| 1969-04-08 | @ NYN | 1 | W 11-10 | 1-0 | 2 | 44,541 | Mudcat Grant | Tom Seaver | Don Shaw | Cal Koonce | Carroll Sembera | 11 | 10 | 1 |
| 1969-04-09 | @ NYN | 2 | L 5-9 | 1-1 | 3 | 13,827 | Bill Stoneman | Jim McAndrew | Tug McGraw | Bill Stoneman | Nolan Ryan | 16 | 19 | -3 |
| 1969-04-10 | @ NYN | 3 | L 2-4 | 1-2 | 4 | 8,608 | Larry Jaster | Gary Gentry | Gary Gentry | Larry Jaster | Cal Koonce | 18 | 23 | -5 |
| 1969-04-11 | @ CHN | 4 | L 0-1 | 1-3 | 4 | 7,281 | Carl Morton | Joe Niekro | Ted Abernathy | Carroll Sembera | | 18 | 24 | -6 |
| 1969-04-12 | @ CHN | 5 | W 7-3 | 2-3 | 3 | 28,599 | Mudcat Grant | Fergie Jenkins | Mudcat Grant | Fergie Jenkins | Carroll Sembera | 25 | 27 | -2 |
| 1969-04-13 | @ CHN | 6 | L 6-7 | 2-4 | 4 | 27,664 | Bill Stoneman | Bill Hands | Phil Regan | Bill Stoneman | | 31 | 34 | -3 |
| 1969-04-14 | vs SLN | 7 | W 8-7 | 3-4 | 3 | 29,184 | Larry Jaster | Nelson Briles | Dan McGinn | Gary Waslewski | | 39 | 41 | -2 |
| 1969-04-15 | vs SLN | 8 | L 3-4 | 3-5 | 4 | 14,718 | Carl Morton | Ray Washburn | Ray Washburn | Don Shaw | Joe Hoerner | 42 | 45 | -3 |
| 1969-04-17 | @ PHI | 9 | W 7-0 | 4-5 | 3 | 6,496 | Bill Stoneman | Jerry Johnson | Bill Stoneman | Jerry Johnson | | 49 | 45 | 4 |
| 1969-04-19 | vs CHN | 10 | L 5-6 | 4-6 | 3 | 16,005 | Mudcat Grant | Ken Holtzman | Phil Regan | Don Shaw | | 54 | 51 | 3 |
| 1969-04-20 | vs CHN | 11 | L 3-6 | 5-7 | 3 | 0 | Carl Morton | Fergie Jenkins | Fergie Jenkins | Carl Morton | | 57 | 57 | 0 |
| 1969-04-20 | vs CHN | 12 | W 4-2 | 5-7 | 3 | 28,025 | Mike Wegener | Joe Niekro | Mike Wegener | Joe Niekro | Dan McGinn | 61 | 59 | 2 |
| 1969-04-21 | @ SLN | 13 | L 4-5 | 5-8 | 3 | 10,946 | Larry Jaster | Ray Washburn | Ray Washburn | Don Shaw | | 65 | 64 | 1 |
| 1969-04-22 | @ SLN | 14 | W 2-0 | 6-8 | 3 | 10,173 | Bill Stoneman | Steve Carlton | Bill Stoneman | Steve Carlton | | 67 | 64 | 3 |
| 1969-04-24 | vs PHI | 15 | L 1-7 | 6-9 | 4 | 5,116 | Mudcat Grant | Rick Wise | Rick Wise | Mudcat Grant | | 68 | 71 | -3 |
| 1969-04-25 | @ PIT | 16 | L 2-8 | 6-10 | 5 | 10,947 | Carl Morton | Steve Blass | Steve Blass | Carl Morton | Chuck Hartenstein | 70 | 79 | -9 |
| 1969-04-26 | @ PIT | 17 | L 3-4 | 6-11 | 6 | 8,372 | Bill Stoneman | Bob Veale | Bob Veale | Bill Stoneman | Chuck Hartenstein | 73 | 83 | -10 |
| 1969-04-27 | @ PIT | 18 | W 4-2 | 7-11 | 4 | 24,425 | Larry Jaster | Dock Ellis | Larry Jaster | Dock Ellis | | 77 | 85 | -8 |
| 1969-04-29 | vs NYN | 19 | L 0-2 | 7-12 | 6 | 8,577 | Mudcat Grant | Jerry Koosman | Nolan Ryan | Mudcat Grant | | 77 | 87 | -10 |
| 1969-04-30 | vs NYN | 20 | L 1-2 | 7-13 | 6 | 19,024 | Mike Wegener | Tom Seaver | Tom Seaver | Mike Wegener | | 78 | 89 | -11 |
| 1969-05-01 | vs NYN | 21 | W 3-2 | 8-13 | 6 | 7,741 | Bill Stoneman | Don Cardwell | Roy Face | Don Cardwell | | 81 | 91 | -10 |
| 1969-05-02 | vs PIT | 22 | L 3-7 | 8-14 | 6 | 11,892 | Larry Jaster | Dock Ellis | Dock Ellis | Larry Jaster | | 84 | 98 | -14 |
| 1969-05-03 | vs PIT | 23 | L 2-4 | 8-15 | 6 | 14,147 | Carl Morton | Bob Moose | Bob Moose | Carl Morton | Chuck Hartenstein | 86 | 102 | -16 |
| 1969-05-04 | vs PIT | 24 | W 6-4 | 9-15 | 6 | 16,931 | Mudcat Grant | Jim Bunning | Roy Face | Ron Kline | | 92 | 106 | -14 |
| 1969-05-06 | @ ATL | 25 | W 4-3 | 10-15 | 6 | 12,713 | Bill Stoneman | Ron Reed | Bill Stoneman | Ron Reed | Roy Face | 96 | 109 | -13 |
| 1969-05-07 | @ ATL | 26 | L 3-5 | 10-16 | 6 | 10,496 | Mike Wegener | Phil Niekro | Phil Niekro | Carroll Sembera | | 99 | 114 | -15 |
| 1969-05-09 | vs CIN | 27 | L 5-8 | 10-17 | 6 | 11,828 | Mudcat Grant | Tony Cloninger | George Culver | Mudcat Grant | | 104 | 122 | -18 |
| 1969-05-10 | vs CIN | 28 | W 7-6 | 11-17 | 6 | 7,079 | Bill Stoneman | Jack Fisher | Dan McGinn | Clay Carroll | Roy Face | 111 | 128 | -17 |
| 1969-05-13 | vs HOU | 29 | L 3-10 | 11-18 | 6 | 11,033 | Mike Wegener | Tom Griffin | Jack Billingham | Dan McGinn | | 114 | 138 | -24 |
| 1969-05-14 | vs HOU | 30 | L 1-3 | 11-19 | 6 | 5,060 | Mudcat Grant | Denny Lemaster | Denny Lemaster | Mudcat Grant | | 115 | 141 | -26 |
| 1969-05-16 | vs ATL | 31 | L 5-7 | 11-20 | 6 | 20,892 | Bill Stoneman | Milt Pappas | Claude Raymond | Roy Face | | 120 | 148 | -28 |
| 1969-05-18 | vs ATL | 32 | L 3-8 | 11-21 | 6 | 29,062 | Mike Wegener | Ron Reed | Ron Reed | Mike Wegener | | 123 | 156 | -33 |
| 1969-05-20 | @ HOU | 33 | L 0-5 | 11-22 | 6 | 12,686 | Mudcat Grant | Larry Dierker | Larry Dierker | Mudcat Grant | | 123 | 161 | -38 |
| 1969-05-21 | @ HOU | 34 | L 2-3 | 11-23 | 6 | 11,649 | Bill Stoneman | Denny Lemaster | Denny Lemaster | Bill Stoneman | Fred Gladding | 125 | 164 | -39 |
| 1969-05-22 | @ HOU | 35 | L 4-7 | 11-24 | 6 | 10,164 | Larry Jaster | Don Wilson | Don Wilson | Larry Jaster | Fred Gladding | 129 | 171 | -42 |
| 1969-05-23 | @ CIN | 36 | L 3-4 | 11-25 | 6 | 7,917 | Jerry Robertson | Jim Maloney | Clay Carroll | Dan McGinn | | 132 | 175 | -43 |
| 1969-05-24 | @ CIN | 37 | L 2-11 | 11-26 | 6 | 19,029 | Mudcat Grant | Tony Cloninger | Tony Cloninger | Mudcat Grant | | 134 | 186 | -52 |
| 1969-05-25 | @ CIN | 38 | L 2-7 | 11-27 | 6 | 7,129 | Bill Stoneman | Jim Merritt | Jim Merritt | Bill Stoneman | Clay Carroll | 136 | 193 | -57 |
| 1969-05-27 | vs LAN | 39 | L 3-5 | 11-28 | 6 | 21,412 | Larry Jaster | Bill Singer | Bill Singer | Dan McGinn | | 139 | 198 | -59 |
| 1969-05-28 | vs LAN | 40 | L 0-6 | 11-29 | 6 | 11,042 | Jerry Robertson | Don Sutton | Don Sutton | Jerry Robertson | | 139 | 204 | -65 |
| 1969-05-29 | vs LAN | 41 | L 3-5 | 11-30 | 6 | 12,414 | Bill Stoneman | Claude Osteen | Claude Osteen | Bill Stoneman | | 142 | 209 | -67 |
| 1969-05-30 | vs SDN | 42 | L 2-3 | 11-31 | 6 | 14,320 | Mike Wegener | Dick Kelley | Jack Baldschun | Dan McGinn | | 144 | 212 | -68 |
| 1969-05-31 | vs SDN | 43 | L 2-6 | 11-32 | 6 | 20,667 | Larry Jaster | Joe Niekro | Joe Niekro | Larry Jaster | | 146 | 218 | -72 |
| 1969-06-01 | vs SDN | 44 | L 2-5 | 11-33 | 6 | 14,005 | Jerry Robertson | Johnny Podres | Johnny Podres | Jerry Robertson | Tommie Sisk | 148 | 223 | -75 |
| 1969-06-03 | vs SFN | 45 | L 3-9 | 11-34 | 6 | 19,399 | Bill Stoneman | Ray Sadecki | Ray Sadecki | Bill Stoneman | Frank Linzy | 151 | 232 | -81 |
| 1969-06-04 | vs SFN | 46 | L 3-8 | 11-35 | 6 | 9,510 | Mike Wegener | Mike McCormick | Mike McCormick | Mike Wegener | Frank Linzy | 154 | 240 | -86 |
| 1969-06-06 | @ LAN | 47 | L 2-4 | 11-36 | 6 | 16,644 | Dan McGinn | Don Sutton | Don Sutton | Dan McGinn | Jim Brewer | 156 | 244 | -88 |
| 1969-06-07 | @ LAN | 48 | L 5-9 | 11-37 | 6 | 18,243 | Bill Stoneman | Claude Osteen | Claude Osteen | Bill Stoneman | | 161 | 253 | -92 |
| 1969-06-08 | @ LAN | 49 | W 4-3 | 12-37 | 6 | 15,628 | Jerry Robertson | Bill Singer | Jerry Robertson | Bill Singer | Roy Face | 165 | 256 | -91 |
| 1969-06-10 | @ SDN | 50 | W 7-4 | 13-37 | 6 | 3,194 | Mike Wegener | Clay Kirby | Roy Face | Jack Baldschun | | 172 | 260 | -88 |
| 1969-06-11 | @ SDN | 51 | L 5-6 | 13-38 | 6 | 3,111 | Bill Stoneman | Dick Kelley | Billy McCool | Howie Reed | | 177 | 266 | -89 |
| 1969-06-12 | @ SDN | 52 | W 4-1 | 14-38 | 6 | 3,513 | Jerry Robertson | Joe Niekro | Howie Reed | Tommie Sisk | | 181 | 267 | -86 |
| 1969-06-13 | @ SFN | 53 | L 2-4 | 14-39 | 6 | 5,893 | Don Shaw | Juan Marichal | Juan Marichal | Don Shaw | | 183 | 271 | -88 |
| 1969-06-14 | @ SFN | 54 | W 8-0 | 15-39 | 6 | 11,724 | Mike Wegener | Bobby Bolin | Mike Wegener | Bobby Bolin | | 191 | 271 | -80 |
| 1969-06-15 | @ SFN | 55 | L 4-7 | 15-41 | 6 | 0 | Bill Stoneman | Gaylord Perry | Frank Linzy | Dan McGinn | | 195 | 278 | -83 |
| 1969-06-15 | @ SFN | 56 | L 1-6 | 15-41 | 6 | 16,483 | Larry Jaster | Mike McCormick | Mike McCormick | Larry Jaster | | 196 | 284 | -88 |
| 1969-06-16 | @ SLN | 57 | L 0-3 | 15-42 | 6 | 14,768 | Jerry Robertson | Nelson Briles | Nelson Briles | Jerry Robertson | | 196 | 287 | -91 |
| 1969-06-17 | @ SLN | 58 | L 0-2 | 15-43 | 6 | 16,309 | Howie Reed | Steve Carlton | Steve Carlton | Dan McGinn | Joe Hoerner | 196 | 289 | -93 |
| 1969-06-18 | @ SLN | 59 | W 5-1 | 16-43 | 6 | 18,719 | Mike Wegener | Dave Giusti | Mike Wegener | Dave Giusti | | 201 | 290 | -89 |
| 1969-06-19 | @ SLN | 60 | L 3-5 | 16-44 | 6 | 17,457 | Bill Stoneman | Ray Washburn | Mudcat Grant | Bill Stoneman | | 204 | 295 | -91 |
| 1969-06-20 | @ CHN | 61 | L 0-2 | 16-45 | 6 | 18,890 | Jerry Robertson | Bill Hands | Bill Hands | Jerry Robertson | | 204 | 297 | -93 |
| 1969-06-21 | @ CHN | 62 | W 3-2 | 17-45 | 6 | 33,750 | Howie Reed | Fergie Jenkins | Howie Reed | Fergie Jenkins | Don Shaw | 207 | 299 | -92 |
| 1969-06-22 | @ CHN | 63 | L 6-7 | 18-46 | 6 | 0 | Gary Waslewski | Rich Nye | Dick Selma | Don Shaw | | 213 | 306 | -93 |
| 1969-06-22 | @ CHN | 64 | W 5-4 | 18-46 | 6 | 22,079 | Mike Wegener | Archie Reynolds | Roy Face | Archie Reynolds | Dan McGinn | 218 | 310 | -92 |
| 1969-06-24 | vs SLN | 65 | W 4-1 | 19-46 | 6 | 10,924 | Bill Stoneman | Dave Giusti | Bill Stoneman | Dave Giusti | | 222 | 311 | -89 |
| 1969-06-25 | vs SLN | 66 | L 1-8 | 19-48 | 6 | 0 | Jerry Robertson | Bob Gibson | Bob Gibson | Jerry Robertson | | 223 | 319 | -96 |
| 1969-06-25 | vs SLN | 67 | L 3-8 | 19-48 | 6 | 28,819 | Mike Wegener | Mudcat Grant | Mudcat Grant | Mike Wegener | | 226 | 327 | -101 |
| 1969-06-26 | vs SLN | 68 | W 8-6 | 20-48 | 6 | 8,748 | Howie Reed | Nelson Briles | Dan McGinn | Nelson Briles | | 234 | 333 | -99 |
| 1969-06-27 | vs PHI | 69 | L 7-8 | 20-49 | 6 | 16,847 | Steve Renko | Bill Champion | Bill Champion | Steve Renko | Bill Wilson | 241 | 341 | -100 |
| 1969-06-28 | vs PHI | 70 | L 8-13 | 20-50 | 6 | 11,150 | Bill Stoneman | Woodie Fryman | Turk Farrell | Bill Stoneman | John Boozer | 249 | 354 | -105 |
| 1969-06-29 | vs PHI | 71 | L 0-2 | 20-52 | 6 | 0 | Jerry Robertson | Lowell Palmer | Lowell Palmer | Jerry Robertson | | 249 | 356 | -107 |
| 1969-06-29 | vs PHI | 72 | L 1-5 | 20-52 | 6 | 27,169 | Mike Wegener | Jerry Johnson | Jerry Johnson | Mike Wegener | | 250 | 361 | -111 |
| 1969-06-30 | vs CHN | 73 | W 5-2 | 21-52 | 6 | 12,508 | Howie Reed | Dave Lemonds | Howie Reed | Dave Lemonds | Dan McGinn | 255 | 363 | -108 |
| 1969-07-01 | vs CHN | 74 | W 11-4 | 22-52 | 6 | 19,858 | Steve Renko | Ken Holtzman | Steve Renko | Ken Holtzman | Roy Face | 266 | 367 | -101 |
| 1969-07-02 | vs CHN | 75 | L 2-4 | 22-53 | 6 | 16,101 | Bill Stoneman | Bill Hands | Bill Hands | Bill Stoneman | | 268 | 371 | -103 |
| 1969-07-03 | vs CHN | 76 | L 4-8 | 22-54 | 6 | 12,194 | Mike Wegener | Dick Selma | Dick Selma | Mike Wegener | Phil Regan | 272 | 379 | -107 |
| 1969-07-04 | @ PHI | 77 | W 8-5 | 24-54 | 6 | 0 | Jerry Robertson | Lowell Palmer | Jerry Robertson | Lowell Palmer | | 280 | 384 | -104 |
| 1969-07-04 | @ PHI | 78 | W 7-3 | 24-54 | 6 | 21,521 | Howie Reed | Jerry Johnson | Howie Reed | Jerry Johnson | Gary Waslewski | 287 | 387 | -100 |
| 1969-07-05 | @ PHI | 79 | W 6-4 | 25-54 | 6 | 3,496 | Steve Renko | Woodie Fryman | Dan McGinn | Woodie Fryman | Dick Radatz | 293 | 391 | -98 |
| 1969-07-06 | @ PHI | 80 | L 2-13 | 26-55 | 6 | 0 | Bill Stoneman | Bill Champion | Bill Champion | Bill Stoneman | | 295 | 404 | -109 |
| 1969-07-06 | @ PHI | 81 | W 5-0 | 26-55 | 6 | 8,664 | Gary Waslewski | Grant Jackson | Gary Waslewski | Grant Jackson | | 300 | 404 | -104 |
| 1969-07-08 | @ PIT | 82 | L 1-8 | 26-56 | 6 | 4,930 | Mike Wegener | Steve Blass | Steve Blass | Mike Wegener | | 301 | 412 | -111 |
| 1969-07-09 | @ PIT | 83 | L 3-4 | 26-58 | 6 | 0 | Jerry Robertson | Jim Bunning | Joe Gibbon | Dick Radatz | | 304 | 416 | -112 |
| 1969-07-09 | @ PIT | 84 | L 2-3 | 26-58 | 6 | 9,372 | Howie Reed | Dock Ellis | Dock Ellis | Howie Reed | Joe Gibbon | 306 | 419 | -113 |
| 1969-07-10 | @ PIT | 85 | L 1-2 | 26-59 | 6 | 4,982 | Gary Waslewski | Bob Veale | Chuck Hartenstein | Dan McGinn | | 307 | 421 | -114 |
| 1969-07-11 | @ NYN | 86 | W 11-4 | 27-59 | 6 | 26,585 | Mike Wegener | Jim McAndrew | Mike Wegener | Jim McAndrew | Dick Radatz | 318 | 425 | -107 |
| 1969-07-13 | @ NYN | 87 | L 3-4 | 27-61 | 6 | 0 | Jerry Robertson | Jerry Koosman | Jerry Koosman | Jerry Robertson | | 321 | 429 | -108 |
| 1969-07-13 | @ NYN | 88 | L 7-9 | 27-61 | 6 | 40,653 | Howie Reed | Nolan Ryan | Cal Koonce | Dan McGinn | Ron Taylor | 328 | 438 | -110 |
| 1969-07-14 | vs PIT | 89 | W 2-0 | 28-61 | 6 | 20,054 | Bill Stoneman | Bob Veale | Bill Stoneman | Bob Veale | | 330 | 438 | -108 |
| 1969-07-15 | vs PIT | 90 | L 3-9 | 28-62 | 6 | 20,876 | Gary Waslewski | Luke Walker | Luke Walker | Gary Waslewski | | 333 | 447 | -114 |
| 1969-07-16 | vs PIT | 91 | L 7-8 | 28-63 | 6 | 24,214 | Mike Wegener | Steve Blass | Joe Gibbon | Dan McGinn | Chuck Hartenstein | 340 | 455 | -115 |
| 1969-07-17 | vs PIT | 92 | W 5-4 | 29-63 | 6 | 11,935 | Howie Reed | Jim Bunning | Don Shaw | Jim Bunning | | 345 | 459 | -114 |
| 1969-07-18 | vs NYN | 93 | L 2-5 | 29-64 | 6 | 23,507 | Jerry Robertson | Jerry Koosman | Jerry Koosman | Jerry Robertson | | 347 | 464 | -117 |
| 1969-07-19 | vs NYN | 94 | W 5-4 | 30-64 | 6 | 21,493 | Bill Stoneman | Tom Seaver | Bill Stoneman | Tom Seaver | | 352 | 468 | -116 |
| 1969-07-20 | vs NYN | 95 | W 3-2 | 31-65 | 6 | 0 | Gary Waslewski | Gary Gentry | Gary Waslewski | Gary Gentry | | 355 | 470 | -115 |
| 1969-07-20 | vs NYN | 96 | L 3-4 | 31-65 | 6 | 27,356 | Mike Wegener | Don Cardwell | Jack DiLauro | Roy Face | | 358 | 474 | -116 |
| 1969-07-24 | @ ATL | 97 | L 6-9 | 31-66 | 6 | 10,467 | Bill Stoneman | Ron Reed | Ron Reed | Dick Radatz | George Stone | 364 | 483 | -119 |
| 1969-07-25 | @ ATL | 98 | W 8-7 | 32-66 | 6 | 13,686 | Gary Waslewski | Phil Niekro | Howie Reed | Phil Niekro | Dan McGinn | 372 | 490 | -118 |
| 1969-07-26 | @ ATL | 99 | W 7-4 | 33-66 | 6 | 25,352 | Jerry Robertson | Pat Jarvis | Dan McGinn | George Stone | Dick Radatz | 379 | 494 | -115 |
| 1969-07-27 | @ ATL | 100 | L 2-8 | 33-67 | 6 | 10,042 | Steve Renko | Jim Britton | Jim Britton | Steve Renko | Cecil Upshaw | 381 | 502 | -121 |
| 1969-07-29 | @ CIN | 101 | L 2-4 | 33-68 | 6 | 9,946 | Bill Stoneman | Jim Merritt | Jim Merritt | Bill Stoneman | | 383 | 506 | -123 |
| 1969-07-30 | @ CIN | 102 | L 3-5 | 33-69 | 6 | 9,733 | Jerry Robertson | Jim Maloney | Wayne Granger | Jerry Robertson | | 386 | 511 | -125 |
| 1969-07-31 | @ CIN | 103 | L 1-6 | 33-70 | 6 | 9,949 | Gary Waslewski | Gerry Arrigo | Gerry Arrigo | Gary Waslewski | | 387 | 517 | -130 |
| 1969-08-01 | vs HOU | 104 | L 3-5 | 33-71 | 6 | 17,611 | Steve Renko | Denny Lemaster | Denny Lemaster | Steve Renko | | 390 | 522 | -132 |
| 1969-08-02 | vs HOU | 105 | L 3-5 | 33-72 | 6 | 12,068 | Mike Wegener | Jim Ray | Jim Ray | Mike Wegener | Fred Gladding | 393 | 527 | -134 |
| 1969-08-03 | vs HOU | 106 | L 3-7 | 34-73 | 6 | 0 | Bill Stoneman | Don Wilson | Don Wilson | Bill Stoneman | | 396 | 534 | -138 |
| 1969-08-03 | vs HOU | 107 | W 1-0 | 34-73 | 6 | 24,235 | Howie Reed | Larry Dierker | Howie Reed | Larry Dierker | | 397 | 534 | -137 |
| 1969-08-04 | vs ATL | 108 | W 7-1 | 35-73 | 6 | 14,091 | Jerry Robertson | George Stone | Jerry Robertson | George Stone | | 404 | 535 | -131 |
| 1969-08-05 | vs ATL | 109 | L 0-1 | 35-75 | 6 | 0 | Gary Waslewski | Jim Britton | Jim Britton | Gary Waslewski | | 404 | 536 | -132 |
| 1969-08-05 | vs ATL | 110 | L 3-4 | 35-75 | 6 | 26,543 | Larry Jaster | Pat Jarvis | Pat Jarvis | Mike Wegener | Cecil Upshaw | 407 | 540 | -133 |
| 1969-08-06 | vs ATL | 111 | L 3-6 | 35-76 | 6 | 14,023 | Steve Renko | Phil Niekro | Phil Niekro | Steve Renko | | 410 | 546 | -136 |
| 1969-08-08 | @ HOU | 112 | L 2-5 | 35-77 | 6 | 18,641 | Howie Reed | Don Wilson | Don Wilson | Howie Reed | Wade Blasingame | 412 | 551 | -139 |
| 1969-08-09 | @ HOU | 113 | L 3-5 | 35-78 | 6 | 34,220 | Jerry Robertson | Larry Dierker | Jack Billingham | Dick Radatz | | 415 | 556 | -141 |
| 1969-08-10 | @ HOU | 114 | L 1-3 | 35-79 | 6 | 21,712 | Gary Waslewski | Denny Lemaster | Denny Lemaster | Gary Waslewski | | 416 | 559 | -143 |
| 1969-08-12 | vs CIN | 115 | W 8-3 | 37-79 | 6 | 0 | Steve Renko | Tony Cloninger | Steve Renko | Tony Cloninger | | 424 | 562 | -138 |
| 1969-08-12 | vs CIN | 116 | W 5-2 | 37-79 | 6 | 26,210 | Bill Stoneman | Gerry Arrigo | Bill Stoneman | Gerry Arrigo | Roy Face | 429 | 564 | -135 |
| 1969-08-13 | vs CIN | 117 | L 3-8 | 37-80 | 6 | 17,162 | Howie Reed | Jack Fisher | Wayne Granger | Dick Radatz | | 432 | 572 | -140 |
| 1969-08-14 | vs CIN | 118 | W 6-3 | 38-80 | 6 | 13,732 | Jerry Robertson | Jim Maloney | Jerry Robertson | Jim Maloney | Dan McGinn | 438 | 575 | -137 |
| 1969-08-15 | vs LAN | 119 | L 2-9 | 38-81 | 6 | 24,336 | Gary Waslewski | Don Sutton | Don Sutton | Gary Waslewski | | 440 | 584 | -144 |
| 1969-08-16 | vs LAN | 120 | L 3-9 | 38-82 | 6 | 24,949 | Larry Jaster | Claude Osteen | Claude Osteen | Larry Jaster | | 443 | 593 | -150 |
| 1969-08-17 | vs LAN | 121 | L 3-9 | 38-83 | 6 | 18,512 | Bill Stoneman | Bill Singer | Jim Brewer | Bill Stoneman | | 446 | 602 | -156 |
| 1969-08-19 | vs SDN | 122 | L 4-5 | 38-84 | 6 | 14,250 | Steve Renko | Al Santorini | Al Santorini | Steve Renko | Jack Baldschun | 450 | 607 | -157 |
| 1969-08-20 | vs SDN | 123 | W 11-10 | 39-84 | 6 | 28,536 | Howie Reed | Tommie Sisk | Bill Stoneman | Gary Ross | | 461 | 617 | -156 |
| 1969-08-21 | vs SDN | 124 | L 0-1 | 39-85 | 6 | 15,334 | Jerry Robertson | Joe Niekro | Joe Niekro | Jerry Robertson | | 461 | 618 | -157 |
| 1969-08-22 | vs SFN | 125 | L 5-7 | 39-87 | 6 | 0 | Mike Wegener | Bobby Bolin | Bobby Bolin | Mike Wegener | Frank Linzy | 466 | 625 | -159 |
| 1969-08-22 | vs SFN | 126 | L 2-10 | 39-87 | 6 | 28,561 | Steve Renko | Mike McCormick | Mike McCormick | Steve Renko | | 468 | 635 | -167 |
| 1969-08-23 | vs SFN | 127 | L 0-6 | 39-88 | 6 | 23,951 | Gary Waslewski | Ray Sadecki | Ray Sadecki | Gary Waslewski | | 468 | 641 | -173 |
| 1969-08-24 | vs SFN | 128 | L 4-6 | 39-89 | 6 | 23,784 | Bill Stoneman | Juan Marichal | Juan Marichal | Claude Raymond | | 472 | 647 | -175 |
| 1969-08-26 | @ LAN | 129 | L 0-6 | 39-90 | 6 | 21,639 | Jerry Robertson | Claude Osteen | Claude Osteen | Jerry Robertson | | 472 | 653 | -181 |
| 1969-08-27 | @ LAN | 130 | L 3-7 | 39-91 | 6 | 17,309 | Howie Reed | Bill Singer | Bill Singer | Howie Reed | | 475 | 660 | -185 |
| 1969-08-28 | @ LAN | 131 | W 9-5 | 40-91 | 6 | 16,557 | Bill Stoneman | Jim Bunning | Claude Raymond | Al McBean | | 484 | 665 | -181 |
| 1969-08-29 | @ SDN | 132 | L 0-3 | 40-92 | 6 | 3,822 | Mike Wegener | Al Santorini | Al Santorini | Mike Wegener | | 484 | 668 | -184 |
| 1969-08-31 | @ SDN | 133 | L 2-5 | 41-93 | 6 | 0 | Jerry Robertson | Dave Roberts | Gary Ross | Jerry Robertson | Billy McCool | 486 | 673 | -187 |
| 1969-08-31 | @ SDN | 134 | W 6-1 | 41-93 | 6 | 4,782 | Steve Renko | Joe Niekro | Steve Renko | Joe Niekro | | 492 | 674 | -182 |
| 1969-09-01 | @ SFN | 135 | L 2-12 | 41-94 | 6 | 10,002 | Bill Stoneman | Ray Sadecki | Ray Sadecki | Bill Stoneman | | 494 | 686 | -192 |
| 1969-09-03 | @ SFN | 136 | L 1-2 | 41-95 | 6 | 3,951 | Mike Wegener | Juan Marichal | Juan Marichal | Mike Wegener | | 495 | 688 | -193 |
| 1969-09-05 | @ SLN | 137 | L 0-1 | 41-96 | 6 | 21,920 | Howie Reed | Nelson Briles | Nelson Briles | Howie Reed | | 495 | 689 | -194 |
| 1969-09-06 | @ SLN | 138 | W 3-2 | 42-96 | 6 | 15,482 | Jerry Robertson | Bob Gibson | Jerry Robertson | Bob Gibson | Dan McGinn | 498 | 691 | -193 |
| 1969-09-07 | @ SLN | 139 | W 3-0 | 43-96 | 6 | 12,437 | Bill Stoneman | Steve Carlton | Bill Stoneman | Steve Carlton | | 501 | 691 | -190 |
| 1969-09-08 | vs PIT | 140 | L 2-6 | 43-97 | 6 | 9,526 | Gary Waslewski | Dock Ellis | Chuck Hartenstein | Claude Raymond | Bruce Dal Canton | 503 | 697 | -194 |
| 1969-09-09 | vs PIT | 141 | W 4-2 | 44-97 | 6 | 9,129 | Steve Renko | Luke Walker | Steve Renko | Luke Walker | | 507 | 699 | -192 |
| 1969-09-10 | @ NYN | 142 | L 2-3 | 44-99 | 6 | 0 | Mike Wegener | Jim McAndrew | Ron Taylor | Bill Stoneman | | 509 | 702 | -193 |
| 1969-09-10 | @ NYN | 143 | L 1-7 | 44-99 | 6 | 23,512 | Howie Reed | Nolan Ryan | Nolan Ryan | Howie Reed | | 510 | 709 | -199 |
| 1969-09-11 | @ NYN | 144 | L 0-4 | 44-100 | 6 | 10,713 | Jerry Robertson | Gary Gentry | Gary Gentry | Jerry Robertson | | 510 | 713 | -203 |
| 1969-09-12 | @ PHI | 145 | W 4-0 | 45-100 | 6 | 2,739 | Bill Stoneman | Bill Champion | Bill Stoneman | Bill Champion | | 514 | 713 | -199 |
| 1969-09-13 | @ PHI | 146 | W 7-5 | 46-100 | 6 | 3,154 | Gary Waslewski | Woodie Fryman | Dan McGinn | Woodie Fryman | Jerry Robertson | 521 | 718 | -197 |
| 1969-09-14 | @ PHI | 147 | W 7-2 | 47-100 | 6 | 3,327 | Steve Renko | Grant Jackson | Steve Renko | Grant Jackson | Claude Raymond | 528 | 720 | -192 |
| 1969-09-15 | vs CHN | 148 | W 8-2 | 48-100 | 6 | 12,011 | Mike Wegener | Dick Selma | Mike Wegener | Dick Selma | | 536 | 722 | -186 |
| 1969-09-16 | vs CHN | 149 | L 4-5 | 48-101 | 6 | 5,216 | Jerry Robertson | Bill Hands | Bill Hands | Jerry Robertson | Phil Regan | 540 | 727 | -187 |
| 1969-09-17 | vs NYN | 150 | L 0-5 | 48-102 | 6 | 10,422 | Gary Waslewski | Jerry Koosman | Jerry Koosman | Gary Waslewski | | 540 | 732 | -192 |
| 1969-09-18 | vs NYN | 151 | L 0-2 | 48-103 | 6 | 13,280 | Bill Stoneman | Tom Seaver | Tom Seaver | Bill Stoneman | | 540 | 734 | -194 |
| 1969-09-19 | vs PHI | 152 | W 10-6 | 50-103 | 6 | 0 | Bob Reynolds | Rick Wise | Gary Waslewski | Rick Wise | Howie Reed | 550 | 740 | -190 |
| 1969-09-19 | vs PHI | 153 | W 3-1 | 50-103 | 6 | 17,083 | Steve Renko | Jeff James | Steve Renko | Jeff James | | 553 | 741 | -188 |
| 1969-09-20 | vs PHI | 154 | L 4-6 | 50-104 | 6 | 12,624 | Mike Wegener | Woodie Fryman | Woodie Fryman | Mike Wegener | | 557 | 747 | -190 |
| 1969-09-21 | vs PHI | 155 | W 7-6 | 51-104 | 6 | 15,822 | Jerry Robertson | Bill Champion | Dan McGinn | Lowell Palmer | | 564 | 753 | -189 |
| 1969-09-23 | @ CHN | 156 | W 7-3 | 52-104 | 6 | 3,047 | Bill Stoneman | Ken Holtzman | Bill Stoneman | Ken Holtzman | | 571 | 756 | -185 |
| 1969-09-24 | @ CHN | 157 | L 3-6 | 52-105 | 6 | 2,217 | Steve Renko | Bill Hands | Bill Hands | Steve Renko | | 574 | 762 | -188 |
| 1969-09-26 | vs SLN | 158 | L 1-12 | 52-106 | 6 | 11,116 | Mike Wegener | Mike Torrez | Mike Torrez | Mike Wegener | Tom Hilgendorf | 575 | 774 | -199 |
| 1969-09-27 | vs SLN | 159 | L 1-2 | 52-107 | 6 | 12,570 | Jerry Robertson | Jerry Reuss | Jerry Reuss | Jerry Robertson | Tom Hilgendorf | 576 | 776 | -200 |
| 1969-09-28 | vs SLN | 160 | L 0-2 | 52-108 | 6 | 23,754 | Bill Stoneman | Bob Gibson | Bob Gibson | Bill Stoneman | | 576 | 778 | -202 |
| 1969-10-01 | @ PIT | 161 | L 4-5 | 52-109 | 6 | 2,496 | Steve Renko | Luke Walker | Joe Gibbon | Howie Reed | | 580 | 783 | -203 |
| 1969-10-02 | @ PIT | 162 | L 2-8 | 52-110 | 6 | 2,700 | Jerry Robertson | Bob Moose | Bob Moose | Jerry Robertson | | 582 | 791 | -209 |