| 1965-04-12 | @ HOU | 1 | W 2-0 | 1-0 | 3 | 42,652 | Chris Short | Bob Bruce | Chris Short | Bob Bruce | | 2 | 0 | 2 |
| 1965-04-14 | vs SFN | 2 | L 2-5 | 1-1 | 4 | 31,922 | Jim Bunning | Gaylord Perry | Gaylord Perry | Jim Bunning | Bob Shaw | 4 | 5 | -1 |
| 1965-04-17 | vs LAN | 3 | W 3-2 | 2-1 | 3 | 17,021 | Chris Short | Don Drysdale | Chris Short | Don Drysdale | Jack Baldschun | 7 | 7 | 0 |
| 1965-04-18 | vs LAN | 4 | L 2-6 | 2-2 | 7 | 11,107 | Bo Belinsky | Sandy Koufax | Sandy Koufax | Bo Belinsky | | 9 | 13 | -4 |
| 1965-04-19 | vs HOU | 5 | W 8-0 | 3-2 | 5 | 4,668 | Jim Bunning | Turk Farrell | Jim Bunning | Turk Farrell | | 17 | 13 | 4 |
| 1965-04-20 | vs HOU | 6 | W 2-1 | 4-2 | 3 | 6,627 | Ray Herbert | Ken Johnson | Jack Baldschun | Hal Woodeshick | | 19 | 14 | 5 |
| 1965-04-21 | vs HOU | 7 | L 4-11 | 4-3 | 5 | 8,267 | Chris Short | Don Nottebart | Dave Giusti | Chris Short | | 23 | 25 | -2 |
| 1965-04-23 | @ LAN | 8 | L 0-4 | 4-4 | 5 | 29,120 | Jim Bunning | Johnny Podres | Johnny Podres | Jim Bunning | | 23 | 29 | -6 |
| 1965-04-24 | @ LAN | 9 | L 3-9 | 4-5 | 7 | 36,500 | Bo Belinsky | Claude Osteen | Claude Osteen | Bo Belinsky | | 26 | 38 | -12 |
| 1965-04-25 | @ LAN | 10 | W 6-4 | 5-5 | 4 | 25,766 | Ray Herbert | Don Drysdale | Ray Herbert | Don Drysdale | Jack Baldschun | 32 | 42 | -10 |
| 1965-04-26 | @ LAN | 11 | W 4-3 | 6-5 | 4 | 24,703 | Chris Short | Sandy Koufax | Chris Short | Sandy Koufax | Jack Baldschun | 36 | 45 | -9 |
| 1965-04-27 | @ SFN | 12 | L 13-14 | 6-6 | 5 | 10,705 | Jim Bunning | Gaylord Perry | Bob Shaw | Ed Roebuck | | 49 | 59 | -10 |
| 1965-04-28 | @ SFN | 13 | L 3-9 | 6-7 | 6 | 7,922 | Ray Culp | Jack Sanford | Ron Herbel | Ray Culp | | 52 | 68 | -16 |
| 1965-04-30 | @ MLN | 14 | L 1-7 | 6-8 | 7 | 2,923 | Ray Herbert | Tony Cloninger | Tony Cloninger | Ray Herbert | | 53 | 75 | -22 |
| 1965-05-01 | @ MLN | 15 | L 1-6 | 6-9 | 8 | 2,486 | Jim Bunning | Wade Blasingame | Wade Blasingame | Jim Bunning | | 54 | 81 | -27 |
| 1965-05-02 | @ MLN | 16 | W 6-0 | 8-9 | 6 | 0 | Chris Short | Denny Lemaster | Chris Short | Denny Lemaster | | 60 | 81 | -21 |
| 1965-05-02 | @ MLN | 17 | W 10-7 | 8-9 | 6 | 8,630 | Bo Belinsky | Hank Fischer | Jack Baldschun | Billy O'Dell | | 70 | 88 | -18 |
| 1965-05-04 | @ NYN | 18 | L 1-2 | 8-10 | 8 | 17,321 | Ray Herbert | Al Jackson | Al Jackson | Ray Herbert | | 71 | 90 | -19 |
| 1965-05-05 | @ NYN | 19 | W 1-0 | 9-10 | 7 | 14,134 | Jim Bunning | Warren Spahn | Jim Bunning | Warren Spahn | | 72 | 90 | -18 |
| 1965-05-07 | vs SLN | 20 | L 0-2 | 9-11 | 8 | 14,499 | Chris Short | Bob Gibson | Bob Gibson | Chris Short | | 72 | 92 | -20 |
| 1965-05-08 | vs SLN | 21 | W 9-8 | 10-11 | 6 | 19,596 | Bo Belinsky | Curt Simmons | Ray Culp | Nelson Briles | | 81 | 100 | -19 |
| 1965-05-09 | vs SLN | 22 | W 4-2 | 11-11 | 5 | 12,930 | Art Mahaffey | Ray Sadecki | Art Mahaffey | Ray Sadecki | Ed Roebuck | 85 | 102 | -17 |
| 1965-05-10 | vs SLN | 23 | W 4-2 | 12-11 | 4 | 14,454 | Jim Bunning | Tracy Stallard | Ed Roebuck | Bob Purkey | | 89 | 104 | -15 |
| 1965-05-11 | vs CIN | 24 | L 1-9 | 12-12 | 5 | 12,438 | Chris Short | John Tsitouris | John Tsitouris | Chris Short | Gerry Arrigo | 90 | 113 | -23 |
| 1965-05-12 | vs CIN | 25 | L 3-4 | 12-13 | 6 | 12,237 | Ray Herbert | Sammy Ellis | Sammy Ellis | Ray Culp | Jim O'Toole | 93 | 117 | -24 |
| 1965-05-13 | vs CIN | 26 | W 7-6 | 13-13 | 5 | 10,573 | Bo Belinsky | Jim Maloney | Jack Baldschun | Jim Duffalo | | 100 | 123 | -23 |
| 1965-05-14 | vs MLN | 27 | W 5-2 | 14-13 | 4 | 19,629 | Art Mahaffey | Billy O'Dell | Art Mahaffey | Billy O'Dell | | 105 | 125 | -20 |
| 1965-05-15 | vs MLN | 28 | W 6-4 | 15-13 | 3 | 8,794 | Jim Bunning | Wade Blasingame | Jim Bunning | Wade Blasingame | Jack Baldschun | 111 | 129 | -18 |
| 1965-05-16 | vs MLN | 29 | L 6-8 | 15-14 | 4 | 16,632 | Chris Short | Denny Lemaster | Billy O'Dell | Jack Baldschun | Wade Blasingame | 117 | 137 | -20 |
| 1965-05-17 | @ SLN | 30 | W 2-1 | 16-14 | 4 | 10,748 | Bo Belinsky | Curt Simmons | Bo Belinsky | Curt Simmons | | 119 | 138 | -19 |
| 1965-05-18 | @ SLN | 31 | L 2-8 | 16-15 | 4 | 8,593 | Art Mahaffey | Ray Sadecki | Ray Sadecki | Art Mahaffey | | 121 | 146 | -25 |
| 1965-05-19 | @ SLN | 32 | L 6-7 | 16-16 | 7 | 18,660 | Jim Bunning | Tracy Stallard | Bob Purkey | Ed Roebuck | | 127 | 153 | -26 |
| 1965-05-20 | @ SLN | 33 | L 2-12 | 16-17 | 7 | 13,741 | Chris Short | Bob Gibson | Bob Gibson | Chris Short | | 129 | 165 | -36 |
| 1965-05-21 | @ CIN | 34 | L 5-6 | 16-18 | 7 | 14,263 | Art Mahaffey | Jim O'Toole | Joey Jay | Art Mahaffey | | 134 | 171 | -37 |
| 1965-05-22 | @ CIN | 35 | L 4-9 | 16-19 | 8 | 21,296 | Bo Belinsky | Joe Nuxhall | Joe Nuxhall | Bo Belinsky | Gerry Arrigo | 138 | 180 | -42 |
| 1965-05-23 | @ CIN | 36 | W 4-3 | 17-19 | 7 | 14,942 | Ray Culp | John Tsitouris | Ed Roebuck | Gerry Arrigo | | 142 | 183 | -41 |
| 1965-05-24 | vs NYN | 37 | L 2-6 | 17-21 | 7 | 0 | Jim Bunning | Warren Spahn | Warren Spahn | Jim Bunning | | 144 | 189 | -45 |
| 1965-05-24 | vs NYN | 38 | L 1-4 | 17-21 | 7 | 21,701 | Chris Short | Frank Lary | Frank Lary | Chris Short | Tug McGraw | 145 | 193 | -48 |
| 1965-05-25 | vs NYN | 39 | W 10-3 | 18-21 | 7 | 6,344 | Ray Herbert | Al Jackson | Ray Herbert | Al Jackson | | 155 | 196 | -41 |
| 1965-05-26 | vs PIT | 40 | L 3-5 | 18-22 | 7 | 10,212 | Art Mahaffey | Don Cardwell | Tommie Sisk | Art Mahaffey | | 158 | 201 | -43 |
| 1965-05-28 | vs CHN | 41 | W 3-1 | 19-22 | 8 | 13,663 | Ray Culp | Bob Buhl | Ray Culp | Bob Buhl | Chris Short | 161 | 202 | -41 |
| 1965-05-29 | vs CHN | 42 | W 4-2 | 20-22 | 7 | 4,962 | Jim Bunning | Larry Jackson | Jim Bunning | Larry Jackson | | 165 | 204 | -39 |
| 1965-05-30 | vs CHN | 43 | L 1-4 | 20-23 | 8 | 11,696 | Ray Herbert | Dick Ellsworth | Dick Ellsworth | Ray Herbert | | 166 | 208 | -42 |
| 1965-05-31 | @ PIT | 44 | L 2-5 | 20-24 | 8 | 16,366 | Chris Short | Don Cardwell | Don Cardwell | Chris Short | Al McBean | 168 | 213 | -45 |
| 1965-06-01 | @ PIT | 45 | L 0-4 | 20-25 | 8 | 10,478 | Art Mahaffey | Bob Veale | Bob Veale | Art Mahaffey | | 168 | 217 | -49 |
| 1965-06-04 | @ CHN | 46 | W 6-0 | 21-25 | 8 | 3,497 | Jim Bunning | Larry Jackson | Jim Bunning | Larry Jackson | | 174 | 217 | -43 |
| 1965-06-05 | @ CHN | 47 | L 8-9 | 21-26 | 8 | 6,049 | Chris Short | Dick Ellsworth | Lindy McDaniel | Gary Wagner | | 182 | 226 | -44 |
| 1965-06-06 | @ CHN | 48 | W 2-1 | 23-26 | 7 | 0 | Ray Culp | Bob Buhl | Ray Culp | Bob Buhl | | 184 | 227 | -43 |
| 1965-06-06 | @ CHN | 49 | W 10-9 | 23-26 | 7 | 16,845 | Art Mahaffey | Larry Jackson | Gary Wagner | Larry Jackson | Ed Roebuck | 194 | 236 | -42 |
| 1965-06-07 | vs LAN | 50 | L 3-14 | 23-27 | 7 | 23,345 | Lew Burdette | Sandy Koufax | Sandy Koufax | Lew Burdette | | 197 | 250 | -53 |
| 1965-06-08 | vs LAN | 51 | L 1-2 | 23-28 | 8 | 14,975 | Jim Bunning | Claude Osteen | Claude Osteen | Jim Bunning | Ron Perranoski | 198 | 252 | -54 |
| 1965-06-09 | vs LAN | 52 | W 7-3 | 24-28 | 8 | 16,241 | Chris Short | Mike Kekich | Chris Short | Mike Kekich | | 205 | 255 | -50 |
| 1965-06-10 | vs LAN | 53 | W 4-0 | 25-28 | 7 | 19,467 | Ray Herbert | Johnny Podres | Ray Herbert | Johnny Podres | | 209 | 255 | -46 |
| 1965-06-11 | vs HOU | 54 | W 6-5 | 26-28 | 6 | 16,825 | Ray Culp | Dave Giusti | Gary Wagner | Jim Owens | | 215 | 260 | -45 |
| 1965-06-12 | vs HOU | 55 | W 5-4 | 27-28 | 5 | 7,870 | Jim Bunning | Turk Farrell | Ed Roebuck | Turk Farrell | | 220 | 264 | -44 |
| 1965-06-13 | vs HOU | 56 | W 5-0 | 28-28 | 6 | 12,936 | Chris Short | Claude Raymond | Chris Short | Claude Raymond | | 225 | 264 | -39 |
| 1965-06-15 | @ MLN | 57 | L 7-12 | 28-29 | 6 | 4,065 | Art Mahaffey | Tony Cloninger | Tony Cloninger | Art Mahaffey | Phil Niekro | 232 | 276 | -44 |
| 1965-06-16 | @ MLN | 58 | W 6-2 | 29-29 | 6 | 3,479 | Jim Bunning | Denny Lemaster | Jim Bunning | Denny Lemaster | | 238 | 278 | -40 |
| 1965-06-17 | @ MLN | 59 | L 2-4 | 29-30 | 6 | 3,674 | Ray Culp | Ken Johnson | Billy O'Dell | Ray Culp | | 240 | 282 | -42 |
| 1965-06-18 | @ LAN | 60 | W 4-2 | 30-30 | 6 | 30,401 | Chris Short | Johnny Podres | Chris Short | Johnny Podres | | 244 | 284 | -40 |
| 1965-06-19 | @ LAN | 61 | L 0-4 | 30-31 | 6 | 20,518 | Ray Herbert | Nick Willhite | Nick Willhite | Ray Herbert | Ron Perranoski | 244 | 288 | -44 |
| 1965-06-20 | @ HOU | 62 | W 3-2 | 32-31 | 5 | 0 | Jim Bunning | Larry Dierker | Jim Bunning | Ron Taylor | Gary Wagner | 247 | 290 | -43 |
| 1965-06-20 | @ HOU | 63 | W 7-1 | 32-31 | 5 | 42,648 | Bo Belinsky | Mike Cuellar | Bo Belinsky | Mike Cuellar | | 254 | 291 | -37 |
| 1965-06-21 | @ HOU | 64 | L 2-6 | 32-32 | 6 | 18,271 | Ray Culp | Turk Farrell | Turk Farrell | Ray Culp | | 256 | 297 | -41 |
| 1965-06-22 | @ HOU | 65 | W 7-2 | 33-32 | 6 | 19,331 | Chris Short | Bob Bruce | Chris Short | Bob Bruce | Gary Wagner | 263 | 299 | -36 |
| 1965-06-24 | @ SFN | 66 | W 3-1 | 34-32 | 5 | 8,738 | Jim Bunning | Juan Marichal | Jim Bunning | Juan Marichal | Ray Herbert | 266 | 300 | -34 |
| 1965-06-25 | @ SFN | 67 | L 1-4 | 34-33 | 5 | 12,948 | Bo Belinsky | Bob Shaw | Bob Shaw | Bo Belinsky | | 267 | 304 | -37 |
| 1965-06-26 | @ SFN | 68 | L 5-6 | 34-34 | 6 | 18,247 | Chris Short | Gaylord Perry | Masanori Murakami | Gary Wagner | | 272 | 310 | -38 |
| 1965-06-27 | @ SFN | 69 | W 6-0 | 35-34 | 6 | 27,015 | Ray Culp | Bobby Bolin | Ray Culp | Bobby Bolin | | 278 | 310 | -32 |
| 1965-06-28 | vs SLN | 70 | W 3-0 | 36-34 | 6 | 19,208 | Chris Short | Tracy Stallard | Chris Short | Tracy Stallard | | 281 | 310 | -29 |
| 1965-06-29 | vs SLN | 71 | W 7-1 | 37-34 | 6 | 19,219 | Bo Belinsky | Bob Purkey | Bo Belinsky | Bob Purkey | | 288 | 311 | -23 |
| 1965-06-30 | vs MLN | 72 | W 3-2 | 38-34 | 5 | 17,771 | Jim Bunning | Wade Blasingame | Gary Wagner | Wade Blasingame | | 291 | 313 | -22 |
| 1965-07-01 | vs MLN | 73 | W 2-1 | 39-34 | 5 | 17,792 | Ray Culp | Ken Johnson | Ray Culp | Ken Johnson | | 293 | 314 | -21 |
| 1965-07-02 | vs CIN | 74 | W 4-3 | 40-34 | 4 | 22,516 | Chris Short | Jim O'Toole | Jack Baldschun | Gerry Arrigo | | 297 | 317 | -20 |
| 1965-07-03 | vs CIN | 75 | L 8-10 | 40-35 | 5 | 25,152 | Ray Herbert | Sammy Ellis | Billy McCool | Ed Roebuck | Roger Craig | 305 | 327 | -22 |
| 1965-07-04 | vs CIN | 76 | L 1-4 | 40-36 | 5 | 14,749 | Bo Belinsky | Joe Nuxhall | Joe Nuxhall | Bo Belinsky | | 306 | 331 | -25 |
| 1965-07-05 | vs PIT | 77 | W 3-1 | 42-36 | 4 | 0 | Jim Bunning | Bob Veale | Jim Bunning | Bob Veale | | 309 | 332 | -23 |
| 1965-07-05 | vs PIT | 78 | W 6-2 | 42-36 | 4 | 25,330 | Art Mahaffey | Wilbur Wood | Ed Roebuck | Wilbur Wood | Gary Wagner | 315 | 334 | -19 |
| 1965-07-06 | vs PIT | 79 | L 4-8 | 42-37 | 4 | 17,357 | Ray Culp | Don Cardwell | Don Cardwell | Ray Culp | | 319 | 342 | -23 |
| 1965-07-07 | vs PIT | 80 | W 1-0 | 43-37 | 4 | 16,632 | Chris Short | Bob Friend | Chris Short | Bob Friend | | 320 | 342 | -22 |
| 1965-07-08 | vs SFN | 81 | L 2-10 | 44-38 | 5 | 0 | Lew Burdette | Gaylord Perry | Gaylord Perry | Lew Burdette | | 322 | 352 | -30 |
| 1965-07-08 | vs SFN | 82 | W 4-2 | 44-38 | 5 | 37,110 | Ray Herbert | Jack Sanford | Ray Herbert | Jack Sanford | | 326 | 354 | -28 |
| 1965-07-09 | vs SFN | 83 | W 10-2 | 45-38 | 3 | 27,954 | Jim Bunning | Jack Sanford | Jim Bunning | Jack Sanford | | 336 | 356 | -20 |
| 1965-07-10 | vs SFN | 84 | L 0-7 | 45-39 | 4 | 32,031 | Ray Culp | Juan Marichal | Juan Marichal | Ray Culp | | 336 | 363 | -27 |
| 1965-07-15 | @ CIN | 85 | L 1-8 | 45-40 | 5 | 15,606 | Chris Short | Joe Nuxhall | Joe Nuxhall | Chris Short | | 337 | 371 | -34 |
| 1965-07-16 | @ CIN | 86 | L 1-5 | 45-41 | 5 | 18,584 | Jim Bunning | Sammy Ellis | Sammy Ellis | Jim Bunning | | 338 | 376 | -38 |
| 1965-07-17 | @ CIN | 87 | W 14-7 | 46-41 | 5 | 8,225 | Ray Culp | John Tsitouris | Ed Roebuck | John Tsitouris | | 352 | 383 | -31 |
| 1965-07-18 | @ SLN | 88 | L 1-3 | 46-42 | 5 | 18,846 | Bo Belinsky | Tracy Stallard | Tracy Stallard | Bo Belinsky | Hal Woodeshick | 353 | 386 | -33 |
| 1965-07-19 | @ SLN | 89 | W 5-2 | 47-42 | 5 | 16,571 | Chris Short | Ray Washburn | Chris Short | Ray Washburn | | 358 | 388 | -30 |
| 1965-07-20 | @ SLN | 90 | L 3-4 | 47-43 | 5 | 10,108 | Jim Bunning | Curt Simmons | Curt Simmons | Jim Bunning | Nelson Briles | 361 | 392 | -31 |
| 1965-07-21 | @ CHN | 91 | L 7-8 | 47-44 | 5 | 9,585 | Ray Culp | Cal Koonce | Bob Hendley | Bo Belinsky | | 368 | 400 | -32 |
| 1965-07-22 | @ CHN | 92 | L 6-10 | 47-45 | 5 | 7,468 | Ray Herbert | Bob Buhl | Bob Buhl | Ray Herbert | Ted Abernathy | 374 | 410 | -36 |
| 1965-07-23 | @ NYN | 93 | L 2-3 | 47-46 | 5 | 38,533 | Chris Short | Jack Fisher | Jack Fisher | Jack Baldschun | | 376 | 413 | -37 |
| 1965-07-24 | @ NYN | 94 | W 5-1 | 48-46 | 5 | 36,921 | Jim Bunning | Tom Parsons | Jim Bunning | Tom Parsons | | 381 | 414 | -33 |
| 1965-07-25 | @ NYN | 95 | L 1-8 | 49-47 | 5 | 0 | Bo Belinsky | Galen Cisco | Galen Cisco | Bo Belinsky | Gary Kroll | 382 | 422 | -40 |
| 1965-07-25 | @ NYN | 96 | W 3-1 | 49-47 | 5 | 36,921 | Ray Culp | Al Jackson | Ray Culp | Al Jackson | | 385 | 423 | -38 |
| 1965-07-27 | @ PIT | 97 | W 3-1 | 50-48 | 5 | 0 | Chris Short | Bob Friend | Gary Wagner | Bob Friend | Jack Baldschun | 388 | 424 | -36 |
| 1965-07-27 | @ PIT | 98 | L 2-3 | 50-48 | 5 | 21,832 | Ray Herbert | Tommie Sisk | Don Schwall | Gary Wagner | | 390 | 427 | -37 |
| 1965-07-28 | @ PIT | 99 | W 1-0 | 51-48 | 5 | 13,207 | Jim Bunning | Vern Law | Jack Baldschun | Don Schwall | | 391 | 427 | -36 |
| 1965-07-29 | @ PIT | 100 | W 5-0 | 52-48 | 5 | 10,160 | Ray Culp | Bob Veale | Ray Culp | Bob Veale | | 396 | 427 | -31 |
| 1965-07-30 | vs NYN | 101 | W 5-3 | 53-48 | 5 | 16,429 | Lew Burdette | Al Jackson | Lew Burdette | Al Jackson | Gary Wagner | 401 | 430 | -29 |
| 1965-07-31 | vs NYN | 102 | L 3-4 | 53-49 | 5 | 10,207 | Chris Short | Jack Fisher | Gary Kroll | Jack Baldschun | Gordie Richardson | 404 | 434 | -30 |
| 1965-08-01 | vs NYN | 103 | W 3-2 | 54-49 | 5 | 8,935 | Jim Bunning | Tom Parsons | Jim Bunning | Tom Parsons | Gary Wagner | 407 | 436 | -29 |
| 1965-08-03 | vs CHN | 104 | L 0-2 | 54-50 | 5 | 17,171 | Ray Culp | Bill Faul | Bill Faul | Ray Culp | | 407 | 438 | -31 |
| 1965-08-04 | vs CHN | 105 | W 7-2 | 55-50 | 5 | 13,515 | Chris Short | Bob Buhl | Chris Short | Bob Buhl | | 414 | 440 | -26 |
| 1965-08-05 | vs CHN | 106 | W 4-3 | 56-50 | 5 | 14,867 | Lew Burdette | Dick Ellsworth | Lew Burdette | Dick Ellsworth | Bo Belinsky | 418 | 443 | -25 |
| 1965-08-06 | vs PIT | 107 | W 4-0 | 57-50 | 5 | 22,155 | Jim Bunning | Bob Friend | Jim Bunning | Bob Friend | | 422 | 443 | -21 |
| 1965-08-07 | vs PIT | 108 | L 3-4 | 57-51 | 5 | 8,204 | Ray Culp | Vern Law | Al McBean | Ray Culp | | 425 | 447 | -22 |
| 1965-08-08 | vs PIT | 109 | L 1-7 | 58-52 | 5 | 0 | Chris Short | Bob Veale | Bob Veale | Chris Short | | 426 | 454 | -28 |
| 1965-08-08 | vs PIT | 110 | W 5-2 | 58-52 | 5 | 29,260 | Ray Herbert | Tommie Sisk | Ray Herbert | Tommie Sisk | | 431 | 456 | -25 |
| 1965-08-09 | @ HOU | 111 | L 0-8 | 58-53 | 5 | 31,209 | Lew Burdette | Robin Roberts | Robin Roberts | Lew Burdette | | 431 | 464 | -33 |
| 1965-08-10 | @ HOU | 112 | W 2-0 | 59-53 | 5 | 24,533 | Jim Bunning | Bob Bruce | Jim Bunning | Bob Bruce | | 433 | 464 | -31 |
| 1965-08-11 | @ HOU | 113 | W 5-1 | 60-53 | 5 | 28,224 | Ray Culp | Danny Coombs | Ray Culp | Danny Coombs | | 438 | 465 | -27 |
| 1965-08-12 | @ HOU | 114 | W 7-3 | 61-53 | 5 | 22,011 | Chris Short | Turk Farrell | Chris Short | Turk Farrell | Ed Roebuck | 445 | 468 | -23 |
| 1965-08-13 | @ SFN | 115 | W 3-2 | 62-53 | 5 | 24,275 | Ray Herbert | Warren Spahn | Bo Belinsky | Warren Spahn | Gary Wagner | 448 | 470 | -22 |
| 1965-08-14 | @ SFN | 116 | W 4-2 | 63-53 | 5 | 23,087 | Jim Bunning | Juan Marichal | Jim Bunning | Juan Marichal | Jack Baldschun | 452 | 472 | -20 |
| 1965-08-15 | @ SFN | 117 | L 9-15 | 63-54 | 5 | 26,931 | Ray Culp | Masanori Murakami | Bill Henry | Ray Culp | Jack Sanford | 461 | 487 | -26 |
| 1965-08-16 | @ LAN | 118 | W 6-1 | 64-54 | 5 | 22,611 | Chris Short | Johnny Podres | Chris Short | Johnny Podres | | 467 | 488 | -21 |
| 1965-08-17 | @ LAN | 119 | L 2-4 | 64-55 | 5 | 23,144 | Ray Herbert | Claude Osteen | Claude Osteen | Ray Herbert | Ron Perranoski | 469 | 492 | -23 |
| 1965-08-18 | @ LAN | 120 | W 6-3 | 65-55 | 5 | 38,267 | Jim Bunning | Sandy Koufax | Gary Wagner | Jim Brewer | | 475 | 495 | -20 |
| 1965-08-20 | vs CIN | 121 | L 2-3 | 65-56 | 5 | 28,709 | Chris Short | Sammy Ellis | Sammy Ellis | Gary Wagner | | 477 | 498 | -21 |
| 1965-08-21 | vs CIN | 122 | L 1-2 | 65-57 | 5 | 10,000 | Ray Culp | Joe Nuxhall | Joe Nuxhall | Jack Baldschun | Billy McCool | 478 | 500 | -22 |
| 1965-08-22 | vs CIN | 123 | W 6-5 | 66-57 | 5 | 8,431 | Jim Bunning | John Tsitouris | Jim Bunning | Roger Craig | Gary Wagner | 484 | 505 | -21 |
| 1965-08-24 | vs HOU | 124 | L 3-4 | 66-58 | 5 | 13,863 | Chris Short | Don Nottebart | Don Nottebart | Gary Wagner | | 487 | 509 | -22 |
| 1965-08-25 | vs HOU | 125 | L 6-7 | 66-59 | 5 | 11,066 | Ray Culp | Bob Bruce | Ron Taylor | Jack Baldschun | Jim Owens | 493 | 516 | -23 |
| 1965-08-26 | vs HOU | 126 | L 4-6 | 66-60 | 6 | 21,805 | Jim Bunning | Robin Roberts | Dave Giusti | Gary Wagner | Jim Owens | 497 | 522 | -25 |
| 1965-08-27 | vs LAN | 127 | L 8-9 | 66-61 | 6 | 26,740 | Ray Herbert | Don Drysdale | Don Drysdale | Ray Herbert | Howie Reed | 505 | 531 | -26 |
| 1965-08-28 | vs LAN | 128 | L 4-8 | 66-62 | 6 | 27,439 | Chris Short | John Purdin | Jim Brewer | Chris Short | Sandy Koufax | 509 | 539 | -30 |
| 1965-08-29 | vs LAN | 129 | W 13-3 | 67-62 | 6 | 21,744 | Ray Culp | Claude Osteen | Ray Culp | Claude Osteen | | 522 | 542 | -20 |
| 1965-08-31 | vs SFN | 130 | L 1-2 | 68-63 | 6 | 0 | Jim Bunning | Ron Herbel | Frank Linzy | Gary Wagner | | 523 | 544 | -21 |
| 1965-08-31 | vs SFN | 131 | W 2-0 | 68-63 | 6 | 33,060 | Lew Burdette | Warren Spahn | Lew Burdette | Warren Spahn | | 525 | 544 | -19 |
| 1965-09-02 | vs SFN | 132 | W 4-3 | 69-64 | 6 | 0 | Chris Short | Juan Marichal | Chris Short | Juan Marichal | | 529 | 547 | -18 |
| 1965-09-02 | vs SFN | 133 | L 2-5 | 69-64 | 6 | 30,410 | Ray Herbert | Bob Shaw | Frank Linzy | Jack Baldschun | | 531 | 552 | -21 |
| 1965-09-03 | @ CIN | 134 | L 7-16 | 69-65 | 6 | 11,421 | Ray Culp | Jim O'Toole | Roger Craig | Grant Jackson | | 538 | 568 | -30 |
| 1965-09-04 | @ CIN | 135 | L 4-5 | 69-66 | 6 | 17,469 | Jim Bunning | John Tsitouris | Joey Jay | Jim Bunning | | 542 | 573 | -31 |
| 1965-09-05 | @ CIN | 136 | L 9-10 | 69-67 | 6 | 18,119 | Lew Burdette | Sammy Ellis | Billy McCool | Jack Baldschun | | 551 | 583 | -32 |
| 1965-09-06 | @ SLN | 137 | L 3-10 | 70-68 | 6 | 0 | Bo Belinsky | Tracy Stallard | Tracy Stallard | Bo Belinsky | | 554 | 593 | -39 |
| 1965-09-06 | @ SLN | 138 | W 10-5 | 70-68 | 6 | 21,867 | Chris Short | Curt Simmons | Chris Short | Curt Simmons | | 564 | 598 | -34 |
| 1965-09-08 | @ MLN | 139 | W 6-5 | 71-68 | 6 | 3,417 | Ray Culp | Ken Johnson | Ray Culp | Ken Johnson | Chris Short | 570 | 603 | -33 |
| 1965-09-10 | vs SLN | 140 | W 5-4 | 72-68 | 6 | 16,333 | Jim Bunning | Bob Gibson | Fergie Jenkins | Hal Woodeshick | | 575 | 607 | -32 |
| 1965-09-11 | vs SLN | 141 | W 3-1 | 73-68 | 6 | 13,558 | Chris Short | Tracy Stallard | Chris Short | Tracy Stallard | | 578 | 608 | -30 |
| 1965-09-13 | vs MLN | 142 | W 4-3 | 74-68 | 6 | 5,647 | Ray Culp | Ken Johnson | Ray Culp | Phil Niekro | | 582 | 611 | -29 |
| 1965-09-14 | vs MLN | 143 | W 2-0 | 75-68 | 6 | 11,050 | Jim Bunning | Hank Fischer | Jim Bunning | Hank Fischer | | 584 | 611 | -27 |
| 1965-09-15 | vs MLN | 144 | L 2-4 | 75-69 | 6 | 10,932 | Chris Short | Tony Cloninger | Tony Cloninger | Chris Short | Dan Osinski | 586 | 615 | -29 |
| 1965-09-16 | vs MLN | 145 | W 8-6 | 76-69 | 6 | 11,336 | Lew Burdette | Bob Sadowski | Gary Wagner | Denny Lemaster | Fergie Jenkins | 594 | 621 | -27 |
| 1965-09-17 | @ PIT | 146 | L 0-4 | 76-70 | 6 | 8,987 | Ray Culp | Don Cardwell | Don Cardwell | Ray Culp | | 594 | 625 | -31 |
| 1965-09-18 | @ PIT | 147 | L 3-4 | 76-71 | 6 | 5,313 | Jim Bunning | Bob Friend | Roy Face | Morrie Steevens | | 597 | 629 | -32 |
| 1965-09-19 | @ PIT | 148 | L 0-1 | 76-72 | 6 | 10,026 | Chris Short | Bob Veale | Bob Veale | Jack Baldschun | | 597 | 630 | -33 |
| 1965-09-20 | @ MLN | 149 | W 4-1 | 77-72 | 6 | 812 | Ray Culp | Wade Blasingame | Ray Culp | Wade Blasingame | | 601 | 631 | -30 |
| 1965-09-21 | @ CHN | 150 | L 5-7 | 77-73 | 6 | 892 | Grant Jackson | Dick Ellsworth | Ted Abernathy | Fergie Jenkins | | 606 | 638 | -32 |
| 1965-09-23 | @ CHN | 151 | W 11-5 | 79-73 | 6 | 0 | Jim Bunning | Larry Jackson | Jim Bunning | Larry Jackson | | 617 | 643 | -26 |
| 1965-09-23 | @ CHN | 152 | W 7-4 | 79-73 | 6 | 1,598 | Chris Short | Bill Faul | Chris Short | Bill Faul | | 624 | 647 | -23 |
| 1965-09-25 | vs NYN | 153 | W 4-1 | 80-74 | 6 | 0 | Ray Culp | Larry Bearnarth | Ray Culp | Larry Bearnarth | | 628 | 648 | -20 |
| 1965-09-25 | vs NYN | 154 | L 1-4 | 80-74 | 6 | 6,825 | Ray Herbert | Carl Willey | Carl Willey | Ray Herbert | | 629 | 652 | -23 |
| 1965-09-26 | vs NYN | 155 | W 5-4 | 81-74 | 6 | 9,029 | Lew Burdette | Rob Gardner | Grant Jackson | Jack Fisher | | 634 | 656 | -22 |
| 1965-09-27 | vs CHN | 156 | L 0-1 | 81-75 | 6 | 4,390 | Jim Bunning | Larry Jackson | Larry Jackson | Jim Bunning | | 634 | 657 | -23 |
| 1965-09-28 | vs CHN | 157 | L 1-2 | 81-76 | 6 | 3,928 | Chris Short | Bill Faul | Bill Faul | Chris Short | | 635 | 659 | -24 |
| 1965-09-29 | vs CHN | 158 | W 7-6 | 82-76 | 6 | 4,609 | Ray Culp | Bob Hendley | Gary Wagner | Lindy McDaniel | | 642 | 665 | -23 |
| 1965-10-02 | @ NYN | 159 | W 6-0 | 83-77 | 6 | 0 | Jim Bunning | Larry Bearnarth | Jim Bunning | Larry Bearnarth | | 648 | 665 | -17 |
| 1965-10-02 | @ NYN | 160 | L 0-0 | 83-77 | 6 | 10,371 | Chris Short | Rob Gardner | | | | 648 | 665 | -17 |
| 1965-10-03 | @ NYN | 161 | W 3-1 | 85-77 | 6 | 0 | Ray Culp | Al Jackson | Ray Culp | Al Jackson | | 651 | 666 | -15 |
| 1965-10-03 | @ NYN | 162 | W 3-1 | 85-77 | 6 | 18,508 | Grant Jackson | Jack Fisher | Fergie Jenkins | Jack Fisher | | 654 | 667 | -13 |