| 1965-04-12 | @ CHN | 1 | L 10-10 | 0-1 | 10 | 19,751 | Bob Gibson | Larry Jackson | | | | 10 | 10 | 0 |
| 1965-04-13 | @ CHN | 2 | L 1-3 | 0-2 | 10 | 9,358 | Curt Simmons | Bob Buhl | Bob Buhl | Curt Simmons | | 11 | 13 | -2 |
| 1965-04-14 | @ CHN | 3 | L 3-7 | 0-3 | 10 | 3,569 | Ray Sadecki | Dick Ellsworth | Dick Ellsworth | Ray Sadecki | | 14 | 20 | -6 |
| 1965-04-15 | vs CIN | 4 | L 4-10 | 0-4 | 10 | 24,364 | Bob Purkey | John Tsitouris | John Tsitouris | Bob Purkey | | 18 | 30 | -12 |
| 1965-04-17 | vs CIN | 5 | W 8-0 | 1-4 | 10 | 15,828 | Bob Gibson | Jim O'Toole | Bob Gibson | Jim O'Toole | | 26 | 30 | -4 |
| 1965-04-18 | vs CIN | 6 | L 2-8 | 1-5 | 10 | 13,754 | Curt Simmons | Sammy Ellis | Sammy Ellis | Curt Simmons | Billy McCool | 28 | 38 | -10 |
| 1965-04-19 | vs CHN | 7 | L 3-7 | 1-6 | 10 | 8,003 | Ray Sadecki | Dick Ellsworth | Dick Ellsworth | Ray Sadecki | Ted Abernathy | 31 | 45 | -14 |
| 1965-04-21 | vs MLN | 8 | W 6-3 | 2-6 | 10 | 10,303 | Bob Purkey | Bob Sadowski | Bob Purkey | Bob Sadowski | | 37 | 48 | -11 |
| 1965-04-23 | @ CIN | 9 | W 6-3 | 3-6 | 10 | 11,389 | Bob Gibson | John Tsitouris | Bob Gibson | John Tsitouris | | 43 | 51 | -8 |
| 1965-04-24 | @ CIN | 10 | L 3-6 | 3-7 | 10 | 3,908 | Tracy Stallard | Sammy Ellis | Sammy Ellis | Tracy Stallard | Billy McCool | 46 | 57 | -11 |
| 1965-04-27 | @ MLN | 11 | L 5-9 | 3-8 | 10 | 1,677 | Bob Purkey | Denny Lemaster | Denny Lemaster | Bob Purkey | Billy O'Dell | 51 | 66 | -15 |
| 1965-04-28 | @ MLN | 12 | W 5-0 | 4-8 | 10 | 1,324 | Bob Gibson | Wade Blasingame | Bob Gibson | Wade Blasingame | | 56 | 66 | -10 |
| 1965-04-29 | @ MLN | 13 | L 1-4 | 4-9 | 10 | 2,182 | Curt Simmons | Bob Sadowski | Bob Sadowski | Curt Simmons | Billy O'Dell | 57 | 70 | -13 |
| 1965-04-30 | vs PIT | 14 | W 3-2 | 5-9 | 10 | 20,401 | Ray Sadecki | Vern Law | Ray Washburn | Vern Law | | 60 | 72 | -12 |
| 1965-05-01 | vs PIT | 15 | W 3-2 | 6-9 | 7 | 9,689 | Tracy Stallard | Don Cardwell | Tracy Stallard | Don Cardwell | | 63 | 74 | -11 |
| 1965-05-02 | vs PIT | 16 | W 9-5 | 8-9 | 5 | 0 | Bob Gibson | Bob Friend | Bob Gibson | Bob Friend | Ron Taylor | 72 | 79 | -7 |
| 1965-05-02 | vs PIT | 17 | W 5-4 | 8-9 | 5 | 23,630 | Bob Purkey | Bob Veale | Ray Washburn | Al McBean | | 77 | 83 | -6 |
| 1965-05-03 | vs SFN | 18 | W 3-1 | 9-9 | 5 | 18,745 | Curt Simmons | Ron Herbel | Curt Simmons | Ron Herbel | | 80 | 84 | -4 |
| 1965-05-04 | vs SFN | 19 | L 2-9 | 9-10 | 6 | 10,604 | Ray Sadecki | Juan Marichal | Juan Marichal | Ray Sadecki | | 82 | 93 | -11 |
| 1965-05-05 | vs SFN | 20 | L 5-10 | 9-11 | 8 | 10,260 | Tracy Stallard | Bob Hendley | Frank Linzy | Ray Washburn | Bill Henry | 87 | 103 | -16 |
| 1965-05-07 | @ PHI | 21 | W 2-0 | 10-11 | 6 | 14,499 | Bob Gibson | Chris Short | Bob Gibson | Chris Short | | 89 | 103 | -14 |
| 1965-05-08 | @ PHI | 22 | L 8-9 | 10-12 | 7 | 19,596 | Curt Simmons | Bo Belinsky | Ray Culp | Nelson Briles | | 97 | 112 | -15 |
| 1965-05-09 | @ PHI | 23 | L 2-4 | 10-13 | 8 | 12,930 | Ray Sadecki | Art Mahaffey | Art Mahaffey | Ray Sadecki | Ed Roebuck | 99 | 116 | -17 |
| 1965-05-10 | @ PHI | 24 | L 2-4 | 10-14 | 8 | 14,454 | Tracy Stallard | Jim Bunning | Ed Roebuck | Bob Purkey | | 101 | 120 | -19 |
| 1965-05-11 | @ NYN | 25 | W 4-3 | 11-14 | 8 | 24,519 | Bob Gibson | Warren Spahn | Bob Gibson | Warren Spahn | | 105 | 123 | -18 |
| 1965-05-12 | @ NYN | 26 | L 1-2 | 11-15 | 8 | 7,723 | Curt Simmons | Jack Fisher | Jack Fisher | Curt Simmons | | 106 | 125 | -19 |
| 1965-05-14 | @ PIT | 27 | W 8-7 | 12-15 | 8 | 9,986 | Ray Sadecki | Joe Gibbon | Barney Schultz | Al McBean | Bob Purkey | 114 | 132 | -18 |
| 1965-05-15 | @ PIT | 28 | W 5-1 | 13-15 | 7 | 5,148 | Tracy Stallard | Vern Law | Tracy Stallard | Vern Law | | 119 | 133 | -14 |
| 1965-05-16 | @ PIT | 29 | W 6-3 | 15-15 | 5 | 0 | Bob Gibson | Don Cardwell | Bob Gibson | Don Cardwell | | 125 | 136 | -11 |
| 1965-05-16 | @ PIT | 30 | W 5-1 | 15-15 | 5 | 11,081 | Ray Washburn | Bob Veale | Ray Washburn | Bob Veale | Bob Purkey | 130 | 137 | -7 |
| 1965-05-17 | vs PHI | 31 | L 1-2 | 15-16 | 5 | 10,748 | Curt Simmons | Bo Belinsky | Bo Belinsky | Curt Simmons | | 131 | 139 | -8 |
| 1965-05-18 | vs PHI | 32 | W 8-2 | 16-16 | 5 | 8,593 | Ray Sadecki | Art Mahaffey | Ray Sadecki | Art Mahaffey | | 139 | 141 | -2 |
| 1965-05-19 | vs PHI | 33 | W 7-6 | 17-16 | 4 | 18,660 | Tracy Stallard | Jim Bunning | Bob Purkey | Ed Roebuck | | 146 | 147 | -1 |
| 1965-05-20 | vs PHI | 34 | W 12-2 | 18-16 | 4 | 13,741 | Bob Gibson | Chris Short | Bob Gibson | Chris Short | | 158 | 149 | 9 |
| 1965-05-21 | vs NYN | 35 | W 5-4 | 19-16 | 3 | 22,274 | Ray Washburn | Al Jackson | Ron Taylor | Dennis Ribant | | 163 | 153 | 10 |
| 1965-05-22 | vs NYN | 36 | W 5-1 | 20-16 | 3 | 20,937 | Curt Simmons | Jack Fisher | Curt Simmons | Jack Fisher | | 168 | 154 | 14 |
| 1965-05-23 | vs NYN | 37 | W 8-7 | 21-16 | 3 | 15,402 | Ray Sadecki | Gary Kroll | Bob Purkey | Tom Parsons | | 176 | 161 | 15 |
| 1965-05-24 | @ LAN | 38 | W 6-4 | 22-16 | 3 | 22,987 | Tracy Stallard | Claude Osteen | Tracy Stallard | Claude Osteen | Barney Schultz | 182 | 165 | 17 |
| 1965-05-25 | @ LAN | 39 | L 0-2 | 22-17 | 4 | 28,515 | Bob Gibson | Don Drysdale | Don Drysdale | Bob Gibson | | 182 | 167 | 15 |
| 1965-05-26 | @ LAN | 40 | W 2-1 | 23-17 | 4 | 30,794 | Curt Simmons | Sandy Koufax | Curt Simmons | Sandy Koufax | | 184 | 168 | 16 |
| 1965-05-27 | @ HOU | 41 | L 1-6 | 23-18 | 4 | 22,430 | Ray Washburn | Turk Farrell | Turk Farrell | Ray Washburn | | 185 | 174 | 11 |
| 1965-05-28 | @ HOU | 42 | L 2-3 | 23-19 | 4 | 31,190 | Ray Sadecki | Dave Giusti | Jim Owens | Ron Taylor | | 187 | 177 | 10 |
| 1965-05-29 | @ HOU | 43 | L 3-4 | 23-20 | 5 | 35,553 | Tracy Stallard | Don Nottebart | Hal Woodeshick | Bob Purkey | | 190 | 181 | 9 |
| 1965-05-30 | @ SFN | 44 | L 2-3 | 23-21 | 5 | 31,919 | Bob Gibson | Ron Herbel | Frank Linzy | Bob Gibson | | 192 | 184 | 8 |
| 1965-05-31 | @ SFN | 45 | L 1-4 | 23-22 | 5 | 23,716 | Curt Simmons | Gaylord Perry | Gaylord Perry | Curt Simmons | | 193 | 188 | 5 |
| 1965-06-01 | @ SFN | 46 | W 2-1 | 24-22 | 5 | 6,592 | Ray Sadecki | Juan Marichal | Ray Sadecki | Juan Marichal | | 195 | 189 | 6 |
| 1965-06-02 | vs LAN | 47 | L 1-4 | 24-23 | 5 | 17,560 | Ray Washburn | Don Drysdale | Don Drysdale | Ray Washburn | Ron Perranoski | 196 | 193 | 3 |
| 1965-06-03 | vs LAN | 48 | L 10-11 | 24-24 | 5 | 19,946 | Bob Purkey | Sandy Koufax | Jim Brewer | Barney Schultz | Bob Miller | 206 | 204 | 2 |
| 1965-06-04 | vs HOU | 49 | L 2-5 | 24-25 | 5 | 24,640 | Bob Gibson | Bob Bruce | Bob Bruce | Bob Gibson | Jim Owens | 208 | 209 | -1 |
| 1965-06-05 | vs HOU | 50 | W 4-3 | 25-25 | 5 | 8,862 | Curt Simmons | Larry Dierker | Ray Washburn | Ken MacKenzie | | 212 | 212 | 0 |
| 1965-06-06 | vs HOU | 51 | L 1-10 | 25-26 | 5 | 20,878 | Ray Sadecki | Claude Raymond | Claude Raymond | Ray Sadecki | | 213 | 222 | -9 |
| 1965-06-08 | vs CIN | 52 | L 4-5 | 25-27 | 5 | 12,109 | Bob Gibson | Gerry Arrigo | Gerry Arrigo | Bob Gibson | Joe Nuxhall | 217 | 227 | -10 |
| 1965-06-09 | vs CIN | 53 | W 6-4 | 26-27 | 5 | 16,126 | Curt Simmons | Joey Jay | Curt Simmons | Joey Jay | Barney Schultz | 223 | 231 | -8 |
| 1965-06-10 | vs CIN | 54 | L 7-8 | 26-28 | 6 | 9,439 | Ray Sadecki | Jim Maloney | John Tsitouris | Ray Sadecki | Billy McCool | 230 | 239 | -9 |
| 1965-06-11 | vs MLN | 55 | L 2-8 | 26-29 | 7 | 14,094 | Ray Washburn | Denny Lemaster | Denny Lemaster | Ray Washburn | Phil Niekro | 232 | 247 | -15 |
| 1965-06-12 | vs MLN | 56 | L 1-4 | 26-30 | 7 | 11,593 | Bob Gibson | Ken Johnson | Ken Johnson | Bob Gibson | | 233 | 251 | -18 |
| 1965-06-13 | vs MLN | 57 | L 2-4 | 27-31 | 7 | 0 | Curt Simmons | Wade Blasingame | Wade Blasingame | Curt Simmons | | 235 | 255 | -20 |
| 1965-06-13 | vs MLN | 58 | W 12-2 | 27-31 | 7 | 25,360 | Bob Purkey | Hank Fischer | Bob Purkey | Hank Fischer | | 247 | 257 | -10 |
| 1965-06-14 | vs PIT | 59 | W 5-2 | 28-31 | 7 | 5,265 | Steve Carlton | Bob Veale | Ron Taylor | Bob Veale | | 252 | 259 | -7 |
| 1965-06-15 | vs PIT | 60 | L 6-10 | 28-32 | 7 | 10,428 | Ray Sadecki | Don Cardwell | Frank Carpin | Tracy Stallard | Al McBean | 258 | 269 | -11 |
| 1965-06-16 | vs PIT | 61 | L 9-10 | 28-33 | 7 | 10,480 | Ray Washburn | Bob Friend | Don Schwall | Barney Schultz | | 267 | 279 | -12 |
| 1965-06-17 | vs PIT | 62 | L 1-4 | 28-34 | 8 | 11,905 | Bob Gibson | Vern Law | Vern Law | Bob Gibson | | 268 | 283 | -15 |
| 1965-06-18 | @ MLN | 63 | W 5-4 | 29-34 | 7 | 10,862 | Curt Simmons | Wade Blasingame | Don Dennis | Phil Niekro | Hal Woodeshick | 273 | 287 | -14 |
| 1965-06-19 | @ MLN | 64 | L 5-6 | 29-35 | 7 | 6,186 | Ray Sadecki | Tony Cloninger | Tony Cloninger | Ray Sadecki | Dan Osinski | 278 | 293 | -15 |
| 1965-06-20 | @ MLN | 65 | W 6-4 | 30-35 | 7 | 10,664 | Bob Purkey | Denny Lemaster | Bob Purkey | Denny Lemaster | Don Dennis | 284 | 297 | -13 |
| 1965-06-22 | @ CIN | 66 | L 4-5 | 30-37 | 8 | 0 | Bob Gibson | Joey Jay | Billy McCool | Hal Woodeshick | | 288 | 302 | -14 |
| 1965-06-22 | @ CIN | 67 | L 2-4 | 30-37 | 8 | 15,848 | Ray Washburn | John Tsitouris | John Tsitouris | Ray Washburn | | 290 | 306 | -16 |
| 1965-06-23 | @ CIN | 68 | L 2-6 | 30-38 | 8 | 11,479 | Curt Simmons | Jim Maloney | Jim Maloney | Curt Simmons | | 292 | 312 | -20 |
| 1965-06-24 | @ CIN | 69 | W 11-4 | 31-38 | 8 | 10,986 | Tracy Stallard | Jim O'Toole | Tracy Stallard | Jim O'Toole | Don Dennis | 303 | 316 | -13 |
| 1965-06-25 | vs CHN | 70 | L 4-12 | 31-39 | 8 | 17,137 | Bob Purkey | Bob Buhl | Bob Buhl | Bob Purkey | Lindy McDaniel | 307 | 328 | -21 |
| 1965-06-26 | vs CHN | 71 | W 8-1 | 32-39 | 8 | 13,746 | Steve Carlton | Cal Koonce | Hal Woodeshick | Cal Koonce | Ray Washburn | 315 | 329 | -14 |
| 1965-06-27 | vs CHN | 72 | W 8-0 | 33-40 | 8 | 0 | Bob Gibson | Ernie Broglio | Bob Gibson | Ernie Broglio | | 323 | 329 | -6 |
| 1965-06-27 | vs CHN | 73 | L 3-6 | 33-40 | 8 | 29,827 | Curt Simmons | Bob Hendley | Bob Humphreys | Don Dennis | Dick Ellsworth | 326 | 335 | -9 |
| 1965-06-28 | @ PHI | 74 | L 0-3 | 33-41 | 8 | 19,208 | Tracy Stallard | Chris Short | Chris Short | Tracy Stallard | | 326 | 338 | -12 |
| 1965-06-29 | @ PHI | 75 | L 1-7 | 33-42 | 9 | 19,219 | Bob Purkey | Bo Belinsky | Bo Belinsky | Bob Purkey | | 327 | 345 | -18 |
| 1965-06-30 | @ PIT | 76 | W 7-1 | 34-42 | 9 | 15,369 | Ray Washburn | Vern Law | Ray Washburn | Vern Law | Hal Woodeshick | 334 | 346 | -12 |
| 1965-07-01 | @ PIT | 77 | W 7-6 | 35-42 | 8 | 11,920 | Curt Simmons | Bob Veale | Hal Woodeshick | Joe Gibbon | Ray Sadecki | 341 | 352 | -11 |
| 1965-07-02 | @ NYN | 78 | W 6-3 | 36-42 | 8 | 31,527 | Bob Gibson | Frank Lary | Bob Gibson | Frank Lary | | 347 | 355 | -8 |
| 1965-07-03 | @ NYN | 79 | W 2-0 | 37-42 | 8 | 28,041 | Tracy Stallard | Jack Fisher | Tracy Stallard | Jack Fisher | Hal Woodeshick | 349 | 355 | -6 |
| 1965-07-04 | @ NYN | 80 | W 6-2 | 38-42 | 7 | 20,006 | Bob Purkey | Galen Cisco | Bob Purkey | Galen Cisco | Don Dennis | 355 | 357 | -2 |
| 1965-07-05 | vs SFN | 81 | W 3-2 | 39-42 | 7 | 20,324 | Ray Washburn | Gaylord Perry | Nelson Briles | Ron Herbel | | 358 | 359 | -1 |
| 1965-07-06 | vs SFN | 82 | W 3-2 | 40-42 | 7 | 31,229 | Curt Simmons | Juan Marichal | Curt Simmons | Juan Marichal | Hal Woodeshick | 361 | 361 | 0 |
| 1965-07-07 | vs SFN | 83 | L 2-4 | 40-43 | 7 | 24,045 | Bob Gibson | Bob Shaw | Masanori Murakami | Bob Gibson | | 363 | 365 | -2 |
| 1965-07-09 | @ CHN | 84 | W 7-3 | 41-43 | 7 | 7,863 | Tracy Stallard | Bob Buhl | Tracy Stallard | Bob Buhl | Hal Woodeshick | 370 | 368 | 2 |
| 1965-07-10 | @ CHN | 85 | L 3-5 | 41-44 | 7 | 16,298 | Ray Washburn | Dick Ellsworth | Dick Ellsworth | Ray Washburn | | 373 | 373 | 0 |
| 1965-07-11 | @ CHN | 86 | L 0-6 | 41-46 | 8 | 0 | Curt Simmons | Larry Jackson | Larry Jackson | Curt Simmons | | 373 | 379 | -6 |
| 1965-07-11 | @ CHN | 87 | L 0-6 | 41-46 | 8 | 34,579 | Ray Sadecki | Cal Koonce | Cal Koonce | Ray Sadecki | | 373 | 385 | -12 |
| 1965-07-15 | vs NYN | 88 | W 6-5 | 42-46 | 8 | 14,829 | Curt Simmons | Jack Fisher | Barney Schultz | Larry Bearnarth | Hal Woodeshick | 379 | 390 | -11 |
| 1965-07-16 | vs NYN | 89 | W 8-5 | 43-46 | 7 | 14,153 | Bob Gibson | Al Jackson | Bob Gibson | Al Jackson | Hal Woodeshick | 387 | 395 | -8 |
| 1965-07-17 | vs NYN | 90 | W 4-1 | 44-46 | 6 | 12,291 | Bob Purkey | Larry Miller | Bob Purkey | Larry Miller | Don Dennis | 391 | 396 | -5 |
| 1965-07-18 | vs PHI | 91 | W 3-1 | 45-46 | 6 | 18,846 | Tracy Stallard | Bo Belinsky | Tracy Stallard | Bo Belinsky | Hal Woodeshick | 394 | 397 | -3 |
| 1965-07-19 | vs PHI | 92 | L 2-5 | 45-47 | 6 | 16,571 | Ray Washburn | Chris Short | Chris Short | Ray Washburn | | 396 | 402 | -6 |
| 1965-07-20 | vs PHI | 93 | W 4-3 | 46-47 | 6 | 10,108 | Curt Simmons | Jim Bunning | Curt Simmons | Jim Bunning | Nelson Briles | 400 | 405 | -5 |
| 1965-07-21 | @ HOU | 94 | L 0-2 | 46-48 | 6 | 43,324 | Bob Gibson | Bob Bruce | Bob Bruce | Bob Gibson | | 400 | 407 | -7 |
| 1965-07-22 | @ HOU | 95 | L 2-3 | 46-49 | 7 | 30,668 | Bob Purkey | Larry Dierker | Larry Dierker | Bob Purkey | | 402 | 410 | -8 |
| 1965-07-23 | @ LAN | 96 | W 4-3 | 47-49 | 7 | 40,286 | Tracy Stallard | Don Drysdale | Ray Washburn | Nick Willhite | | 406 | 413 | -7 |
| 1965-07-24 | @ LAN | 97 | W 3-2 | 48-49 | 7 | 48,998 | Ray Sadecki | Sandy Koufax | Don Dennis | Ron Perranoski | Hal Woodeshick | 409 | 415 | -6 |
| 1965-07-25 | @ LAN | 98 | L 1-5 | 48-50 | 7 | 31,710 | Curt Simmons | Claude Osteen | Claude Osteen | Curt Simmons | | 410 | 420 | -10 |
| 1965-07-26 | @ SFN | 99 | W 7-4 | 49-50 | 7 | 13,869 | Bob Gibson | Juan Marichal | Bob Gibson | Juan Marichal | Don Dennis | 417 | 424 | -7 |
| 1965-07-27 | @ SFN | 100 | W 3-0 | 50-50 | 7 | 21,552 | Bob Purkey | Warren Spahn | Bob Purkey | Warren Spahn | | 420 | 424 | -4 |
| 1965-07-28 | @ SFN | 101 | L 5-8 | 50-51 | 6 | 12,711 | Tracy Stallard | Ron Herbel | Ron Herbel | Tracy Stallard | Frank Linzy | 425 | 432 | -7 |
| 1965-07-30 | vs LAN | 102 | L 2-4 | 50-52 | 7 | 29,497 | Curt Simmons | Claude Osteen | Bob Miller | Don Dennis | Ron Perranoski | 427 | 436 | -9 |
| 1965-07-31 | vs LAN | 103 | W 4-3 | 51-52 | 6 | 30,109 | Bob Gibson | Don Drysdale | Bob Gibson | Ron Perranoski | | 431 | 439 | -8 |
| 1965-08-01 | vs LAN | 104 | L 2-3 | 51-53 | 7 | 30,605 | Ray Sadecki | Sandy Koufax | Sandy Koufax | Ray Sadecki | | 433 | 442 | -9 |
| 1965-08-02 | vs LAN | 105 | W 6-5 | 52-53 | 7 | 20,518 | Tracy Stallard | Johnny Podres | Tracy Stallard | Ron Perranoski | Don Dennis | 439 | 447 | -8 |
| 1965-08-03 | vs HOU | 106 | L 7-10 | 53-54 | 7 | 0 | Bob Purkey | Larry Dierker | Larry Dierker | Bob Purkey | Ron Taylor | 446 | 457 | -11 |
| 1965-08-03 | vs HOU | 107 | W 7-0 | 53-54 | 7 | 17,818 | Ray Washburn | Turk Farrell | Ray Washburn | Turk Farrell | | 453 | 457 | -4 |
| 1965-08-04 | vs HOU | 108 | W 9-4 | 54-54 | 7 | 12,066 | Curt Simmons | Don Nottebart | Curt Simmons | Don Nottebart | | 462 | 461 | 1 |
| 1965-08-05 | vs HOU | 109 | W 3-1 | 55-54 | 7 | 11,334 | Bob Gibson | Bob Bruce | Bob Gibson | Bob Bruce | | 465 | 462 | 3 |
| 1965-08-06 | vs SFN | 110 | L 2-3 | 55-55 | 7 | 16,754 | Ray Sadecki | Gaylord Perry | Gaylord Perry | Ray Sadecki | Masanori Murakami | 467 | 465 | 2 |
| 1965-08-07 | vs SFN | 111 | L 4-10 | 55-56 | 7 | 18,737 | Tracy Stallard | Bob Shaw | Bob Shaw | Tracy Stallard | Frank Linzy | 471 | 475 | -4 |
| 1965-08-08 | vs SFN | 112 | L 4-6 | 55-57 | 7 | 21,983 | Curt Simmons | Warren Spahn | Warren Spahn | Curt Simmons | Jack Sanford | 475 | 481 | -6 |
| 1965-08-10 | @ MLN | 113 | L 3-5 | 55-58 | 7 | 7,960 | Bob Gibson | Tony Cloninger | Tony Cloninger | Bob Gibson | | 478 | 486 | -8 |
| 1965-08-11 | @ MLN | 114 | L 2-5 | 55-59 | 8 | 9,580 | Ray Washburn | Ken Johnson | Ken Johnson | Ray Washburn | | 480 | 491 | -11 |
| 1965-08-12 | @ MLN | 115 | W 5-4 | 56-59 | 8 | 7,191 | Tracy Stallard | Wade Blasingame | Bob Purkey | Phil Niekro | | 485 | 495 | -10 |
| 1965-08-13 | vs CIN | 116 | W 7-2 | 57-59 | 7 | 21,272 | Curt Simmons | Jim Maloney | Curt Simmons | Jim Maloney | Nelson Briles | 492 | 497 | -5 |
| 1965-08-14 | vs CIN | 117 | L 2-4 | 57-60 | 7 | 16,484 | Ray Sadecki | Joe Nuxhall | Joe Nuxhall | Ray Sadecki | Billy McCool | 494 | 501 | -7 |
| 1965-08-15 | vs CIN | 118 | W 12-7 | 58-60 | 7 | 19,547 | Bob Gibson | Sammy Ellis | Ray Washburn | John Tsitouris | Hal Woodeshick | 506 | 508 | -2 |
| 1965-08-16 | vs MLN | 119 | L 8-10 | 58-61 | 7 | 19,763 | Bob Purkey | Wade Blasingame | Billy O'Dell | Nelson Briles | | 514 | 518 | -4 |
| 1965-08-17 | vs MLN | 120 | L 1-4 | 58-62 | 7 | 14,656 | Tracy Stallard | Denny Lemaster | Denny Lemaster | Tracy Stallard | | 515 | 522 | -7 |
| 1965-08-18 | vs MLN | 121 | L 3-5 | 58-63 | 7 | 13,903 | Curt Simmons | Tony Cloninger | Tony Cloninger | Ray Washburn | | 518 | 527 | -9 |
| 1965-08-19 | vs MLN | 122 | W 5-4 | 59-63 | 7 | 11,493 | Ray Sadecki | Ken Johnson | Ray Sadecki | Ken Johnson | Hal Woodeshick | 523 | 531 | -8 |
| 1965-08-20 | @ NYN | 123 | W 8-1 | 60-63 | 7 | 28,055 | Bob Gibson | Al Jackson | Bob Gibson | Al Jackson | | 531 | 532 | -1 |
| 1965-08-21 | @ NYN | 124 | L 2-6 | 60-64 | 7 | 15,941 | Bob Purkey | Jack Fisher | Jack Fisher | Bob Purkey | | 533 | 538 | -5 |
| 1965-08-22 | @ NYN | 125 | L 5-7 | 60-66 | 7 | 0 | Tracy Stallard | Darrell Sutherland | Gordie Richardson | Don Dennis | Dave Eilers | 538 | 545 | -7 |
| 1965-08-22 | @ NYN | 126 | L 2-4 | 60-66 | 7 | 22,522 | Ray Washburn | Tug McGraw | Tug McGraw | Ray Washburn | | 540 | 549 | -9 |
| 1965-08-23 | vs CHN | 127 | W 10-2 | 61-66 | 7 | 13,301 | Curt Simmons | Larry Jackson | Curt Simmons | Larry Jackson | | 550 | 551 | -1 |
| 1965-08-24 | vs CHN | 128 | W 7-6 | 62-66 | 7 | 8,156 | Ray Sadecki | Bill Faul | Nelson Briles | Ted Abernathy | | 557 | 557 | 0 |
| 1965-08-25 | vs CHN | 129 | L 3-6 | 62-67 | 7 | 11,879 | Bob Gibson | Dick Ellsworth | Dick Ellsworth | Bob Gibson | Ted Abernathy | 560 | 563 | -3 |
| 1965-08-26 | vs CHN | 130 | W 7-4 | 63-67 | 7 | 10,692 | Bob Purkey | Billy Hoeft | Bob Purkey | Billy Hoeft | Ray Washburn | 567 | 567 | 0 |
| 1965-08-27 | @ CIN | 131 | W 6-5 | 64-67 | 7 | 23,595 | Tracy Stallard | Joey Jay | Hal Woodeshick | Billy McCool | Bob Gibson | 573 | 572 | 1 |
| 1965-08-28 | @ CIN | 132 | L 2-8 | 64-68 | 7 | 25,825 | Curt Simmons | Jim Maloney | Jim Maloney | Curt Simmons | Ted Davidson | 575 | 580 | -5 |
| 1965-08-29 | @ CIN | 133 | W 10-4 | 65-68 | 7 | 22,596 | Ray Sadecki | Sammy Ellis | Ray Sadecki | Sammy Ellis | | 585 | 584 | 1 |
| 1965-08-31 | @ CHN | 134 | W 3-0 | 66-68 | 7 | 4,036 | Bob Gibson | Dick Ellsworth | Bob Gibson | Dick Ellsworth | | 588 | 584 | 4 |
| 1965-09-01 | @ CHN | 135 | W 9-0 | 67-68 | 7 | 6,397 | Tracy Stallard | Larry Jackson | Tracy Stallard | Larry Jackson | | 597 | 584 | 13 |
| 1965-09-02 | @ CHN | 136 | L 3-5 | 67-69 | 7 | 5,014 | Curt Simmons | Bob Hendley | Bob Hendley | Curt Simmons | Ted Abernathy | 600 | 589 | 11 |
| 1965-09-03 | vs NYN | 137 | L 3-6 | 67-70 | 7 | 13,774 | Ray Sadecki | Dick Selma | Dick Selma | Ray Sadecki | Gordie Richardson | 603 | 595 | 8 |
| 1965-09-05 | vs NYN | 138 | W 3-0 | 69-70 | 7 | 0 | Bob Gibson | Tug McGraw | Bob Gibson | Tug McGraw | | 606 | 595 | 11 |
| 1965-09-05 | vs NYN | 139 | W 3-1 | 69-70 | 7 | 18,952 | Ray Washburn | Rob Gardner | Ray Washburn | Rob Gardner | Nelson Briles | 609 | 596 | 13 |
| 1965-09-06 | vs PHI | 140 | W 10-3 | 70-71 | 7 | 0 | Tracy Stallard | Bo Belinsky | Tracy Stallard | Bo Belinsky | | 619 | 599 | 20 |
| 1965-09-06 | vs PHI | 141 | L 5-10 | 70-71 | 7 | 21,867 | Curt Simmons | Chris Short | Chris Short | Curt Simmons | | 624 | 609 | 15 |
| 1965-09-08 | vs PIT | 142 | L 1-2 | 70-72 | 7 | 9,714 | Ray Sadecki | Bob Friend | Bob Friend | Ray Sadecki | | 625 | 611 | 14 |
| 1965-09-10 | @ PHI | 143 | L 4-5 | 70-73 | 7 | 16,333 | Bob Gibson | Jim Bunning | Fergie Jenkins | Hal Woodeshick | | 629 | 616 | 13 |
| 1965-09-11 | @ PHI | 144 | L 1-3 | 70-74 | 7 | 13,558 | Tracy Stallard | Chris Short | Chris Short | Tracy Stallard | | 630 | 619 | 11 |
| 1965-09-14 | @ PIT | 145 | W 3-2 | 71-74 | 7 | 8,224 | Bob Gibson | Bob Friend | Bob Gibson | Bob Friend | Hal Woodeshick | 633 | 621 | 12 |
| 1965-09-15 | @ PIT | 146 | W 7-3 | 72-74 | 7 | 6,725 | Ray Sadecki | Bob Veale | Ray Sadecki | Bob Veale | Nelson Briles | 640 | 624 | 16 |
| 1965-09-16 | @ PIT | 147 | W 2-1 | 73-74 | 7 | 4,788 | Tracy Stallard | Tommie Sisk | Tracy Stallard | Al McBean | Hal Woodeshick | 642 | 625 | 17 |
| 1965-09-17 | vs LAN | 148 | L 2-3 | 73-75 | 7 | 19,042 | Curt Simmons | Don Drysdale | Don Drysdale | Curt Simmons | Ron Perranoski | 644 | 628 | 16 |
| 1965-09-18 | vs LAN | 149 | L 0-1 | 73-76 | 7 | 29,063 | Ray Washburn | Sandy Koufax | Sandy Koufax | Ray Washburn | | 644 | 629 | 15 |
| 1965-09-19 | vs LAN | 150 | L 0-5 | 73-77 | 7 | 23,941 | Bob Gibson | Claude Osteen | Claude Osteen | Bob Gibson | Ron Perranoski | 644 | 634 | 10 |
| 1965-09-21 | vs HOU | 151 | W 3-0 | 74-77 | 7 | 4,348 | Ray Sadecki | Chris Zachary | Ray Sadecki | Chris Zachary | Hal Woodeshick | 647 | 634 | 13 |
| 1965-09-22 | vs HOU | 152 | W 4-1 | 75-77 | 7 | 5,896 | Larry Jaster | Jim Ray | Larry Jaster | Jim Ray | | 651 | 635 | 16 |
| 1965-09-24 | @ LAN | 153 | L 3-4 | 75-78 | 7 | 37,450 | Bob Gibson | Claude Osteen | Ron Perranoski | Bob Gibson | | 654 | 639 | 15 |
| 1965-09-25 | @ LAN | 154 | L 0-2 | 75-79 | 7 | 31,532 | Nelson Briles | Sandy Koufax | Sandy Koufax | Nelson Briles | | 654 | 641 | 13 |
| 1965-09-26 | @ LAN | 155 | L 0-1 | 75-80 | 7 | 40,317 | Ray Sadecki | Don Drysdale | Don Drysdale | Ray Sadecki | | 654 | 642 | 12 |
| 1965-09-27 | @ SFN | 156 | L 4-8 | 75-81 | 7 | 8,280 | Tracy Stallard | Warren Spahn | Frank Linzy | Tracy Stallard | | 658 | 650 | 8 |
| 1965-09-28 | @ SFN | 157 | W 9-1 | 76-81 | 7 | 18,449 | Larry Jaster | Ron Herbel | Larry Jaster | Ron Herbel | | 667 | 651 | 16 |
| 1965-09-29 | @ SFN | 158 | W 8-6 | 77-81 | 7 | 10,345 | Bob Gibson | Bob Shaw | Bob Gibson | Bob Shaw | Hal Woodeshick | 675 | 657 | 18 |
| 1965-09-30 | @ HOU | 159 | W 19-8 | 78-81 | 7 | 7,494 | Nelson Briles | Jim Ray | Nelson Briles | Jim Ray | Dennis Aust | 694 | 665 | 29 |
| 1965-10-01 | @ HOU | 160 | L 2-4 | 78-82 | 7 | 10,247 | Ray Sadecki | Robin Roberts | Robin Roberts | Ray Sadecki | Claude Raymond | 696 | 669 | 27 |
| 1965-10-02 | @ HOU | 161 | W 6-3 | 79-82 | 7 | 12,698 | Larry Jaster | Don Arlich | Larry Jaster | Ron Taylor | | 702 | 672 | 30 |
| 1965-10-03 | @ HOU | 162 | W 5-2 | 80-82 | 7 | 13,535 | Bob Gibson | Carroll Sembera | Bob Gibson | Carroll Sembera | | 707 | 674 | 33 |