| 1965-04-12 | vs SFN | 1 | W 1-0 | 1-0 | 2 | 28,189 | Bob Veale | Juan Marichal | Bob Veale | Juan Marichal | | 1 | 0 | 1 |
| 1965-04-13 | vs SFN | 2 | W 5-2 | 2-0 | 2 | 4,444 | Bob Friend | Jack Sanford | Bob Friend | Jack Sanford | Al McBean | 6 | 2 | 4 |
| 1965-04-14 | vs LAN | 3 | L 1-3 | 2-1 | 3 | 7,770 | Joe Gibbon | Claude Osteen | Claude Osteen | Joe Gibbon | | 7 | 5 | 2 |
| 1965-04-17 | vs HOU | 4 | W 3-2 | 3-1 | 2 | 6,129 | Bob Veale | Don Nottebart | Roy Face | Jim Owens | | 10 | 7 | 3 |
| 1965-04-18 | vs HOU | 5 | L 1-3 | 4-2 | 3 | 0 | Vern Law | Bob Bruce | Bob Bruce | Vern Law | | 11 | 10 | 1 |
| 1965-04-18 | vs HOU | 6 | W 5-4 | 4-2 | 3 | 7,176 | Don Cardwell | Don Larsen | Al McBean | Ken MacKenzie | | 16 | 14 | 2 |
| 1965-04-20 | @ SFN | 7 | W 3-1 | 5-2 | 2 | 37,784 | Bob Friend | Bobby Bolin | Bob Friend | Bobby Bolin | Al McBean | 19 | 15 | 4 |
| 1965-04-21 | @ SFN | 8 | L 2-3 | 5-3 | 4 | 12,022 | Joe Gibbon | Juan Marichal | Juan Marichal | Joe Gibbon | | 21 | 18 | 3 |
| 1965-04-23 | @ HOU | 9 | L 3-4 | 5-4 | 4 | 25,399 | Bob Veale | Bob Bruce | Dave Giusti | Al McBean | | 24 | 22 | 2 |
| 1965-04-24 | @ HOU | 10 | L 0-5 | 5-5 | 4 | 30,736 | Vern Law | Turk Farrell | Turk Farrell | Vern Law | | 24 | 27 | -3 |
| 1965-04-25 | @ HOU | 11 | L 4-5 | 5-6 | 7 | 19,116 | Don Cardwell | Ken Johnson | Claude Raymond | Roy Face | | 28 | 32 | -4 |
| 1965-04-26 | @ HOU | 12 | L 0-2 | 5-7 | 7 | 15,053 | Bob Friend | Dave Giusti | Dave Giusti | Bob Friend | | 28 | 34 | -6 |
| 1965-04-27 | @ LAN | 13 | L 4-5 | 5-8 | 9 | 17,630 | Joe Gibbon | Johnny Podres | Howie Reed | Joe Gibbon | Bob Miller | 32 | 39 | -7 |
| 1965-04-28 | @ LAN | 14 | W 2-0 | 6-8 | 7 | 17,464 | Bob Veale | Claude Osteen | Bob Veale | Claude Osteen | | 34 | 39 | -5 |
| 1965-04-30 | @ SLN | 15 | L 2-3 | 6-9 | 8 | 20,401 | Vern Law | Ray Sadecki | Ray Washburn | Vern Law | | 36 | 42 | -6 |
| 1965-05-01 | @ SLN | 16 | L 2-3 | 6-10 | 9 | 9,689 | Don Cardwell | Tracy Stallard | Tracy Stallard | Don Cardwell | | 38 | 45 | -7 |
| 1965-05-02 | @ SLN | 17 | L 5-9 | 6-12 | 9 | 0 | Bob Friend | Bob Gibson | Bob Gibson | Bob Friend | Ron Taylor | 43 | 54 | -11 |
| 1965-05-02 | @ SLN | 18 | L 4-5 | 6-12 | 9 | 23,630 | Bob Veale | Bob Purkey | Ray Washburn | Al McBean | | 47 | 59 | -12 |
| 1965-05-04 | @ CHN | 19 | W 6-3 | 7-12 | 9 | 1,527 | Joe Gibbon | Cal Koonce | Al McBean | Ernie Broglio | | 53 | 62 | -9 |
| 1965-05-05 | @ CHN | 20 | L 1-3 | 7-13 | 9 | 2,093 | Vern Law | Bob Buhl | Bob Buhl | Vern Law | | 54 | 65 | -11 |
| 1965-05-06 | @ CHN | 21 | L 3-5 | 7-14 | 10 | 1,471 | Don Cardwell | Larry Jackson | Larry Jackson | Don Schwall | Ted Abernathy | 57 | 70 | -13 |
| 1965-05-07 | vs CIN | 22 | W 5-4 | 8-14 | 9 | 9,052 | Bob Friend | Sammy Ellis | Tommie Sisk | Roger Craig | | 62 | 74 | -12 |
| 1965-05-08 | vs CIN | 23 | L 1-10 | 8-15 | 10 | 5,790 | Bob Veale | Jim Maloney | Jim Maloney | Bob Veale | | 63 | 84 | -21 |
| 1965-05-09 | vs CIN | 24 | L 3-5 | 8-16 | 10 | 6,858 | Joe Gibbon | Joey Jay | Gerry Arrigo | Al McBean | Billy McCool | 66 | 89 | -23 |
| 1965-05-11 | vs MLN | 25 | W 4-3 | 8-16 | 10 | 4,694 | Don Cardwell | Wade Blasingame | Don Cardwell | Wade Blasingame | Al McBean | 70 | 92 | -22 |
| 1965-05-12 | vs MLN | 26 | L 4-5 | 8-16 | 10 | 4,464 | Bob Friend | Denny Lemaster | Denny Lemaster | Tom Butters | Billy O'Dell | 74 | 97 | -23 |
| 1965-05-13 | vs MLN | 27 | L 4-5 | 8-16 | 10 | 4,165 | Bob Veale | Tony Cloninger | Phil Niekro | Don Schwall | | 78 | 102 | -24 |
| 1965-05-14 | vs SLN | 28 | L 7-8 | 8-17 | 10 | 9,986 | Joe Gibbon | Ray Sadecki | Barney Schultz | Al McBean | Bob Purkey | 85 | 110 | -25 |
| 1965-05-15 | vs SLN | 29 | L 1-5 | 8-18 | 10 | 5,148 | Vern Law | Tracy Stallard | Tracy Stallard | Vern Law | | 86 | 115 | -29 |
| 1965-05-16 | vs SLN | 30 | L 3-6 | 8-20 | 10 | 0 | Don Cardwell | Bob Gibson | Bob Gibson | Don Cardwell | | 89 | 121 | -32 |
| 1965-05-16 | vs SLN | 31 | L 1-5 | 8-20 | 10 | 11,081 | Bob Veale | Ray Washburn | Ray Washburn | Bob Veale | Bob Purkey | 90 | 126 | -36 |
| 1965-05-19 | @ CIN | 32 | L 1-3 | 8-21 | 10 | 6,743 | Joe Gibbon | Jim Maloney | Billy McCool | Joe Gibbon | | 91 | 129 | -38 |
| 1965-05-20 | @ CIN | 33 | L 3-11 | 8-22 | 10 | 5,209 | Bob Friend | Sammy Ellis | Sammy Ellis | Bob Friend | | 94 | 140 | -46 |
| 1965-05-21 | @ MLN | 34 | W 6-1 | 8-22 | 10 | 2,679 | Vern Law | Denny Lemaster | Vern Law | Denny Lemaster | Al McBean | 100 | 141 | -41 |
| 1965-05-22 | @ MLN | 35 | W 9-4 | 8-22 | 10 | 2,662 | Don Cardwell | Tony Cloninger | Tommie Sisk | Tony Cloninger | Al McBean | 109 | 145 | -36 |
| 1965-05-23 | @ MLN | 36 | W 10-1 | 8-22 | 10 | 2,053 | Bob Veale | Bob Sadowski | Bob Veale | Bob Sadowski | | 119 | 146 | -27 |
| 1965-05-24 | vs CHN | 37 | W 6-4 | 9-22 | 10 | 5,360 | Joe Gibbon | Lew Burdette | Don Schwall | Ernie Broglio | Al McBean | 125 | 150 | -25 |
| 1965-05-25 | vs CHN | 38 | W 7-6 | 10-22 | 10 | 6,403 | Bob Friend | Larry Jackson | Frank Carpin | Jack Warner | | 132 | 156 | -24 |
| 1965-05-26 | @ PHI | 39 | W 5-3 | 11-22 | 10 | 10,212 | Don Cardwell | Art Mahaffey | Tommie Sisk | Art Mahaffey | | 137 | 159 | -22 |
| 1965-05-28 | @ NYN | 40 | W 6-1 | 12-22 | 10 | 32,011 | Bob Veale | Warren Spahn | Bob Veale | Warren Spahn | | 143 | 160 | -17 |
| 1965-05-29 | @ NYN | 41 | W 7-4 | 13-22 | 10 | 11,297 | Joe Gibbon | Frank Lary | Don Schwall | Frank Lary | Al McBean | 150 | 164 | -14 |
| 1965-05-30 | @ NYN | 42 | W 9-1 | 15-22 | 9 | 0 | Bob Friend | Al Jackson | Bob Friend | Al Jackson | | 159 | 165 | -6 |
| 1965-05-30 | @ NYN | 43 | W 12-0 | 15-22 | 9 | 41,552 | Vern Law | Tom Parsons | Vern Law | Tom Parsons | | 171 | 165 | 6 |
| 1965-05-31 | vs PHI | 44 | W 5-2 | 16-22 | 9 | 16,366 | Don Cardwell | Chris Short | Don Cardwell | Chris Short | Al McBean | 176 | 167 | 9 |
| 1965-06-01 | vs PHI | 45 | W 4-0 | 17-22 | 9 | 10,478 | Bob Veale | Art Mahaffey | Bob Veale | Art Mahaffey | | 180 | 167 | 13 |
| 1965-06-03 | vs NYN | 46 | L 6-8 | 17-23 | 9 | 9,169 | Joe Gibbon | Galen Cisco | Galen Cisco | Joe Gibbon | Tom Parsons | 186 | 175 | 11 |
| 1965-06-04 | vs NYN | 47 | L 1-2 | 17-24 | 9 | 11,026 | Bob Friend | Jack Fisher | Jack Fisher | Bob Friend | | 187 | 177 | 10 |
| 1965-06-05 | vs NYN | 48 | W 9-0 | 18-24 | 9 | 6,581 | Vern Law | Gary Kroll | Vern Law | Gary Kroll | | 196 | 177 | 19 |
| 1965-06-06 | vs NYN | 49 | W 5-3 | 20-24 | 8 | 0 | Don Cardwell | Al Jackson | Don Cardwell | Al Jackson | | 201 | 180 | 21 |
| 1965-06-06 | vs NYN | 50 | W 3-0 | 20-24 | 8 | 16,387 | Bob Veale | Warren Spahn | Bob Veale | Warren Spahn | | 204 | 180 | 24 |
| 1965-06-08 | vs HOU | 51 | W 7-6 | 21-24 | 7 | 8,084 | Bob Friend | Turk Farrell | Joe Gibbon | Hal Woodeshick | | 211 | 186 | 25 |
| 1965-06-09 | vs HOU | 52 | W 11-3 | 22-24 | 6 | 9,412 | Vern Law | Don Nottebart | Vern Law | Don Nottebart | | 222 | 189 | 33 |
| 1965-06-10 | vs HOU | 53 | W 4-2 | 23-24 | 5 | 9,839 | Bob Veale | Bob Bruce | Bob Veale | Bob Bruce | | 226 | 191 | 35 |
| 1965-06-11 | vs SFN | 54 | W 5-3 | 24-24 | 5 | 24,708 | Don Cardwell | Bill Hands | Don Cardwell | Bill Hands | Frank Carpin | 231 | 194 | 37 |
| 1965-06-12 | vs SFN | 55 | L 0-4 | 24-25 | 6 | 12,213 | Bob Friend | Bob Shaw | Bob Shaw | Bob Friend | Frank Linzy | 231 | 198 | 33 |
| 1965-06-13 | vs SFN | 56 | W 2-1 | 25-25 | 5 | 20,091 | Vern Law | Gaylord Perry | Vern Law | Gaylord Perry | | 233 | 199 | 34 |
| 1965-06-14 | @ SLN | 57 | L 2-5 | 25-26 | 6 | 5,265 | Bob Veale | Steve Carlton | Ron Taylor | Bob Veale | | 235 | 204 | 31 |
| 1965-06-15 | @ SLN | 58 | W 10-6 | 26-26 | 5 | 10,428 | Don Cardwell | Ray Sadecki | Frank Carpin | Tracy Stallard | Al McBean | 245 | 210 | 35 |
| 1965-06-16 | @ SLN | 59 | W 10-9 | 27-26 | 5 | 10,480 | Bob Friend | Ray Washburn | Don Schwall | Barney Schultz | | 255 | 219 | 36 |
| 1965-06-17 | @ SLN | 60 | W 4-1 | 28-26 | 5 | 11,905 | Vern Law | Bob Gibson | Vern Law | Bob Gibson | | 259 | 220 | 39 |
| 1965-06-18 | @ HOU | 61 | L 1-5 | 28-27 | 5 | 24,286 | Bob Veale | Bob Bruce | Bob Bruce | Bob Veale | | 260 | 225 | 35 |
| 1965-06-19 | @ HOU | 62 | W 5-3 | 29-27 | 5 | 27,785 | Don Cardwell | Claude Raymond | Joe Gibbon | Don Nottebart | Frank Carpin | 265 | 228 | 37 |
| 1965-06-20 | @ SFN | 63 | L 3-4 | 29-29 | 6 | 0 | Bob Friend | Bob Shaw | Ron Herbel | Al McBean | | 268 | 232 | 36 |
| 1965-06-20 | @ SFN | 64 | L 3-7 | 29-29 | 6 | 39,757 | Don Schwall | Bobby Bolin | Bobby Bolin | Don Schwall | Frank Linzy | 271 | 239 | 32 |
| 1965-06-22 | @ SFN | 65 | W 6-0 | 30-29 | 5 | 10,537 | Vern Law | Gaylord Perry | Vern Law | Gaylord Perry | | 277 | 239 | 38 |
| 1965-06-23 | @ SFN | 66 | L 1-6 | 30-30 | 6 | 8,209 | Bob Veale | Jack Sanford | Ron Herbel | Bob Veale | Frank Linzy | 278 | 245 | 33 |
| 1965-06-24 | @ LAN | 67 | W 13-3 | 31-30 | 6 | 28,867 | Don Cardwell | Don Drysdale | Don Cardwell | Don Drysdale | | 291 | 248 | 43 |
| 1965-06-25 | @ LAN | 68 | L 1-4 | 31-31 | 6 | 32,060 | Bob Friend | Sandy Koufax | Sandy Koufax | Bob Friend | | 292 | 252 | 40 |
| 1965-06-26 | @ LAN | 69 | W 6-1 | 32-31 | 5 | 21,769 | Vern Law | Claude Osteen | Vern Law | Claude Osteen | | 298 | 253 | 45 |
| 1965-06-27 | @ LAN | 70 | W 10-2 | 33-31 | 5 | 33,161 | Bob Veale | Johnny Podres | Bob Veale | Johnny Podres | | 308 | 255 | 53 |
| 1965-06-28 | vs CIN | 71 | W 5-4 | 34-31 | 5 | 15,302 | Don Cardwell | Jim O'Toole | Don Cardwell | Jim O'Toole | Al McBean | 313 | 259 | 54 |
| 1965-06-29 | vs CIN | 72 | W 2-1 | 35-32 | 5 | 0 | Bob Friend | Sammy Ellis | Don Schwall | Billy McCool | | 315 | 260 | 55 |
| 1965-06-29 | vs CIN | 73 | L 5-7 | 35-32 | 5 | 28,589 | Joe Gibbon | Joe Nuxhall | Joe Nuxhall | Joe Gibbon | Roger Craig | 320 | 267 | 53 |
| 1965-06-30 | vs SLN | 74 | L 1-7 | 35-33 | 6 | 15,369 | Vern Law | Ray Washburn | Ray Washburn | Vern Law | Hal Woodeshick | 321 | 274 | 47 |
| 1965-07-01 | vs SLN | 75 | L 6-7 | 35-34 | 6 | 11,920 | Bob Veale | Curt Simmons | Hal Woodeshick | Joe Gibbon | Ray Sadecki | 327 | 281 | 46 |
| 1965-07-02 | vs MLN | 76 | W 8-3 | 35-34 | 6 | 12,352 | Don Cardwell | Tony Cloninger | Don Cardwell | Tony Cloninger | Don Schwall | 335 | 284 | 51 |
| 1965-07-03 | vs MLN | 77 | W 9-5 | 35-34 | 6 | 9,460 | Bob Friend | Bob Sadowski | Bob Friend | Bob Sadowski | Frank Carpin | 344 | 289 | 55 |
| 1965-07-04 | vs MLN | 78 | L 2-5 | 35-34 | 6 | 16,145 | Vern Law | Hank Fischer | Hank Fischer | Vern Law | | 346 | 294 | 52 |
| 1965-07-05 | @ PHI | 79 | L 1-3 | 35-36 | 6 | 0 | Bob Veale | Jim Bunning | Jim Bunning | Bob Veale | | 347 | 297 | 50 |
| 1965-07-05 | @ PHI | 80 | L 2-6 | 35-36 | 6 | 25,330 | Wilbur Wood | Art Mahaffey | Ed Roebuck | Wilbur Wood | Gary Wagner | 349 | 303 | 46 |
| 1965-07-06 | @ PHI | 81 | W 8-4 | 36-36 | 6 | 17,357 | Don Cardwell | Ray Culp | Don Cardwell | Ray Culp | | 357 | 307 | 50 |
| 1965-07-07 | @ PHI | 82 | L 0-1 | 36-37 | 6 | 16,632 | Bob Friend | Chris Short | Chris Short | Bob Friend | | 357 | 308 | 49 |
| 1965-07-08 | vs LAN | 83 | L 4-9 | 36-38 | 6 | 22,247 | Vern Law | Claude Osteen | Howie Reed | Vern Law | | 361 | 317 | 44 |
| 1965-07-09 | vs LAN | 84 | W 4-1 | 37-38 | 6 | 16,284 | Bob Veale | Johnny Podres | Bob Veale | Nick Willhite | | 365 | 318 | 47 |
| 1965-07-10 | vs LAN | 85 | L 4-8 | 37-39 | 6 | 14,880 | Don Cardwell | Don Drysdale | Don Drysdale | Don Cardwell | Ron Perranoski | 369 | 326 | 43 |
| 1965-07-11 | vs LAN | 86 | L 2-4 | 38-40 | 6 | 0 | Joe Gibbon | Sandy Koufax | Sandy Koufax | Joe Gibbon | | 371 | 330 | 41 |
| 1965-07-11 | vs LAN | 87 | W 4-3 | 38-40 | 6 | 37,631 | Bob Friend | Claude Osteen | Frank Carpin | Bob Miller | | 375 | 333 | 42 |
| 1965-07-15 | @ MLN | 88 | L 6-9 | 38-40 | 6 | 5,180 | Vern Law | Ken Johnson | Ken Johnson | Vern Law | Dan Osinski | 381 | 342 | 39 |
| 1965-07-16 | @ MLN | 89 | L 2-12 | 38-40 | 6 | 6,090 | Bob Veale | Wade Blasingame | Wade Blasingame | Bob Veale | | 383 | 354 | 29 |
| 1965-07-17 | @ MLN | 90 | L 5-6 | 38-41 | 7 | 4,518 | Don Cardwell | Bob Sadowski | Billy O'Dell | Frank Carpin | | 388 | 360 | 28 |
| 1965-07-18 | @ CIN | 91 | W 6-5 | 39-42 | 7 | 0 | Bob Friend | Jim Maloney | Don Schwall | Roger Craig | | 394 | 365 | 29 |
| 1965-07-18 | @ CIN | 92 | L 4-8 | 39-42 | 7 | 25,637 | Joe Gibbon | Joey Jay | Joey Jay | Joe Gibbon | Billy McCool | 398 | 373 | 25 |
| 1965-07-19 | @ CIN | 93 | W 3-1 | 40-42 | 7 | 11,096 | Vern Law | Joe Nuxhall | Vern Law | Joe Nuxhall | | 401 | 374 | 27 |
| 1965-07-20 | @ CIN | 94 | W 8-6 | 41-42 | 7 | 9,669 | Bob Veale | Sammy Ellis | Bob Veale | Sammy Ellis | Al McBean | 409 | 380 | 29 |
| 1965-07-21 | vs NYN | 95 | L 0-1 | 41-43 | 7 | 22,670 | Don Cardwell | Al Jackson | Al Jackson | Don Cardwell | | 409 | 381 | 28 |
| 1965-07-23 | @ CHN | 96 | W 6-0 | 42-43 | 6 | 5,288 | Bob Friend | Dick Ellsworth | Bob Friend | Dick Ellsworth | | 415 | 381 | 34 |
| 1965-07-24 | @ CHN | 97 | W 8-5 | 43-43 | 6 | 9,578 | Vern Law | Larry Jackson | Vern Law | Larry Jackson | Al McBean | 423 | 386 | 37 |
| 1965-07-25 | @ CHN | 98 | W 3-2 | 44-44 | 6 | 0 | Bob Veale | Cal Koonce | Vern Law | Lindy McDaniel | | 426 | 388 | 38 |
| 1965-07-25 | @ CHN | 99 | L 0-5 | 44-44 | 6 | 20,777 | Don Cardwell | Bill Faul | Bill Faul | Don Cardwell | | 426 | 393 | 33 |
| 1965-07-27 | vs PHI | 100 | L 1-3 | 45-45 | 6 | 0 | Bob Friend | Chris Short | Gary Wagner | Bob Friend | Jack Baldschun | 427 | 396 | 31 |
| 1965-07-27 | vs PHI | 101 | W 3-2 | 45-45 | 6 | 21,832 | Tommie Sisk | Ray Herbert | Don Schwall | Gary Wagner | | 430 | 398 | 32 |
| 1965-07-28 | vs PHI | 102 | L 0-1 | 45-46 | 7 | 13,207 | Vern Law | Jim Bunning | Jack Baldschun | Don Schwall | | 430 | 399 | 31 |
| 1965-07-29 | vs PHI | 103 | L 0-5 | 45-47 | 7 | 10,160 | Bob Veale | Ray Culp | Ray Culp | Bob Veale | | 430 | 404 | 26 |
| 1965-07-30 | vs CHN | 104 | W 3-1 | 46-47 | 6 | 11,382 | Don Cardwell | Ernie Broglio | Don Cardwell | Ernie Broglio | | 433 | 405 | 28 |
| 1965-07-31 | vs CHN | 105 | L 6-7 | 46-48 | 7 | 7,431 | Tommie Sisk | Bob Buhl | Bob Buhl | Tommie Sisk | Ted Abernathy | 439 | 412 | 27 |
| 1965-08-01 | vs CHN | 106 | W 8-2 | 48-48 | 6 | 0 | Al McBean | Dick Ellsworth | Al McBean | Dick Ellsworth | Don Schwall | 447 | 414 | 33 |
| 1965-08-01 | vs CHN | 107 | W 3-1 | 48-48 | 6 | 14,741 | Joe Gibbon | Larry Jackson | Joe Gibbon | Larry Jackson | Don Schwall | 450 | 415 | 35 |
| 1965-08-03 | @ NYN | 108 | W 7-0 | 49-48 | 6 | 24,597 | Vern Law | Galen Cisco | Vern Law | Galen Cisco | | 457 | 415 | 42 |
| 1965-08-04 | @ NYN | 109 | W 3-0 | 50-48 | 6 | 20,703 | Bob Veale | Jack Fisher | Bob Veale | Jack Fisher | Don Schwall | 460 | 415 | 45 |
| 1965-08-05 | @ NYN | 110 | W 11-3 | 51-48 | 6 | 19,374 | Don Cardwell | Al Jackson | Don Cardwell | Al Jackson | | 471 | 418 | 53 |
| 1965-08-06 | @ PHI | 111 | L 0-4 | 51-49 | 6 | 22,155 | Bob Friend | Jim Bunning | Jim Bunning | Bob Friend | | 471 | 422 | 49 |
| 1965-08-07 | @ PHI | 112 | W 4-3 | 52-49 | 6 | 8,204 | Vern Law | Ray Culp | Al McBean | Ray Culp | | 475 | 425 | 50 |
| 1965-08-08 | @ PHI | 113 | W 7-1 | 53-50 | 6 | 0 | Bob Veale | Chris Short | Bob Veale | Chris Short | | 482 | 426 | 56 |
| 1965-08-08 | @ PHI | 114 | L 2-5 | 53-50 | 6 | 29,260 | Tommie Sisk | Ray Herbert | Ray Herbert | Tommie Sisk | | 484 | 431 | 53 |
| 1965-08-10 | @ SFN | 115 | L 3-4 | 53-51 | 6 | 14,457 | Don Cardwell | Juan Marichal | Juan Marichal | Don Cardwell | | 487 | 435 | 52 |
| 1965-08-12 | @ SFN | 116 | L 3-4 | 54-52 | 6 | 0 | Bob Friend | Bob Shaw | Frank Linzy | Don Schwall | | 490 | 439 | 51 |
| 1965-08-12 | @ SFN | 117 | W 5-2 | 54-52 | 6 | 20,435 | Vern Law | Gaylord Perry | Vern Law | Gaylord Perry | | 495 | 441 | 54 |
| 1965-08-13 | @ LAN | 118 | L 1-3 | 54-53 | 6 | 32,551 | Bob Veale | Claude Osteen | Claude Osteen | Bob Veale | | 496 | 444 | 52 |
| 1965-08-14 | @ LAN | 119 | L 0-1 | 54-54 | 6 | 29,237 | Don Cardwell | Sandy Koufax | Sandy Koufax | Don Cardwell | | 496 | 445 | 51 |
| 1965-08-15 | @ LAN | 120 | W 4-2 | 55-54 | 6 | 25,175 | Tommie Sisk | Don Drysdale | Tommie Sisk | Don Drysdale | Al McBean | 500 | 447 | 53 |
| 1965-08-16 | @ HOU | 121 | L 0-3 | 55-55 | 6 | 26,549 | Bob Friend | Robin Roberts | Robin Roberts | Bob Friend | | 500 | 450 | 50 |
| 1965-08-17 | @ HOU | 122 | W 8-6 | 56-55 | 6 | 24,863 | Vern Law | Turk Farrell | Vern Law | Turk Farrell | Al McBean | 508 | 456 | 52 |
| 1965-08-18 | @ HOU | 123 | W 8-7 | 57-55 | 6 | 30,470 | Bob Veale | Don Nottebart | Bob Veale | Don Nottebart | Al McBean | 516 | 463 | 53 |
| 1965-08-20 | vs MLN | 124 | L 3-4 | 57-55 | 6 | 18,653 | Don Cardwell | Wade Blasingame | Wade Blasingame | Don Cardwell | | 519 | 467 | 52 |
| 1965-08-21 | vs MLN | 125 | W 3-0 | 58-55 | 6 | 10,259 | Bob Friend | Denny Lemaster | Bob Friend | Denny Lemaster | | 522 | 467 | 55 |
| 1965-08-22 | vs MLN | 126 | W 5-4 | 58-55 | 6 | 14,112 | Bob Veale | Tony Cloninger | Don Schwall | Dan Osinski | | 527 | 471 | 56 |
| 1965-08-23 | vs SFN | 127 | W 6-2 | 59-55 | 6 | 15,016 | Vern Law | Warren Spahn | Vern Law | Warren Spahn | | 533 | 473 | 60 |
| 1965-08-24 | vs SFN | 128 | W 5-2 | 60-55 | 6 | 15,497 | Don Cardwell | Bob Shaw | Don Cardwell | Bob Shaw | | 538 | 475 | 63 |
| 1965-08-25 | vs SFN | 129 | W 3-3 | 61-55 | 6 | 13,348 | Bob Friend | Bobby Bolin | | | | 541 | 478 | 63 |
| 1965-08-26 | vs SFN | 130 | W 8-0 | 63-55 | 5 | 0 | Bob Veale | Ron Herbel | Bob Veale | Ron Herbel | | 549 | 478 | 71 |
| 1965-08-26 | vs SFN | 131 | W 6-5 | 63-55 | 5 | 18,893 | Tommie Sisk | Gaylord Perry | Tommie Sisk | Gaylord Perry | Al McBean | 555 | 483 | 72 |
| 1965-08-27 | vs HOU | 132 | W 10-9 | 64-55 | 5 | 12,917 | Vern Law | Turk Farrell | Al McBean | Mike Cuellar | | 565 | 492 | 73 |
| 1965-08-28 | vs HOU | 133 | L 6-9 | 64-56 | 5 | 7,051 | Don Cardwell | Larry Dierker | Larry Dierker | Don Schwall | Dave Giusti | 571 | 501 | 70 |
| 1965-08-29 | vs HOU | 134 | W 4-2 | 65-56 | 5 | 30,002 | Bob Friend | Don Nottebart | Wilbur Wood | Don Nottebart | Joe Gibbon | 575 | 503 | 72 |
| 1965-09-01 | vs LAN | 135 | W 3-2 | 67-56 | 5 | 0 | Tommie Sisk | Sandy Koufax | Joe Gibbon | Sandy Koufax | | 578 | 505 | 73 |
| 1965-09-01 | vs LAN | 136 | W 2-1 | 67-56 | 5 | 26,394 | Vern Law | Don Drysdale | Vern Law | Don Drysdale | | 580 | 506 | 74 |
| 1965-09-02 | vs LAN | 137 | L 1-7 | 67-57 | 5 | 29,200 | Bob Veale | Claude Osteen | Claude Osteen | Bob Veale | Ron Perranoski | 581 | 513 | 68 |
| 1965-09-03 | @ MLN | 138 | L 3-4 | 67-57 | 5 | 5,349 | Don Cardwell | Ken Johnson | Ken Johnson | Don Cardwell | Dan Osinski | 584 | 517 | 67 |
| 1965-09-04 | @ MLN | 139 | L 3-8 | 67-57 | 5 | 2,471 | Bob Friend | Tony Cloninger | Tony Cloninger | Bob Friend | Billy O'Dell | 587 | 525 | 62 |
| 1965-09-05 | @ MLN | 140 | W 2-1 | 68-57 | 5 | 20,409 | Tommie Sisk | Bob Sadowski | Tommie Sisk | Bob Sadowski | | 589 | 526 | 63 |
| 1965-09-06 | @ CIN | 141 | W 3-1 | 70-57 | 5 | 0 | Bob Veale | Joey Jay | Bob Veale | Joey Jay | | 592 | 527 | 65 |
| 1965-09-06 | @ CIN | 142 | W 4-2 | 70-57 | 5 | 16,323 | Joe Gibbon | Jim Maloney | Al McBean | Jim Maloney | | 596 | 529 | 67 |
| 1965-09-07 | @ CIN | 143 | L 0-5 | 70-58 | 5 | 7,153 | Don Cardwell | Sammy Ellis | Sammy Ellis | Don Cardwell | | 596 | 534 | 62 |
| 1965-09-08 | @ SLN | 144 | W 2-1 | 71-58 | 5 | 9,714 | Bob Friend | Ray Sadecki | Bob Friend | Ray Sadecki | | 598 | 535 | 63 |
| 1965-09-10 | vs CIN | 145 | W 7-0 | 72-58 | 5 | 20,694 | Bob Veale | Joey Jay | Bob Veale | Joey Jay | | 605 | 535 | 70 |
| 1965-09-11 | vs CIN | 146 | L 2-3 | 72-59 | 5 | 9,570 | Tommie Sisk | Jim Maloney | Jim Maloney | Tommie Sisk | | 607 | 538 | 69 |
| 1965-09-13 | vs CIN | 147 | W 8-4 | 73-59 | 5 | 1,299 | Vern Law | Sammy Ellis | Vern Law | Sammy Ellis | | 615 | 542 | 73 |
| 1965-09-14 | vs SLN | 148 | L 2-3 | 73-60 | 5 | 8,224 | Bob Friend | Bob Gibson | Bob Gibson | Bob Friend | Hal Woodeshick | 617 | 545 | 72 |
| 1965-09-15 | vs SLN | 149 | L 3-7 | 73-61 | 5 | 6,725 | Bob Veale | Ray Sadecki | Ray Sadecki | Bob Veale | Nelson Briles | 620 | 552 | 68 |
| 1965-09-16 | vs SLN | 150 | L 1-2 | 73-62 | 5 | 4,788 | Tommie Sisk | Tracy Stallard | Tracy Stallard | Al McBean | Hal Woodeshick | 621 | 554 | 67 |
| 1965-09-17 | vs PHI | 151 | W 4-0 | 74-62 | 5 | 8,987 | Don Cardwell | Ray Culp | Don Cardwell | Ray Culp | | 625 | 554 | 71 |
| 1965-09-18 | vs PHI | 152 | W 4-3 | 75-62 | 5 | 5,313 | Bob Friend | Jim Bunning | Roy Face | Morrie Steevens | | 629 | 557 | 72 |
| 1965-09-19 | vs PHI | 153 | W 1-0 | 76-62 | 4 | 10,026 | Bob Veale | Chris Short | Bob Veale | Jack Baldschun | | 630 | 557 | 73 |
| 1965-09-20 | vs NYN | 154 | W 10-0 | 77-62 | 4 | 3,892 | Tommie Sisk | Jack Fisher | Tommie Sisk | Jack Fisher | | 640 | 557 | 83 |
| 1965-09-21 | vs NYN | 155 | W 6-5 | 78-62 | 4 | 4,660 | Don Cardwell | Al Jackson | Roy Face | Dave Eilers | | 646 | 562 | 84 |
| 1965-09-22 | vs NYN | 156 | W 6-2 | 79-62 | 4 | 4,964 | Bob Friend | Tug McGraw | Bob Friend | Tug McGraw | | 652 | 564 | 88 |
| 1965-09-25 | @ CHN | 157 | L 3-6 | 79-63 | 4 | 2,903 | Bob Veale | Bob Hendley | Bob Hendley | Bob Veale | Ted Abernathy | 655 | 570 | 85 |
| 1965-09-26 | @ CHN | 158 | W 5-3 | 80-63 | 4 | 2,097 | Don Cardwell | Cal Koonce | Don Schwall | Ted Abernathy | | 660 | 573 | 87 |
| 1965-09-28 | @ NYN | 159 | L 0-1 | 80-64 | 4 | 6,995 | Tommie Sisk | Dennis Ribant | Darrell Sutherland | Roy Face | | 660 | 574 | 86 |
| 1965-09-29 | @ NYN | 160 | W 4-2 | 81-64 | 3 | 2,807 | Bob Friend | Dick Selma | Don Schwall | Dick Selma | Al McBean | 664 | 576 | 88 |
| 1965-10-01 | vs CHN | 161 | W 2-1 | 81-64 | 3 | 3,441 | Bob Veale | Dick Ellsworth | Roy Face | Dick Ellsworth | | 666 | 577 | 89 |
| 1965-10-02 | vs CHN | 162 | W 3-0 | 81-64 | 3 | 3,626 | Don Cardwell | Larry Jackson | Don Cardwell | Larry Jackson | | 669 | 577 | 92 |
| 1965-10-03 | vs CHN | 163 | W 6-3 | 81-64 | 3 | 26,527 | Tommie Sisk | Bill Faul | Roy Face | Ted Abernathy | Al McBean | 675 | 580 | 95 |