| 1965-04-12 | vs LAN | 1 | L 1-6 | 0-1 | 6 | 37,999 | Al Jackson | Don Drysdale | Don Drysdale | Al Jackson | | 1 | 6 | -5 |
| 1965-04-14 | vs HOU | 2 | L 6-7 | 0-2 | 9 | 7,277 | Warren Spahn | Turk Farrell | Turk Farrell | Larry Bearnarth | Jim Owens | 7 | 13 | -6 |
| 1965-04-15 | vs HOU | 3 | W 5-4 | 1-2 | 7 | 7,894 | Jack Fisher | Ken Johnson | Jim Bethke | Claude Raymond | | 12 | 17 | -5 |
| 1965-04-17 | vs SFN | 4 | L 0-4 | 1-3 | 8 | 34,945 | Tom Parsons | Juan Marichal | Juan Marichal | Tom Parsons | | 12 | 21 | -9 |
| 1965-04-18 | vs SFN | 5 | L 1-4 | 2-4 | 8 | 0 | Al Jackson | Jack Sanford | Jack Sanford | Al Jackson | Bob Shaw | 13 | 25 | -12 |
| 1965-04-18 | vs SFN | 6 | W 7-1 | 2-4 | 8 | 44,179 | Gary Kroll | Gaylord Perry | Gary Kroll | Gaylord Perry | | 20 | 26 | -6 |
| 1965-04-20 | @ LAN | 7 | W 3-2 | 3-4 | 7 | 36,161 | Warren Spahn | Claude Osteen | Warren Spahn | Claude Osteen | | 23 | 28 | -5 |
| 1965-04-21 | @ LAN | 8 | L 1-5 | 3-5 | 8 | 18,134 | Carl Willey | Don Drysdale | Don Drysdale | Carl Willey | Bob Miller | 24 | 33 | -9 |
| 1965-04-22 | @ LAN | 9 | L 1-2 | 3-6 | 8 | 20,888 | Jack Fisher | Sandy Koufax | Sandy Koufax | Jack Fisher | | 25 | 35 | -10 |
| 1965-04-23 | @ SFN | 10 | W 9-8 | 4-6 | 8 | 14,037 | Gary Kroll | Gaylord Perry | Dennis Ribant | Jim Duffalo | | 34 | 43 | -9 |
| 1965-04-24 | @ SFN | 11 | W 7-6 | 5-6 | 6 | 14,702 | Tom Parsons | Jack Sanford | Gary Kroll | Bob Shaw | Dennis Ribant | 41 | 49 | -8 |
| 1965-04-25 | @ SFN | 12 | L 0-5 | 6-7 | 6 | 0 | Al Jackson | Juan Marichal | Juan Marichal | Al Jackson | | 41 | 54 | -13 |
| 1965-04-25 | @ SFN | 13 | W 4-3 | 6-7 | 6 | 33,905 | Warren Spahn | Bobby Bolin | Warren Spahn | Bobby Bolin | | 45 | 57 | -12 |
| 1965-04-27 | @ HOU | 14 | L 2-3 | 6-8 | 8 | 16,837 | Jack Fisher | Don Nottebart | Hal Woodeshick | Dennis Ribant | | 47 | 60 | -13 |
| 1965-04-28 | @ HOU | 15 | L 9-12 | 6-9 | 8 | 27,690 | Frank Lary | Bob Bruce | Jim Owens | Tug McGraw | Claude Raymond | 56 | 72 | -16 |
| 1965-04-30 | @ CIN | 16 | L 1-6 | 6-10 | 9 | 5,216 | Warren Spahn | John Tsitouris | John Tsitouris | Warren Spahn | | 57 | 78 | -21 |
| 1965-05-01 | @ CIN | 17 | L 2-9 | 6-11 | 10 | 3,961 | Gary Kroll | Sammy Ellis | Sammy Ellis | Gary Kroll | | 59 | 87 | -28 |
| 1965-05-02 | @ CIN | 18 | L 4-9 | 6-13 | 10 | 0 | Jack Fisher | Jim Maloney | Jim Maloney | Jack Fisher | | 63 | 96 | -33 |
| 1965-05-02 | @ CIN | 19 | L 8-10 | 6-13 | 10 | 17,242 | Galen Cisco | Joe Nuxhall | Bill Henry | Jack Fisher | Billy McCool | 71 | 106 | -35 |
| 1965-05-04 | vs PHI | 20 | W 2-1 | 7-13 | 10 | 17,321 | Al Jackson | Ray Herbert | Al Jackson | Ray Herbert | | 73 | 107 | -34 |
| 1965-05-05 | vs PHI | 21 | L 0-1 | 7-14 | 10 | 14,134 | Warren Spahn | Jim Bunning | Jim Bunning | Warren Spahn | | 73 | 108 | -35 |
| 1965-05-08 | vs MLN | 22 | W 4-2 | 8-14 | 9 | 15,739 | Jack Fisher | Denny Lemaster | Jack Fisher | Denny Lemaster | Dennis Ribant | 77 | 110 | -33 |
| 1965-05-09 | vs MLN | 23 | L 2-8 | 9-15 | 9 | 0 | Al Jackson | Tony Cloninger | Tony Cloninger | Al Jackson | | 79 | 118 | -39 |
| 1965-05-09 | vs MLN | 24 | W 5-4 | 9-15 | 9 | 30,774 | Larry Bearnarth | Clay Carroll | Jim Bethke | Bobby Tiefenauer | | 84 | 122 | -38 |
| 1965-05-11 | vs SLN | 25 | L 3-4 | 9-16 | 9 | 24,519 | Warren Spahn | Bob Gibson | Bob Gibson | Warren Spahn | | 87 | 126 | -39 |
| 1965-05-12 | vs SLN | 26 | W 2-1 | 10-16 | 9 | 7,723 | Jack Fisher | Curt Simmons | Jack Fisher | Curt Simmons | | 89 | 127 | -38 |
| 1965-05-14 | vs CIN | 27 | W 5-3 | 11-16 | 9 | 37,552 | Al Jackson | Joey Jay | Al Jackson | Joe Nuxhall | | 94 | 130 | -36 |
| 1965-05-15 | vs CIN | 28 | L 7-12 | 11-17 | 9 | 21,592 | Galen Cisco | Jim O'Toole | Billy McCool | Galen Cisco | | 101 | 142 | -41 |
| 1965-05-16 | vs CIN | 29 | W 6-2 | 13-17 | 9 | 0 | Jack Fisher | John Tsitouris | Jack Fisher | John Tsitouris | Dennis Ribant | 107 | 144 | -37 |
| 1965-05-16 | vs CIN | 30 | W 8-5 | 13-17 | 9 | 48,536 | Warren Spahn | Sammy Ellis | Warren Spahn | Sammy Ellis | Frank Lary | 115 | 149 | -34 |
| 1965-05-18 | @ MLN | 31 | L 3-4 | 13-18 | 9 | 3,134 | Gary Kroll | Tony Cloninger | Tony Cloninger | Gary Kroll | | 118 | 153 | -35 |
| 1965-05-19 | @ MLN | 32 | L 5-7 | 13-19 | 9 | 2,355 | Galen Cisco | Bob Sadowski | Bob Sadowski | Galen Cisco | Billy O'Dell | 123 | 160 | -37 |
| 1965-05-20 | @ MLN | 33 | L 1-7 | 13-20 | 9 | 17,433 | Warren Spahn | Wade Blasingame | Wade Blasingame | Warren Spahn | | 124 | 167 | -43 |
| 1965-05-21 | @ SLN | 34 | L 4-5 | 13-21 | 9 | 22,274 | Al Jackson | Ray Washburn | Ron Taylor | Dennis Ribant | | 128 | 172 | -44 |
| 1965-05-22 | @ SLN | 35 | L 1-5 | 13-22 | 9 | 20,937 | Jack Fisher | Curt Simmons | Curt Simmons | Jack Fisher | | 129 | 177 | -48 |
| 1965-05-23 | @ SLN | 36 | L 7-8 | 13-23 | 9 | 15,402 | Gary Kroll | Ray Sadecki | Bob Purkey | Tom Parsons | | 136 | 185 | -49 |
| 1965-05-24 | @ PHI | 37 | W 6-2 | 15-23 | 9 | 0 | Warren Spahn | Jim Bunning | Warren Spahn | Jim Bunning | | 142 | 187 | -45 |
| 1965-05-24 | @ PHI | 38 | W 4-1 | 15-23 | 9 | 21,701 | Frank Lary | Chris Short | Frank Lary | Chris Short | Tug McGraw | 146 | 188 | -42 |
| 1965-05-25 | @ PHI | 39 | L 3-10 | 15-24 | 9 | 6,344 | Al Jackson | Ray Herbert | Ray Herbert | Al Jackson | | 149 | 198 | -49 |
| 1965-05-26 | vs CHN | 40 | L 6-8 | 15-25 | 9 | 16,809 | Jack Fisher | Dick Ellsworth | Lindy McDaniel | Dennis Ribant | | 155 | 206 | -51 |
| 1965-05-27 | vs CHN | 41 | W 8-5 | 16-25 | 9 | 9,561 | Gary Kroll | Cal Koonce | Gary Kroll | Cal Koonce | Larry Bearnarth | 163 | 211 | -48 |
| 1965-05-28 | vs PIT | 42 | L 1-6 | 16-26 | 9 | 32,011 | Warren Spahn | Bob Veale | Bob Veale | Warren Spahn | | 164 | 217 | -53 |
| 1965-05-29 | vs PIT | 43 | L 4-7 | 16-27 | 9 | 11,297 | Frank Lary | Joe Gibbon | Don Schwall | Frank Lary | Al McBean | 168 | 224 | -56 |
| 1965-05-30 | vs PIT | 44 | L 1-9 | 16-29 | 10 | 0 | Al Jackson | Bob Friend | Bob Friend | Al Jackson | | 169 | 233 | -64 |
| 1965-05-30 | vs PIT | 45 | L 0-12 | 16-29 | 10 | 41,552 | Tom Parsons | Vern Law | Vern Law | Tom Parsons | | 169 | 245 | -76 |
| 1965-05-31 | @ CHN | 46 | W 5-2 | 17-30 | 10 | 0 | Jack Fisher | Cal Koonce | Jack Fisher | Cal Koonce | | 174 | 247 | -73 |
| 1965-05-31 | @ CHN | 47 | L 3-3 | 17-30 | 10 | 32,250 | Gary Kroll | Ernie Broglio | | | | 177 | 250 | -73 |
| 1965-06-01 | @ CHN | 48 | W 10-5 | 18-30 | 10 | 2,270 | Warren Spahn | Bob Buhl | Larry Bearnarth | Bob Buhl | | 187 | 255 | -68 |
| 1965-06-03 | @ PIT | 49 | W 8-6 | 19-30 | 10 | 9,169 | Galen Cisco | Joe Gibbon | Galen Cisco | Joe Gibbon | Tom Parsons | 195 | 261 | -66 |
| 1965-06-04 | @ PIT | 50 | W 2-1 | 20-30 | 10 | 11,026 | Jack Fisher | Bob Friend | Jack Fisher | Bob Friend | | 197 | 262 | -65 |
| 1965-06-05 | @ PIT | 51 | L 0-9 | 20-31 | 10 | 6,581 | Gary Kroll | Vern Law | Vern Law | Gary Kroll | | 197 | 271 | -74 |
| 1965-06-06 | @ PIT | 52 | L 3-5 | 20-33 | 10 | 0 | Al Jackson | Don Cardwell | Don Cardwell | Al Jackson | | 200 | 276 | -76 |
| 1965-06-06 | @ PIT | 53 | L 0-3 | 20-33 | 10 | 16,387 | Warren Spahn | Bob Veale | Bob Veale | Warren Spahn | | 200 | 279 | -79 |
| 1965-06-08 | vs SFN | 54 | L 1-2 | 20-34 | 10 | 34,659 | Galen Cisco | Bob Shaw | Bob Shaw | Galen Cisco | Frank Linzy | 201 | 281 | -80 |
| 1965-06-09 | vs SFN | 55 | L 2-4 | 20-35 | 10 | 37,660 | Jack Fisher | Gaylord Perry | Gaylord Perry | Jack Fisher | | 203 | 285 | -82 |
| 1965-06-10 | vs SFN | 56 | L 0-3 | 20-36 | 10 | 24,458 | Gary Kroll | Juan Marichal | Juan Marichal | Gary Kroll | | 203 | 288 | -85 |
| 1965-06-11 | vs LAN | 57 | L 1-2 | 20-37 | 10 | 55,023 | Warren Spahn | Don Drysdale | Don Drysdale | Warren Spahn | | 204 | 290 | -86 |
| 1965-06-12 | vs LAN | 58 | L 0-5 | 20-38 | 10 | 38,915 | Al Jackson | Sandy Koufax | Sandy Koufax | Al Jackson | | 204 | 295 | -91 |
| 1965-06-13 | vs LAN | 59 | L 2-5 | 20-40 | 10 | 0 | Jack Fisher | Claude Osteen | Claude Osteen | Jack Fisher | Bob Miller | 206 | 300 | -94 |
| 1965-06-13 | vs LAN | 60 | L 3-4 | 20-40 | 10 | 57,175 | Galen Cisco | Nick Willhite | Ron Perranoski | Gary Kroll | Johnny Podres | 209 | 304 | -95 |
| 1965-06-14 | @ CIN | 61 | W 1-0 | 21-40 | 10 | 5,989 | Frank Lary | Jim Maloney | Larry Bearnarth | Jim Maloney | | 210 | 304 | -94 |
| 1965-06-15 | @ CIN | 62 | L 1-5 | 21-41 | 10 | 8,620 | Warren Spahn | Sammy Ellis | Sammy Ellis | Warren Spahn | | 211 | 309 | -98 |
| 1965-06-16 | @ CIN | 63 | L 4-8 | 21-42 | 10 | 7,641 | Al Jackson | Jim O'Toole | Jim O'Toole | Al Jackson | John Tsitouris | 215 | 317 | -102 |
| 1965-06-18 | @ SFN | 64 | L 0-3 | 21-43 | 10 | 12,788 | Galen Cisco | Jack Sanford | Jack Sanford | Galen Cisco | Frank Linzy | 215 | 320 | -105 |
| 1965-06-19 | @ SFN | 65 | L 1-2 | 21-44 | 10 | 17,069 | Jack Fisher | Juan Marichal | Juan Marichal | Jack Fisher | | 216 | 322 | -106 |
| 1965-06-20 | @ LAN | 66 | L 1-2 | 22-45 | 10 | 0 | Warren Spahn | Sandy Koufax | Sandy Koufax | Warren Spahn | | 217 | 324 | -107 |
| 1965-06-20 | @ LAN | 67 | W 3-2 | 22-45 | 10 | 52,248 | Frank Lary | Don Drysdale | Larry Miller | Don Drysdale | | 220 | 326 | -106 |
| 1965-06-21 | @ LAN | 68 | W 1-0 | 23-45 | 10 | 18,867 | Al Jackson | Claude Osteen | Al Jackson | Claude Osteen | | 221 | 326 | -105 |
| 1965-06-22 | @ LAN | 69 | L 2-4 | 23-46 | 10 | 20,633 | Galen Cisco | Johnny Podres | Howie Reed | Tom Parsons | Ron Perranoski | 223 | 330 | -107 |
| 1965-06-24 | @ HOU | 70 | L 2-4 | 23-47 | 10 | 22,329 | Jack Fisher | Claude Raymond | Claude Raymond | Jack Fisher | Jim Owens | 225 | 334 | -109 |
| 1965-06-25 | @ HOU | 71 | L 2-6 | 23-48 | 10 | 27,161 | Warren Spahn | Larry Dierker | Larry Dierker | Warren Spahn | Dave Giusti | 227 | 340 | -113 |
| 1965-06-26 | @ HOU | 72 | L 0-2 | 23-49 | 10 | 33,500 | Frank Lary | Turk Farrell | Turk Farrell | Frank Lary | | 227 | 342 | -115 |
| 1965-06-27 | @ HOU | 73 | L 2-4 | 23-50 | 10 | 25,224 | Al Jackson | Bob Bruce | Bob Bruce | Al Jackson | Mike Cuellar | 229 | 346 | -117 |
| 1965-06-28 | vs MLN | 74 | W 5-2 | 25-50 | 10 | 0 | Jack Fisher | Tony Cloninger | Jack Fisher | Tony Cloninger | | 234 | 348 | -114 |
| 1965-06-28 | vs MLN | 75 | W 6-3 | 25-50 | 10 | 38,033 | Galen Cisco | Hank Fischer | Gary Kroll | Hank Fischer | | 240 | 351 | -111 |
| 1965-06-29 | vs MLN | 76 | L 6-8 | 25-51 | 10 | 23,791 | Warren Spahn | Dick Kelley | Bob Sadowski | Warren Spahn | Ken Johnson | 246 | 359 | -113 |
| 1965-06-30 | vs CIN | 77 | W 6-3 | 26-51 | 10 | 20,946 | Tom Parsons | John Tsitouris | Gary Kroll | John Tsitouris | | 252 | 362 | -110 |
| 1965-07-01 | vs CIN | 78 | W 5-1 | 27-51 | 10 | 14,738 | Al Jackson | Jim Maloney | Al Jackson | Jim Maloney | | 257 | 363 | -106 |
| 1965-07-02 | vs SLN | 79 | L 3-6 | 27-52 | 10 | 31,527 | Frank Lary | Bob Gibson | Bob Gibson | Frank Lary | | 260 | 369 | -109 |
| 1965-07-03 | vs SLN | 80 | L 0-2 | 27-53 | 10 | 28,041 | Jack Fisher | Tracy Stallard | Tracy Stallard | Jack Fisher | Hal Woodeshick | 260 | 371 | -111 |
| 1965-07-04 | vs SLN | 81 | L 2-6 | 27-54 | 10 | 20,006 | Galen Cisco | Bob Purkey | Bob Purkey | Galen Cisco | Don Dennis | 262 | 377 | -115 |
| 1965-07-05 | vs CHN | 82 | W 3-2 | 29-54 | 10 | 0 | Warren Spahn | Dick Ellsworth | Larry Bearnarth | Dick Ellsworth | | 265 | 379 | -114 |
| 1965-07-05 | vs CHN | 83 | W 3-0 | 29-54 | 10 | 35,900 | Tom Parsons | Bill Faul | Tom Parsons | Bill Faul | | 268 | 379 | -111 |
| 1965-07-07 | vs CHN | 84 | L 3-8 | 29-55 | 10 | 17,916 | Al Jackson | Larry Jackson | Larry Jackson | Al Jackson | Ted Abernathy | 271 | 387 | -116 |
| 1965-07-09 | vs HOU | 85 | L 2-6 | 29-56 | 10 | 29,645 | Jack Fisher | Larry Dierker | Larry Dierker | Jack Fisher | Ron Taylor | 273 | 393 | -120 |
| 1965-07-10 | vs HOU | 86 | L 1-10 | 29-57 | 10 | 13,837 | Warren Spahn | Turk Farrell | Turk Farrell | Warren Spahn | Ron Taylor | 274 | 403 | -129 |
| 1965-07-15 | @ SLN | 87 | L 5-6 | 29-58 | 10 | 14,829 | Jack Fisher | Curt Simmons | Barney Schultz | Larry Bearnarth | Hal Woodeshick | 279 | 409 | -130 |
| 1965-07-16 | @ SLN | 88 | L 5-8 | 29-59 | 10 | 14,153 | Al Jackson | Bob Gibson | Bob Gibson | Al Jackson | Hal Woodeshick | 284 | 417 | -133 |
| 1965-07-17 | @ SLN | 89 | L 1-4 | 29-60 | 10 | 12,291 | Larry Miller | Bob Purkey | Bob Purkey | Larry Miller | Don Dennis | 285 | 421 | -136 |
| 1965-07-18 | @ MLN | 90 | L 1-5 | 29-62 | 10 | 0 | Tom Parsons | Tony Cloninger | Tony Cloninger | Tom Parsons | | 286 | 426 | -140 |
| 1965-07-18 | @ MLN | 91 | L 4-5 | 29-62 | 10 | 12,127 | Gary Kroll | Hank Fischer | Dick Kelley | Gary Kroll | | 290 | 431 | -141 |
| 1965-07-19 | @ MLN | 92 | L 0-6 | 29-63 | 10 | 5,591 | Jack Fisher | Ken Johnson | Ken Johnson | Jack Fisher | | 290 | 437 | -147 |
| 1965-07-20 | @ MLN | 93 | L 1-7 | 29-64 | 10 | 4,414 | Galen Cisco | Hank Fischer | Hank Fischer | Galen Cisco | Billy O'Dell | 291 | 444 | -153 |
| 1965-07-21 | @ PIT | 94 | W 1-0 | 30-64 | 10 | 22,670 | Al Jackson | Don Cardwell | Al Jackson | Don Cardwell | | 292 | 444 | -152 |
| 1965-07-23 | vs PHI | 95 | W 3-2 | 31-64 | 10 | 38,533 | Jack Fisher | Chris Short | Jack Fisher | Jack Baldschun | | 295 | 446 | -151 |
| 1965-07-24 | vs PHI | 96 | L 1-5 | 31-65 | 10 | 36,921 | Tom Parsons | Jim Bunning | Jim Bunning | Tom Parsons | | 296 | 451 | -155 |
| 1965-07-25 | vs PHI | 97 | W 8-1 | 32-66 | 10 | 0 | Galen Cisco | Bo Belinsky | Galen Cisco | Bo Belinsky | Gary Kroll | 304 | 452 | -148 |
| 1965-07-25 | vs PHI | 98 | L 1-3 | 32-66 | 10 | 36,921 | Al Jackson | Ray Culp | Ray Culp | Al Jackson | | 305 | 455 | -150 |
| 1965-07-27 | @ CHN | 99 | L 3-6 | 32-67 | 10 | 6,410 | Jack Fisher | Bob Buhl | Bob Buhl | Jack Fisher | Ted Abernathy | 308 | 461 | -153 |
| 1965-07-28 | @ CHN | 100 | L 2-7 | 32-69 | 10 | 0 | Tom Parsons | Dick Ellsworth | Dick Ellsworth | Tom Parsons | | 310 | 468 | -158 |
| 1965-07-28 | @ CHN | 101 | L 0-9 | 32-69 | 10 | 13,151 | Tug McGraw | Larry Jackson | Larry Jackson | Tug McGraw | | 310 | 477 | -167 |
| 1965-07-29 | @ CHN | 102 | W 14-0 | 33-70 | 10 | 0 | Galen Cisco | Cal Koonce | Galen Cisco | Cal Koonce | | 324 | 477 | -153 |
| 1965-07-29 | @ CHN | 103 | L 1-2 | 33-70 | 10 | 11,256 | Dennis Musgraves | Bill Faul | Ted Abernathy | Larry Bearnarth | | 325 | 479 | -154 |
| 1965-07-30 | @ PHI | 104 | L 3-5 | 33-71 | 10 | 16,429 | Al Jackson | Lew Burdette | Lew Burdette | Al Jackson | Gary Wagner | 328 | 484 | -156 |
| 1965-07-31 | @ PHI | 105 | W 4-3 | 34-71 | 10 | 10,207 | Jack Fisher | Chris Short | Gary Kroll | Jack Baldschun | Gordie Richardson | 332 | 487 | -155 |
| 1965-08-01 | @ PHI | 106 | L 2-3 | 34-72 | 10 | 8,935 | Tom Parsons | Jim Bunning | Jim Bunning | Tom Parsons | Gary Wagner | 334 | 490 | -156 |
| 1965-08-03 | vs PIT | 107 | L 0-7 | 34-73 | 10 | 24,597 | Galen Cisco | Vern Law | Vern Law | Galen Cisco | | 334 | 497 | -163 |
| 1965-08-04 | vs PIT | 108 | L 0-3 | 34-74 | 10 | 20,703 | Jack Fisher | Bob Veale | Bob Veale | Jack Fisher | Don Schwall | 334 | 500 | -166 |
| 1965-08-05 | vs PIT | 109 | L 3-11 | 34-75 | 10 | 19,374 | Al Jackson | Don Cardwell | Don Cardwell | Al Jackson | | 337 | 511 | -174 |
| 1965-08-06 | vs CHN | 110 | L 3-4 | 34-76 | 10 | 18,555 | Tom Parsons | Larry Jackson | Larry Jackson | Tom Parsons | Ted Abernathy | 340 | 515 | -175 |
| 1965-08-07 | vs CHN | 111 | L 1-7 | 34-77 | 10 | 12,766 | Galen Cisco | Bill Faul | Billy Hoeft | Galen Cisco | | 341 | 522 | -181 |
| 1965-08-08 | vs CHN | 112 | L 6-7 | 34-79 | 10 | 0 | Jack Fisher | Bob Buhl | Lindy McDaniel | Jack Fisher | Ted Abernathy | 347 | 529 | -182 |
| 1965-08-08 | vs CHN | 113 | L 10-14 | 34-79 | 10 | 25,067 | Gary Kroll | Ernie Broglio | Ted Abernathy | Tom Parsons | | 357 | 543 | -186 |
| 1965-08-10 | @ LAN | 114 | L 3-4 | 34-80 | 10 | 36,815 | Al Jackson | Sandy Koufax | Sandy Koufax | Al Jackson | | 360 | 547 | -187 |
| 1965-08-11 | @ LAN | 115 | L 0-1 | 34-81 | 10 | 23,376 | Larry Miller | Don Drysdale | Don Drysdale | Gordie Richardson | | 360 | 548 | -188 |
| 1965-08-13 | @ HOU | 116 | L 2-3 | 34-82 | 10 | 27,978 | Jack Fisher | Don Nottebart | Don Nottebart | Jack Fisher | | 362 | 551 | -189 |
| 1965-08-14 | @ HOU | 117 | W 1-0 | 35-82 | 10 | 41,732 | Galen Cisco | Larry Dierker | Darrell Sutherland | Dave Giusti | | 363 | 551 | -188 |
| 1965-08-15 | @ HOU | 118 | W 3-0 | 36-82 | 10 | 33,952 | Al Jackson | Bob Bruce | Al Jackson | Bob Bruce | | 366 | 551 | -185 |
| 1965-08-16 | @ SFN | 119 | L 2-3 | 36-83 | 10 | 6,779 | Tom Parsons | Bob Shaw | Bob Shaw | Bob Moorhead | | 368 | 554 | -186 |
| 1965-08-17 | @ SFN | 120 | L 2-3 | 36-84 | 10 | 7,656 | Jack Fisher | Gaylord Perry | Bobby Bolin | Jack Fisher | | 370 | 557 | -187 |
| 1965-08-18 | @ SFN | 121 | L 0-5 | 36-85 | 10 | 8,841 | Larry Miller | Juan Marichal | Juan Marichal | Larry Miller | | 370 | 562 | -192 |
| 1965-08-20 | vs SLN | 122 | L 1-8 | 36-86 | 10 | 28,055 | Al Jackson | Bob Gibson | Bob Gibson | Al Jackson | | 371 | 570 | -199 |
| 1965-08-21 | vs SLN | 123 | W 6-2 | 37-86 | 10 | 15,941 | Jack Fisher | Bob Purkey | Jack Fisher | Bob Purkey | | 377 | 572 | -195 |
| 1965-08-22 | vs SLN | 124 | W 7-5 | 39-86 | 10 | 0 | Darrell Sutherland | Tracy Stallard | Gordie Richardson | Don Dennis | Dave Eilers | 384 | 577 | -193 |
| 1965-08-22 | vs SLN | 125 | W 4-2 | 39-86 | 10 | 22,522 | Tug McGraw | Ray Washburn | Tug McGraw | Ray Washburn | | 388 | 579 | -191 |
| 1965-08-23 | vs LAN | 126 | L 4-8 | 39-87 | 10 | 33,393 | Larry Miller | Don Drysdale | Don Drysdale | Larry Miller | Bob Miller | 392 | 587 | -195 |
| 1965-08-24 | vs LAN | 127 | W 4-3 | 40-87 | 10 | 37,023 | Al Jackson | Howie Reed | Dave Eilers | Bob Miller | | 396 | 590 | -194 |
| 1965-08-25 | vs LAN | 128 | W 7-5 | 41-87 | 10 | 32,432 | Jack Fisher | Claude Osteen | Gordie Richardson | Claude Osteen | | 403 | 595 | -192 |
| 1965-08-26 | vs LAN | 129 | W 5-2 | 42-87 | 10 | 45,950 | Tug McGraw | Sandy Koufax | Tug McGraw | Sandy Koufax | Jack Fisher | 408 | 597 | -189 |
| 1965-08-27 | vs SFN | 130 | L 2-9 | 42-88 | 10 | 56,167 | Darrell Sutherland | Warren Spahn | Warren Spahn | Darrell Sutherland | Frank Linzy | 410 | 606 | -196 |
| 1965-08-28 | vs SFN | 131 | W 3-0 | 43-88 | 10 | 48,147 | Galen Cisco | Bob Shaw | Galen Cisco | Bob Shaw | Al Jackson | 413 | 606 | -193 |
| 1965-08-29 | vs SFN | 132 | L 3-8 | 43-89 | 10 | 46,033 | Jack Fisher | Bobby Bolin | Bobby Bolin | Jack Fisher | Masanori Murakami | 416 | 614 | -198 |
| 1965-08-31 | vs HOU | 133 | L 3-4 | 43-91 | 10 | 0 | Larry Miller | Robin Roberts | Robin Roberts | Larry Miller | Jim Owens | 419 | 618 | -199 |
| 1965-08-31 | vs HOU | 134 | L 2-3 | 43-91 | 10 | 25,562 | Tug McGraw | Bob Bruce | Bob Bruce | Tug McGraw | | 421 | 621 | -200 |
| 1965-09-01 | vs HOU | 135 | W 4-1 | 44-92 | 10 | 0 | Al Jackson | Danny Coombs | Al Jackson | Danny Coombs | | 425 | 622 | -197 |
| 1965-09-01 | vs HOU | 136 | L 5-8 | 44-92 | 10 | 13,880 | Rob Gardner | Turk Farrell | Turk Farrell | Rob Gardner | Dave Giusti | 430 | 630 | -200 |
| 1965-09-02 | vs HOU | 137 | L 3-4 | 44-93 | 10 | 11,430 | Jack Fisher | Larry Dierker | Larry Dierker | Jack Fisher | Claude Raymond | 433 | 634 | -201 |
| 1965-09-03 | @ SLN | 138 | W 6-3 | 45-93 | 10 | 13,774 | Dick Selma | Ray Sadecki | Dick Selma | Ray Sadecki | Gordie Richardson | 439 | 637 | -198 |
| 1965-09-05 | @ SLN | 139 | L 0-3 | 45-95 | 10 | 0 | Tug McGraw | Bob Gibson | Bob Gibson | Tug McGraw | | 439 | 640 | -201 |
| 1965-09-05 | @ SLN | 140 | L 1-3 | 45-95 | 10 | 18,952 | Rob Gardner | Ray Washburn | Ray Washburn | Rob Gardner | Nelson Briles | 440 | 643 | -203 |
| 1965-09-06 | @ MLN | 141 | L 2-4 | 45-97 | 10 | 0 | Al Jackson | Hank Fischer | Hank Fischer | Al Jackson | Phil Niekro | 442 | 647 | -205 |
| 1965-09-06 | @ MLN | 142 | L 1-3 | 45-97 | 10 | 7,213 | Jack Fisher | Wade Blasingame | Wade Blasingame | Jack Fisher | Phil Niekro | 443 | 650 | -207 |
| 1965-09-08 | @ CIN | 143 | L 2-11 | 45-98 | 10 | 6,458 | Carl Willey | Jim O'Toole | Jim O'Toole | Carl Willey | | 445 | 661 | -216 |
| 1965-09-09 | @ CIN | 144 | L 2-3 | 45-99 | 10 | 6,519 | Tug McGraw | John Tsitouris | Sammy Ellis | Gordie Richardson | | 447 | 664 | -217 |
| 1965-09-10 | vs MLN | 145 | L 1-3 | 45-100 | 10 | 26,661 | Jack Fisher | Wade Blasingame | Billy O'Dell | Jack Fisher | Phil Niekro | 448 | 667 | -219 |
| 1965-09-11 | vs MLN | 146 | L 0-9 | 45-101 | 10 | 17,241 | Al Jackson | Tony Cloninger | Tony Cloninger | Al Jackson | | 448 | 676 | -228 |
| 1965-09-12 | vs MLN | 147 | W 1-0 | 46-101 | 10 | 13,500 | Dick Selma | Bob Sadowski | Dick Selma | Bob Sadowski | | 449 | 676 | -227 |
| 1965-09-14 | vs CIN | 148 | L 6-13 | 46-102 | 10 | 11,825 | Tug McGraw | Jim O'Toole | Jim O'Toole | Tug McGraw | Billy McCool | 455 | 689 | -234 |
| 1965-09-15 | vs CIN | 149 | L 1-2 | 46-103 | 10 | 8,837 | Jack Fisher | Jim Maloney | Jim Maloney | Jack Fisher | | 456 | 691 | -235 |
| 1965-09-16 | vs CIN | 150 | W 7-3 | 47-103 | 10 | 4,965 | Al Jackson | John Tsitouris | Al Jackson | John Tsitouris | Dave Eilers | 463 | 694 | -231 |
| 1965-09-18 | @ CHN | 151 | L 3-4 | 47-104 | 10 | 3,930 | Tug McGraw | Larry Jackson | Larry Jackson | Tug McGraw | Ted Abernathy | 466 | 698 | -232 |
| 1965-09-19 | @ CHN | 152 | W 8-6 | 48-104 | 10 | 5,981 | Dick Selma | Bob Hendley | Darrell Sutherland | Bob Hendley | | 474 | 704 | -230 |
| 1965-09-20 | @ PIT | 153 | L 0-10 | 48-105 | 10 | 3,892 | Jack Fisher | Tommie Sisk | Tommie Sisk | Jack Fisher | | 474 | 714 | -240 |
| 1965-09-21 | @ PIT | 154 | L 5-6 | 48-106 | 10 | 4,660 | Al Jackson | Don Cardwell | Roy Face | Dave Eilers | | 479 | 720 | -241 |
| 1965-09-22 | @ PIT | 155 | L 2-6 | 48-107 | 10 | 4,964 | Tug McGraw | Bob Friend | Bob Friend | Tug McGraw | | 481 | 726 | -245 |
| 1965-09-25 | @ PHI | 156 | L 1-4 | 49-108 | 10 | 0 | Larry Bearnarth | Ray Culp | Ray Culp | Larry Bearnarth | | 482 | 730 | -248 |
| 1965-09-25 | @ PHI | 157 | W 4-1 | 49-108 | 10 | 6,825 | Carl Willey | Ray Herbert | Carl Willey | Ray Herbert | | 486 | 731 | -245 |
| 1965-09-26 | @ PHI | 158 | L 4-5 | 49-109 | 10 | 9,029 | Rob Gardner | Lew Burdette | Grant Jackson | Jack Fisher | | 490 | 736 | -246 |
| 1965-09-28 | vs PIT | 159 | W 1-0 | 50-109 | 10 | 6,995 | Dennis Ribant | Tommie Sisk | Darrell Sutherland | Roy Face | | 491 | 736 | -245 |
| 1965-09-29 | vs PIT | 160 | L 2-4 | 50-110 | 10 | 2,807 | Dick Selma | Bob Friend | Don Schwall | Dick Selma | Al McBean | 493 | 740 | -247 |
| 1965-10-02 | vs PHI | 161 | L 0-6 | 51-111 | 10 | 0 | Larry Bearnarth | Jim Bunning | Jim Bunning | Larry Bearnarth | | 493 | 746 | -253 |
| 1965-10-02 | vs PHI | 162 | W 0-0 | 51-111 | 10 | 10,371 | Rob Gardner | Chris Short | | | | 493 | 746 | -253 |
| 1965-10-03 | vs PHI | 163 | L 1-3 | 51-113 | 10 | 0 | Al Jackson | Ray Culp | Ray Culp | Al Jackson | | 494 | 749 | -255 |
| 1965-10-03 | vs PHI | 164 | L 1-3 | 51-113 | 10 | 18,508 | Jack Fisher | Grant Jackson | Fergie Jenkins | Jack Fisher | | 495 | 752 | -257 |