| 1950-04-18 | @ WS1 | 1 | L 7-8 | - | | 29,320 | Carl Scheib | Ray Scarborough | Ray Scarborough | Carl Scheib | Mickey Harris | 7 | 8 | -1 |
| 1950-04-19 | @ WS1 | 2 | W 6-1 | - | | 10,153 | Hank Wyse | Sid Hudson | Hank Wyse | Sid Hudson | Bob Hooper | 13 | 9 | 4 |
| 1950-04-21 | vs BOS | 3 | L 2-8 | - | | 8,184 | Lou Brissie | Mickey McDermott | Mickey McDermott | Lou Brissie | | 15 | 17 | -2 |
| 1950-04-22 | vs BOS | 4 | W 6-5 | - | | 6,977 | Alex Kellner | Chuck Stobbs | Alex Kellner | Ellis Kinder | | 21 | 22 | -1 |
| 1950-04-23 | vs BOS | 5 | W 9-4 | - | | 0 | Bobby Shantz | Joe Dobson | Bobby Shantz | Joe Dobson | Bob Hooper | 30 | 26 | 4 |
| 1950-04-23 | vs BOS | 6 | L 2-12 | - | | 14,135 | Hank Wyse | Mel Parnell | Mel Parnell | Hank Wyse | | 32 | 38 | -6 |
| 1950-04-25 | vs NYA | 7 | L 3-6 | - | | 4,371 | Lou Brissie | Vic Raschi | Vic Raschi | Lou Brissie | | 35 | 44 | -9 |
| 1950-04-26 | vs WS1 | 8 | L 3-5 | - | | 6,303 | Bobby Shantz | Sid Hudson | Sid Hudson | Bobby Shantz | | 38 | 49 | -11 |
| 1950-04-27 | vs WS1 | 9 | W 4-3 | - | | 3,290 | Hank Wyse | Joe Haynes | Bob Hooper | Joe Haynes | | 42 | 52 | -10 |
| 1950-04-28 | @ BOS | 10 | L 1-4 | - | | 5,333 | Alex Kellner | Mel Parnell | Mel Parnell | Alex Kellner | | 43 | 56 | -13 |
| 1950-04-30 | @ BOS | 11 | L 0-19 | - | | 0 | Dick Fowler | Joe Dobson | Joe Dobson | Dick Fowler | | 43 | 75 | -32 |
| 1950-04-30 | @ BOS | 12 | L 5-6 | - | | 34,697 | Hank Wyse | Chuck Stobbs | Chuck Stobbs | Hank Wyse | Al Papai | 48 | 81 | -33 |
| 1950-05-04 | vs DET | 13 | L 5-8 | - | | 1,901 | Lou Brissie | Art Houtteman | Art Houtteman | Lou Brissie | | 53 | 89 | -36 |
| 1950-05-06 | vs SLA | 14 | W 12-4 | - | | 2,592 | Alex Kellner | Dick Starr | Alex Kellner | Dick Starr | | 65 | 93 | -28 |
| 1950-05-07 | vs CHA | 15 | L 3-7 | - | | 0 | Lou Brissie | Bill Wight | Bill Wight | Lou Brissie | | 68 | 100 | -32 |
| 1950-05-07 | vs CHA | 16 | W 4-2 | - | | 11,257 | Bob Hooper | Randy Gumpert | Bob Hooper | Randy Gumpert | Carl Scheib | 72 | 102 | -30 |
| 1950-05-09 | vs CLE | 17 | W 9-8 | - | | 11,908 | Hank Wyse | Steve Gromek | Hank Wyse | Steve Gromek | Carl Scheib | 81 | 110 | -29 |
| 1950-05-10 | vs CLE | 18 | L 4-6 | - | | 5,616 | Bobby Shantz | Bob Lemon | Bob Lemon | Bob Hooper | Jesse Flores | 85 | 116 | -31 |
| 1950-05-11 | vs CLE | 19 | L 3-4 | - | | 3,035 | Alex Kellner | Mike Garcia | Jesse Flores | Alex Kellner | | 88 | 120 | -32 |
| 1950-05-12 | @ NYA | 20 | L 2-3 | - | | 38,958 | Lou Brissie | Tommy Byrne | Tommy Byrne | Lou Brissie | | 90 | 123 | -33 |
| 1950-05-13 | @ NYA | 21 | L 3-9 | - | | 32,610 | Hank Wyse | Vic Raschi | Vic Raschi | Hank Wyse | Bob Porterfield | 93 | 132 | -39 |
| 1950-05-14 | @ NYA | 22 | W 9-8 | - | | 24,058 | Bob Hooper | Eddie Lopat | Bobby Shantz | Eddie Lopat | | 102 | 140 | -38 |
| 1950-05-16 | @ CLE | 23 | L 4-15 | - | | 12,396 | Alex Kellner | Early Wynn | Early Wynn | Carl Scheib | | 106 | 155 | -49 |
| 1950-05-17 | @ CLE | 24 | W 7-5 | - | | 12,471 | Dick Fowler | Bob Feller | Bobby Shantz | Jesse Flores | Carl Scheib | 113 | 160 | -47 |
| 1950-05-18 | @ CLE | 25 | L 3-4 | - | | 5,251 | Lou Brissie | Steve Gromek | Al Benton | Lou Brissie | | 116 | 164 | -48 |
| 1950-05-19 | @ DET | 26 | L 8-14 | - | | 3,855 | Hank Wyse | Virgil Trucks | Fred Hutchinson | Hank Wyse | | 124 | 178 | -54 |
| 1950-05-20 | @ DET | 27 | L 3-5 | - | | 20,296 | Bobby Shantz | Art Houtteman | Art Houtteman | Bobby Shantz | | 127 | 183 | -56 |
| 1950-05-21 | @ SLA | 28 | L 6-11 | - | | 0 | Alex Kellner | Cliff Fannin | Stubby Overmire | Alex Kellner | | 133 | 194 | -61 |
| 1950-05-21 | @ SLA | 29 | W 8-3 | - | | 7,421 | Bob Hooper | Joe Ostrowski | Bob Hooper | Joe Ostrowski | Lou Brissie | 141 | 197 | -56 |
| 1950-05-23 | @ SLA | 30 | L 1-7 | - | | 3,692 | Carl Scheib | Al Widmar | Al Widmar | Carl Scheib | | 142 | 204 | -62 |
| 1950-05-24 | @ CHA | 31 | L 7-10 | - | | 2,875 | Dick Fowler | Mickey Haefner | Luis Aloma | Bob Hooper | Billy Pierce | 149 | 214 | -65 |
| 1950-05-25 | @ CHA | 32 | W 6-1 | - | | 2,133 | Bobby Shantz | Bill Wight | Bobby Shantz | Bill Wight | | 155 | 215 | -60 |
| 1950-05-26 | vs NYA | 33 | L 0-2 | - | | 11,636 | Alex Kellner | Eddie Lopat | Eddie Lopat | Alex Kellner | Joe Page | 155 | 217 | -62 |
| 1950-05-27 | vs NYA | 34 | W 6-1 | - | | 7,482 | Lou Brissie | Allie Reynolds | Lou Brissie | Allie Reynolds | | 161 | 218 | -57 |
| 1950-05-28 | vs NYA | 35 | L 3-6 | - | | 0 | Dick Fowler | Vic Raschi | Vic Raschi | Bob Hooper | Joe Page | 164 | 224 | -60 |
| 1950-05-28 | vs NYA | 36 | W 6-5 | - | | 26,833 | Carl Scheib | Fred Sanford | Carl Scheib | Joe Page | Alex Kellner | 170 | 229 | -59 |
| 1950-05-30 | vs WS1 | 37 | L 3-4 | - | | 0 | Bobby Shantz | Dick Weik | Joe Haynes | Bobby Shantz | Mickey Harris | 173 | 233 | -60 |
| 1950-05-30 | vs WS1 | 38 | W 5-1 | - | | 9,557 | Bob Hooper | Steve Nagy | Bob Hooper | Steve Nagy | | 178 | 234 | -56 |
| 1950-06-02 | vs DET | 39 | L 2-8 | - | | 0 | Lou Brissie | Ted Gray | Ted Gray | Lou Brissie | | 180 | 242 | -62 |
| 1950-06-02 | vs DET | 40 | L 5-16 | - | | 17,449 | Alex Kellner | Fred Hutchinson | Fred Hutchinson | Alex Kellner | | 185 | 258 | -73 |
| 1950-06-03 | vs DET | 41 | L 1-6 | - | | 2,714 | Bobby Shantz | Hal Newhouser | Hal Newhouser | Bobby Shantz | | 186 | 264 | -78 |
| 1950-06-04 | vs SLA | 42 | L 5-12 | - | | 0 | Carl Scheib | Ned Garver | Ned Garver | Carl Scheib | | 191 | 276 | -85 |
| 1950-06-04 | vs SLA | 43 | W 13-6 | - | | 3,227 | Bob Hooper | Lou Kretlow | Bob Hooper | Lou Kretlow | Alex Kellner | 204 | 282 | -78 |
| 1950-06-06 | vs SLA | 44 | L 5-6 | - | | 2,750 | Lou Brissie | Cliff Fannin | Tom Ferrick | Hank Wyse | Al Widmar | 209 | 288 | -79 |
| 1950-06-07 | vs CHA | 45 | W 5-0 | - | | 2,536 | Bobby Shantz | Ray Scarborough | Bobby Shantz | Ray Scarborough | | 214 | 288 | -74 |
| 1950-06-08 | vs CHA | 46 | W 5-4 | - | | 2,280 | Alex Kellner | Bob Cain | Alex Kellner | Randy Gumpert | | 219 | 292 | -73 |
| 1950-06-09 | vs CHA | 47 | L 2-3 | - | | 2,709 | Bob Hooper | Bill Wight | Bill Wight | Bob Hooper | | 221 | 295 | -74 |
| 1950-06-10 | vs CLE | 48 | L 3-7 | - | | 3,811 | Lou Brissie | Mike Garcia | Mike Garcia | Lou Brissie | | 224 | 302 | -78 |
| 1950-06-11 | vs CLE | 49 | L 3-6 | - | | 0 | Bobby Shantz | Bob Lemon | Bob Lemon | Bobby Shantz | Al Benton | 227 | 308 | -81 |
| 1950-06-11 | vs CLE | 50 | W 9-6 | - | | 14,241 | Alex Kellner | Steve Gromek | Alex Kellner | Steve Gromek | Bob Hooper | 236 | 314 | -78 |
| 1950-06-13 | @ DET | 51 | L 5-6 | - | | 31,894 | Bob Hooper | Art Houtteman | Art Houtteman | Hank Wyse | | 241 | 320 | -79 |
| 1950-06-14 | @ DET | 52 | W 8-2 | - | | 9,190 | Lou Brissie | Dizzy Trout | Lou Brissie | Dizzy Trout | | 249 | 322 | -73 |
| 1950-06-15 | @ DET | 53 | L 3-7 | - | | 8,105 | Bobby Shantz | Fred Hutchinson | Fred Hutchinson | Bobby Shantz | | 252 | 329 | -77 |
| 1950-06-16 | @ CLE | 54 | L 2-3 | - | | 26,102 | Alex Kellner | Early Wynn | Early Wynn | Alex Kellner | | 254 | 332 | -78 |
| 1950-06-17 | @ CLE | 55 | L 7-8 | - | | 9,232 | Bob Hooper | Gene Bearden | Dick Weik | Carl Scheib | | 261 | 340 | -79 |
| 1950-06-18 | @ CLE | 56 | L 0-7 | - | | 0 | Dick Fowler | Bob Feller | Bob Feller | Dick Fowler | | 261 | 347 | -86 |
| 1950-06-18 | @ CLE | 57 | L 2-21 | - | | 35,521 | Lou Brissie | Mike Garcia | Mike Garcia | Lou Brissie | | 263 | 368 | -105 |
| 1950-06-20 | @ SLA | 58 | L 0-1 | - | | 2,919 | Lou Brissie | Ned Garver | Ned Garver | Lou Brissie | | 263 | 369 | -106 |
| 1950-06-21 | @ SLA | 59 | W 4-2 | - | | 3,037 | Bob Hooper | Al Widmar | Bob Hooper | Al Widmar | Lou Brissie | 267 | 371 | -104 |
| 1950-06-22 | @ SLA | 60 | W 8-4 | - | | 2,102 | Bobby Shantz | Stubby Overmire | Bobby Shantz | Stubby Overmire | Lou Brissie | 275 | 375 | -100 |
| 1950-06-23 | @ CHA | 61 | L 5-11 | - | | 22,971 | Alex Kellner | Randy Gumpert | Randy Gumpert | Alex Kellner | Luis Aloma | 280 | 386 | -106 |
| 1950-06-25 | @ CHA | 62 | L 6-7 | - | | 0 | Lou Brissie | Bill Wight | Bill Wight | Lou Brissie | Luis Aloma | 286 | 393 | -107 |
| 1950-06-25 | @ CHA | 63 | W 13-4 | - | | 25,126 | Bob Hooper | Bob Cain | Bob Hooper | Bob Cain | | 299 | 397 | -98 |
| 1950-06-27 | vs BOS | 64 | L 5-7 | - | | 7,419 | Bobby Shantz | Mel Parnell | Joe Dobson | Hank Wyse | | 304 | 404 | -100 |
| 1950-06-28 | vs BOS | 65 | L 2-6 | - | | 6,774 | Lou Brissie | Ellis Kinder | Ellis Kinder | Lou Brissie | | 306 | 410 | -104 |
| 1950-06-29 | vs BOS | 66 | L 14-22 | - | | 2,808 | Bob Hooper | Chuck Stobbs | Al Papai | Bob Hooper | Mickey McDermott | 320 | 432 | -112 |
| 1950-06-30 | @ WS1 | 67 | W 7-6 | - | | 0 | Hank Wyse | Connie Marrero | Hank Wyse | Connie Marrero | Lou Brissie | 327 | 438 | -111 |
| 1950-06-30 | @ WS1 | 68 | W 4-2 | - | | 12,219 | Alex Kellner | Sandy Consuegra | Alex Kellner | Sandy Consuegra | | 331 | 440 | -109 |
| 1950-07-01 | @ WS1 | 69 | L 2-3 | - | | 6,675 | Bobby Shantz | Bob Ross | Jim Pearce | Bobby Shantz | Mickey Harris | 333 | 443 | -110 |
| 1950-07-02 | @ WS1 | 70 | W 7-4 | - | | 7,315 | Bob Hooper | Bob Kuzava | Bob Hooper | Bob Kuzava | Lou Brissie | 340 | 447 | -107 |
| 1950-07-05 | @ NYA | 71 | L 8-12 | - | | 13,330 | Alex Kellner | Tommy Byrne | Tommy Byrne | Alex Kellner | Joe Ostrowski | 348 | 459 | -111 |
| 1950-07-06 | @ NYA | 72 | L 4-5 | - | | 12,027 | Bobby Shantz | Whitey Ford | Tom Ferrick | Lou Brissie | | 352 | 464 | -112 |
| 1950-07-07 | vs WS1 | 73 | L 5-7 | - | | 2,464 | Bob Hooper | Connie Marrero | Joe Haynes | Bob Hooper | Mickey Harris | 357 | 471 | -114 |
| 1950-07-08 | vs WS1 | 74 | W 6-0 | - | | 1,578 | Lou Brissie | Al Sima | Lou Brissie | Al Sima | | 363 | 471 | -108 |
| 1950-07-09 | vs WS1 | 75 | W 6-5 | - | | 0 | Dick Fowler | Sid Hudson | Dick Fowler | Sid Hudson | Lou Brissie | 369 | 476 | -107 |
| 1950-07-09 | vs WS1 | 76 | L 0-2 | - | | 4,131 | Alex Kellner | Bob Kuzava | Bob Kuzava | Alex Kellner | | 369 | 478 | -109 |
| 1950-07-14 | vs SLA | 77 | W 3-2 | - | | 0 | Lou Brissie | Don Johnson | Lou Brissie | Cuddles Marshall | | 372 | 480 | -108 |
| 1950-07-14 | vs SLA | 78 | L 2-5 | - | | 3,077 | Bobby Shantz | Al Widmar | Al Widmar | Bobby Shantz | | 374 | 485 | -111 |
| 1950-07-15 | vs SLA | 79 | L 2-3 | - | | 1,121 | Dick Fowler | Ned Garver | Ned Garver | Dick Fowler | | 376 | 488 | -112 |
| 1950-07-16 | vs DET | 80 | W 5-2 | - | | 0 | Alex Kellner | Art Houtteman | Alex Kellner | Art Houtteman | | 381 | 490 | -109 |
| 1950-07-16 | vs DET | 81 | L 6-7 | - | | 7,047 | Bob Hooper | Ted Gray | Hal White | Bob Hooper | | 387 | 497 | -110 |
| 1950-07-17 | vs DET | 82 | L 6-8 | - | | 0 | Lou Brissie | Hal Newhouser | Hal Newhouser | Carl Scheib | Paul Calvert | 393 | 505 | -112 |
| 1950-07-17 | vs DET | 83 | L 1-3 | - | | 8,145 | Hank Wyse | Saul Rogovin | Saul Rogovin | Hank Wyse | | 394 | 508 | -114 |
| 1950-07-18 | vs CLE | 84 | L 2-10 | - | | 4,699 | Bobby Shantz | Bob Lemon | Bob Lemon | Bobby Shantz | Al Benton | 396 | 518 | -122 |
| 1950-07-19 | vs CLE | 85 | L 0-4 | - | | 4,580 | Dick Fowler | Bob Feller | Bob Feller | Dick Fowler | | 396 | 522 | -126 |
| 1950-07-20 | vs CLE | 86 | L 2-3 | - | | 2,948 | Alex Kellner | Steve Gromek | Sam Zoldak | Alex Kellner | | 398 | 525 | -127 |
| 1950-07-21 | vs CHA | 87 | W 7-6 | - | | 1,512 | Lou Brissie | Bob Cain | Hank Wyse | Ken Holcombe | | 405 | 531 | -126 |
| 1950-07-22 | vs CHA | 88 | L 1-6 | - | | 4,657 | Bobby Shantz | Billy Pierce | Billy Pierce | Bobby Shantz | | 406 | 537 | -131 |
| 1950-07-23 | vs CHA | 89 | W 2-1 | - | | 0 | Hank Wyse | Bill Wight | Hank Wyse | Bill Wight | | 408 | 538 | -130 |
| 1950-07-23 | vs CHA | 90 | W 5-4 | - | | 3,541 | Bob Hooper | Ray Scarborough | Carl Scheib | Luis Aloma | | 413 | 542 | -129 |
| 1950-07-25 | @ CLE | 91 | L 6-7 | - | | 22,880 | Alex Kellner | Bob Feller | Bob Feller | Alex Kellner | Bob Lemon | 419 | 549 | -130 |
| 1950-07-26 | @ CLE | 92 | L 2-6 | - | | 19,025 | Dick Fowler | Mike Garcia | Sam Zoldak | Dick Fowler | | 421 | 555 | -134 |
| 1950-07-27 | @ CLE | 93 | W 7-2 | - | | 13,224 | Lou Brissie | Steve Gromek | Lou Brissie | Steve Gromek | | 428 | 557 | -129 |
| 1950-07-28 | @ DET | 94 | W 7-6 | - | | 37,324 | Hank Wyse | Hal Newhouser | Bob Hooper | Hal White | | 435 | 563 | -128 |
| 1950-07-29 | @ DET | 95 | L 5-8 | - | | 12,836 | Bobby Shantz | Ted Gray | Marlin Stuart | Hank Wyse | | 440 | 571 | -131 |
| 1950-07-30 | @ DET | 96 | L 10-12 | - | | 23,146 | Bob Hooper | Saul Rogovin | Fred Hutchinson | Alex Kellner | Hal Newhouser | 450 | 583 | -133 |
| 1950-08-01 | @ CHA | 97 | L 1-8 | - | | 8,079 | Moe Burtschy | Billy Pierce | Billy Pierce | Moe Burtschy | | 451 | 591 | -140 |
| 1950-08-02 | @ CHA | 98 | W 10-3 | - | | 1,729 | Carl Scheib | Ray Scarborough | Carl Scheib | Ray Scarborough | | 461 | 594 | -133 |
| 1950-08-03 | @ CHA | 99 | L 0-1 | - | | 2,259 | Hank Wyse | Randy Gumpert | Randy Gumpert | Hank Wyse | | 461 | 595 | -134 |
| 1950-08-04 | @ SLA | 100 | W 12-9 | - | | 2,971 | Lou Brissie | Fritz Dorish | Bob Hooper | Jack Bruner | | 473 | 604 | -131 |
| 1950-08-05 | @ SLA | 101 | L 0-4 | - | | 3,276 | Alex Kellner | Stubby Overmire | Stubby Overmire | Alex Kellner | | 473 | 608 | -135 |
| 1950-08-06 | @ SLA | 102 | L 3-10 | - | | 7,652 | Carl Scheib | Ned Garver | Ned Garver | Carl Scheib | | 476 | 618 | -142 |
| 1950-08-08 | vs WS1 | 103 | W 5-0 | - | | 6,120 | Lou Brissie | Sid Hudson | Lou Brissie | Sid Hudson | | 481 | 618 | -137 |
| 1950-08-09 | vs WS1 | 104 | W 7-6 | - | | 6,055 | Hank Wyse | Connie Marrero | Bob Hooper | Mickey Harris | | 488 | 624 | -136 |
| 1950-08-10 | @ NYA | 105 | W 5-3 | - | | 9,399 | Alex Kellner | Eddie Lopat | Alex Kellner | Eddie Lopat | Lou Brissie | 493 | 627 | -134 |
| 1950-08-11 | @ NYA | 106 | L 6-7 | - | | 27,002 | Joe Coleman | Tommy Byrne | Tom Ferrick | Joe Coleman | | 499 | 634 | -135 |
| 1950-08-12 | @ NYA | 107 | L 2-7 | - | | 18,618 | Carl Scheib | Allie Reynolds | Allie Reynolds | Carl Scheib | | 501 | 641 | -140 |
| 1950-08-13 | @ NYA | 108 | W 5-2 | - | | 25,251 | Lou Brissie | Vic Raschi | Lou Brissie | Vic Raschi | | 506 | 643 | -137 |
| 1950-08-15 | @ BOS | 109 | L 4-9 | - | | 25,519 | Alex Kellner | Willard Nixon | Willard Nixon | Alex Kellner | | 510 | 652 | -142 |
| 1950-08-15 | @ BOS | 110 | L 3-8 | - | | 0 | Hank Wyse | Mel Parnell | Mel Parnell | Hank Wyse | | 513 | 660 | -147 |
| 1950-08-16 | @ BOS | 111 | L 3-11 | - | | 0 | Joe Coleman | Chuck Stobbs | Chuck Stobbs | Joe Coleman | | 516 | 671 | -155 |
| 1950-08-16 | @ BOS | 112 | L 7-12 | - | | 22,388 | Bob Hooper | Walt Masterson | Mickey McDermott | Bob Hooper | | 523 | 683 | -160 |
| 1950-08-17 | @ BOS | 113 | L 6-10 | - | | 11,692 | Joe Murray | Ellis Kinder | Ellis Kinder | Joe Murray | | 529 | 693 | -164 |
| 1950-08-18 | vs NYA | 114 | L 2-3 | - | | 6,054 | Lou Brissie | Vic Raschi | Vic Raschi | Lou Brissie | | 531 | 696 | -165 |
| 1950-08-19 | vs NYA | 115 | L 2-6 | - | | 3,105 | Hank Wyse | Tommy Byrne | Tommy Byrne | Hank Wyse | Tom Ferrick | 533 | 702 | -169 |
| 1950-08-20 | vs NYA | 116 | L 4-6 | - | | 0 | Alex Kellner | Eddie Lopat | Eddie Lopat | Alex Kellner | | 537 | 708 | -171 |
| 1950-08-20 | vs NYA | 117 | L 2-5 | - | | 11,017 | Joe Coleman | Whitey Ford | Whitey Ford | Joe Coleman | | 539 | 713 | -174 |
| 1950-08-23 | vs CHA | 118 | L 0-1 | - | | 0 | Lou Brissie | Ray Scarborough | Ray Scarborough | Lou Brissie | | 539 | 714 | -175 |
| 1950-08-23 | vs CHA | 119 | W 6-5 | - | | 1,568 | Hank Wyse | Randy Gumpert | Hank Wyse | Randy Gumpert | Bob Hooper | 545 | 719 | -174 |
| 1950-08-25 | vs CLE | 120 | L 2-6 | - | | 5,204 | Alex Kellner | Mike Garcia | Mike Garcia | Alex Kellner | | 547 | 725 | -178 |
| 1950-08-26 | vs CLE | 121 | L 4-5 | - | | 3,181 | Joe Coleman | Jesse Flores | Bob Lemon | Joe Coleman | | 551 | 730 | -179 |
| 1950-08-27 | vs DET | 122 | W 4-3 | - | | 0 | Hank Wyse | Ray Herbert | Bob Hooper | Ray Herbert | | 555 | 733 | -178 |
| 1950-08-27 | vs DET | 123 | L 1-8 | - | | 8,884 | Lou Brissie | Art Houtteman | Art Houtteman | Lou Brissie | | 556 | 741 | -185 |
| 1950-08-28 | vs DET | 124 | W 4-3 | - | | 1,372 | Bobby Shantz | Hal Newhouser | Bobby Shantz | Hal Newhouser | | 560 | 744 | -184 |
| 1950-08-30 | vs SLA | 125 | L 1-2 | - | | 0 | Alex Kellner | Ned Garver | Ned Garver | Alex Kellner | | 561 | 746 | -185 |
| 1950-08-30 | vs SLA | 126 | L 6-7 | - | | 1,356 | Hank Wyse | Al Widmar | Duane Pillette | Joe Murray | Don Johnson | 567 | 753 | -186 |
| 1950-08-31 | vs SLA | 127 | L 3-4 | - | | 0 | Lou Brissie | Dick Starr | Dick Starr | Lou Brissie | | 570 | 757 | -187 |
| 1950-08-31 | vs SLA | 128 | W 3-2 | - | | 1,161 | Bob Hooper | Cliff Fannin | Bob Hooper | Cliff Fannin | | 573 | 759 | -186 |
| 1950-09-01 | vs BOS | 129 | W 4-2 | - | | 4,878 | Bobby Shantz | Chuck Stobbs | Bobby Shantz | Chuck Stobbs | | 577 | 761 | -184 |
| 1950-09-02 | vs BOS | 130 | L 3-9 | - | | 2,294 | Carl Scheib | Mel Parnell | Mel Parnell | Carl Scheib | Mickey McDermott | 580 | 770 | -190 |
| 1950-09-04 | @ NYA | 131 | L 1-2 | - | | 0 | Lou Brissie | Vic Raschi | Vic Raschi | Lou Brissie | | 581 | 772 | -191 |
| 1950-09-04 | @ NYA | 132 | W 4-3 | - | | 59,773 | Alex Kellner | Tommy Byrne | Alex Kellner | Tommy Byrne | | 585 | 775 | -190 |
| 1950-09-06 | @ WS1 | 133 | L 0-3 | - | | 2,735 | Bobby Shantz | Sandy Consuegra | Sandy Consuegra | Bobby Shantz | | 585 | 778 | -193 |
| 1950-09-07 | @ WS1 | 134 | W 4-2 | - | | 2,156 | Hank Wyse | Gene Bearden | Hank Wyse | Gene Bearden | Bob Hooper | 589 | 780 | -191 |
| 1950-09-08 | @ WS1 | 135 | L 4-10 | - | | 2,767 | Joe Murray | Julio Moreno | Julio Moreno | Joe Murray | | 593 | 790 | -197 |
| 1950-09-09 | @ BOS | 136 | L 3-8 | - | | 0 | Lou Brissie | Willard Nixon | Willard Nixon | Lou Brissie | | 596 | 798 | -202 |
| 1950-09-09 | @ BOS | 137 | L 3-11 | - | | 22,153 | Alex Kellner | Walt Masterson | Walt Masterson | Alex Kellner | | 599 | 809 | -210 |
| 1950-09-10 | @ BOS | 138 | L 2-6 | - | | 22,147 | Hank Wyse | Chuck Stobbs | Chuck Stobbs | Hank Wyse | Ellis Kinder | 601 | 815 | -214 |
| 1950-09-12 | @ SLA | 139 | L 0-6 | - | | 2,454 | Bob Hooper | Al Widmar | Al Widmar | Bob Hooper | | 601 | 821 | -220 |
| 1950-09-13 | @ SLA | 140 | L 3-4 | - | | 2,625 | Lou Brissie | Ned Garver | Ned Garver | Carl Scheib | | 604 | 825 | -221 |
| 1950-09-14 | @ CHA | 141 | L 2-5 | - | | 1,204 | Bobby Shantz | Bob Cain | Bob Cain | Bobby Shantz | Luis Aloma | 606 | 830 | -224 |
| 1950-09-15 | @ CHA | 142 | W 4-1 | - | | 3,131 | Hank Wyse | Ray Scarborough | Hank Wyse | Ray Scarborough | Lou Brissie | 610 | 831 | -221 |
| 1950-09-16 | @ CHA | 143 | L 3-10 | - | | 1,568 | Alex Kellner | Billy Pierce | Billy Pierce | Alex Kellner | | 613 | 841 | -228 |
| 1950-09-17 | @ CLE | 144 | W 10-9 | - | | 11,810 | Lou Brissie | Dick Rozek | Bob Hooper | Early Wynn | | 623 | 850 | -227 |
| 1950-09-19 | @ DET | 145 | L 4-12 | - | | 5,322 | Hank Wyse | Art Houtteman | Art Houtteman | Hank Wyse | | 627 | 862 | -235 |
| 1950-09-20 | @ DET | 146 | L 5-6 | - | | 7,571 | Alex Kellner | Dizzy Trout | Hal White | Bob Hooper | | 632 | 868 | -236 |
| 1950-09-21 | @ DET | 147 | L 2-8 | - | | 5,194 | Joe Coleman | Fred Hutchinson | Fred Hutchinson | Joe Coleman | | 634 | 876 | -242 |
| 1950-09-23 | @ WS1 | 148 | W 16-5 | - | | 4,636 | Hank Wyse | Julio Moreno | Hank Wyse | Julio Moreno | | 650 | 881 | -231 |
| 1950-09-24 | @ WS1 | 149 | L 1-3 | - | | 2,731 | Johnny Kucab | Carlos Pascual | Carlos Pascual | Johnny Kucab | | 651 | 884 | -233 |
| 1950-09-25 | vs BOS | 150 | L 0-8 | - | | 0 | Alex Kellner | Mel Parnell | Mel Parnell | Alex Kellner | | 651 | 892 | -241 |
| 1950-09-25 | vs BOS | 151 | L 0-3 | - | | 1,773 | Bobby Shantz | Harry Taylor | Harry Taylor | Bobby Shantz | | 651 | 895 | -244 |
| 1950-09-27 | vs NYA | 152 | W 8-7 | - | | 2,418 | Joe Coleman | Eddie Lopat | Bob Hooper | Whitey Ford | | 659 | 902 | -243 |
| 1950-09-28 | vs NYA | 153 | L 6-8 | - | | 2,273 | Bob Hooper | Vic Raschi | Allie Reynolds | Bobby Shantz | | 665 | 910 | -245 |
| 1950-10-01 | vs WS1 | 154 | W 5-3 | - | | 1,387 | Johnny Kucab | Joe Haynes | Johnny Kucab | Joe Haynes | | 670 | 913 | -243 |