| 1960-04-19 | vs WS1 | 1 | W 3-2 | 1-0 | 1 | 32,747 | Jerry Walker | Pedro Ramos | Jack Fisher | Pedro Ramos | | 3 | 2 | 1 |
| 1960-04-20 | vs WS1 | 2 | L 7-8 | 1-1 | 4 | 11,087 | Milt Pappas | Russ Kemmerer | Tex Clevenger | Rip Coleman | Jack Kralick | 10 | 10 | 0 |
| 1960-04-21 | vs WS1 | 3 | L 5-6 | 1-2 | 5 | 9,377 | Steve Barber | Don Lee | Chuck Stobbs | Jack Fisher | | 15 | 16 | -1 |
| 1960-04-22 | @ NYA | 4 | L 0-5 | 1-3 | 7 | 36,386 | Hoyt Wilhelm | Whitey Ford | Whitey Ford | Hoyt Wilhelm | Ralph Terry | 15 | 21 | -6 |
| 1960-04-23 | @ NYA | 5 | L 2-3 | 1-4 | 7 | 18,653 | Rip Coleman | Bill Short | Bill Short | Rip Coleman | Ryne Duren | 17 | 24 | -7 |
| 1960-04-24 | @ NYA | 6 | L 9-15 | 1-5 | 8 | 19,460 | Jack Fisher | Jim Coates | Jim Coates | Jack Fisher | Johnny James | 26 | 39 | -13 |
| 1960-04-25 | @ WS1 | 7 | W 3-2 | 2-5 | 7 | 8,459 | Milt Pappas | Russ Kemmerer | Milt Pappas | Russ Kemmerer | | 29 | 41 | -12 |
| 1960-04-26 | @ WS1 | 8 | W 11-10 | 3-5 | 7 | 2,343 | Jerry Walker | Don Lee | Chuck Estrada | Camilo Pascual | | 40 | 51 | -11 |
| 1960-04-27 | vs BOS | 9 | W 8-3 | 4-5 | 5 | 6,247 | Arnie Portocarrero | Frank Sullivan | Arnie Portocarrero | Frank Sullivan | | 48 | 54 | -6 |
| 1960-04-28 | vs BOS | 10 | W 6-1 | 5-5 | 4 | 6,058 | Steve Barber | Bill Monbouquette | Steve Barber | Bill Monbouquette | | 54 | 55 | -1 |
| 1960-04-29 | vs NYA | 11 | W 2-1 | 6-5 | 4 | 17,913 | Hal Brown | Bill Short | Hal Brown | Bill Short | | 56 | 56 | 0 |
| 1960-04-30 | vs NYA | 12 | L 0-16 | 6-6 | 4 | 13,267 | Milt Pappas | Jim Coates | Jim Coates | Milt Pappas | | 56 | 72 | -16 |
| 1960-05-01 | vs NYA | 13 | W 9-5 | 7-6 | 4 | 11,474 | Chuck Estrada | Ralph Terry | Chuck Estrada | John Gabler | | 65 | 77 | -12 |
| 1960-05-02 | vs CHA | 14 | W 11-6 | 8-6 | 3 | 8,254 | Jerry Walker | Herb Score | Arnie Portocarrero | Don Ferrarese | | 76 | 83 | -7 |
| 1960-05-03 | vs CHA | 15 | L 3-5 | 8-7 | 4 | 10,701 | Steve Barber | Billy Pierce | Billy Pierce | Steve Barber | | 79 | 88 | -9 |
| 1960-05-04 | vs CHA | 16 | W 6-4 | 9-7 | 3 | 9,364 | Hoyt Wilhelm | Early Wynn | Hoyt Wilhelm | Frank Baumann | Jerry Walker | 85 | 92 | -7 |
| 1960-05-05 | vs CLE | 17 | L 6-11 | 9-8 | 4 | 8,816 | Milt Pappas | Wynn Hawkins | Wynn Hawkins | Milt Pappas | Gary Bell | 91 | 103 | -12 |
| 1960-05-06 | vs CLE | 18 | W 9-2 | 10-8 | 3 | 12,510 | Hal Brown | Dick Stigman | Hal Brown | Dick Stigman | | 100 | 105 | -5 |
| 1960-05-07 | vs CLE | 19 | L 1-3 | 10-9 | 5 | 11,133 | Chuck Estrada | Gary Bell | Gary Bell | Chuck Estrada | | 101 | 108 | -7 |
| 1960-05-10 | vs KC1 | 20 | L 0-10 | 10-10 | 5 | 5,788 | Hoyt Wilhelm | Dick Hall | Dick Hall | Hoyt Wilhelm | | 101 | 118 | -17 |
| 1960-05-11 | vs KC1 | 21 | W 5-3 | 11-10 | 5 | 6,427 | Arnie Portocarrero | Bud Daley | Milt Pappas | Marty Kutyna | | 106 | 121 | -15 |
| 1960-05-14 | @ BOS | 22 | W 5-2 | 12-10 | 5 | 10,703 | Jerry Walker | Bill Monbouquette | Jack Fisher | Ted Bowsfield | | 111 | 123 | -12 |
| 1960-05-15 | @ BOS | 23 | W 2-1 | 14-10 | 1 | 0 | Steve Barber | Jerry Casale | Steve Barber | Jerry Casale | | 113 | 124 | -11 |
| 1960-05-15 | @ BOS | 24 | W 7-4 | 14-10 | 1 | 21,157 | Hal Brown | Frank Sullivan | Hal Brown | Frank Sullivan | Chuck Estrada | 120 | 128 | -8 |
| 1960-05-16 | @ KC1 | 25 | W 2-1 | 15-10 | 1 | 6,819 | Arnie Portocarrero | Ned Garver | Arnie Portocarrero | Ned Garver | Jack Fisher | 122 | 129 | -7 |
| 1960-05-17 | @ KC1 | 26 | L 2-4 | 15-11 | 3 | 7,365 | Milt Pappas | Don Larsen | Leo Kiely | Milt Pappas | | 124 | 133 | -9 |
| 1960-05-18 | @ KC1 | 27 | W 5-4 | 16-11 | 2 | 6,964 | Hoyt Wilhelm | Ray Herbert | Steve Barber | Leo Kiely | | 129 | 137 | -8 |
| 1960-05-19 | @ KC1 | 28 | L 4-7 | 16-12 | 2 | 5,367 | Chuck Estrada | Bud Daley | Bud Daley | Jack Fisher | Marty Kutyna | 133 | 144 | -11 |
| 1960-05-20 | @ DET | 29 | L 3-4 | 16-13 | 3 | 17,159 | Jerry Walker | Don Mossi | Tom Morgan | Milt Pappas | | 136 | 148 | -12 |
| 1960-05-21 | @ DET | 30 | W 7-4 | 17-13 | 3 | 7,230 | Arnie Portocarrero | Frank Lary | Gordon Jones | Frank Lary | | 143 | 152 | -9 |
| 1960-05-22 | @ CLE | 31 | W 7-6 | 18-13 | 2 | 12,268 | Hal Brown | Gary Bell | Jack Fisher | Gary Bell | | 150 | 158 | -8 |
| 1960-05-24 | @ CHA | 32 | W 6-1 | 19-13 | 1 | 23,114 | Steve Barber | Herb Score | Steve Barber | Herb Score | | 156 | 159 | -3 |
| 1960-05-25 | @ CHA | 33 | W 3-2 | 20-13 | 1 | 5,518 | Chuck Estrada | Early Wynn | Chuck Estrada | Early Wynn | | 159 | 161 | -2 |
| 1960-05-26 | @ NYA | 34 | L 0-2 | 20-14 | 2 | 18,297 | Hal Brown | Whitey Ford | Whitey Ford | Hal Brown | | 159 | 163 | -4 |
| 1960-05-27 | @ NYA | 35 | W 3-2 | 21-14 | 1 | 7,387 | Hoyt Wilhelm | Art Ditmar | Hoyt Wilhelm | Art Ditmar | | 162 | 165 | -3 |
| 1960-05-29 | vs BOS | 36 | W 6-1 | 23-14 | 1 | 0 | Steve Barber | Frank Sullivan | Steve Barber | Frank Sullivan | | 168 | 166 | 2 |
| 1960-05-29 | vs BOS | 37 | W 5-4 | 23-14 | 1 | 11,483 | Jack Fisher | Tom Borland | Milt Pappas | Tom Borland | | 173 | 170 | 3 |
| 1960-05-30 | vs BOS | 38 | W 7-5 | 24-15 | 1 | 0 | Chuck Estrada | Bill Monbouquette | Chuck Estrada | Bill Monbouquette | Hoyt Wilhelm | 180 | 175 | 5 |
| 1960-05-30 | vs BOS | 39 | L 3-12 | 24-15 | 1 | 31,620 | Arnie Portocarrero | Ted Bowsfield | Ted Bowsfield | Arnie Portocarrero | Mike Fornieles | 183 | 187 | -4 |
| 1960-05-31 | vs NYA | 40 | W 3-2 | 25-15 | 1 | 19,103 | Jerry Walker | Whitey Ford | Jerry Walker | Whitey Ford | Steve Barber | 186 | 189 | -3 |
| 1960-06-01 | vs NYA | 41 | W 4-1 | 26-15 | 1 | 23,762 | Hal Brown | Duke Maas | Hal Brown | Duke Maas | | 190 | 190 | 0 |
| 1960-06-02 | vs NYA | 42 | W 6-5 | 27-15 | 1 | 42,755 | Hoyt Wilhelm | Jim Coates | Chuck Estrada | Art Ditmar | | 196 | 195 | 1 |
| 1960-06-03 | @ WS1 | 43 | L 1-4 | 27-16 | 1 | 11,668 | Milt Pappas | Hal Woodeshick | Hal Woodeshick | Milt Pappas | | 197 | 199 | -2 |
| 1960-06-04 | vs WS1 | 44 | L 1-7 | 27-17 | 1 | 18,582 | Steve Barber | Chuck Stobbs | Chuck Stobbs | Steve Barber | Tex Clevenger | 198 | 206 | -8 |
| 1960-06-05 | @ WS1 | 45 | W 6-5 | 28-17 | 1 | 10,703 | Jerry Walker | Pedro Ramos | Hal Brown | Tex Clevenger | Hoyt Wilhelm | 204 | 211 | -7 |
| 1960-06-06 | vs WS1 | 46 | W 6-1 | 29-17 | 1 | 9,508 | Chuck Estrada | Jim Kaat | Chuck Estrada | Jim Kaat | | 210 | 212 | -2 |
| 1960-06-07 | vs DET | 47 | L 2-5 | 29-18 | 1 | 30,579 | Hoyt Wilhelm | Don Mossi | Don Mossi | Hoyt Wilhelm | | 212 | 217 | -5 |
| 1960-06-08 | vs DET | 48 | L 0-2 | 29-19 | 2 | 12,984 | Jack Fisher | Frank Lary | Frank Lary | Jack Fisher | | 212 | 219 | -7 |
| 1960-06-09 | vs DET | 49 | L 5-7 | 29-21 | 2 | 0 | Milt Pappas | Paul Foytack | Dave Sisler | Arnie Portocarrero | | 217 | 226 | -9 |
| 1960-06-09 | vs DET | 50 | L 4-7 | 29-21 | 2 | 17,489 | Hal Brown | Pete Burnside | Pete Burnside | Hal Brown | Hank Aguirre | 221 | 233 | -12 |
| 1960-06-10 | vs KC1 | 51 | W 5-4 | 30-21 | 2 | 18,841 | Steve Barber | Dick Hall | Hal Brown | Marty Kutyna | | 226 | 237 | -11 |
| 1960-06-11 | vs KC1 | 52 | W 6-5 | 31-21 | 1 | 16,731 | Jerry Walker | Ray Herbert | Jack Fisher | Leo Kiely | | 232 | 242 | -10 |
| 1960-06-12 | vs KC1 | 53 | L 1-6 | 31-23 | 2 | 0 | Chuck Estrada | Bud Daley | Bud Daley | Chuck Estrada | | 233 | 248 | -15 |
| 1960-06-12 | vs KC1 | 54 | L 3-5 | 31-23 | 2 | 13,312 | Hoyt Wilhelm | Bob Trowbridge | Johnny Kucks | Hoyt Wilhelm | | 236 | 253 | -17 |
| 1960-06-14 | @ CLE | 55 | W 7-4 | 32-23 | 2 | 11,319 | Milt Pappas | Gary Bell | Milt Pappas | Gary Bell | Jerry Walker | 243 | 257 | -14 |
| 1960-06-15 | @ CLE | 56 | L 2-10 | 33-24 | 2 | 0 | Steve Barber | Jim Perry | Jim Perry | Steve Barber | | 245 | 267 | -22 |
| 1960-06-15 | @ CLE | 57 | W 13-5 | 33-24 | 2 | 17,876 | Hal Brown | Bobby Locke | Hoyt Wilhelm | Mudcat Grant | | 258 | 272 | -14 |
| 1960-06-16 | @ CLE | 58 | W 3-2 | 34-24 | 1 | 6,076 | Jack Fisher | Ted Bowsfield | Jack Fisher | Barry Latman | | 261 | 274 | -13 |
| 1960-06-17 | @ DET | 59 | W 3-1 | 35-24 | 1 | 29,079 | Jerry Walker | Frank Lary | Jerry Walker | Frank Lary | Gordon Jones | 264 | 275 | -11 |
| 1960-06-18 | @ DET | 60 | L 3-5 | 35-25 | 1 | 16,274 | Chuck Estrada | Pete Burnside | Ray Semproch | Billy Hoeft | | 267 | 280 | -13 |
| 1960-06-19 | @ DET | 61 | W 2-0 | 37-25 | 1 | 0 | Hoyt Wilhelm | Jim Bunning | Hoyt Wilhelm | Jim Bunning | | 269 | 280 | -11 |
| 1960-06-19 | @ DET | 62 | W 1-0 | 37-25 | 1 | 38,109 | Milt Pappas | Don Mossi | Milt Pappas | Don Mossi | | 270 | 280 | -10 |
| 1960-06-21 | @ CHA | 63 | L 3-4 | 37-26 | 2 | 22,881 | Steve Barber | Billy Pierce | Frank Baumann | Chuck Estrada | | 273 | 284 | -11 |
| 1960-06-22 | @ CHA | 64 | L 1-3 | 37-27 | 2 | 25,062 | Jack Fisher | Early Wynn | Early Wynn | Jack Fisher | | 274 | 287 | -13 |
| 1960-06-23 | @ CHA | 65 | W 5-3 | 38-27 | 2 | 11,118 | Jerry Walker | Frank Baumann | Chuck Estrada | Gerry Staley | Hoyt Wilhelm | 279 | 290 | -11 |
| 1960-06-24 | @ KC1 | 66 | W 6-5 | 39-27 | 2 | 16,623 | Hal Brown | Don Larsen | Hoyt Wilhelm | Ray Herbert | | 285 | 295 | -10 |
| 1960-06-25 | @ KC1 | 67 | W 11-2 | 40-27 | 1 | 6,585 | Milt Pappas | Bud Daley | Milt Pappas | Bud Daley | | 296 | 297 | -1 |
| 1960-06-26 | @ KC1 | 68 | W 9-2 | 41-27 | 1 | 9,612 | Chuck Estrada | Dick Hall | Chuck Estrada | Dick Hall | | 305 | 299 | 6 |
| 1960-06-27 | vs WS1 | 69 | L 2-5 | 41-28 | 1 | 13,286 | Jack Fisher | Jack Kralick | Jack Kralick | Hoyt Wilhelm | | 307 | 304 | 3 |
| 1960-06-28 | vs CLE | 70 | L 2-3 | 41-29 | 2 | 18,406 | Steve Barber | Gary Bell | Johnny Klippstein | Gordon Jones | | 309 | 307 | 2 |
| 1960-06-29 | vs CLE | 71 | L 3-5 | 41-30 | 3 | 15,524 | Jerry Walker | Dick Stigman | Dick Stigman | Jerry Walker | | 312 | 312 | 0 |
| 1960-06-30 | vs CLE | 72 | W 9-1 | 42-30 | 2 | 14,757 | Hal Brown | Ted Bowsfield | Hal Brown | Ted Bowsfield | | 321 | 313 | 8 |
| 1960-07-01 | vs CHA | 73 | W 4-0 | 43-30 | 2 | 16,204 | Milt Pappas | Billy Pierce | Milt Pappas | Billy Pierce | | 325 | 313 | 12 |
| 1960-07-02 | vs CHA | 74 | L 7-8 | 43-31 | 2 | 23,367 | Chuck Estrada | Early Wynn | Dick Donovan | Chuck Estrada | Frank Baumann | 332 | 321 | 11 |
| 1960-07-03 | vs CHA | 75 | L 1-2 | 43-32 | 3 | 11,967 | Jack Fisher | Herb Score | Gerry Staley | Jack Fisher | | 333 | 323 | 10 |
| 1960-07-04 | @ BOS | 76 | L 7-10 | 44-33 | 3 | 0 | Steve Barber | Bill Monbouquette | Mike Fornieles | Hoyt Wilhelm | Frank Sullivan | 340 | 333 | 7 |
| 1960-07-04 | @ BOS | 77 | W 8-6 | 44-33 | 3 | 20,206 | Jerry Walker | Tom Borland | Billy Hoeft | Billy Muffett | | 348 | 339 | 9 |
| 1960-07-05 | @ BOS | 78 | W 9-4 | 45-33 | 3 | 17,302 | Chuck Estrada | Tom Brewer | Chuck Estrada | Tom Brewer | | 357 | 343 | 14 |
| 1960-07-06 | vs NYA | 79 | L 2-5 | 45-34 | 3 | 36,183 | Hal Brown | Whitey Ford | Whitey Ford | Hal Brown | | 359 | 348 | 11 |
| 1960-07-07 | vs NYA | 80 | L 3-6 | 45-35 | 3 | 30,647 | Milt Pappas | Bob Turley | Duke Maas | Milt Pappas | Bobby Shantz | 362 | 354 | 8 |
| 1960-07-08 | vs WS1 | 81 | L 5-9 | 45-36 | 3 | 7,926 | Jack Fisher | Pedro Ramos | Pedro Ramos | Jack Fisher | | 367 | 363 | 4 |
| 1960-07-09 | vs WS1 | 82 | L 2-7 | 45-37 | 4 | 7,319 | Hoyt Wilhelm | Hal Woodeshick | Rudy Hernandez | Chuck Estrada | | 369 | 370 | -1 |
| 1960-07-10 | vs WS1 | 83 | L 1-2 | 45-38 | 4 | 6,166 | Jerry Walker | Jack Kralick | Tex Clevenger | Jerry Walker | | 370 | 372 | -2 |
| 1960-07-15 | @ CHA | 84 | W 5-2 | 46-38 | 4 | 43,704 | Milt Pappas | Billy Pierce | Milt Pappas | Billy Pierce | | 375 | 374 | 1 |
| 1960-07-16 | @ CHA | 85 | W 4-3 | 47-38 | 3 | 16,599 | Jerry Walker | Frank Baumann | Hoyt Wilhelm | Gerry Staley | | 379 | 377 | 2 |
| 1960-07-17 | @ CHA | 86 | L 1-2 | 47-40 | 4 | 0 | Steve Barber | Bob Shaw | Bob Shaw | Steve Barber | | 380 | 379 | 1 |
| 1960-07-17 | @ CHA | 87 | L 2-14 | 47-40 | 4 | 28,295 | Jack Fisher | Early Wynn | Early Wynn | Jack Fisher | | 382 | 393 | -11 |
| 1960-07-18 | @ KC1 | 88 | L 1-5 | 47-41 | 4 | 6,567 | Hal Brown | Ned Garver | Ned Garver | Hal Brown | | 383 | 398 | -15 |
| 1960-07-19 | @ KC1 | 89 | W 9-3 | 48-41 | 4 | 8,152 | Chuck Estrada | Bud Daley | Hoyt Wilhelm | Bud Daley | | 392 | 401 | -9 |
| 1960-07-20 | @ KC1 | 90 | L 3-4 | 48-42 | 4 | 9,902 | Milt Pappas | Ray Herbert | Ray Herbert | Milt Pappas | | 395 | 405 | -10 |
| 1960-07-22 | vs DET | 91 | W 2-1 | 49-42 | 4 | 24,892 | Steve Barber | Pete Burnside | Jack Fisher | Pete Burnside | | 397 | 406 | -9 |
| 1960-07-23 | vs DET | 92 | L 1-4 | 50-43 | 4 | 0 | Jerry Walker | Hank Aguirre | Hank Aguirre | Jerry Walker | | 398 | 410 | -12 |
| 1960-07-23 | vs DET | 93 | W 4-3 | 50-43 | 4 | 25,276 | Hal Brown | Phil Regan | Hoyt Wilhelm | Phil Regan | | 402 | 413 | -11 |
| 1960-07-24 | vs DET | 94 | W 2-1 | 51-43 | 3 | 7,177 | Chuck Estrada | Jim Bunning | Chuck Estrada | Dave Sisler | | 404 | 414 | -10 |
| 1960-07-26 | vs KC1 | 95 | L 1-2 | 51-44 | 3 | 9,147 | Milt Pappas | Johnny Kucks | Johnny Kucks | Milt Pappas | | 405 | 416 | -11 |
| 1960-07-28 | vs KC1 | 96 | W 5-0 | 52-44 | 3 | 6,073 | Steve Barber | Bud Daley | Steve Barber | Bud Daley | | 410 | 416 | -6 |
| 1960-07-29 | vs CLE | 97 | L 1-3 | 52-45 | 3 | 21,608 | Jack Fisher | Jack Harshman | Jack Harshman | Jack Fisher | Dick Stigman | 411 | 419 | -8 |
| 1960-07-30 | vs CLE | 98 | W 4-3 | 53-45 | 3 | 6,614 | Chuck Estrada | Mudcat Grant | Chuck Estrada | Johnny Klippstein | | 415 | 422 | -7 |
| 1960-07-31 | vs CLE | 99 | W 6-5 | 54-45 | 3 | 9,465 | Hal Brown | Gary Bell | Wes Stock | Gary Bell | Jack Fisher | 421 | 427 | -6 |
| 1960-08-01 | vs CHA | 100 | W 2-1 | 55-45 | 3 | 11,971 | Milt Pappas | Herb Score | Milt Pappas | Herb Score | | 423 | 428 | -5 |
| 1960-08-02 | vs CHA | 101 | W 6-2 | 56-45 | 3 | 22,703 | Steve Barber | Billy Pierce | Steve Barber | Billy Pierce | Jerry Walker | 429 | 430 | -1 |
| 1960-08-03 | vs CHA | 102 | W 6-5 | 57-45 | 3 | 13,917 | Hoyt Wilhelm | Frank Baumann | Wes Stock | Turk Lown | | 435 | 435 | 0 |
| 1960-08-05 | @ CLE | 103 | L 3-4 | 57-46 | 3 | 24,275 | Chuck Estrada | Jim Perry | Jim Perry | Chuck Estrada | Johnny Klippstein | 438 | 439 | -1 |
| 1960-08-06 | @ CLE | 104 | W 5-2 | 58-46 | 3 | 9,203 | Jack Fisher | Jack Harshman | Hal Brown | Jack Harshman | Jerry Walker | 443 | 441 | 2 |
| 1960-08-07 | @ CLE | 105 | W 8-6 | 60-46 | 3 | 0 | Steve Barber | Mudcat Grant | Jack Fisher | Bobby Locke | Wes Stock | 451 | 447 | 4 |
| 1960-08-07 | @ CLE | 106 | W 9-2 | 60-46 | 3 | 35,515 | Milt Pappas | Dick Stigman | Milt Pappas | Dick Stigman | | 460 | 449 | 11 |
| 1960-08-09 | @ DET | 107 | W 3-0 | 61-46 | 2 | 22,007 | Chuck Estrada | Frank Lary | Chuck Estrada | Frank Lary | | 463 | 449 | 14 |
| 1960-08-10 | @ DET | 108 | W 4-2 | 62-46 | 2 | 7,984 | Jerry Walker | Pete Burnside | Jerry Walker | Pete Burnside | Hoyt Wilhelm | 467 | 451 | 16 |
| 1960-08-11 | @ DET | 109 | W 6-1 | 63-46 | 2 | 8,193 | Jack Fisher | Don Mossi | Jack Fisher | Don Mossi | | 473 | 452 | 21 |
| 1960-08-12 | vs BOS | 110 | W 4-3 | 64-46 | 1 | 20,691 | Steve Barber | Billy Muffett | Chuck Estrada | Mike Fornieles | | 477 | 455 | 22 |
| 1960-08-13 | vs BOS | 111 | W 8-7 | 65-46 | 1 | 23,672 | Milt Pappas | Tom Brewer | Hoyt Wilhelm | Tom Sturdivant | | 485 | 462 | 23 |
| 1960-08-14 | vs BOS | 112 | L 2-3 | 65-47 | 1 | 11,542 | Steve Barber | Bill Monbouquette | Mike Fornieles | Hal Brown | | 487 | 465 | 22 |
| 1960-08-15 | @ NYA | 113 | L 3-4 | 65-48 | 2 | 24,233 | Jerry Walker | Art Ditmar | Art Ditmar | Hoyt Wilhelm | | 490 | 469 | 21 |
| 1960-08-16 | @ NYA | 114 | L 0-1 | 65-49 | 3 | 30,149 | Chuck Estrada | Whitey Ford | Whitey Ford | Chuck Estrada | | 490 | 470 | 20 |
| 1960-08-17 | vs WS1 | 115 | L 7-11 | 65-50 | 3 | 18,280 | Jack Fisher | Don Lee | Tex Clevenger | Wes Stock | | 497 | 481 | 16 |
| 1960-08-18 | vs WS1 | 116 | W 10-8 | 66-50 | 2 | 12,374 | Milt Pappas | Jack Kralick | Milt Pappas | Jack Kralick | Jerry Walker | 507 | 489 | 18 |
| 1960-08-20 | @ BOS | 117 | L 6-8 | 67-51 | 3 | 17,437 | Chuck Estrada | Bill Monbouquette | Bill Monbouquette | Chuck Estrada | Mike Fornieles | 513 | 497 | 16 |
| 1960-08-20 | @ BOS | 118 | W 6-0 | 67-51 | 3 | 20,177 | Hal Brown | Earl Wilson | Hal Brown | Earl Wilson | | 519 | 497 | 22 |
| 1960-08-21 | @ BOS | 119 | W 10-4 | 68-51 | 2 | 23,141 | Steve Barber | Ike Delock | Steve Barber | Ike Delock | Wes Stock | 529 | 501 | 28 |
| 1960-08-23 | vs DET | 120 | L 3-5 | 68-52 | 3 | 16,665 | Milt Pappas | Phil Regan | Bill Fischer | Wes Stock | | 532 | 506 | 26 |
| 1960-08-24 | vs DET | 121 | W 9-2 | 69-52 | 2 | 15,147 | Jack Fisher | Bob Bruce | Jack Fisher | Bob Bruce | | 541 | 508 | 33 |
| 1960-08-25 | vs DET | 122 | W 9-3 | 70-52 | 2 | 14,941 | Chuck Estrada | Frank Lary | Chuck Estrada | Frank Lary | | 550 | 511 | 39 |
| 1960-08-26 | vs KC1 | 123 | W 2-1 | 72-52 | 2 | 0 | Steve Barber | Ned Garver | Steve Barber | Ned Garver | | 552 | 512 | 40 |
| 1960-08-26 | vs KC1 | 124 | W 11-3 | 72-52 | 2 | 16,582 | Hal Brown | Bud Daley | Hoyt Wilhelm | Bud Daley | | 563 | 515 | 48 |
| 1960-08-27 | vs KC1 | 125 | L 3-5 | 72-53 | 3 | 7,913 | Jerry Walker | Ray Herbert | Ray Herbert | Jerry Walker | | 566 | 520 | 46 |
| 1960-08-28 | vs CHA | 126 | W 3-1 | 73-53 | 2 | 14,945 | Milt Pappas | Early Wynn | Milt Pappas | Early Wynn | Hoyt Wilhelm | 569 | 521 | 48 |
| 1960-08-29 | vs CHA | 127 | W 4-0 | 74-53 | 2 | 22,372 | Jack Fisher | Herb Score | Jack Fisher | Herb Score | | 573 | 521 | 52 |
| 1960-08-30 | vs CLE | 128 | W 4-1 | 75-53 | 2 | 14,185 | Chuck Estrada | Jim Perry | Chuck Estrada | Jim Perry | | 577 | 522 | 55 |
| 1960-08-31 | vs CLE | 129 | W 6-3 | 76-53 | 2 | 17,024 | Steve Barber | Dick Stigman | Hal Brown | Dick Stigman | | 583 | 525 | 58 |
| 1960-09-02 | vs NYA | 130 | W 5-0 | 77-53 | 1 | 44,518 | Milt Pappas | Whitey Ford | Milt Pappas | Whitey Ford | | 588 | 525 | 63 |
| 1960-09-03 | vs NYA | 131 | W 2-0 | 78-53 | 1 | 35,499 | Jack Fisher | Art Ditmar | Jack Fisher | Art Ditmar | | 590 | 525 | 65 |
| 1960-09-04 | vs NYA | 132 | W 6-2 | 79-53 | 1 | 34,587 | Chuck Estrada | Bill Stafford | Chuck Estrada | Bill Stafford | Hoyt Wilhelm | 596 | 527 | 69 |
| 1960-09-05 | @ WS1 | 133 | L 0-4 | 80-54 | 1 | 0 | Steve Barber | Chuck Stobbs | Chuck Stobbs | Steve Barber | Hal Woodeshick | 596 | 531 | 65 |
| 1960-09-05 | @ WS1 | 134 | W 3-1 | 80-54 | 1 | 26,568 | Hal Brown | Pedro Ramos | Hal Brown | Pedro Ramos | | 599 | 532 | 67 |
| 1960-09-07 | @ CLE | 135 | L 2-3 | 80-55 | 1 | 7,514 | Milt Pappas | Jim Perry | Jim Perry | Milt Pappas | | 601 | 535 | 66 |
| 1960-09-08 | @ CLE | 136 | W 9-0 | 81-55 | 1 | 6,513 | Jack Fisher | Dick Stigman | Jack Fisher | Dick Stigman | | 610 | 535 | 75 |
| 1960-09-09 | @ CHA | 137 | L 2-5 | 81-56 | 1 | 37,008 | Chuck Estrada | Bob Shaw | Bob Shaw | Chuck Estrada | Frank Baumann | 612 | 540 | 72 |
| 1960-09-10 | @ CHA | 138 | L 2-3 | 81-57 | 2 | 20,546 | Hal Brown | Herb Score | Frank Baumann | Hoyt Wilhelm | | 614 | 543 | 71 |
| 1960-09-11 | @ KC1 | 139 | W 4-0 | 82-57 | 2 | 16,212 | Steve Barber | Ned Garver | Steve Barber | Ned Garver | Chuck Estrada | 618 | 543 | 75 |
| 1960-09-13 | @ DET | 140 | L 1-3 | 82-58 | 2 | 7,827 | Milt Pappas | Jim Bunning | Jim Bunning | Milt Pappas | | 619 | 546 | 73 |
| 1960-09-14 | @ DET | 141 | W 11-10 | 83-58 | 1 | 3,182 | Jack Fisher | Bob Bruce | Chuck Estrada | Hank Aguirre | Steve Barber | 630 | 556 | 74 |
| 1960-09-16 | @ NYA | 142 | L 2-4 | 83-59 | 2 | 50,332 | Steve Barber | Whitey Ford | Whitey Ford | Steve Barber | Bobby Shantz | 632 | 560 | 72 |
| 1960-09-17 | @ NYA | 143 | L 3-5 | 83-60 | 2 | 49,055 | Chuck Estrada | Bob Turley | Jim Coates | Chuck Estrada | Luis Arroyo | 635 | 565 | 70 |
| 1960-09-18 | @ NYA | 144 | L 3-7 | 83-62 | 2 | 0 | Jack Fisher | Art Ditmar | Art Ditmar | Jack Fisher | Jim Coates | 638 | 572 | 66 |
| 1960-09-18 | @ NYA | 145 | L 0-2 | 83-62 | 2 | 53,876 | Milt Pappas | Ralph Terry | Ralph Terry | Milt Pappas | | 638 | 574 | 64 |
| 1960-09-20 | vs BOS | 146 | W 4-3 | 84-62 | 2 | 18,914 | Hal Brown | Tom Brewer | Billy Hoeft | Tom Brewer | Hoyt Wilhelm | 642 | 577 | 65 |
| 1960-09-21 | vs BOS | 147 | L 1-4 | 84-63 | 3 | 19,457 | Steve Barber | Ike Delock | Ike Delock | Steve Barber | | 643 | 581 | 62 |
| 1960-09-23 | @ WS1 | 148 | L 0-4 | 84-64 | 3 | 9,233 | Chuck Estrada | Chuck Stobbs | Chuck Stobbs | Chuck Estrada | | 643 | 585 | 58 |
| 1960-09-24 | @ WS1 | 149 | W 10-9 | 85-64 | 3 | 4,618 | Jack Fisher | Don Lee | Hoyt Wilhelm | Hal Woodeshick | | 653 | 594 | 59 |
| 1960-09-25 | @ WS1 | 150 | W 3-1 | 86-64 | 2 | 6,448 | Milt Pappas | Jack Kralick | Milt Pappas | Jack Kralick | Steve Barber | 656 | 595 | 61 |
| 1960-09-27 | @ BOS | 151 | W 17-3 | 87-64 | 2 | 5,840 | Hal Brown | Ike Delock | Hal Brown | Ike Delock | Gordon Jones | 673 | 598 | 75 |
| 1960-09-28 | @ BOS | 152 | L 4-5 | 87-65 | 2 | 10,454 | Steve Barber | Billy Muffett | Mike Fornieles | Jack Fisher | | 677 | 603 | 74 |
| 1960-10-01 | @ WS1 | 153 | W 3-2 | 88-65 | 2 | 2,641 | Chuck Estrada | Jack Kralick | Chuck Estrada | Jack Kralick | | 680 | 605 | 75 |
| 1960-10-02 | @ WS1 | 154 | W 2-1 | 89-65 | 2 | 4,768 | Milt Pappas | Pedro Ramos | Milt Pappas | Pedro Ramos | | 682 | 606 | 76 |