jose Pena | Rich Nye | 301 | 194 | 107 |
| 1969-06-14 | @ CIN | 59 | W 9-8 | 41-18 | 1 | 16,008 | Ken Holtzman | Tony Cloninger | Phil Regan | Wayne Granger | Fergie Jenkins | 310 | 202 | 108 |
| 1969-06-15 | @ CIN | 60 | L 6-7 | 42-19 | 1 | 0 | Bill Hands | Jim Merritt | Clay Carroll | Phil Regan | | 316 | 209 | 107 |
| 1969-06-15 | @ CIN | 61 | W 5-4 | 42-19 | 1 | 26,511 | Archie Reynolds | Gerry Arrigo | Rich Nye | Gerry Arrigo | Ken Johnson | 321 | 213 | 108 |
| 1969-06-16 | @ PIT | 62 | L 8-9 | 42-20 | 1 | 8,810 | Dick Selma | Jim Bunning | Bruce Dal Canton | Phil Regan | Steve Blass | 329 | 222 | 107 |
| 1969-06-17 | @ PIT | 63 | L 0-1 | 42-22 | 1 | 0 | Fergie Jenkins | Bob Veale | Bob Veale | Fergie Jenkins | Bruce Dal Canton | 329 | 223 | 106 |
| 1969-06-17 | @ PIT | 64 | L 3-4 | 42-22 | 1 | 26,817 | Dick Selma | Gene Garber | Steve Blass | Ted Abernathy | | 332 | 227 | 105 |
| 1969-06-18 | @ PIT | 65 | L 2-3 | 42-23 | 1 | 12,198 | Ken Holtzman | Dock Ellis | Joe Gibbon | Phil Regan | | 334 | 230 | 104 |
| 1969-06-20 | vs MON | 66 | W 2-0 | 43-23 | 1 | 18,890 | Bill Hands | Jerry Robertson | Bill Hands | Jerry Robertson | | 336 | 230 | 106 |
| 1969-06-21 | vs MON | 67 | L 2-3 | 43-24 | 1 | 33,750 | Fergie Jenkins | Howie Reed | Howie Reed | Fergie Jenkins | Don Shaw | 338 | 233 | 105 |
| 1969-06-22 | vs MON | 68 | W 7-6 | 44-25 | 1 | 0 | Rich Nye | Gary Waslewski | Dick Selma | Don Shaw | | 345 | 239 | 106 |
| 1969-06-22 | vs MON | 69 | L 4-5 | 44-25 | 1 | 22,079 | Archie Reynolds | Mike Wegener | Roy Face | Archie Reynolds | Dan McGinn | 349 | 244 | 105 |
| 1969-06-23 | vs PIT | 70 | W 5-4 | 45-25 | 1 | 12,500 | Ken Holtzman | Bob Moose | Phil Regan | Bruce Dal Canton | | 354 | 248 | 106 |
| 1969-06-24 | vs PIT | 71 | W 3-2 | 46-25 | 1 | 17,530 | Bill Hands | Jim Bunning | Bill Hands | Jim Bunning | | 357 | 250 | 107 |
| 1969-06-25 | vs PIT | 72 | W 5-2 | 47-25 | 1 | 26,434 | Fergie Jenkins | Bob Veale | Fergie Jenkins | Bob Veale | | 362 | 252 | 110 |
| 1969-06-26 | vs PIT | 73 | W 7-5 | 48-25 | 1 | 29,473 | Dick Selma | Dock Ellis | Phil Regan | Bruce Dal Canton | | 369 | 257 | 112 |
| 1969-06-27 | vs SLN | 74 | L 1-3 | 48-26 | 1 | 29,224 | Ken Holtzman | Steve Carlton | Steve Carlton | Ken Holtzman | | 370 | 260 | 110 |
| 1969-06-28 | vs SLN | 75 | W 3-1 | 49-26 | 1 | 29,285 | Bill Hands | Dave Giusti | Bill Hands | Dave Giusti | | 373 | 261 | 112 |
| 1969-06-29 | vs SLN | 76 | W 3-1 | 51-26 | 1 | 0 | Fergie Jenkins | Bob Gibson | Fergie Jenkins | Bob Gibson | | 376 | 262 | 114 |
| 1969-06-29 | vs SLN | 77 | W 12-1 | 51-26 | 1 | 41,060 | Dick Selma | Mudcat Grant | Dick Selma | Mudcat Grant | | 388 | 263 | 125 |
| 1969-06-30 | @ MON | 78 | L 2-5 | 51-27 | 1 | 12,508 | Dave Lemonds | Howie Reed | Howie Reed | Dave Lemonds | Dan McGinn | 390 | 268 | 122 |
| 1969-07-01 | @ MON | 79 | L 4-11 | 51-28 | 1 | 19,858 | Ken Holtzman | Steve Renko | Steve Renko | Ken Holtzman | Roy Face | 394 | 279 | 115 |
| 1969-07-02 | @ MON | 80 | W 4-2 | 52-28 | 1 | 16,101 | Bill Hands | Bill Stoneman | Bill Hands | Bill Stoneman | | 398 | 281 | 117 |
| 1969-07-03 | @ MON | 81 | W 8-4 | 53-28 | 1 | 12,194 | Dick Selma | Mike Wegener | Dick Selma | Mike Wegener | Phil Regan | 406 | 285 | 121 |
| 1969-07-04 | @ SLN | 82 | W 3-1 | 54-28 | 1 | 28,177 | Fergie Jenkins | Bob Gibson | Fergie Jenkins | Bob Gibson | | 409 | 286 | 123 |
| 1969-07-05 | @ SLN | 83 | L 1-5 | 54-29 | 1 | 35,767 | Ken Holtzman | Nelson Briles | Nelson Briles | Ken Holtzman | | 410 | 291 | 119 |
| 1969-07-06 | @ SLN | 84 | L 2-4 | 54-31 | 1 | 0 | Bill Hands | Steve Carlton | Steve Carlton | Bill Hands | Joe Hoerner | 412 | 295 | 117 |
| 1969-07-06 | @ SLN | 85 | L 3-6 | 54-31 | 1 | 48,294 | Rich Nye | Mike Torrez | Chuck Taylor | Rich Nye | | 415 | 301 | 114 |
| 1969-07-08 | @ NYN | 86 | L 3-4 | 54-32 | 1 | 55,096 | Fergie Jenkins | Jerry Koosman | Jerry Koosman | Fergie Jenkins | | 418 | 305 | 113 |
| 1969-07-09 | @ NYN | 87 | L 0-4 | 54-33 | 1 | 50,709 | Ken Holtzman | Tom Seaver | Tom Seaver | Ken Holtzman | | 418 | 309 | 109 |
| 1969-07-10 | @ NYN | 88 | W 6-2 | 55-33 | 1 | 36,012 | Bill Hands | Gary Gentry | Bill Hands | Gary Gentry | | 424 | 311 | 113 |
| 1969-07-11 | vs PHI | 89 | L 5-7 | 55-34 | 1 | 24,509 | Dick Selma | Bill Champion | John Boozer | Ted Abernathy | Bill Wilson | 429 | 318 | 111 |
| 1969-07-12 | vs PHI | 90 | W 7-4 | 56-34 | 1 | 26,732 | Fergie Jenkins | Rick Wise | Fergie Jenkins | Rick Wise | Phil Regan | 436 | 322 | 114 |
| 1969-07-13 | vs PHI | 91 | W 6-0 | 58-34 | 1 | 0 | Ken Holtzman | Woodie Fryman | Ken Holtzman | Woodie Fryman | | 442 | 322 | 120 |
| 1969-07-13 | vs PHI | 92 | W 6-4 | 58-34 | 1 | 34,913 | Jim Colborn | Lowell Palmer | Jim Colborn | Lowell Palmer | Rich Nye | 448 | 326 | 122 |
| 1969-07-14 | vs NYN | 93 | W 1-0 | 59-34 | 1 | 37,473 | Bill Hands | Tom Seaver | Bill Hands | Tom Seaver | Phil Regan | 449 | 326 | 123 |
| 1969-07-15 | vs NYN | 94 | L 4-5 | 59-35 | 1 | 38,608 | Dick Selma | Gary Gentry | Gary Gentry | Dick Selma | Ron Taylor | 453 | 331 | 122 |
| 1969-07-16 | vs NYN | 95 | L 5-9 | 59-36 | 1 | 36,795 | Fergie Jenkins | Don Cardwell | Cal Koonce | Fergie Jenkins | Ron Taylor | 458 | 340 | 118 |
| 1969-07-18 | @ PHI | 96 | W 9-5 | 60-36 | 1 | 16,751 | Ken Holtzman | Woodie Fryman | Phil Regan | Bill Wilson | | 467 | 345 | 122 |
| 1969-07-19 | @ PHI | 97 | L 3-5 | 60-37 | 1 | 4,801 | Bill Hands | Lowell Palmer | Rick Wise | Bill Hands | | 470 | 350 | 120 |
| 1969-07-20 | @ PHI | 98 | W 1-0 | 62-37 | 1 | 0 | Fergie Jenkins | Grant Jackson | Fergie Jenkins | Grant Jackson | | 471 | 350 | 121 |
| 1969-07-20 | @ PHI | 99 | W 6-1 | 62-37 | 1 | 12,393 | Dick Selma | Bill Champion | Dick Selma | Bill Champion | | 477 | 351 | 126 |
| 1969-07-24 | vs LAN | 100 | W 5-3 | 63-37 | 1 | 26,476 | Ken Holtzman | Don Sutton | Ken Holtzman | Don Sutton | Phil Regan | 482 | 354 | 128 |
| 1969-07-25 | vs LAN | 101 | L 2-4 | 63-38 | 1 | 20,844 | Fergie Jenkins | Claude Osteen | Claude Osteen | Fergie Jenkins | Jim Brewer | 484 | 358 | 126 |
| 1969-07-26 | vs LAN | 102 | W 3-2 | 64-38 | 1 | 29,172 | Dick Selma | Bill Singer | Phil Regan | Jim Brewer | | 487 | 360 | 127 |
| 1969-07-27 | vs LAN | 103 | L 2-6 | 64-39 | 1 | 30,291 | Fergie Jenkins | Don Drysdale | Don Drysdale | Fergie Jenkins | Pete Mikkelsen | 489 | 366 | 123 |
| 1969-07-28 | vs SFN | 104 | W 4-3 | 65-39 | 1 | 9,439 | Bill Hands | Juan Marichal | Rich Nye | Juan Marichal | | 493 | 369 | 124 |
| 1969-07-29 | vs SFN | 105 | L 2-4 | 65-40 | 1 | 34,008 | Jim Colborn | Ron Bryant | Frank Linzy | Ted Abernathy | | 495 | 373 | 122 |
| 1969-07-30 | vs SFN | 106 | L 3-6 | 65-41 | 1 | 31,642 | Dick Selma | Gaylord Perry | Gaylord Perry | Rich Nye | | 498 | 379 | 119 |
| 1969-07-31 | vs SFN | 107 | W 12-2 | 66-41 | 1 | 24,168 | Fergie Jenkins | Bobby Bolin | Fergie Jenkins | Bobby Bolin | | 510 | 381 | 129 |
| 1969-08-01 | vs SDN | 108 | W 5-2 | 67-41 | 1 | 16,921 | Bill Hands | Clay Kirby | Bill Hands | Clay Kirby | Phil Regan | 515 | 383 | 132 |
| 1969-08-02 | vs SDN | 109 | W 4-1 | 68-41 | 1 | 26,984 | Ken Holtzman | Al Santorini | Ken Holtzman | Al Santorini | | 519 | 384 | 135 |
| 1969-08-03 | vs SDN | 110 | W 4-3 | 69-41 | 1 | 32,566 | Dick Selma | Joe Niekro | Dick Selma | Joe Niekro | Phil Regan | 523 | 387 | 136 |
| 1969-08-04 | @ HOU | 111 | W 9-3 | 70-41 | 1 | 31,722 | Fergie Jenkins | Tom Griffin | Fergie Jenkins | Tom Griffin | | 532 | 390 | 142 |
| 1969-08-05 | @ HOU | 112 | W 5-2 | 71-41 | 1 | 26,041 | Bill Hands | Denny Lemaster | Bill Hands | Denny Lemaster | Phil Regan | 537 | 392 | 145 |
| 1969-08-06 | @ HOU | 113 | W 5-4 | 72-41 | 1 | 29,449 | Rich Nye | Jack Billingham | Rich Nye | Jack Billingham | Dick Selma | 542 | 396 | 146 |
| 1969-08-08 | @ LAN | 114 | L 0-5 | 72-42 | 1 | 35,173 | Fergie Jenkins | Bill Singer | Bill Singer | Fergie Jenkins | | 542 | 401 | 141 |
| 1969-08-09 | @ LAN | 115 | W 4-0 | 73-42 | 1 | 48,748 | Bill Hands | Alan Foster | Bill Hands | Alan Foster | | 546 | 401 | 145 |
| 1969-08-10 | @ LAN | 116 | L 2-4 | 73-43 | 1 | 27,595 | Ken Holtzman | Don Sutton | Don Sutton | Ken Holtzman | Pete Mikkelsen | 548 | 405 | 143 |
| 1969-08-12 | @ SDN | 117 | W 4-0 | 74-43 | 1 | 9,794 | Fergie Jenkins | Al Santorini | Fergie Jenkins | Al Santorini | | 552 | 405 | 147 |
| 1969-08-13 | @ SDN | 118 | W 4-2 | 75-43 | 1 | 9,625 | Bill Hands | Joe Niekro | Bill Hands | Joe Niekro | | 556 | 407 | 149 |
| 1969-08-15 | @ SFN | 119 | L 0-3 | 75-44 | 1 | 12,224 | Ken Holtzman | Juan Marichal | Juan Marichal | Ken Holtzman | | 556 | 410 | 146 |
| 1969-08-16 | @ SFN | 120 | W 3-0 | 76-44 | 1 | 16,236 | Fergie Jenkins | Gaylord Perry | Fergie Jenkins | Gaylord Perry | | 559 | 410 | 149 |
| 1969-08-17 | @ SFN | 121 | L 3-5 | 77-45 | 1 | 0 | Bill Hands | Bobby Bolin | Frank Linzy | Bill Hands | | 562 | 415 | 147 |
| 1969-08-17 | @ SFN | 122 | W 3-1 | 77-45 | 1 | 25,586 | Dick Selma | Ron Bryant | Dick Selma | Ron Bryant | Phil Regan | 565 | 416 | 149 |
| 1969-08-19 | vs ATL | 123 | W 3-0 | 78-45 | 1 | 37,514 | Ken Holtzman | Phil Niekro | Ken Holtzman | Phil Niekro | | 568 | 416 | 152 |
| 1969-08-20 | vs ATL | 124 | L 2-6 | 78-46 | 1 | 34,709 | Fergie Jenkins | Ron Reed | Ron Reed | Fergie Jenkins | | 570 | 422 | 148 |
| 1969-08-21 | vs ATL | 125 | L 1-3 | 78-47 | 1 | 29,866 | Bill Hands | Jim Britton | Jim Britton | Bill Hands | | 571 | 425 | 146 |
| 1969-08-22 | vs HOU | 126 | L 2-8 | 78-48 | 1 | 19,897 | Dick Selma | Larry Dierker | Larry Dierker | Dick Selma | | 573 | 433 | 140 |
| 1969-08-23 | vs HOU | 127 | W 11-5 | 79-48 | 1 | 27,665 | Ken Holtzman | Tom Griffin | Ken Holtzman | Fred Gladding | | 584 | 438 | 146 |
| 1969-08-24 | vs HOU | 128 | W 10-9 | 80-49 | 1 | 0 | Fergie Jenkins | Jack Billingham | Phil Regan | Fred Gladding | Hank Aguirre | 594 | 447 | 147 |
| 1969-08-24 | vs HOU | 129 | L 2-3 | 80-49 | 1 | 40,439 | Ken Johnson | Don Wilson | Don Wilson | Ken Johnson | | 596 | 450 | 146 |
| 1969-08-25 | vs CIN | 130 | L 8-9 | 80-50 | 1 | 30,479 | Bill Hands | Gary Nolan | Gary Nolan | Bill Hands | Pedro Ramos | 604 | 459 | 145 |
| 1969-08-26 | vs CIN | 131 | L 7-8 | 80-51 | 1 | 31,473 | Dick Selma | Jim Merritt | Jim Merritt | Dick Selma | Wayne Granger | 611 | 467 | 144 |
| 1969-08-27 | vs CIN | 132 | L 3-6 | 80-52 | 1 | 31,867 | Ken Holtzman | Tony Cloninger | Tony Cloninger | Ken Holtzman | Clay Carroll | 614 | 473 | 141 |
| 1969-08-28 | vs CIN | 133 | W 3-1 | 81-52 | 1 | 29,092 | Fergie Jenkins | Gerry Arrigo | Fergie Jenkins | Gerry Arrigo | | 617 | 474 | 143 |
| 1969-08-29 | @ ATL | 134 | W 2-1 | 82-52 | 1 | 36,413 | Bill Hands | Pat Jarvis | Bill Hands | Pat Jarvis | | 619 | 475 | 144 |
| 1969-08-30 | @ ATL | 135 | W 5-4 | 83-52 | 1 | 26,630 | Dick Selma | Ron Reed | Ken Johnson | Ron Reed | Phil Regan | 624 | 479 | 145 |
| 1969-08-31 | @ ATL | 136 | W 8-4 | 84-52 | 1 | 33,142 | Ken Holtzman | Phil Niekro | Ken Holtzman | Phil Niekro | Phil Regan | 632 | 483 | 149 |
| 1969-09-02 | @ CIN | 137 | W 8-2 | 85-52 | 1 | 11,604 | Fergie Jenkins | Tony Cloninger | Fergie Jenkins | Tony Cloninger | | 640 | 485 | 155 |
| 1969-09-03 | @ CIN | 138 | L 0-2 | 85-53 | 1 | 5,960 | Bill Hands | Jim Maloney | Jim Maloney | Bill Hands | | 640 | 487 | 153 |
| 1969-09-05 | vs PIT | 139 | L 2-9 | 85-54 | 1 | 10,411 | Ken Holtzman | Steve Blass | Steve Blass | Ken Holtzman | | 642 | 496 | 146 |
| 1969-09-06 | vs PIT | 140 | L 4-13 | 85-55 | 1 | 24,566 | Fergie Jenkins | Bob Veale | Bob Veale | Fergie Jenkins | | 646 | 509 | 137 |
| 1969-09-07 | vs PIT | 141 | L 5-7 | 85-56 | 1 | 28,698 | Dick Selma | Bob Moose | Bruce Dal Canton | Ken Johnson | | 651 | 516 | 135 |
| 1969-09-08 | @ NYN | 142 | L 2-3 | 85-57 | 1 | 43,274 | Bill Hands | Jerry Koosman | Jerry Koosman | Bill Hands | | 653 | 519 | 134 |
| 1969-09-09 | @ NYN | 143 | L 1-7 | 85-58 | 1 | 51,448 | Fergie Jenkins | Tom Seaver | Tom Seaver | Fergie Jenkins | | 654 | 526 | 128 |
| 1969-09-10 | @ PHI | 144 | L 2-6 | 85-59 | 2 | 4,164 | Ken Holtzman | Rick Wise | Rick Wise | Ken Holtzman | | 656 | 532 | 124 |
| 1969-09-11 | @ PHI | 145 | L 3-4 | 85-60 | 2 | 4,255 | Dick Selma | Jeff James | Jeff James | Dick Selma | Grant Jackson | 659 | 536 | 123 |
| 1969-09-12 | @ SLN | 146 | W 5-1 | 86-60 | 2 | 31,717 | Bill Hands | Chuck Taylor | Bill Hands | Chuck Taylor | | 664 | 537 | 127 |
| 1969-09-13 | @ SLN | 147 | L 4-7 | 86-61 | 2 | 46,548 | Fergie Jenkins | Nelson Briles | Mudcat Grant | Fergie Jenkins | Joe Hoerner | 668 | 544 | 124 |
| 1969-09-14 | @ SLN | 148 | L 1-2 | 86-62 | 2 | 43,764 | Ken Holtzman | Bob Gibson | Bob Gibson | Ken Holtzman | | 669 | 546 | 123 |
| 1969-09-15 | @ MON | 149 | L 2-8 | 86-63 | 2 | 12,011 | Dick Selma | Mike Wegener | Mike Wegener | Dick Selma | | 671 | 554 | 117 |
| 1969-09-16 | @ MON | 150 | W 5-4 | 87-63 | 2 | 5,216 | Bill Hands | Jerry Robertson | Bill Hands | Jerry Robertson | Phil Regan | 676 | 558 | 118 |
| 1969-09-17 | vs PHI | 151 | W 9-7 | 88-63 | 2 | 6,062 | Fergie Jenkins | Jerry Johnson | Fergie Jenkins | Bill Champion | Rich Nye | 685 | 565 | 120 |
| 1969-09-18 | vs PHI | 152 | L 3-5 | 88-64 | 2 | 5,796 | Joe Decker | Grant Jackson | Grant Jackson | Phil Regan | | 688 | 570 | 118 |
| 1969-09-19 | vs SLN | 153 | W 2-1 | 89-65 | 2 | 0 | Ken Holtzman | Bob Gibson | Ken Holtzman | Bob Gibson | | 690 | 571 | 119 |
| 1969-09-19 | vs SLN | 154 | L 2-7 | 89-65 | 2 | 15,376 | Dick Selma | Mike Torrez | Mike Torrez | Dick Selma | | 692 | 578 | 114 |
| 1969-09-20 | vs SLN | 155 | L 1-4 | 89-66 | 2 | 28,194 | Bill Hands | Steve Carlton | Steve Carlton | Bill Hands | Mudcat Grant | 693 | 582 | 111 |
| 1969-09-21 | vs SLN | 156 | W 4-3 | 90-66 | 2 | 28,287 | Fergie Jenkins | Chuck Taylor | Fergie Jenkins | Chuck Taylor | | 697 | 585 | 112 |
| 1969-09-23 | vs MON | 157 | L 3-7 | 90-67 | 2 | 3,047 | Ken Holtzman | Bill Stoneman | Bill Stoneman | Ken Holtzman | | 700 | 592 | 108 |
| 1969-09-24 | vs MON | 158 | W 6-3 | 91-67 | 2 | 2,217 | Bill Hands | Steve Renko | Bill Hands | Steve Renko | | 706 | 595 | 111 |
| 1969-09-26 | @ PIT | 159 | L 0-2 | 91-68 | 2 | 4,973 | Fergie Jenkins | Dock Ellis | Dock Ellis | Fergie Jenkins | | 706 | 597 | 109 |
| 1969-09-27 | @ PIT | 160 | L 1-4 | 91-69 | 2 | 4,157 | Ken Holtzman | Steve Blass | Steve Blass | Ken Holtzman | Bob Moose | 707 | 601 | 106 |
| 1969-09-28 | @ PIT | 161 | W 3-1 | 92-69 | 2 | 24,435 | Bill Hands | Bob Veale | Bill Hands | Bob Veale | | 710 | 602 | 108 |
| 1969-10-01 | vs NYN | 162 | L 5-6 | 92-70 | 2 | 10,136 | Ken Holtzman | Jerry Koosman | Ron Taylor | Dick Selma | Bob Johnson | 715 | 608 | 107 |
| 1969-10-02 | vs NYN | 163 | W 5-3 | 93-70 | 2 | 9,981 | Bill Hands | Gary Gentry | Joe Decker | Don Cardwell | | 720 | 611 | 109 |