| 1965-04-12 | vs MLN | 1 | L 2-4 | 0-1 | 8 | 28,467 | Jim O'Toole | Tony Cloninger | Tony Cloninger | Jim O'Toole | | 2 | 4 | -2 |
| 1965-04-13 | vs MLN | 2 | W 8-3 | 1-1 | 5 | 4,236 | Sammy Ellis | Wade Blasingame | Sammy Ellis | Denny Lemaster | | 10 | 7 | 3 |
| 1965-04-15 | @ SLN | 3 | W 10-4 | 2-1 | 5 | 24,364 | John Tsitouris | Bob Purkey | John Tsitouris | Bob Purkey | | 20 | 11 | 9 |
| 1965-04-17 | @ SLN | 4 | L 0-8 | 2-2 | 5 | 15,828 | Jim O'Toole | Bob Gibson | Bob Gibson | Jim O'Toole | | 20 | 19 | 1 |
| 1965-04-18 | @ SLN | 5 | W 8-2 | 3-2 | 5 | 13,754 | Sammy Ellis | Curt Simmons | Sammy Ellis | Curt Simmons | Billy McCool | 28 | 21 | 7 |
| 1965-04-19 | @ MLN | 6 | W 2-0 | 4-2 | 3 | 2,804 | Jim Maloney | Wade Blasingame | Jim Maloney | Wade Blasingame | | 30 | 21 | 9 |
| 1965-04-21 | @ CHN | 7 | W 9-2 | 5-2 | 1 | 6,752 | Joey Jay | Larry Jackson | Joey Jay | Larry Jackson | | 39 | 23 | 16 |
| 1965-04-22 | @ CHN | 8 | L 2-3 | 5-3 | 3 | 3,813 | Jim O'Toole | Cal Koonce | Ted Abernathy | Billy McCool | | 41 | 26 | 15 |
| 1965-04-23 | vs SLN | 9 | L 3-6 | 5-4 | 3 | 11,389 | John Tsitouris | Bob Gibson | Bob Gibson | John Tsitouris | | 44 | 32 | 12 |
| 1965-04-24 | vs SLN | 10 | W 6-3 | 6-4 | 3 | 3,908 | Sammy Ellis | Tracy Stallard | Sammy Ellis | Tracy Stallard | Billy McCool | 50 | 35 | 15 |
| 1965-04-27 | vs CHN | 11 | W 5-3 | 7-4 | 3 | 3,795 | Jim Maloney | Dick Ellsworth | Jim Maloney | Dick Ellsworth | Roger Craig | 55 | 38 | 17 |
| 1965-04-28 | vs CHN | 12 | W 3-2 | 8-4 | 1 | 3,561 | Joey Jay | Larry Jackson | Bill Henry | Ernie Broglio | | 58 | 40 | 18 |
| 1965-04-29 | vs CHN | 13 | L 3-6 | 8-5 | 3 | 4,216 | Jim O'Toole | Cal Koonce | Cal Koonce | Jim O'Toole | | 61 | 46 | 15 |
| 1965-04-30 | vs NYN | 14 | W 6-1 | 9-5 | 2 | 5,216 | John Tsitouris | Warren Spahn | John Tsitouris | Warren Spahn | | 67 | 47 | 20 |
| 1965-05-01 | vs NYN | 15 | W 9-2 | 10-5 | 2 | 3,961 | Sammy Ellis | Gary Kroll | Sammy Ellis | Gary Kroll | | 76 | 49 | 27 |
| 1965-05-02 | vs NYN | 16 | W 9-4 | 12-5 | 1 | 0 | Jim Maloney | Jack Fisher | Jim Maloney | Jack Fisher | | 85 | 53 | 32 |
| 1965-05-02 | vs NYN | 17 | W 10-8 | 12-5 | 1 | 17,242 | Joe Nuxhall | Galen Cisco | Bill Henry | Jack Fisher | Billy McCool | 95 | 61 | 34 |
| 1965-05-04 | vs LAN | 18 | L 6-8 | 12-6 | 1 | 9,767 | Joey Jay | Don Drysdale | Jim Brewer | Joey Jay | | 101 | 69 | 32 |
| 1965-05-05 | vs LAN | 19 | L 2-4 | 12-7 | 2 | 9,753 | Jim O'Toole | Sandy Koufax | Sandy Koufax | Jim O'Toole | | 103 | 73 | 30 |
| 1965-05-06 | vs LAN | 20 | L 3-4 | 12-8 | 2 | 7,821 | John Tsitouris | Johnny Podres | Johnny Podres | John Tsitouris | Bob Miller | 106 | 77 | 29 |
| 1965-05-07 | @ PIT | 21 | L 4-5 | 12-9 | 3 | 9,052 | Sammy Ellis | Bob Friend | Tommie Sisk | Roger Craig | | 110 | 82 | 28 |
| 1965-05-08 | @ PIT | 22 | W 10-1 | 13-9 | 3 | 5,790 | Jim Maloney | Bob Veale | Jim Maloney | Bob Veale | | 120 | 83 | 37 |
| 1965-05-09 | @ PIT | 23 | W 5-3 | 14-9 | 2 | 6,858 | Joey Jay | Joe Gibbon | Gerry Arrigo | Al McBean | Billy McCool | 125 | 86 | 39 |
| 1965-05-11 | @ PHI | 24 | W 9-1 | 15-9 | 2 | 12,438 | John Tsitouris | Chris Short | John Tsitouris | Chris Short | Gerry Arrigo | 134 | 87 | 47 |
| 1965-05-12 | @ PHI | 25 | W 4-3 | 16-9 | 2 | 12,237 | Sammy Ellis | Ray Herbert | Sammy Ellis | Ray Culp | Jim O'Toole | 138 | 90 | 48 |
| 1965-05-13 | @ PHI | 26 | L 6-7 | 16-10 | 2 | 10,573 | Jim Maloney | Bo Belinsky | Jack Baldschun | Jim Duffalo | | 144 | 97 | 47 |
| 1965-05-14 | @ NYN | 27 | L 3-5 | 16-11 | 2 | 37,552 | Joey Jay | Al Jackson | Al Jackson | Joe Nuxhall | | 147 | 102 | 45 |
| 1965-05-15 | @ NYN | 28 | W 12-7 | 17-11 | 2 | 21,592 | Jim O'Toole | Galen Cisco | Billy McCool | Galen Cisco | | 159 | 109 | 50 |
| 1965-05-16 | @ NYN | 29 | L 2-6 | 17-13 | 2 | 0 | John Tsitouris | Jack Fisher | Jack Fisher | John Tsitouris | Dennis Ribant | 161 | 115 | 46 |
| 1965-05-16 | @ NYN | 30 | L 5-8 | 17-13 | 2 | 48,536 | Sammy Ellis | Warren Spahn | Warren Spahn | Sammy Ellis | Frank Lary | 166 | 123 | 43 |
| 1965-05-19 | vs PIT | 31 | W 3-1 | 18-13 | 2 | 6,743 | Jim Maloney | Joe Gibbon | Billy McCool | Joe Gibbon | | 169 | 124 | 45 |
| 1965-05-20 | vs PIT | 32 | W 11-3 | 19-13 | 2 | 5,209 | Sammy Ellis | Bob Friend | Sammy Ellis | Bob Friend | | 180 | 127 | 53 |
| 1965-05-21 | vs PHI | 33 | W 6-5 | 20-13 | 2 | 14,263 | Jim O'Toole | Art Mahaffey | Joey Jay | Art Mahaffey | | 186 | 132 | 54 |
| 1965-05-22 | vs PHI | 34 | W 9-4 | 21-13 | 2 | 21,296 | Joe Nuxhall | Bo Belinsky | Joe Nuxhall | Bo Belinsky | Gerry Arrigo | 195 | 136 | 59 |
| 1965-05-23 | vs PHI | 35 | L 3-4 | 21-14 | 2 | 14,942 | John Tsitouris | Ray Culp | Ed Roebuck | Gerry Arrigo | | 198 | 140 | 58 |
| 1965-05-24 | @ HOU | 36 | W 5-2 | 22-14 | 2 | 15,496 | Jim Maloney | Dave Giusti | Jim Maloney | Dave Giusti | Joey Jay | 203 | 142 | 61 |
| 1965-05-25 | @ HOU | 37 | W 7-4 | 23-14 | 2 | 15,148 | Sammy Ellis | Don Nottebart | Sammy Ellis | Jim Owens | | 210 | 146 | 64 |
| 1965-05-26 | @ HOU | 38 | L 3-8 | 23-15 | 2 | 9,247 | Billy McCool | Bob Bruce | Bob Bruce | Billy McCool | | 213 | 154 | 59 |
| 1965-05-27 | @ SFN | 39 | L 2-9 | 23-16 | 2 | 7,588 | Joe Nuxhall | Gaylord Perry | Gaylord Perry | Joe Nuxhall | | 215 | 163 | 52 |
| 1965-05-28 | @ SFN | 40 | L 7-12 | 23-17 | 3 | 17,219 | John Tsitouris | Bob Shaw | Bob Shaw | John Tsitouris | | 222 | 175 | 47 |
| 1965-05-29 | @ SFN | 41 | L 4-6 | 23-18 | 3 | 17,583 | Gerry Arrigo | Jack Sanford | Bobby Bolin | Billy McCool | Frank Linzy | 226 | 181 | 45 |
| 1965-05-30 | @ LAN | 42 | L 5-12 | 23-19 | 4 | 36,309 | Sammy Ellis | Sandy Koufax | Sandy Koufax | Sammy Ellis | | 231 | 193 | 38 |
| 1965-05-31 | @ LAN | 43 | L 3-4 | 24-20 | 4 | 0 | Jim Maloney | Johnny Podres | Ron Perranoski | Jim Maloney | | 234 | 197 | 37 |
| 1965-05-31 | @ LAN | 44 | W 6-1 | 24-20 | 4 | 50,997 | Joey Jay | Claude Osteen | Joey Jay | Claude Osteen | | 240 | 198 | 42 |
| 1965-06-02 | vs HOU | 45 | W 5-2 | 25-20 | 3 | 5,592 | Sammy Ellis | Dave Giusti | Sammy Ellis | Dave Giusti | | 245 | 200 | 45 |
| 1965-06-03 | vs HOU | 46 | L 3-8 | 25-21 | 3 | 4,393 | Gerry Arrigo | Don Nottebart | Don Nottebart | Gerry Arrigo | Hal Woodeshick | 248 | 208 | 40 |
| 1965-06-04 | vs SFN | 47 | W 4-2 | 26-21 | 3 | 15,668 | Joey Jay | Gaylord Perry | Joey Jay | Gaylord Perry | Billy McCool | 252 | 210 | 42 |
| 1965-06-05 | vs SFN | 48 | L 0-1 | 26-22 | 3 | 25,262 | Jim Maloney | Juan Marichal | Juan Marichal | Jim Maloney | | 252 | 211 | 41 |
| 1965-06-06 | vs SFN | 49 | W 6-0 | 27-22 | 3 | 16,899 | Sammy Ellis | Bill Hands | Sammy Ellis | Bill Hands | | 258 | 211 | 47 |
| 1965-06-08 | @ SLN | 50 | W 5-4 | 28-22 | 3 | 12,109 | Gerry Arrigo | Bob Gibson | Gerry Arrigo | Bob Gibson | Joe Nuxhall | 263 | 215 | 48 |
| 1965-06-09 | @ SLN | 51 | L 4-6 | 28-23 | 3 | 16,126 | Joey Jay | Curt Simmons | Curt Simmons | Joey Jay | Barney Schultz | 267 | 221 | 46 |
| 1965-06-10 | @ SLN | 52 | W 8-7 | 29-23 | 3 | 9,439 | Jim Maloney | Ray Sadecki | John Tsitouris | Ray Sadecki | Billy McCool | 275 | 228 | 47 |
| 1965-06-11 | @ CHN | 53 | W 4-3 | 30-23 | 3 | 4,529 | Sammy Ellis | Bob Buhl | Billy McCool | Bob Buhl | | 279 | 231 | 48 |
| 1965-06-12 | @ CHN | 54 | L 2-3 | 30-24 | 3 | 3,672 | Jim O'Toole | Dick Ellsworth | Dick Ellsworth | Jim O'Toole | Ted Abernathy | 281 | 234 | 47 |
| 1965-06-13 | @ CHN | 55 | L 7-9 | 31-25 | 3 | 0 | Gerry Arrigo | Cal Koonce | Cal Koonce | Gerry Arrigo | Ted Abernathy | 288 | 243 | 45 |
| 1965-06-13 | @ CHN | 56 | W 7-0 | 31-25 | 3 | 18,132 | Joey Jay | Bob Hendley | Joey Jay | Bob Hendley | | 295 | 243 | 52 |
| 1965-06-14 | vs NYN | 57 | L 0-1 | 31-26 | 3 | 5,989 | Jim Maloney | Frank Lary | Larry Bearnarth | Jim Maloney | | 295 | 244 | 51 |
| 1965-06-15 | vs NYN | 58 | W 5-1 | 32-26 | 3 | 8,620 | Sammy Ellis | Warren Spahn | Sammy Ellis | Warren Spahn | | 300 | 245 | 55 |
| 1965-06-16 | vs NYN | 59 | W 8-4 | 33-26 | 3 | 7,641 | Jim O'Toole | Al Jackson | Jim O'Toole | Al Jackson | John Tsitouris | 308 | 249 | 59 |
| 1965-06-18 | vs CHN | 60 | W 3-1 | 34-26 | 3 | 12,959 | Joey Jay | Cal Koonce | Joey Jay | Cal Koonce | Billy McCool | 311 | 250 | 61 |
| 1965-06-19 | vs CHN | 61 | W 9-4 | 35-26 | 3 | 6,976 | Jim Maloney | Larry Jackson | Jim Maloney | Larry Jackson | Joe Nuxhall | 320 | 254 | 66 |
| 1965-06-20 | vs CHN | 62 | L 5-8 | 36-27 | 3 | 0 | Sammy Ellis | Bob Buhl | Bob Buhl | Sammy Ellis | Ted Abernathy | 325 | 262 | 63 |
| 1965-06-20 | vs CHN | 63 | W 9-8 | 36-27 | 3 | 22,640 | Jim O'Toole | Dick Ellsworth | Sammy Ellis | Ted Abernathy | | 334 | 270 | 64 |
| 1965-06-22 | vs SLN | 64 | W 5-4 | 38-27 | 3 | 0 | Joey Jay | Bob Gibson | Billy McCool | Hal Woodeshick | | 339 | 274 | 65 |
| 1965-06-22 | vs SLN | 65 | W 4-2 | 38-27 | 3 | 15,848 | John Tsitouris | Ray Washburn | John Tsitouris | Ray Washburn | | 343 | 276 | 67 |
| 1965-06-23 | vs SLN | 66 | W 6-2 | 39-27 | 3 | 11,479 | Jim Maloney | Curt Simmons | Jim Maloney | Curt Simmons | | 349 | 278 | 71 |
| 1965-06-24 | vs SLN | 67 | L 4-11 | 39-28 | 3 | 10,986 | Jim O'Toole | Tracy Stallard | Tracy Stallard | Jim O'Toole | Don Dennis | 353 | 289 | 64 |
| 1965-06-25 | @ MLN | 68 | W 3-1 | 40-28 | 2 | 6,347 | Sammy Ellis | Dick Kelley | Sammy Ellis | Billy O'Dell | | 356 | 290 | 66 |
| 1965-06-26 | @ MLN | 69 | L 1-2 | 40-29 | 3 | 5,002 | Joey Jay | Ken Johnson | Ken Johnson | Billy McCool | | 357 | 292 | 65 |
| 1965-06-27 | @ MLN | 70 | W 10-9 | 42-29 | 2 | 0 | John Tsitouris | Wade Blasingame | Billy McCool | Billy O'Dell | | 367 | 301 | 66 |
| 1965-06-27 | @ MLN | 71 | W 10-2 | 42-29 | 2 | 13,918 | Jim Maloney | Bob Sadowski | Jim Maloney | Bob Sadowski | | 377 | 303 | 74 |
| 1965-06-28 | @ PIT | 72 | L 4-5 | 42-30 | 2 | 15,302 | Jim O'Toole | Don Cardwell | Don Cardwell | Jim O'Toole | Al McBean | 381 | 308 | 73 |
| 1965-06-29 | @ PIT | 73 | L 1-2 | 43-31 | 2 | 0 | Sammy Ellis | Bob Friend | Don Schwall | Billy McCool | | 382 | 310 | 72 |
| 1965-06-29 | @ PIT | 74 | W 7-5 | 43-31 | 2 | 28,589 | Joe Nuxhall | Joe Gibbon | Joe Nuxhall | Joe Gibbon | Roger Craig | 389 | 315 | 74 |
| 1965-06-30 | @ NYN | 75 | L 3-6 | 43-32 | 2 | 20,946 | John Tsitouris | Tom Parsons | Gary Kroll | John Tsitouris | | 392 | 321 | 71 |
| 1965-07-01 | @ NYN | 76 | L 1-5 | 43-33 | 2 | 14,738 | Jim Maloney | Al Jackson | Al Jackson | Jim Maloney | | 393 | 326 | 67 |
| 1965-07-02 | @ PHI | 77 | L 3-4 | 43-34 | 2 | 22,516 | Jim O'Toole | Chris Short | Jack Baldschun | Gerry Arrigo | | 396 | 330 | 66 |
| 1965-07-03 | @ PHI | 78 | W 10-8 | 44-34 | 2 | 25,152 | Sammy Ellis | Ray Herbert | Billy McCool | Ed Roebuck | Roger Craig | 406 | 338 | 68 |
| 1965-07-04 | @ PHI | 79 | W 4-1 | 45-34 | 2 | 14,749 | Joe Nuxhall | Bo Belinsky | Joe Nuxhall | Bo Belinsky | | 410 | 339 | 71 |
| 1965-07-05 | vs LAN | 80 | W 7-4 | 46-34 | 1 | 29,047 | Jim Maloney | Nick Willhite | Jim Maloney | Bob Miller | Billy McCool | 417 | 343 | 74 |
| 1965-07-06 | vs LAN | 81 | L 7-11 | 46-35 | 2 | 18,833 | Jim O'Toole | Don Drysdale | Don Drysdale | Jim O'Toole | Ron Perranoski | 424 | 354 | 70 |
| 1965-07-07 | vs LAN | 82 | W 7-6 | 47-35 | 1 | 25,785 | Sammy Ellis | Sandy Koufax | Joe Nuxhall | Bob Miller | | 431 | 360 | 71 |
| 1965-07-09 | vs MLN | 83 | W 6-2 | 48-35 | 1 | 15,972 | Jim Maloney | Hank Fischer | Jim Maloney | Hank Fischer | | 437 | 362 | 75 |
| 1965-07-10 | vs MLN | 84 | W 9-8 | 49-35 | 1 | 25,413 | Joe Nuxhall | Wade Blasingame | Joe Nuxhall | Wade Blasingame | Billy McCool | 446 | 370 | 76 |
| 1965-07-11 | vs MLN | 85 | L 1-2 | 49-36 | 1 | 24,692 | Sammy Ellis | Ken Johnson | Ken Johnson | Sammy Ellis | Tony Cloninger | 447 | 372 | 75 |
| 1965-07-15 | vs PHI | 86 | W 8-1 | 50-36 | 1 | 15,606 | Joe Nuxhall | Chris Short | Joe Nuxhall | Chris Short | | 455 | 373 | 82 |
| 1965-07-16 | vs PHI | 87 | W 5-1 | 51-36 | 1 | 18,584 | Sammy Ellis | Jim Bunning | Sammy Ellis | Jim Bunning | | 460 | 374 | 86 |
| 1965-07-17 | vs PHI | 88 | L 7-14 | 51-37 | 2 | 8,225 | John Tsitouris | Ray Culp | Ed Roebuck | John Tsitouris | | 467 | 388 | 79 |
| 1965-07-18 | vs PIT | 89 | L 5-6 | 52-38 | 2 | 0 | Jim Maloney | Bob Friend | Don Schwall | Roger Craig | | 472 | 394 | 78 |
| 1965-07-18 | vs PIT | 90 | W 8-4 | 52-38 | 2 | 25,637 | Joey Jay | Joe Gibbon | Joey Jay | Joe Gibbon | Billy McCool | 480 | 398 | 82 |
| 1965-07-19 | vs PIT | 91 | L 1-3 | 52-39 | 2 | 11,096 | Joe Nuxhall | Vern Law | Vern Law | Joe Nuxhall | | 481 | 401 | 80 |
| 1965-07-20 | vs PIT | 92 | L 6-8 | 52-40 | 2 | 9,669 | Sammy Ellis | Bob Veale | Bob Veale | Sammy Ellis | Al McBean | 487 | 409 | 78 |
| 1965-07-21 | @ SFN | 93 | L 4-5 | 52-41 | 3 | 14,554 | John Tsitouris | Juan Marichal | Masanori Murakami | Roger Craig | | 491 | 414 | 77 |
| 1965-07-22 | @ SFN | 94 | W 5-4 | 53-41 | 3 | 17,696 | Jim Maloney | Warren Spahn | Jim Maloney | Frank Linzy | Billy McCool | 496 | 418 | 78 |
| 1965-07-23 | @ HOU | 95 | W 9-1 | 54-41 | 2 | 31,595 | Joey Jay | Claude Raymond | Joey Jay | Claude Raymond | | 505 | 419 | 86 |
| 1965-07-24 | @ HOU | 96 | L 2-4 | 55-42 | 2 | 30,738 | Sammy Ellis | Don Nottebart | Don Nottebart | Sammy Ellis | | 507 | 423 | 84 |
| 1965-07-24 | @ HOU | 97 | W 2-0 | 55-42 | 2 | 42,595 | Joe Nuxhall | Turk Farrell | Joe Nuxhall | Turk Farrell | | 509 | 423 | 86 |
| 1965-07-25 | @ HOU | 98 | W 3-1 | 56-42 | 2 | 36,515 | John Tsitouris | Mike Cuellar | John Tsitouris | Mike Cuellar | Billy McCool | 512 | 424 | 88 |
| 1965-07-26 | @ LAN | 99 | L 4-5 | 56-43 | 2 | 39,978 | Jim Maloney | Johnny Podres | Johnny Podres | Jim Maloney | Ron Perranoski | 516 | 429 | 87 |
| 1965-07-27 | @ LAN | 100 | L 7-9 | 56-44 | 3 | 46,537 | Joey Jay | Don Drysdale | Ron Perranoski | Joey Jay | | 523 | 438 | 85 |
| 1965-07-28 | @ LAN | 101 | W 4-1 | 57-44 | 3 | 53,604 | Sammy Ellis | Sandy Koufax | Sammy Ellis | Sandy Koufax | | 527 | 439 | 88 |
| 1965-07-30 | vs HOU | 102 | W 7-1 | 58-44 | 2 | 18,646 | Joe Nuxhall | Don Nottebart | Joe Nuxhall | Don Nottebart | | 534 | 440 | 94 |
| 1965-07-31 | vs HOU | 103 | W 11-4 | 59-44 | 2 | 6,778 | Jim Maloney | Bob Bruce | Jim Maloney | Bob Bruce | Sammy Ellis | 545 | 444 | 101 |
| 1965-08-01 | vs HOU | 104 | W 6-4 | 60-45 | 2 | 0 | Joey Jay | Mike Cuellar | Ted Davidson | Mike Cuellar | Billy McCool | 551 | 448 | 103 |
| 1965-08-01 | vs HOU | 105 | L 6-7 | 60-45 | 2 | 16,286 | John Tsitouris | Dave Giusti | Jim Owens | Billy McCool | Turk Farrell | 557 | 455 | 102 |
| 1965-08-03 | vs SFN | 106 | L 3-6 | 60-46 | 3 | 17,318 | Sammy Ellis | Bob Shaw | Frank Linzy | Bobby Locke | Bobby Bolin | 560 | 461 | 99 |
| 1965-08-04 | vs SFN | 107 | L 3-4 | 60-47 | 3 | 16,370 | Jim O'Toole | Juan Marichal | Juan Marichal | Ted Davidson | | 563 | 465 | 98 |
| 1965-08-05 | vs SFN | 108 | L 7-18 | 60-48 | 4 | 14,669 | John Tsitouris | Ron Herbel | Bobby Bolin | John Tsitouris | Masanori Murakami | 570 | 483 | 87 |
| 1965-08-06 | vs LAN | 109 | W 5-4 | 61-48 | 4 | 25,668 | Joey Jay | Johnny Podres | Billy McCool | Ron Perranoski | | 575 | 487 | 88 |
| 1965-08-07 | vs LAN | 110 | L 3-5 | 61-49 | 4 | 27,844 | Sammy Ellis | Howie Reed | Howie Reed | Sammy Ellis | Ron Perranoski | 578 | 492 | 86 |
| 1965-08-08 | vs LAN | 111 | W 18-0 | 62-49 | 4 | 28,335 | Jim Maloney | Don Drysdale | Jim Maloney | Don Drysdale | | 596 | 492 | 104 |
| 1965-08-10 | vs CHN | 112 | W 6-2 | 63-49 | 4 | 11,924 | Sammy Ellis | Dick Ellsworth | Sammy Ellis | Dick Ellsworth | | 602 | 494 | 108 |
| 1965-08-11 | vs CHN | 113 | L 2-7 | 63-50 | 4 | 11,790 | Jim O'Toole | Larry Jackson | Larry Jackson | Jim O'Toole | | 604 | 501 | 103 |
| 1965-08-13 | @ SLN | 114 | L 2-7 | 63-51 | 4 | 21,272 | Jim Maloney | Curt Simmons | Curt Simmons | Jim Maloney | Nelson Briles | 606 | 508 | 98 |
| 1965-08-14 | @ SLN | 115 | W 4-2 | 64-51 | 4 | 16,484 | Joe Nuxhall | Ray Sadecki | Joe Nuxhall | Ray Sadecki | Billy McCool | 610 | 510 | 100 |
| 1965-08-15 | @ SLN | 116 | L 7-12 | 64-52 | 4 | 19,547 | Sammy Ellis | Bob Gibson | Ray Washburn | John Tsitouris | Hal Woodeshick | 617 | 522 | 95 |
| 1965-08-17 | @ CHN | 117 | W 6-4 | 65-52 | 4 | 7,780 | Ted Davidson | Dick Ellsworth | Ted Davidson | Dick Ellsworth | Sammy Ellis | 623 | 526 | 97 |
| 1965-08-19 | @ CHN | 118 | W 1-0 | 66-53 | 4 | 0 | Jim Maloney | Larry Jackson | Jim Maloney | Larry Jackson | | 624 | 526 | 98 |
| 1965-08-19 | @ CHN | 119 | L 4-5 | 66-53 | 4 | 11,342 | Joey Jay | Cal Koonce | Lindy McDaniel | Billy McCool | | 628 | 531 | 97 |
| 1965-08-20 | @ PHI | 120 | W 3-2 | 67-53 | 4 | 28,709 | Sammy Ellis | Chris Short | Sammy Ellis | Gary Wagner | | 631 | 533 | 98 |
| 1965-08-21 | @ PHI | 121 | W 2-1 | 68-53 | 4 | 10,000 | Joe Nuxhall | Ray Culp | Joe Nuxhall | Jack Baldschun | Billy McCool | 633 | 534 | 99 |
| 1965-08-22 | @ PHI | 122 | L 5-6 | 68-54 | 4 | 8,431 | John Tsitouris | Jim Bunning | Jim Bunning | Roger Craig | Gary Wagner | 638 | 540 | 98 |
| 1965-08-23 | @ MLN | 123 | L 6-7 | 68-55 | 4 | 12,565 | Joey Jay | Ken Johnson | Ken Johnson | Joey Jay | Billy O'Dell | 644 | 547 | 97 |
| 1965-08-24 | @ MLN | 124 | W 3-2 | 69-55 | 4 | 12,413 | Jim Maloney | Wade Blasingame | Jim Maloney | Billy O'Dell | Billy McCool | 647 | 549 | 98 |
| 1965-08-25 | @ MLN | 125 | W 7-4 | 70-55 | 4 | 7,773 | Sammy Ellis | Denny Lemaster | Sammy Ellis | Dan Osinski | Billy McCool | 654 | 553 | 101 |
| 1965-08-26 | @ MLN | 126 | W 3-1 | 71-55 | 3 | 8,266 | Joe Nuxhall | Tony Cloninger | Ted Davidson | Tony Cloninger | | 657 | 554 | 103 |
| 1965-08-27 | vs SLN | 127 | L 5-6 | 71-56 | 3 | 23,595 | Joey Jay | Tracy Stallard | Hal Woodeshick | Billy McCool | Bob Gibson | 662 | 560 | 102 |
| 1965-08-28 | vs SLN | 128 | W 8-2 | 72-56 | 3 | 25,825 | Jim Maloney | Curt Simmons | Jim Maloney | Curt Simmons | Ted Davidson | 670 | 562 | 108 |
| 1965-08-29 | vs SLN | 129 | L 4-10 | 72-57 | 3 | 22,596 | Sammy Ellis | Ray Sadecki | Ray Sadecki | Sammy Ellis | | 674 | 572 | 102 |
| 1965-08-31 | vs MLN | 130 | L 3-5 | 72-58 | 3 | 19,645 | Joey Jay | Tony Cloninger | Tony Cloninger | Joey Jay | Bob Sadowski | 677 | 577 | 100 |
| 1965-09-01 | vs MLN | 131 | W 7-6 | 74-58 | 1 | 0 | Sammy Ellis | Wade Blasingame | Billy McCool | Billy O'Dell | | 684 | 583 | 101 |
| 1965-09-01 | vs MLN | 132 | W 2-0 | 74-58 | 1 | 13,809 | Jim Maloney | Denny Lemaster | Jim Maloney | Denny Lemaster | | 686 | 583 | 103 |
| 1965-09-02 | vs MLN | 133 | L 3-4 | 74-59 | 3 | 11,049 | Gerry Arrigo | Hank Fischer | Hank Fischer | Ted Davidson | Phil Niekro | 689 | 587 | 102 |
| 1965-09-03 | vs PHI | 134 | W 16-7 | 75-59 | 2 | 11,421 | Jim O'Toole | Ray Culp | Roger Craig | Grant Jackson | | 705 | 594 | 111 |
| 1965-09-04 | vs PHI | 135 | W 5-4 | 76-59 | 2 | 17,469 | John Tsitouris | Jim Bunning | Joey Jay | Jim Bunning | | 710 | 598 | 112 |
| 1965-09-05 | vs PHI | 136 | W 10-9 | 77-59 | 2 | 18,119 | Sammy Ellis | Lew Burdette | Billy McCool | Jack Baldschun | | 720 | 607 | 113 |
| 1965-09-06 | vs PIT | 137 | L 1-3 | 77-61 | 4 | 0 | Joey Jay | Bob Veale | Bob Veale | Joey Jay | | 721 | 610 | 111 |
| 1965-09-06 | vs PIT | 138 | L 2-4 | 77-61 | 4 | 16,323 | Jim Maloney | Joe Gibbon | Al McBean | Jim Maloney | | 723 | 614 | 109 |
| 1965-09-07 | vs PIT | 139 | W 5-0 | 78-61 | 3 | 7,153 | Sammy Ellis | Don Cardwell | Sammy Ellis | Don Cardwell | | 728 | 614 | 114 |
| 1965-09-08 | vs NYN | 140 | W 11-2 | 79-61 | 2 | 6,458 | Jim O'Toole | Carl Willey | Jim O'Toole | Carl Willey | | 739 | 616 | 123 |
| 1965-09-09 | vs NYN | 141 | W 3-2 | 80-61 | 2 | 6,519 | John Tsitouris | Tug McGraw | Sammy Ellis | Gordie Richardson | | 742 | 618 | 124 |
| 1965-09-10 | @ PIT | 142 | L 0-7 | 80-62 | 3 | 20,694 | Joey Jay | Bob Veale | Bob Veale | Joey Jay | | 742 | 625 | 117 |
| 1965-09-11 | @ PIT | 143 | W 3-2 | 81-62 | 3 | 9,570 | Jim Maloney | Tommie Sisk | Jim Maloney | Tommie Sisk | | 745 | 627 | 118 |
| 1965-09-13 | @ PIT | 144 | L 4-8 | 81-63 | 3 | 1,299 | Sammy Ellis | Vern Law | Vern Law | Sammy Ellis | | 749 | 635 | 114 |
| 1965-09-14 | @ NYN | 145 | W 13-6 | 82-63 | 2 | 11,825 | Jim O'Toole | Tug McGraw | Jim O'Toole | Tug McGraw | Billy McCool | 762 | 641 | 121 |
| 1965-09-15 | @ NYN | 146 | W 2-1 | 83-63 | 2 | 8,837 | Jim Maloney | Jack Fisher | Jim Maloney | Jack Fisher | | 764 | 642 | 122 |
| 1965-09-16 | @ NYN | 147 | L 3-7 | 83-64 | 2 | 4,965 | John Tsitouris | Al Jackson | Al Jackson | John Tsitouris | Dave Eilers | 767 | 649 | 118 |
| 1965-09-17 | vs HOU | 148 | W 4-2 | 84-64 | 2 | 10,431 | Sammy Ellis | Larry Dierker | Sammy Ellis | Larry Dierker | Billy McCool | 771 | 651 | 120 |
| 1965-09-19 | vs HOU | 149 | L 6-8 | 85-65 | 3 | 0 | Joey Jay | Bob Bruce | Claude Raymond | Ted Davidson | | 777 | 659 | 118 |
| 1965-09-19 | vs HOU | 150 | W 4-3 | 85-65 | 3 | 19,907 | Joe Nuxhall | Jack Lamabe | Joe Nuxhall | Jack Lamabe | Billy McCool | 781 | 662 | 119 |
| 1965-09-20 | vs SFN | 151 | L 0-4 | 85-66 | 3 | 14,070 | Jim Maloney | Bobby Bolin | Bobby Bolin | Jim Maloney | Masanori Murakami | 781 | 666 | 115 |
| 1965-09-21 | vs SFN | 152 | W 7-4 | 86-66 | 3 | 14,840 | Jim O'Toole | Bob Shaw | Ted Davidson | Frank Linzy | Billy McCool | 788 | 670 | 118 |
| 1965-09-22 | vs SFN | 153 | W 7-1 | 87-66 | 3 | 18,387 | Sammy Ellis | Juan Marichal | Sammy Ellis | Juan Marichal | | 795 | 671 | 124 |
| 1965-09-25 | @ HOU | 154 | W 1-0 | 88-66 | 3 | 24,443 | Jim Maloney | Robin Roberts | Jim Maloney | Dave Giusti | | 796 | 671 | 125 |
| 1965-09-26 | @ HOU | 155 | L 2-4 | 88-67 | 3 | 15,540 | Joe Nuxhall | Bob Bruce | Turk Farrell | Billy McCool | | 798 | 675 | 123 |
| 1965-09-27 | @ LAN | 156 | L 1-6 | 88-68 | 3 | 32,593 | Sammy Ellis | Johnny Podres | Johnny Podres | Sammy Ellis | Ron Perranoski | 799 | 681 | 118 |
| 1965-09-28 | @ LAN | 157 | L 1-2 | 88-69 | 3 | 38,424 | Jim O'Toole | Claude Osteen | Howie Reed | Joey Jay | | 800 | 683 | 117 |
| 1965-09-29 | @ LAN | 158 | L 0-5 | 88-70 | 4 | 52,312 | Jim Maloney | Sandy Koufax | Sandy Koufax | Jim Maloney | | 800 | 688 | 112 |
| 1965-09-30 | @ SFN | 159 | L 3-5 | 88-71 | 4 | 14,502 | Joe Nuxhall | Juan Marichal | Masanori Murakami | Joe Nuxhall | | 803 | 693 | 110 |
| 1965-10-01 | @ SFN | 160 | W 17-2 | 89-71 | 4 | 29,220 | Sammy Ellis | Bobby Bolin | Sammy Ellis | Bobby Bolin | | 820 | 695 | 125 |
| 1965-10-02 | @ SFN | 161 | L 2-3 | 89-72 | 4 | 28,052 | Jim O'Toole | Ron Herbel | Ron Herbel | Jim O'Toole | Frank Linzy | 822 | 698 | 124 |
| 1965-10-03 | @ SFN | 162 | L 3-6 | 89-73 | 4 | 39,489 | Billy McCool | Dick Estelle | Bobby Bolin | Billy McCool | | 825 | 704 | 121 |