| 1950-04-18 | vs DET | 1 | L 6-7 | - | | 65,744 | Bob Lemon | Fred Hutchinson | Art Houtteman | Jesse Flores | Paul Calvert | 6 | 7 | -1 |
| 1950-04-20 | vs DET | 2 | L 4-5 | - | | 4,964 | Early Wynn | Ted Gray | Ted Gray | Early Wynn | | 10 | 12 | -2 |
| 1950-04-22 | @ SLA | 3 | W 6-2 | - | | 10,166 | Bob Feller | Stubby Overmire | Bob Feller | Stubby Overmire | | 16 | 14 | 2 |
| 1950-04-23 | @ SLA | 4 | W 9-6 | - | | 0 | Bob Lemon | Ed Albrecht | Bob Lemon | Ribs Raney | | 25 | 20 | 5 |
| 1950-04-23 | @ SLA | 5 | W 7-5 | - | | 18,146 | Sam Zoldak | Ned Garver | Steve Gromek | Ned Garver | Jesse Flores | 32 | 25 | 7 |
| 1950-04-28 | @ DET | 6 | W 6-1 | - | | 15,155 | Bob Feller | Ted Gray | Bob Feller | Ted Gray | | 38 | 26 | 12 |
| 1950-04-29 | vs SLA | 7 | L 1-5 | - | | 7,919 | Bob Lemon | Joe Ostrowski | Joe Ostrowski | Bob Lemon | | 39 | 31 | 8 |
| 1950-05-02 | @ BOS | 8 | L 1-6 | - | | 11,591 | Mike Garcia | Mickey McDermott | Mickey McDermott | Mike Garcia | | 40 | 37 | 3 |
| 1950-05-03 | @ BOS | 9 | L 2-7 | - | | 14,582 | Bob Feller | Ellis Kinder | Ellis Kinder | Bob Feller | | 42 | 44 | -2 |
| 1950-05-04 | @ BOS | 10 | W 5-4 | - | | 13,138 | Bob Lemon | Mel Parnell | Bob Lemon | Mel Parnell | | 47 | 48 | -1 |
| 1950-05-06 | @ NYA | 11 | W 5-4 | - | | 0 | Early Wynn | Allie Reynolds | Early Wynn | Allie Reynolds | Bob Lemon | 52 | 52 | 0 |
| 1950-05-06 | @ NYA | 12 | L 4-7 | - | | 34,730 | Sam Zoldak | Fred Sanford | Fred Sanford | Sam Zoldak | Joe Page | 56 | 59 | -3 |
| 1950-05-07 | @ WS1 | 13 | L 5-10 | - | | 23,138 | Mike Garcia | Connie Marrero | Mickey Harris | Jesse Flores | | 61 | 69 | -8 |
| 1950-05-08 | @ WS1 | 14 | L 2-4 | - | | 19,985 | Bob Feller | Sid Hudson | Sid Hudson | Bob Feller | | 63 | 73 | -10 |
| 1950-05-09 | @ PHA | 15 | L 8-9 | - | | 11,908 | Steve Gromek | Hank Wyse | Hank Wyse | Steve Gromek | Carl Scheib | 71 | 82 | -11 |
| 1950-05-10 | @ PHA | 16 | W 6-4 | - | | 5,616 | Bob Lemon | Bobby Shantz | Bob Lemon | Bob Hooper | Jesse Flores | 77 | 86 | -9 |
| 1950-05-11 | @ PHA | 17 | W 4-3 | - | | 3,035 | Mike Garcia | Alex Kellner | Jesse Flores | Alex Kellner | | 81 | 89 | -8 |
| 1950-05-12 | vs CHA | 18 | W 5-1 | - | | 26,932 | Early Wynn | Bill Wight | Early Wynn | Bill Wight | Marino Pieretti | 86 | 90 | -4 |
| 1950-05-13 | vs CHA | 19 | W 6-2 | - | | 8,547 | Bob Feller | Bob Cain | Jesse Flores | Bob Cain | | 92 | 92 | 0 |
| 1950-05-14 | vs CHA | 20 | L 2-3 | - | | 0 | Bob Lemon | Mickey Haefner | Mickey Haefner | Bob Lemon | | 94 | 95 | -1 |
| 1950-05-14 | vs CHA | 21 | W 3-1 | - | | 27,968 | Mike Garcia | Billy Pierce | Mike Garcia | Billy Pierce | | 97 | 96 | 1 |
| 1950-05-16 | vs PHA | 22 | W 15-4 | - | | 12,396 | Early Wynn | Alex Kellner | Early Wynn | Carl Scheib | | 112 | 100 | 12 |
| 1950-05-17 | vs PHA | 23 | L 5-7 | - | | 12,471 | Bob Feller | Dick Fowler | Bobby Shantz | Jesse Flores | Carl Scheib | 117 | 107 | 10 |
| 1950-05-18 | vs PHA | 24 | W 4-3 | - | | 5,251 | Steve Gromek | Lou Brissie | Al Benton | Lou Brissie | | 121 | 110 | 11 |
| 1950-05-19 | vs BOS | 25 | W 4-1 | - | | 34,892 | Mike Garcia | Mel Parnell | Sam Zoldak | Mel Parnell | | 125 | 111 | 14 |
| 1950-05-20 | vs BOS | 26 | W 8-5 | - | | 21,528 | Bob Lemon | Chuck Stobbs | Bob Lemon | Chuck Stobbs | | 133 | 116 | 17 |
| 1950-05-21 | vs NYA | 27 | L 5-14 | - | | 0 | Early Wynn | Eddie Lopat | Eddie Lopat | Early Wynn | | 138 | 130 | 8 |
| 1950-05-21 | vs NYA | 28 | L 4-12 | - | | 79,570 | Bob Feller | Allie Reynolds | Allie Reynolds | Bob Feller | | 142 | 142 | 0 |
| 1950-05-22 | vs NYA | 29 | L 2-7 | - | | 23,035 | Mike Garcia | Vic Raschi | Vic Raschi | Mike Garcia | | 144 | 149 | -5 |
| 1950-05-24 | vs WS1 | 30 | W 5-4 | - | | 13,082 | Early Wynn | Steve Nagy | Gene Bearden | Joe Haynes | | 149 | 153 | -4 |
| 1950-05-25 | vs WS1 | 31 | W 3-0 | - | | 5,691 | Bob Lemon | Dick Weik | Bob Lemon | Dick Weik | | 152 | 153 | -1 |
| 1950-05-26 | @ CHA | 32 | W 2-1 | - | | 9,879 | Bob Feller | Bob Cain | Bob Feller | Bob Cain | | 154 | 154 | 0 |
| 1950-05-27 | @ CHA | 33 | L 1-6 | - | | 2,325 | Mike Garcia | Billy Pierce | Billy Pierce | Mike Garcia | | 155 | 160 | -5 |
| 1950-05-28 | @ CHA | 34 | L 0-2 | - | | 0 | Early Wynn | Bill Wight | Bill Wight | Early Wynn | | 155 | 162 | -7 |
| 1950-05-28 | @ CHA | 35 | W 7-0 | - | | 23,559 | Steve Gromek | Mickey Haefner | Steve Gromek | Mickey Haefner | | 162 | 162 | 0 |
| 1950-05-30 | @ DET | 36 | W 4-0 | - | | 0 | Bob Lemon | Art Houtteman | Bob Lemon | Art Houtteman | | 166 | 162 | 4 |
| 1950-05-30 | @ DET | 37 | L 2-5 | - | | 55,537 | Gene Bearden | Hal Newhouser | Hal Newhouser | Gene Bearden | | 168 | 167 | 1 |
| 1950-06-02 | @ BOS | 38 | L 5-11 | - | | 35,473 | Bob Feller | Joe Dobson | Joe Dobson | Bob Feller | | 173 | 178 | -5 |
| 1950-06-03 | @ BOS | 39 | L 9-11 | - | | 23,612 | Mike Garcia | Mel Parnell | Al Papai | Mike Garcia | | 182 | 189 | -7 |
| 1950-06-04 | @ NYA | 40 | L 0-7 | - | | 44,781 | Bob Lemon | Eddie Lopat | Eddie Lopat | Bob Lemon | | 182 | 196 | -14 |
| 1950-06-05 | @ NYA | 41 | W 3-2 | - | | 57,629 | Bob Feller | Allie Reynolds | Bob Feller | Allie Reynolds | | 185 | 198 | -13 |
| 1950-06-06 | @ NYA | 42 | W 16-2 | - | | 17,867 | Mike Garcia | Bob Porterfield | Mike Garcia | Bob Porterfield | | 201 | 200 | 1 |
| 1950-06-07 | @ WS1 | 43 | L 4-5 | - | | 17,526 | Early Wynn | Sid Hudson | Sid Hudson | Early Wynn | | 205 | 205 | 0 |
| 1950-06-08 | @ WS1 | 44 | L 6-7 | - | | 16,589 | Bob Lemon | Bob Kuzava | Mickey Harris | Gene Bearden | | 211 | 212 | -1 |
| 1950-06-09 | @ WS1 | 45 | W 8-7 | - | | 5,482 | Bob Feller | Connie Marrero | Bob Feller | Connie Marrero | Sam Zoldak | 219 | 219 | 0 |
| 1950-06-10 | @ PHA | 46 | W 7-3 | - | | 3,811 | Mike Garcia | Lou Brissie | Mike Garcia | Lou Brissie | | 226 | 222 | 4 |
| 1950-06-11 | @ PHA | 47 | W 6-3 | - | | 0 | Bob Lemon | Bobby Shantz | Bob Lemon | Bobby Shantz | Al Benton | 232 | 225 | 7 |
| 1950-06-11 | @ PHA | 48 | L 6-9 | - | | 14,241 | Steve Gromek | Alex Kellner | Alex Kellner | Steve Gromek | Bob Hooper | 238 | 234 | 4 |
| 1950-06-13 | vs BOS | 49 | L 1-8 | - | | 25,496 | Bob Feller | Chuck Stobbs | Chuck Stobbs | Bob Feller | | 239 | 242 | -3 |
| 1950-06-14 | vs BOS | 50 | W 7-3 | - | | 28,368 | Mike Garcia | Ellis Kinder | Mike Garcia | Ellis Kinder | | 246 | 245 | 1 |
| 1950-06-15 | vs BOS | 51 | W 3-1 | - | | 12,684 | Bob Lemon | Walt Masterson | Bob Lemon | Walt Masterson | | 249 | 246 | 3 |
| 1950-06-16 | vs PHA | 52 | W 3-2 | - | | 26,102 | Early Wynn | Alex Kellner | Early Wynn | Alex Kellner | | 252 | 248 | 4 |
| 1950-06-17 | vs PHA | 53 | W 8-7 | - | | 9,232 | Gene Bearden | Bob Hooper | Dick Weik | Carl Scheib | | 260 | 255 | 5 |
| 1950-06-18 | vs PHA | 54 | W 7-0 | - | | 0 | Bob Feller | Dick Fowler | Bob Feller | Dick Fowler | | 267 | 255 | 12 |
| 1950-06-18 | vs PHA | 55 | W 21-2 | - | | 35,521 | Mike Garcia | Lou Brissie | Mike Garcia | Lou Brissie | | 288 | 257 | 31 |
| 1950-06-20 | vs NYA | 56 | L 2-8 | - | | 57,733 | Bob Lemon | Eddie Lopat | Eddie Lopat | Bob Lemon | | 290 | 265 | 25 |
| 1950-06-21 | vs NYA | 57 | W 5-1 | - | | 16,737 | Early Wynn | Vic Raschi | Early Wynn | Vic Raschi | | 295 | 266 | 29 |
| 1950-06-22 | vs NYA | 58 | W 6-2 | - | | 18,407 | Bob Feller | Joe Ostrowski | Bob Feller | Joe Ostrowski | | 301 | 268 | 33 |
| 1950-06-23 | vs WS1 | 59 | W 13-4 | - | | 26,627 | Bob Lemon | Bob Ross | Bob Lemon | Bob Ross | | 314 | 272 | 42 |
| 1950-06-24 | vs WS1 | 60 | W 6-5 | - | | 12,219 | Gene Bearden | Sid Hudson | Steve Gromek | Mickey Harris | | 320 | 277 | 43 |
| 1950-06-25 | vs WS1 | 61 | W 7-6 | - | | 0 | Early Wynn | Connie Marrero | Early Wynn | Connie Marrero | Jesse Flores | 327 | 283 | 44 |
| 1950-06-25 | vs WS1 | 62 | L 3-5 | - | | 33,667 | Dick Weik | Sandy Consuegra | Sandy Consuegra | Dick Weik | Mickey Harris | 330 | 288 | 42 |
| 1950-06-27 | @ SLA | 63 | L 3-4 | - | | 4,050 | Bob Feller | Al Widmar | Al Widmar | Bob Feller | | 333 | 292 | 41 |
| 1950-06-28 | @ SLA | 64 | W 18-2 | - | | 2,491 | Bob Lemon | Fritz Dorish | Bob Lemon | Fritz Dorish | | 351 | 294 | 57 |
| 1950-06-29 | @ SLA | 65 | W 4-1 | - | | 2,273 | Steve Gromek | Duane Pillette | Steve Gromek | Duane Pillette | | 355 | 295 | 60 |
| 1950-06-30 | vs DET | 66 | W 11-3 | - | | 50,882 | Mike Garcia | Hal Newhouser | Mike Garcia | Hal Newhouser | | 366 | 298 | 68 |
| 1950-07-01 | vs DET | 67 | W 7-4 | - | | 28,056 | Early Wynn | Hal White | Early Wynn | Hal White | Al Benton | 373 | 302 | 71 |
| 1950-07-02 | vs DET | 68 | L 5-8 | - | | 0 | Bob Lemon | Art Houtteman | Hal Newhouser | Dick Weik | | 378 | 310 | 68 |
| 1950-07-02 | vs DET | 69 | W 5-3 | - | | 78,187 | Bob Feller | Ted Gray | Bob Feller | Ted Gray | Al Benton | 383 | 313 | 70 |
| 1950-07-03 | vs SLA | 70 | L 2-4 | - | | 11,656 | Steve Gromek | Dick Starr | Dick Starr | Steve Gromek | Cuddles Marshall | 385 | 317 | 68 |
| 1950-07-04 | vs SLA | 71 | W 8-7 | - | | 0 | Dick Rozek | Duane Pillette | Steve Gromek | Fritz Dorish | | 393 | 324 | 69 |
| 1950-07-04 | vs SLA | 72 | L 3-8 | - | | 25,799 | Mike Garcia | Don Johnson | Don Johnson | Mike Garcia | Al Widmar | 396 | 332 | 64 |
| 1950-07-05 | vs CHA | 73 | W 8-3 | - | | 23,006 | Bob Lemon | Billy Pierce | Bob Lemon | Billy Pierce | | 404 | 335 | 69 |
| 1950-07-06 | vs CHA | 74 | W 5-2 | - | | 13,405 | Early Wynn | Ray Scarborough | Early Wynn | Ray Scarborough | | 409 | 337 | 72 |
| 1950-07-07 | @ DET | 75 | L 2-5 | - | | 55,145 | Bob Feller | Ted Gray | Ted Gray | Bob Feller | | 411 | 342 | 69 |
| 1950-07-08 | @ DET | 76 | L 4-5 | - | | 33,239 | Steve Gromek | Hal Newhouser | Hal Newhouser | Steve Gromek | Dizzy Trout | 415 | 347 | 68 |
| 1950-07-09 | @ DET | 77 | W 6-2 | - | | 0 | Bob Lemon | Art Houtteman | Bob Lemon | Art Houtteman | | 421 | 349 | 72 |
| 1950-07-09 | @ DET | 78 | W 5-2 | - | | 54,299 | Mike Garcia | Saul Rogovin | Early Wynn | Saul Rogovin | | 426 | 351 | 75 |
| 1950-07-14 | @ NYA | 79 | W 5-1 | - | | 42,105 | Bob Lemon | Tommy Byrne | Bob Lemon | Tommy Byrne | | 431 | 352 | 79 |
| 1950-07-15 | @ NYA | 80 | L 3-4 | - | | 26,124 | Bob Feller | Eddie Lopat | Eddie Lopat | Early Wynn | | 434 | 356 | 78 |
| 1950-07-16 | @ BOS | 81 | L 10-13 | - | | 0 | Mike Garcia | Mel Parnell | Willard Nixon | Gene Bearden | Ellis Kinder | 444 | 369 | 75 |
| 1950-07-16 | @ BOS | 82 | W 8-4 | - | | 33,009 | Steve Gromek | Walt Masterson | Steve Gromek | Walt Masterson | Bob Lemon | 452 | 373 | 79 |
| 1950-07-17 | @ BOS | 83 | W 11-6 | - | | 12,438 | Early Wynn | Joe Dobson | Al Benton | Joe Dobson | | 463 | 379 | 84 |
| 1950-07-17 | @ BOS | 84 | L 5-7 | - | | 24,966 | Mike Garcia | Mickey McDermott | Joe Dobson | Marino Pieretti | | 468 | 386 | 82 |
| 1950-07-18 | @ PHA | 85 | W 10-2 | - | | 4,699 | Bob Lemon | Bobby Shantz | Bob Lemon | Bobby Shantz | Al Benton | 478 | 388 | 90 |
| 1950-07-19 | @ PHA | 86 | W 4-0 | - | | 4,580 | Bob Feller | Dick Fowler | Bob Feller | Dick Fowler | | 482 | 388 | 94 |
| 1950-07-20 | @ PHA | 87 | W 3-2 | - | | 2,948 | Steve Gromek | Alex Kellner | Sam Zoldak | Alex Kellner | | 485 | 390 | 95 |
| 1950-07-21 | @ WS1 | 88 | L 2-3 | - | | 18,735 | Mike Garcia | Connie Marrero | Connie Marrero | Mike Garcia | | 487 | 393 | 94 |
| 1950-07-22 | @ WS1 | 89 | W 8-3 | - | | 24,228 | Early Wynn | Sid Hudson | Sam Zoldak | Elmer Singleton | | 495 | 396 | 99 |
| 1950-07-23 | @ WS1 | 90 | W 6-2 | - | | 19,339 | Bob Lemon | Bob Kuzava | Bob Lemon | Bob Kuzava | | 501 | 398 | 103 |
| 1950-07-25 | vs PHA | 91 | W 7-6 | - | | 22,880 | Bob Feller | Alex Kellner | Bob Feller | Alex Kellner | Bob Lemon | 508 | 404 | 104 |
| 1950-07-26 | vs PHA | 92 | W 6-2 | - | | 19,025 | Mike Garcia | Dick Fowler | Sam Zoldak | Dick Fowler | | 514 | 406 | 108 |
| 1950-07-27 | vs PHA | 93 | L 2-7 | - | | 13,224 | Steve Gromek | Lou Brissie | Lou Brissie | Steve Gromek | | 516 | 413 | 103 |
| 1950-07-28 | vs BOS | 94 | W 13-1 | - | | 50,349 | Early Wynn | Mickey McDermott | Early Wynn | Mickey McDermott | | 529 | 414 | 115 |
| 1950-07-29 | vs BOS | 95 | W 4-1 | - | | 29,904 | Bob Lemon | Chuck Stobbs | Bob Lemon | Chuck Stobbs | | 533 | 415 | 118 |
| 1950-07-30 | vs BOS | 96 | W 6-5 | - | | 0 | Bob Feller | Walt Masterson | Al Benton | Ellis Kinder | | 539 | 420 | 119 |
| 1950-07-30 | vs BOS | 97 | L 3-6 | - | | 71,513 | Sam Zoldak | Willard Nixon | Willard Nixon | Sam Zoldak | Mel Parnell | 542 | 426 | 116 |
| 1950-08-01 | vs WS1 | 98 | W 8-2 | - | | 16,864 | Early Wynn | Sid Hudson | Early Wynn | Sid Hudson | | 550 | 428 | 122 |
| 1950-08-02 | vs WS1 | 99 | W 11-0 | - | | 20,224 | Bob Lemon | Connie Marrero | Bob Lemon | Connie Marrero | | 561 | 428 | 133 |
| 1950-08-04 | vs NYA | 100 | L 0-1 | - | | 66,743 | Bob Feller | Vic Raschi | Vic Raschi | Bob Feller | | 561 | 429 | 132 |
| 1950-08-05 | vs NYA | 101 | W 4-2 | - | | 40,987 | Early Wynn | Eddie Lopat | Early Wynn | Allie Reynolds | | 565 | 431 | 134 |
| 1950-08-06 | vs NYA | 102 | L 0-9 | - | | 66,726 | Bob Lemon | Tommy Byrne | Tommy Byrne | Bob Lemon | | 565 | 440 | 125 |
| 1950-08-09 | @ SLA | 103 | W 4-3 | - | | 0 | Bob Feller | Al Widmar | Al Benton | Al Widmar | Jesse Flores | 569 | 443 | 126 |
| 1950-08-09 | @ SLA | 104 | L 8-10 | - | | 7,986 | Early Wynn | Dick Starr | Cliff Fannin | Al Benton | | 577 | 453 | 124 |
| 1950-08-10 | @ SLA | 105 | W 5-4 | - | | 4,412 | Bob Lemon | Stubby Overmire | Bob Lemon | Stubby Overmire | | 582 | 457 | 125 |
| 1950-08-11 | @ CHA | 106 | W 3-2 | - | | 6,554 | Mike Garcia | Billy Pierce | Mike Garcia | Billy Pierce | | 585 | 459 | 126 |
| 1950-08-12 | @ CHA | 107 | L 4-11 | - | | 7,259 | Steve Gromek | Howie Judson | Luis Aloma | Steve Gromek | | 589 | 470 | 119 |
| 1950-08-13 | @ CHA | 108 | W 5-2 | - | | 0 | Bob Feller | Bill Wight | Bob Feller | Bill Wight | Sam Zoldak | 594 | 472 | 122 |
| 1950-08-13 | @ CHA | 109 | L 5-7 | - | | 37,940 | Dick Weik | Ray Scarborough | Ray Scarborough | Dick Weik | Ken Holcombe | 599 | 479 | 120 |
| 1950-08-14 | vs DET | 110 | W 3-2 | - | | 60,120 | Early Wynn | Hal Newhouser | Early Wynn | Hal Newhouser | | 602 | 481 | 121 |
| 1950-08-15 | vs DET | 111 | L 1-4 | - | | 40,299 | Bob Lemon | Art Houtteman | Art Houtteman | Bob Lemon | Marlin Stuart | 603 | 485 | 118 |
| 1950-08-16 | vs SLA | 112 | W 2-0 | - | | 0 | Jesse Flores | Al Widmar | Jesse Flores | Al Widmar | | 605 | 485 | 120 |
| 1950-08-16 | vs SLA | 113 | W 2-1 | - | | 27,016 | Mike Garcia | Don Johnson | Mike Garcia | Don Johnson | | 607 | 486 | 121 |
| 1950-08-17 | vs SLA | 114 | W 5-4 | - | | 15,301 | Bob Feller | Dick Starr | Steve Gromek | Cliff Fannin | | 612 | 490 | 122 |
| 1950-08-19 | vs CHA | 115 | W 1-0 | - | | 13,745 | Early Wynn | Ken Holcombe | Early Wynn | Ken Holcombe | | 613 | 490 | 123 |
| 1950-08-20 | vs CHA | 116 | L 1-2 | - | | 0 | Bob Lemon | Bill Wight | Bill Wight | Bob Lemon | | 614 | 492 | 122 |
| 1950-08-20 | vs CHA | 117 | L 5-6 | - | | 48,885 | Mike Garcia | Billy Pierce | Billy Pierce | Mike Garcia | | 619 | 498 | 121 |
| 1950-08-22 | @ WS1 | 118 | W 5-1 | - | | 14,873 | Bob Feller | Gene Bearden | Bob Feller | Gene Bearden | | 624 | 499 | 125 |
| 1950-08-24 | @ WS1 | 119 | W 3-1 | - | | 0 | Early Wynn | Sid Hudson | Early Wynn | Sid Hudson | | 627 | 500 | 127 |
| 1950-08-24 | @ WS1 | 120 | W 5-3 | - | | 20,628 | Bob Lemon | Sandy Consuegra | Bob Lemon | Sandy Consuegra | Sam Zoldak | 632 | 503 | 129 |
| 1950-08-25 | @ PHA | 121 | W 6-2 | - | | 5,204 | Mike Garcia | Alex Kellner | Mike Garcia | Alex Kellner | | 638 | 505 | 133 |
| 1950-08-26 | @ PHA | 122 | W 5-4 | - | | 3,181 | Jesse Flores | Joe Coleman | Bob Lemon | Joe Coleman | | 643 | 509 | 134 |
| 1950-08-27 | @ BOS | 123 | L 9-11 | - | | 31,747 | Bob Feller | Willard Nixon | Chuck Stobbs | Al Benton | Joe Dobson | 652 | 520 | 132 |
| 1950-08-28 | @ BOS | 124 | L 14-15 | - | | 28,328 | Bob Lemon | Mickey McDermott | Willard Nixon | Bob Feller | Ellis Kinder | 666 | 535 | 131 |
| 1950-08-29 | @ NYA | 125 | L 5-6 | - | | 0 | Early Wynn | Vic Raschi | Vic Raschi | Early Wynn | | 671 | 541 | 130 |
| 1950-08-30 | @ NYA | 126 | L 3-4 | - | | 0 | Bob Feller | Whitey Ford | Tom Ferrick | Bob Feller | | 674 | 545 | 129 |
| 1950-08-30 | @ NYA | 127 | L 0-3 | - | | 30,516 | Mike Garcia | Eddie Lopat | Eddie Lopat | Mike Garcia | | 674 | 548 | 126 |
| 1950-08-31 | @ NYA | 128 | L 5-7 | - | | 21,020 | Bob Lemon | Tommy Byrne | Tommy Byrne | Bob Lemon | Tom Ferrick | 679 | 555 | 124 |
| 1950-09-02 | @ SLA | 129 | W 4-2 | - | | 2,491 | Early Wynn | Stubby Overmire | Early Wynn | Stubby Overmire | | 683 | 557 | 126 |
| 1950-09-03 | @ SLA | 130 | W 8-1 | - | | 5,163 | Bob Feller | Don Johnson | Bob Feller | Don Johnson | | 691 | 558 | 133 |
| 1950-09-04 | @ CHA | 131 | L 1-7 | - | | 0 | Bob Lemon | Bob Cain | Bob Cain | Bob Lemon | Luis Aloma | 692 | 565 | 127 |
| 1950-09-04 | @ CHA | 132 | W 1-0 | - | | 33,489 | Mike Garcia | Randy Gumpert | Mike Garcia | Randy Gumpert | Sam Zoldak | 693 | 565 | 128 |
| 1950-09-05 | @ CHA | 133 | W 3-2 | - | | 2,577 | Steve Gromek | Billy Pierce | Steve Gromek | Billy Pierce | | 696 | 567 | 129 |
| 1950-09-06 | @ DET | 134 | L 3-5 | - | | 52,555 | Early Wynn | Hal Newhouser | Hal Newhouser | Early Wynn | | 699 | 572 | 127 |
| 1950-09-07 | @ DET | 135 | L 13-13 | - | | 26,617 | Bob Feller | Art Houtteman | | | | 712 | 585 | 127 |
| 1950-09-08 | vs SLA | 136 | L 4-5 | - | | 0 | Mike Garcia | Al Widmar | Duane Pillette | Mike Garcia | | 716 | 590 | 126 |
| 1950-09-08 | vs SLA | 137 | L 0-6 | - | | 18,736 | Bob Lemon | Don Johnson | Don Johnson | Bob Lemon | | 716 | 596 | 120 |
| 1950-09-09 | vs SLA | 138 | L 1-2 | - | | 15,867 | Steve Gromek | Ned Garver | Ned Garver | Steve Gromek | | 717 | 598 | 119 |
| 1950-09-10 | vs SLA | 139 | L 1-2 | - | | 12,885 | Bob Feller | Stubby Overmire | Stubby Overmire | Bob Feller | | 718 | 600 | 118 |
| 1950-09-12 | vs NYA | 140 | W 8-7 | - | | 29,454 | Early Wynn | Allie Reynolds | Steve Gromek | Tom Ferrick | | 726 | 607 | 119 |
| 1950-09-13 | vs NYA | 141 | L 3-10 | - | | 10,490 | Bob Lemon | Eddie Lopat | Eddie Lopat | Bob Lemon | Whitey Ford | 729 | 617 | 112 |
| 1950-09-15 | vs WS1 | 142 | W 4-2 | - | | 0 | Al Aber | Julio Moreno | Al Aber | Mickey Harris | | 733 | 619 | 114 |
| 1950-09-15 | vs WS1 | 143 | L 1-4 | - | | 11,471 | Mike Garcia | Sid Hudson | Sid Hudson | Mike Garcia | | 734 | 623 | 111 |
| 1950-09-16 | vs WS1 | 144 | W 5-1 | - | | 5,705 | Bob Feller | Sandy Consuegra | Bob Feller | Sandy Consuegra | | 739 | 624 | 115 |
| 1950-09-17 | vs PHA | 145 | L 9-10 | - | | 11,810 | Dick Rozek | Lou Brissie | Bob Hooper | Early Wynn | | 748 | 634 | 114 |
| 1950-09-20 | vs BOS | 146 | W 6-3 | - | | 0 | Bob Lemon | Chuck Stobbs | Bob Lemon | Chuck Stobbs | | 754 | 637 | 117 |
| 1950-09-20 | vs BOS | 147 | W 7-1 | - | | 11,852 | Early Wynn | Joe Dobson | Early Wynn | Joe Dobson | | 761 | 638 | 123 |
| 1950-09-22 | vs DET | 148 | W 4-3 | - | | 29,909 | Bob Feller | Hal Newhouser | Bob Feller | Hal Newhouser | | 765 | 641 | 124 |
| 1950-09-23 | vs DET | 149 | W 10-2 | - | | 17,315 | Mike Garcia | Art Houtteman | Mike Garcia | Art Houtteman | | 775 | 643 | 132 |
| 1950-09-24 | vs DET | 150 | W 2-1 | - | | 35,092 | Bob Lemon | Ted Gray | Bob Lemon | Ted Gray | | 777 | 644 | 133 |
| 1950-09-26 | vs CHA | 151 | W 2-0 | - | | 8,870 | Early Wynn | Bob Cain | Early Wynn | Bob Cain | | 779 | 644 | 135 |
| 1950-09-27 | vs CHA | 152 | W 7-0 | - | | 5,429 | Bob Feller | Ray Scarborough | Bob Feller | Ray Scarborough | | 786 | 644 | 142 |
| 1950-09-29 | @ DET | 153 | W 12-2 | - | | 9,814 | Bob Lemon | Ted Gray | Bob Lemon | Ted Gray | | 798 | 646 | 152 |
| 1950-09-30 | @ DET | 154 | L 1-3 | - | | 24,178 | Mike Garcia | Hal Newhouser | Hal Newhouser | Mike Garcia | | 799 | 649 | 150 |
| 1950-10-01 | @ DET | 155 | W 7-5 | - | | 49,110 | Marino Pieretti | Marlin Stuart | Steve Gromek | Marlin Stuart | | 806 | 654 | 152 |