| 1965-04-12 | vs SLN | 1 | W 10-10 | 1-0 | 1 | 19,751 | Larry Jackson | Bob Gibson | | | | 10 | 10 | 0 |
| 1965-04-13 | vs SLN | 2 | W 3-1 | 2-0 | 1 | 9,358 | Bob Buhl | Curt Simmons | Bob Buhl | Curt Simmons | | 13 | 11 | 2 |
| 1965-04-14 | vs SLN | 3 | W 7-3 | 3-0 | 1 | 3,569 | Dick Ellsworth | Ray Sadecki | Dick Ellsworth | Ray Sadecki | | 20 | 14 | 6 |
| 1965-04-15 | @ MLN | 4 | L 1-5 | 3-1 | 2 | 33,874 | Larry Jackson | Bob Sadowski | Bob Sadowski | Larry Jackson | | 21 | 19 | 2 |
| 1965-04-17 | @ MLN | 5 | W 9-4 | 4-1 | 1 | 3,362 | Cal Koonce | Tony Cloninger | Cal Koonce | Tony Cloninger | Ted Abernathy | 30 | 23 | 7 |
| 1965-04-18 | @ MLN | 6 | L 6-9 | 4-2 | 2 | 3,391 | Bob Buhl | Denny Lemaster | Billy O'Dell | Frank Baumann | | 36 | 32 | 4 |
| 1965-04-19 | @ SLN | 7 | W 7-3 | 5-2 | 2 | 8,003 | Dick Ellsworth | Ray Sadecki | Dick Ellsworth | Ray Sadecki | Ted Abernathy | 43 | 35 | 8 |
| 1965-04-21 | vs CIN | 8 | L 2-9 | 5-3 | 3 | 6,752 | Larry Jackson | Joey Jay | Joey Jay | Larry Jackson | | 45 | 44 | 1 |
| 1965-04-22 | vs CIN | 9 | W 3-2 | 6-3 | 2 | 3,813 | Cal Koonce | Jim O'Toole | Ted Abernathy | Billy McCool | | 48 | 46 | 2 |
| 1965-04-24 | vs MLN | 10 | W 3-1 | 7-3 | 2 | 4,281 | Bob Buhl | Tony Cloninger | Bob Buhl | Tony Cloninger | Ted Abernathy | 51 | 47 | 4 |
| 1965-04-27 | @ CIN | 11 | L 3-5 | 7-4 | 2 | 3,795 | Dick Ellsworth | Jim Maloney | Jim Maloney | Dick Ellsworth | Roger Craig | 54 | 52 | 2 |
| 1965-04-28 | @ CIN | 12 | L 2-3 | 7-5 | 4 | 3,561 | Larry Jackson | Joey Jay | Bill Henry | Ernie Broglio | | 56 | 55 | 1 |
| 1965-04-29 | @ CIN | 13 | W 6-3 | 8-5 | 2 | 4,216 | Cal Koonce | Jim O'Toole | Cal Koonce | Jim O'Toole | | 62 | 58 | 4 |
| 1965-04-30 | @ HOU | 14 | L 3-4 | 8-6 | 4 | 27,491 | Bob Buhl | Turk Farrell | Turk Farrell | Bob Buhl | Hal Woodeshick | 65 | 62 | 3 |
| 1965-05-01 | @ HOU | 15 | L 4-6 | 8-8 | 5 | 13,048 | Lew Burdette | Ken Johnson | Ken Johnson | Lew Burdette | Claude Raymond | 69 | 68 | 1 |
| 1965-05-01 | @ HOU | 16 | L 1-6 | 8-8 | 5 | 37,255 | Dick Ellsworth | Dave Giusti | Dave Giusti | Dick Ellsworth | | 70 | 74 | -4 |
| 1965-05-02 | @ HOU | 17 | W 6-3 | 9-8 | 4 | 32,775 | Larry Jackson | Don Nottebart | Larry Jackson | Don Nottebart | Ted Abernathy | 76 | 77 | -1 |
| 1965-05-04 | vs PIT | 18 | L 3-6 | 9-9 | 4 | 1,527 | Cal Koonce | Joe Gibbon | Al McBean | Ernie Broglio | | 79 | 83 | -4 |
| 1965-05-05 | vs PIT | 19 | W 3-1 | 10-9 | 5 | 2,093 | Bob Buhl | Vern Law | Bob Buhl | Vern Law | | 82 | 84 | -2 |
| 1965-05-06 | vs PIT | 20 | W 5-3 | 11-9 | 4 | 1,471 | Larry Jackson | Don Cardwell | Larry Jackson | Don Schwall | Ted Abernathy | 87 | 87 | 0 |
| 1965-05-07 | vs HOU | 21 | L 4-5 | 11-10 | 5 | 3,424 | Lew Burdette | Dave Giusti | Dave Giusti | Lew Burdette | Jim Owens | 91 | 92 | -1 |
| 1965-05-08 | vs HOU | 22 | L 6-11 | 11-11 | 4 | 10,186 | Cal Koonce | Don Nottebart | Larry Dierker | Cal Koonce | | 97 | 103 | -6 |
| 1965-05-09 | vs HOU | 23 | L 5-11 | 12-12 | 4 | 0 | Bob Buhl | Ken Johnson | Ken Johnson | Bob Buhl | Jim Owens | 102 | 114 | -12 |
| 1965-05-09 | vs HOU | 24 | W 7-1 | 12-12 | 4 | 17,796 | Dick Ellsworth | Bob Bruce | Dick Ellsworth | Bob Bruce | Ted Abernathy | 109 | 115 | -6 |
| 1965-05-11 | @ SFN | 25 | L 0-3 | 12-13 | 7 | 9,912 | Larry Jackson | Ron Herbel | Ron Herbel | Larry Jackson | Frank Linzy | 109 | 118 | -9 |
| 1965-05-12 | @ SFN | 26 | W 7-3 | 13-13 | 4 | 6,356 | Cal Koonce | Juan Marichal | Cal Koonce | Juan Marichal | Ted Abernathy | 116 | 121 | -5 |
| 1965-05-13 | @ SFN | 27 | L 3-6 | 13-14 | 7 | 4,610 | Ernie Broglio | Jack Sanford | Jack Sanford | Ernie Broglio | Frank Linzy | 119 | 127 | -8 |
| 1965-05-14 | @ LAN | 28 | W 2-1 | 14-14 | 6 | 26,356 | Bob Buhl | John Purdin | Bob Buhl | John Purdin | Ted Abernathy | 121 | 128 | -7 |
| 1965-05-15 | @ LAN | 29 | L 1-3 | 14-15 | 6 | 22,047 | Dick Ellsworth | Claude Osteen | Bob Miller | Dick Ellsworth | Jim Brewer | 122 | 131 | -9 |
| 1965-05-16 | @ LAN | 30 | W 5-3 | 15-16 | 7 | 0 | Larry Jackson | Johnny Podres | Larry Jackson | Ron Perranoski | | 127 | 134 | -7 |
| 1965-05-16 | @ LAN | 31 | L 2-3 | 15-16 | 7 | 45,739 | Cal Koonce | Don Drysdale | Don Drysdale | Lindy McDaniel | | 129 | 137 | -8 |
| 1965-05-18 | vs SFN | 32 | W 7-6 | 16-16 | 6 | 4,936 | Ernie Broglio | Jack Sanford | Bob Humphreys | Ron Herbel | Ted Abernathy | 136 | 143 | -7 |
| 1965-05-19 | vs SFN | 33 | W 2-1 | 17-16 | 6 | 4,282 | Bob Buhl | Gaylord Perry | Bob Buhl | Gaylord Perry | Ted Abernathy | 138 | 144 | -6 |
| 1965-05-20 | vs SFN | 34 | L 0-2 | 17-17 | 6 | 4,451 | Larry Jackson | Bob Shaw | Bob Shaw | Larry Jackson | Masanori Murakami | 138 | 146 | -8 |
| 1965-05-21 | vs LAN | 35 | W 4-3 | 18-17 | 6 | 4,716 | Dick Ellsworth | Don Drysdale | Dick Ellsworth | Don Drysdale | | 142 | 149 | -7 |
| 1965-05-22 | vs LAN | 36 | L 1-3 | 18-18 | 6 | 17,922 | Cal Koonce | Sandy Koufax | Sandy Koufax | Cal Koonce | | 143 | 152 | -9 |
| 1965-05-23 | vs LAN | 37 | W 3-2 | 19-18 | 6 | 17,139 | Bob Buhl | Johnny Podres | Dick Ellsworth | Howie Reed | | 146 | 154 | -8 |
| 1965-05-24 | @ PIT | 38 | L 4-6 | 19-19 | 6 | 5,360 | Lew Burdette | Joe Gibbon | Don Schwall | Ernie Broglio | Al McBean | 150 | 160 | -10 |
| 1965-05-25 | @ PIT | 39 | L 6-7 | 19-20 | 6 | 6,403 | Larry Jackson | Bob Friend | Frank Carpin | Jack Warner | | 156 | 167 | -11 |
| 1965-05-26 | @ NYN | 40 | W 8-6 | 20-20 | 6 | 16,809 | Dick Ellsworth | Jack Fisher | Lindy McDaniel | Dennis Ribant | | 164 | 173 | -9 |
| 1965-05-27 | @ NYN | 41 | L 5-8 | 20-21 | 6 | 9,561 | Cal Koonce | Gary Kroll | Gary Kroll | Cal Koonce | Larry Bearnarth | 169 | 181 | -12 |
| 1965-05-28 | @ PHI | 42 | L 1-3 | 20-22 | 6 | 13,663 | Bob Buhl | Ray Culp | Ray Culp | Bob Buhl | Chris Short | 170 | 184 | -14 |
| 1965-05-29 | @ PHI | 43 | L 2-4 | 20-23 | 8 | 4,962 | Larry Jackson | Jim Bunning | Jim Bunning | Larry Jackson | | 172 | 188 | -16 |
| 1965-05-30 | @ PHI | 44 | W 4-1 | 21-23 | 6 | 11,696 | Dick Ellsworth | Ray Herbert | Dick Ellsworth | Ray Herbert | | 176 | 189 | -13 |
| 1965-05-31 | vs NYN | 45 | L 2-5 | 22-24 | 7 | 0 | Cal Koonce | Jack Fisher | Jack Fisher | Cal Koonce | | 178 | 194 | -16 |
| 1965-05-31 | vs NYN | 46 | W 3-3 | 22-24 | 7 | 32,250 | Ernie Broglio | Gary Kroll | | | | 181 | 197 | -16 |
| 1965-06-01 | vs NYN | 47 | L 5-10 | 22-25 | 7 | 2,270 | Bob Buhl | Warren Spahn | Larry Bearnarth | Bob Buhl | | 186 | 207 | -21 |
| 1965-06-04 | vs PHI | 48 | L 0-6 | 22-26 | 7 | 3,497 | Larry Jackson | Jim Bunning | Jim Bunning | Larry Jackson | | 186 | 213 | -27 |
| 1965-06-05 | vs PHI | 49 | W 9-8 | 23-26 | 7 | 6,049 | Dick Ellsworth | Chris Short | Lindy McDaniel | Gary Wagner | | 195 | 221 | -26 |
| 1965-06-06 | vs PHI | 50 | L 1-2 | 23-28 | 9 | 0 | Bob Buhl | Ray Culp | Ray Culp | Bob Buhl | | 196 | 223 | -27 |
| 1965-06-06 | vs PHI | 51 | L 9-10 | 23-28 | 9 | 16,845 | Larry Jackson | Art Mahaffey | Gary Wagner | Larry Jackson | Ed Roebuck | 205 | 233 | -28 |
| 1965-06-08 | vs MLN | 52 | L 2-8 | 23-29 | 9 | 4,039 | Dick Ellsworth | Ken Johnson | Bob Sadowski | Lindy McDaniel | Billy O'Dell | 207 | 241 | -34 |
| 1965-06-09 | vs MLN | 53 | W 4-2 | 24-29 | 9 | 4,273 | Cal Koonce | Wade Blasingame | Cal Koonce | Wade Blasingame | | 211 | 243 | -32 |
| 1965-06-10 | vs MLN | 54 | L 4-6 | 24-30 | 9 | 4,595 | Larry Jackson | Tony Cloninger | Tony Cloninger | Larry Jackson | Ken Johnson | 215 | 249 | -34 |
| 1965-06-11 | vs CIN | 55 | L 3-4 | 24-31 | 9 | 4,529 | Bob Buhl | Sammy Ellis | Billy McCool | Bob Buhl | | 218 | 253 | -35 |
| 1965-06-12 | vs CIN | 56 | W 3-2 | 25-31 | 8 | 3,672 | Dick Ellsworth | Jim O'Toole | Dick Ellsworth | Jim O'Toole | Ted Abernathy | 221 | 255 | -34 |
| 1965-06-13 | vs CIN | 57 | W 9-7 | 26-32 | 8 | 0 | Cal Koonce | Gerry Arrigo | Cal Koonce | Gerry Arrigo | Ted Abernathy | 230 | 262 | -32 |
| 1965-06-13 | vs CIN | 58 | L 0-7 | 26-32 | 8 | 18,132 | Bob Hendley | Joey Jay | Joey Jay | Bob Hendley | | 230 | 269 | -39 |
| 1965-06-14 | @ HOU | 59 | W 2-0 | 27-32 | 8 | 26,761 | Larry Jackson | Bob Bruce | Larry Jackson | Bob Bruce | | 232 | 269 | -37 |
| 1965-06-15 | @ HOU | 60 | W 5-0 | 28-32 | 8 | 19,167 | Bob Buhl | Larry Dierker | Bob Buhl | Larry Dierker | Ted Abernathy | 237 | 269 | -32 |
| 1965-06-16 | @ HOU | 61 | L 2-3 | 28-33 | 8 | 21,835 | Dick Ellsworth | Turk Farrell | Jim Owens | Lindy McDaniel | | 239 | 272 | -33 |
| 1965-06-17 | @ HOU | 62 | W 6-5 | 29-33 | 7 | 16,616 | Bob Hendley | Dave Giusti | Ernie Broglio | Jim Owens | Ted Abernathy | 245 | 277 | -32 |
| 1965-06-18 | @ CIN | 63 | L 1-3 | 29-34 | 8 | 12,959 | Cal Koonce | Joey Jay | Joey Jay | Cal Koonce | Billy McCool | 246 | 280 | -34 |
| 1965-06-19 | @ CIN | 64 | L 4-9 | 29-35 | 8 | 6,976 | Larry Jackson | Jim Maloney | Jim Maloney | Larry Jackson | Joe Nuxhall | 250 | 289 | -39 |
| 1965-06-20 | @ CIN | 65 | W 8-5 | 30-36 | 8 | 0 | Bob Buhl | Sammy Ellis | Bob Buhl | Sammy Ellis | Ted Abernathy | 258 | 294 | -36 |
| 1965-06-20 | @ CIN | 66 | L 8-9 | 30-36 | 8 | 22,640 | Dick Ellsworth | Jim O'Toole | Sammy Ellis | Ted Abernathy | | 266 | 303 | -37 |
| 1965-06-22 | @ MLN | 67 | W 6-1 | 31-36 | 7 | 6,340 | Cal Koonce | Ken Johnson | Cal Koonce | Ken Johnson | Lindy McDaniel | 272 | 304 | -32 |
| 1965-06-23 | @ MLN | 68 | L 2-6 | 31-37 | 7 | 7,440 | Larry Jackson | Wade Blasingame | Wade Blasingame | Larry Jackson | | 274 | 310 | -36 |
| 1965-06-24 | @ MLN | 69 | W 3-1 | 32-37 | 7 | 5,689 | Dick Ellsworth | Tony Cloninger | Dick Ellsworth | Tony Cloninger | | 277 | 311 | -34 |
| 1965-06-25 | @ SLN | 70 | W 12-4 | 33-37 | 7 | 17,137 | Bob Buhl | Bob Purkey | Bob Buhl | Bob Purkey | Lindy McDaniel | 289 | 315 | -26 |
| 1965-06-26 | @ SLN | 71 | L 1-8 | 33-38 | 7 | 13,746 | Cal Koonce | Steve Carlton | Hal Woodeshick | Cal Koonce | Ray Washburn | 290 | 323 | -33 |
| 1965-06-27 | @ SLN | 72 | L 0-8 | 34-39 | 7 | 0 | Ernie Broglio | Bob Gibson | Bob Gibson | Ernie Broglio | | 290 | 331 | -41 |
| 1965-06-27 | @ SLN | 73 | W 6-3 | 34-39 | 7 | 29,827 | Bob Hendley | Curt Simmons | Bob Humphreys | Don Dennis | Dick Ellsworth | 296 | 334 | -38 |
| 1965-06-28 | vs HOU | 74 | W 7-2 | 35-39 | 7 | 4,464 | Larry Jackson | Dave Giusti | Larry Jackson | Dave Giusti | | 303 | 336 | -33 |
| 1965-06-30 | vs LAN | 75 | W 4-1 | 36-40 | 7 | 0 | Dick Ellsworth | Claude Osteen | Dick Ellsworth | Claude Osteen | | 307 | 337 | -30 |
| 1965-06-30 | vs LAN | 76 | L 3-4 | 36-40 | 7 | 17,950 | Bob Buhl | Nick Willhite | Bob Miller | Billy Hoeft | | 310 | 341 | -31 |
| 1965-07-01 | vs LAN | 77 | W 6-3 | 37-40 | 7 | 7,420 | Bob Hendley | Johnny Podres | Lindy McDaniel | Johnny Podres | Ted Abernathy | 316 | 344 | -28 |
| 1965-07-02 | vs SFN | 78 | L 0-4 | 37-41 | 7 | 5,943 | Cal Koonce | Juan Marichal | Juan Marichal | Cal Koonce | | 316 | 348 | -32 |
| 1965-07-03 | vs SFN | 79 | W 4-1 | 38-41 | 7 | 16,287 | Larry Jackson | Bob Shaw | Larry Jackson | Bob Shaw | | 320 | 349 | -29 |
| 1965-07-04 | vs SFN | 80 | L 4-7 | 38-42 | 8 | 21,651 | Bob Buhl | Ron Herbel | Bobby Bolin | Lindy McDaniel | Frank Linzy | 324 | 356 | -32 |
| 1965-07-05 | @ NYN | 81 | L 2-3 | 38-44 | 8 | 0 | Dick Ellsworth | Warren Spahn | Larry Bearnarth | Dick Ellsworth | | 326 | 359 | -33 |
| 1965-07-05 | @ NYN | 82 | L 0-3 | 38-44 | 8 | 35,900 | Bill Faul | Tom Parsons | Tom Parsons | Bill Faul | | 326 | 362 | -36 |
| 1965-07-07 | @ NYN | 83 | W 8-3 | 39-44 | 8 | 17,916 | Larry Jackson | Al Jackson | Larry Jackson | Al Jackson | Ted Abernathy | 334 | 365 | -31 |
| 1965-07-09 | vs SLN | 84 | L 3-7 | 39-45 | 8 | 7,863 | Bob Buhl | Tracy Stallard | Tracy Stallard | Bob Buhl | Hal Woodeshick | 337 | 372 | -35 |
| 1965-07-10 | vs SLN | 85 | W 5-3 | 40-45 | 8 | 16,298 | Dick Ellsworth | Ray Washburn | Dick Ellsworth | Ray Washburn | | 342 | 375 | -33 |
| 1965-07-11 | vs SLN | 86 | W 6-0 | 42-45 | 7 | 0 | Larry Jackson | Curt Simmons | Larry Jackson | Curt Simmons | | 348 | 375 | -27 |
| 1965-07-11 | vs SLN | 87 | W 6-0 | 42-45 | 7 | 34,579 | Cal Koonce | Ray Sadecki | Cal Koonce | Ray Sadecki | | 354 | 375 | -21 |
| 1965-07-14 | vs MLN | 88 | W 5-2 | 43-46 | 7 | 0 | Bob Buhl | Tony Cloninger | Bob Buhl | Tony Cloninger | Ted Abernathy | 359 | 377 | -18 |
| 1965-07-14 | vs MLN | 89 | L 3-6 | 43-46 | 7 | 20,273 | Bill Faul | Hank Fischer | Hank Fischer | Bill Faul | | 362 | 383 | -21 |
| 1965-07-15 | @ LAN | 90 | L 0-5 | 43-47 | 7 | 25,538 | Dick Ellsworth | Don Drysdale | Don Drysdale | Dick Ellsworth | | 362 | 388 | -26 |
| 1965-07-16 | @ LAN | 91 | L 0-3 | 43-48 | 8 | 47,947 | Larry Jackson | Sandy Koufax | Sandy Koufax | Larry Jackson | | 362 | 391 | -29 |
| 1965-07-17 | @ LAN | 92 | L 2-7 | 43-49 | 8 | 31,228 | Cal Koonce | Claude Osteen | Claude Osteen | Cal Koonce | | 364 | 398 | -34 |
| 1965-07-18 | @ LAN | 93 | L 3-4 | 43-50 | 8 | 27,508 | Bob Buhl | Nick Willhite | Howie Reed | Bob Hendley | | 367 | 402 | -35 |
| 1965-07-19 | @ SFN | 94 | W 6-2 | 44-50 | 8 | 6,649 | Dick Ellsworth | Jack Sanford | Dick Ellsworth | Jack Sanford | Ted Abernathy | 373 | 404 | -31 |
| 1965-07-20 | @ SFN | 95 | L 0-2 | 44-51 | 8 | 6,975 | Larry Jackson | Bob Shaw | Bob Shaw | Larry Jackson | | 373 | 406 | -33 |
| 1965-07-21 | vs PHI | 96 | W 8-7 | 45-51 | 8 | 9,585 | Cal Koonce | Ray Culp | Bob Hendley | Bo Belinsky | | 381 | 413 | -32 |
| 1965-07-22 | vs PHI | 97 | W 10-6 | 46-51 | 8 | 7,468 | Bob Buhl | Ray Herbert | Bob Buhl | Ray Herbert | Ted Abernathy | 391 | 419 | -28 |
| 1965-07-23 | vs PIT | 98 | L 0-6 | 46-52 | 8 | 5,288 | Dick Ellsworth | Bob Friend | Bob Friend | Dick Ellsworth | | 391 | 425 | -34 |
| 1965-07-24 | vs PIT | 99 | L 5-8 | 46-53 | 8 | 9,578 | Larry Jackson | Vern Law | Vern Law | Larry Jackson | Al McBean | 396 | 433 | -37 |
| 1965-07-25 | vs PIT | 100 | L 2-3 | 47-54 | 8 | 0 | Cal Koonce | Bob Veale | Vern Law | Lindy McDaniel | | 398 | 436 | -38 |
| 1965-07-25 | vs PIT | 101 | W 5-0 | 47-54 | 8 | 20,777 | Bill Faul | Don Cardwell | Bill Faul | Don Cardwell | | 403 | 436 | -33 |
| 1965-07-27 | vs NYN | 102 | W 6-3 | 48-54 | 8 | 6,410 | Bob Buhl | Jack Fisher | Bob Buhl | Jack Fisher | Ted Abernathy | 409 | 439 | -30 |
| 1965-07-28 | vs NYN | 103 | W 7-2 | 50-54 | 8 | 0 | Dick Ellsworth | Tom Parsons | Dick Ellsworth | Tom Parsons | | 416 | 441 | -25 |
| 1965-07-28 | vs NYN | 104 | W 9-0 | 50-54 | 8 | 13,151 | Larry Jackson | Tug McGraw | Larry Jackson | Tug McGraw | | 425 | 441 | -16 |
| 1965-07-29 | vs NYN | 105 | L 0-14 | 51-55 | 8 | 0 | Cal Koonce | Galen Cisco | Galen Cisco | Cal Koonce | | 425 | 455 | -30 |
| 1965-07-29 | vs NYN | 106 | W 2-1 | 51-55 | 8 | 11,256 | Bill Faul | Dennis Musgraves | Ted Abernathy | Larry Bearnarth | | 427 | 456 | -29 |
| 1965-07-30 | @ PIT | 107 | L 1-3 | 51-56 | 8 | 11,382 | Ernie Broglio | Don Cardwell | Don Cardwell | Ernie Broglio | | 428 | 459 | -31 |
| 1965-07-31 | @ PIT | 108 | W 7-6 | 52-56 | 8 | 7,431 | Bob Buhl | Tommie Sisk | Bob Buhl | Tommie Sisk | Ted Abernathy | 435 | 465 | -30 |
| 1965-08-01 | @ PIT | 109 | L 2-8 | 52-58 | 8 | 0 | Dick Ellsworth | Al McBean | Al McBean | Dick Ellsworth | Don Schwall | 437 | 473 | -36 |
| 1965-08-01 | @ PIT | 110 | L 1-3 | 52-58 | 8 | 14,741 | Larry Jackson | Joe Gibbon | Joe Gibbon | Larry Jackson | Don Schwall | 438 | 476 | -38 |
| 1965-08-03 | @ PHI | 111 | W 2-0 | 53-58 | 8 | 17,171 | Bill Faul | Ray Culp | Bill Faul | Ray Culp | | 440 | 476 | -36 |
| 1965-08-04 | @ PHI | 112 | L 2-7 | 53-59 | 8 | 13,515 | Bob Buhl | Chris Short | Chris Short | Bob Buhl | | 442 | 483 | -41 |
| 1965-08-05 | @ PHI | 113 | L 3-4 | 53-60 | 8 | 14,867 | Dick Ellsworth | Lew Burdette | Lew Burdette | Dick Ellsworth | Bo Belinsky | 445 | 487 | -42 |
| 1965-08-06 | @ NYN | 114 | W 4-3 | 54-60 | 8 | 18,555 | Larry Jackson | Tom Parsons | Larry Jackson | Tom Parsons | Ted Abernathy | 449 | 490 | -41 |
| 1965-08-07 | @ NYN | 115 | W 7-1 | 55-60 | 8 | 12,766 | Bill Faul | Galen Cisco | Billy Hoeft | Galen Cisco | | 456 | 491 | -35 |
| 1965-08-08 | @ NYN | 116 | W 7-6 | 57-60 | 8 | 0 | Bob Buhl | Jack Fisher | Lindy McDaniel | Jack Fisher | Ted Abernathy | 463 | 497 | -34 |
| 1965-08-08 | @ NYN | 117 | W 14-10 | 57-60 | 8 | 25,067 | Ernie Broglio | Gary Kroll | Ted Abernathy | Tom Parsons | | 477 | 507 | -30 |
| 1965-08-10 | @ CIN | 118 | L 2-6 | 57-61 | 8 | 11,924 | Dick Ellsworth | Sammy Ellis | Sammy Ellis | Dick Ellsworth | | 479 | 513 | -34 |
| 1965-08-11 | @ CIN | 119 | W 7-2 | 58-61 | 7 | 11,790 | Larry Jackson | Jim O'Toole | Larry Jackson | Jim O'Toole | | 486 | 515 | -29 |
| 1965-08-13 | vs MLN | 120 | L 3-8 | 58-62 | 8 | 11,331 | Bob Buhl | Denny Lemaster | Denny Lemaster | Bob Buhl | | 489 | 523 | -34 |
| 1965-08-14 | vs MLN | 121 | L 2-8 | 58-63 | 8 | 14,067 | Bill Faul | Tony Cloninger | Tony Cloninger | Bill Faul | Bob Sadowski | 491 | 531 | -40 |
| 1965-08-15 | vs MLN | 122 | L 3-4 | 58-64 | 8 | 16,486 | Larry Jackson | Ken Johnson | Billy O'Dell | Ted Abernathy | Dan Osinski | 494 | 535 | -41 |
| 1965-08-17 | vs CIN | 123 | L 4-6 | 58-65 | 8 | 7,780 | Dick Ellsworth | Ted Davidson | Ted Davidson | Dick Ellsworth | Sammy Ellis | 498 | 541 | -43 |
| 1965-08-19 | vs CIN | 124 | L 0-1 | 59-66 | 8 | 0 | Larry Jackson | Jim Maloney | Jim Maloney | Larry Jackson | | 498 | 542 | -44 |
| 1965-08-19 | vs CIN | 125 | W 5-4 | 59-66 | 8 | 11,342 | Cal Koonce | Joey Jay | Lindy McDaniel | Billy McCool | | 503 | 546 | -43 |
| 1965-08-20 | vs HOU | 126 | L 4-7 | 60-67 | 8 | 0 | Bob Buhl | Bob Bruce | Bob Bruce | Ted Abernathy | | 507 | 553 | -46 |
| 1965-08-20 | vs HOU | 127 | W 2-0 | 60-67 | 8 | 7,936 | Bill Faul | Larry Dierker | Bill Faul | Larry Dierker | | 509 | 553 | -44 |
| 1965-08-21 | vs HOU | 128 | L 2-9 | 60-68 | 8 | 6,362 | Dick Ellsworth | Robin Roberts | Robin Roberts | Dick Ellsworth | | 511 | 562 | -51 |
| 1965-08-22 | vs HOU | 129 | W 3-1 | 61-68 | 8 | 9,106 | Billy Hoeft | Turk Farrell | Billy Hoeft | Turk Farrell | | 514 | 563 | -49 |
| 1965-08-23 | @ SLN | 130 | L 2-10 | 61-69 | 8 | 13,301 | Larry Jackson | Curt Simmons | Curt Simmons | Larry Jackson | | 516 | 573 | -57 |
| 1965-08-24 | @ SLN | 131 | L 6-7 | 61-70 | 8 | 8,156 | Bill Faul | Ray Sadecki | Nelson Briles | Ted Abernathy | | 522 | 580 | -58 |
| 1965-08-25 | @ SLN | 132 | W 6-3 | 62-70 | 8 | 11,879 | Dick Ellsworth | Bob Gibson | Dick Ellsworth | Bob Gibson | Ted Abernathy | 528 | 583 | -55 |
| 1965-08-26 | @ SLN | 133 | L 4-7 | 62-71 | 8 | 10,692 | Billy Hoeft | Bob Purkey | Bob Purkey | Billy Hoeft | Ray Washburn | 532 | 590 | -58 |
| 1965-08-27 | @ MLN | 134 | W 5-3 | 63-71 | 8 | 20,723 | Bob Buhl | Ken Johnson | Bob Buhl | Ken Johnson | Ted Abernathy | 537 | 593 | -56 |
| 1965-08-28 | @ MLN | 135 | W 3-1 | 64-71 | 8 | 9,241 | Larry Jackson | Wade Blasingame | Larry Jackson | Wade Blasingame | Ted Abernathy | 540 | 594 | -54 |
| 1965-08-29 | @ MLN | 136 | W 10-2 | 65-71 | 8 | 13,062 | Bill Faul | Hank Fischer | Bill Faul | Hank Fischer | | 550 | 596 | -46 |
| 1965-08-31 | vs SLN | 137 | L 0-3 | 65-72 | 8 | 4,036 | Dick Ellsworth | Bob Gibson | Bob Gibson | Dick Ellsworth | | 550 | 599 | -49 |
| 1965-09-01 | vs SLN | 138 | L 0-9 | 65-73 | 8 | 6,397 | Larry Jackson | Tracy Stallard | Tracy Stallard | Larry Jackson | | 550 | 608 | -58 |
| 1965-09-02 | vs SLN | 139 | W 5-3 | 66-73 | 8 | 5,014 | Bob Hendley | Curt Simmons | Bob Hendley | Curt Simmons | Ted Abernathy | 555 | 611 | -56 |
| 1965-09-03 | vs SFN | 140 | W 5-4 | 67-73 | 8 | 6,986 | Bill Faul | Bobby Bolin | Bill Faul | Bobby Bolin | Ted Abernathy | 560 | 615 | -55 |
| 1965-09-04 | vs SFN | 141 | L 3-7 | 67-74 | 8 | 7,151 | Bob Buhl | Ron Herbel | Ron Herbel | Bob Buhl | Frank Linzy | 563 | 622 | -59 |
| 1965-09-05 | vs SFN | 142 | L 2-4 | 67-75 | 8 | 18,878 | Dick Ellsworth | Juan Marichal | Juan Marichal | Dick Ellsworth | | 565 | 626 | -61 |
| 1965-09-06 | @ HOU | 143 | L 1-2 | 67-76 | 8 | 31,814 | Larry Jackson | Turk Farrell | Turk Farrell | Larry Jackson | | 566 | 628 | -62 |
| 1965-09-09 | @ LAN | 144 | L 0-1 | 67-77 | 8 | 29,139 | Bob Hendley | Sandy Koufax | Sandy Koufax | Bob Hendley | | 566 | 629 | -63 |
| 1965-09-10 | @ SFN | 145 | L 2-5 | 67-78 | 8 | 20,587 | Dick Ellsworth | Ron Herbel | Ron Herbel | Dick Ellsworth | Bill Henry | 568 | 634 | -66 |
| 1965-09-11 | @ SFN | 146 | L 4-6 | 67-79 | 8 | 21,217 | Bill Faul | Bob Shaw | Bob Shaw | Bill Faul | Gaylord Perry | 572 | 640 | -68 |
| 1965-09-12 | @ SFN | 147 | L 3-4 | 67-81 | 8 | 0 | Larry Jackson | Bobby Bolin | Bobby Bolin | Larry Jackson | Bill Henry | 575 | 644 | -69 |
| 1965-09-12 | @ SFN | 148 | L 2-9 | 67-81 | 8 | 41,070 | Bob Buhl | Warren Spahn | Warren Spahn | Bob Buhl | | 577 | 653 | -76 |
| 1965-09-14 | vs LAN | 149 | W 2-1 | 68-81 | 8 | 6,220 | Bob Hendley | Sandy Koufax | Bob Hendley | Sandy Koufax | | 579 | 654 | -75 |
| 1965-09-15 | vs LAN | 150 | W 8-6 | 69-81 | 8 | 1,886 | Dick Ellsworth | Don Drysdale | Dick Ellsworth | Howie Reed | Billy Hoeft | 587 | 660 | -73 |
| 1965-09-16 | vs LAN | 151 | L 0-2 | 69-82 | 8 | 550 | Bill Faul | Claude Osteen | Claude Osteen | Bill Faul | Sandy Koufax | 587 | 662 | -75 |
| 1965-09-18 | vs NYN | 152 | W 4-3 | 70-82 | 8 | 3,930 | Larry Jackson | Tug McGraw | Larry Jackson | Tug McGraw | Ted Abernathy | 591 | 665 | -74 |
| 1965-09-19 | vs NYN | 153 | L 6-8 | 70-83 | 8 | 5,981 | Bob Hendley | Dick Selma | Darrell Sutherland | Bob Hendley | | 597 | 673 | -76 |
| 1965-09-21 | vs PHI | 154 | W 7-5 | 71-83 | 8 | 892 | Dick Ellsworth | Grant Jackson | Ted Abernathy | Fergie Jenkins | | 604 | 678 | -74 |
| 1965-09-23 | vs PHI | 155 | L 5-11 | 71-85 | 8 | 0 | Larry Jackson | Jim Bunning | Jim Bunning | Larry Jackson | | 609 | 689 | -80 |
| 1965-09-23 | vs PHI | 156 | L 4-7 | 71-85 | 8 | 1,598 | Bill Faul | Chris Short | Chris Short | Bill Faul | | 613 | 696 | -83 |
| 1965-09-25 | vs PIT | 157 | W 6-3 | 72-85 | 8 | 2,903 | Bob Hendley | Bob Veale | Bob Hendley | Bob Veale | Ted Abernathy | 619 | 699 | -80 |
| 1965-09-26 | vs PIT | 158 | L 3-5 | 72-86 | 8 | 2,097 | Cal Koonce | Don Cardwell | Don Schwall | Ted Abernathy | | 622 | 704 | -82 |
| 1965-09-27 | @ PHI | 159 | W 1-0 | 73-86 | 8 | 4,390 | Larry Jackson | Jim Bunning | Larry Jackson | Jim Bunning | | 623 | 704 | -81 |
| 1965-09-28 | @ PHI | 160 | W 2-1 | 74-86 | 8 | 3,928 | Bill Faul | Chris Short | Bill Faul | Chris Short | | 625 | 705 | -80 |
| 1965-09-29 | @ PHI | 161 | L 6-7 | 74-87 | 8 | 4,609 | Bob Hendley | Ray Culp | Gary Wagner | Lindy McDaniel | | 631 | 712 | -81 |
| 1965-10-01 | @ PIT | 162 | L 1-2 | 74-87 | 8 | 3,441 | Dick Ellsworth | Bob Veale | Roy Face | Dick Ellsworth | | 632 | 714 | -82 |
| 1965-10-02 | @ PIT | 163 | L 0-3 | 74-87 | 8 | 3,626 | Larry Jackson | Don Cardwell | Don Cardwell | Larry Jackson | | 632 | 717 | -85 |
| 1965-10-03 | @ PIT | 164 | L 3-6 | 74-87 | 8 | 26,527 | Bill Faul | Tommie Sisk | Roy Face | Ted Abernathy | Al McBean | 635 | 723 | -88 |