| 1950-04-18 | @ NY1 | 1 | W 11-4 | - | | 32,441 | Warren Spahn | Larry Jansen | Warren Spahn | Larry Jansen | | 11 | 4 | 7 |
| 1950-04-19 | @ NY1 | 2 | W 10-6 | - | | 9,425 | Johnny Sain | Sheldon Jones | Johnny Sain | Sheldon Jones | | 21 | 10 | 11 |
| 1950-04-21 | vs PHI | 3 | W 2-2 | - | | 7,308 | Vern Bickford | Ken Heintzelman | | | | 23 | 12 | 11 |
| 1950-04-22 | vs PHI | 4 | W 3-2 | - | | 7,607 | Warren Spahn | Curt Simmons | Warren Spahn | Curt Simmons | | 26 | 14 | 12 |
| 1950-04-23 | vs PHI | 5 | W 4-3 | - | | 0 | Johnny Sain | Blix Donnelly | Johnny Sain | Blix Donnelly | | 30 | 17 | 13 |
| 1950-04-23 | vs PHI | 6 | L 5-6 | - | | 10,302 | Johnny Antonelli | Robin Roberts | Jim Konstanty | Bobby Hogue | | 35 | 23 | 12 |
| 1950-04-24 | vs BRO | 7 | L 4-6 | - | | 18,478 | Dick Donovan | Don Newcombe | Don Newcombe | Dick Donovan | Willie Ramsdell | 39 | 29 | 10 |
| 1950-04-25 | vs BRO | 8 | L 0-3 | - | | 6,033 | Vern Bickford | Joe Hatten | Joe Hatten | Vern Bickford | | 39 | 32 | 7 |
| 1950-04-27 | vs NY1 | 9 | W 2-1 | - | | 5,780 | Warren Spahn | Monty Kennedy | Warren Spahn | Dave Koslo | | 41 | 33 | 8 |
| 1950-04-28 | @ PHI | 10 | L 1-6 | - | | 22,231 | Johnny Sain | Curt Simmons | Curt Simmons | Johnny Sain | | 42 | 39 | 3 |
| 1950-04-29 | @ PHI | 11 | L 1-2 | - | | 5,064 | Vern Bickford | Bob Miller | Bob Miller | Vern Bickford | | 43 | 41 | 2 |
| 1950-04-30 | @ PHI | 12 | W 4-1 | - | | 0 | Normie Roy | Russ Meyer | Normie Roy | Russ Meyer | | 47 | 42 | 5 |
| 1950-04-30 | @ PHI | 13 | L 3-9 | - | | 14,201 | Dick Donovan | Robin Roberts | Robin Roberts | Dick Donovan | | 50 | 51 | -1 |
| 1950-05-02 | @ PIT | 14 | L 1-6 | - | | 24,115 | Warren Spahn | Murry Dickson | Murry Dickson | Warren Spahn | | 51 | 57 | -6 |
| 1950-05-03 | @ PIT | 15 | W 15-4 | - | | 9,389 | Johnny Sain | Bill Werle | Johnny Sain | Vic Lombardi | | 66 | 61 | 5 |
| 1950-05-04 | @ CIN | 16 | W 12-6 | - | | 2,617 | Vern Bickford | Herm Wehmeier | Bob Chipman | Herm Wehmeier | | 78 | 67 | 11 |
| 1950-05-05 | @ CIN | 17 | W 13-1 | - | | 12,260 | Warren Spahn | Howie Fox | Warren Spahn | Howie Fox | | 91 | 68 | 23 |
| 1950-05-06 | @ CIN | 18 | W 15-11 | - | | 3,328 | Normie Roy | Ken Raffensberger | Normie Roy | Ken Raffensberger | Bob Chipman | 106 | 79 | 27 |
| 1950-05-07 | @ SLN | 19 | L 0-15 | - | | 22,676 | Johnny Sain | Howie Pollet | Howie Pollet | Johnny Sain | | 106 | 94 | 12 |
| 1950-05-08 | @ SLN | 20 | L 3-10 | - | | 8,809 | Vern Bickford | Gerry Staley | Gerry Staley | Vern Bickford | | 109 | 104 | 5 |
| 1950-05-10 | @ CHN | 21 | L 3-6 | - | | 8,203 | Warren Spahn | Doyle Lade | Doyle Lade | Warren Spahn | Paul Minner | 112 | 110 | 2 |
| 1950-05-11 | @ CHN | 22 | W 3-0 | - | | 6,381 | Johnny Sain | Bill Voiselle | Johnny Sain | Bill Voiselle | | 115 | 110 | 5 |
| 1950-05-13 | @ BRO | 23 | W 12-2 | - | | 19,488 | Vern Bickford | Joe Hatten | Vern Bickford | Joe Hatten | | 127 | 112 | 15 |
| 1950-05-14 | @ BRO | 24 | L 4-6 | - | | 24,611 | Warren Spahn | Bud Podbielan | Bud Podbielan | Warren Spahn | Jack Banta | 131 | 118 | 13 |
| 1950-05-16 | vs PIT | 25 | W 3-0 | - | | 10,273 | Johnny Sain | Murry Dickson | Johnny Sain | Murry Dickson | | 134 | 118 | 16 |
| 1950-05-17 | vs PIT | 26 | L 1-4 | - | | 13,384 | Vern Bickford | Cliff Chambers | Cliff Chambers | Vern Bickford | | 135 | 122 | 13 |
| 1950-05-20 | vs SLN | 27 | L 4-7 | - | | 9,576 | Warren Spahn | Harry Brecheen | Fred Martin | Warren Spahn | Cloyd Boyer | 139 | 129 | 10 |
| 1950-05-21 | vs CHN | 28 | W 3-2 | - | | 0 | Johnny Sain | Paul Minner | Johnny Sain | Paul Minner | | 142 | 131 | 11 |
| 1950-05-21 | vs CHN | 29 | W 4-3 | - | | 18,048 | Vern Bickford | Johnny Vander Meer | Vern Bickford | Monk Dubiel | | 146 | 134 | 12 |
| 1950-05-23 | vs CIN | 30 | L 2-6 | - | | 10,199 | Normie Roy | Willie Ramsdell | Willie Ramsdell | Normie Roy | | 148 | 140 | 8 |
| 1950-05-24 | vs CIN | 31 | W 4-1 | - | | 6,167 | Warren Spahn | Ewell Blackwell | Warren Spahn | Ewell Blackwell | | 152 | 141 | 11 |
| 1950-05-26 | vs BRO | 32 | L 1-5 | - | | 29,795 | Johnny Sain | Jack Banta | Jack Banta | Johnny Sain | | 153 | 146 | 7 |
| 1950-05-27 | vs BRO | 33 | W 7-1 | - | | 24,903 | Vern Bickford | Don Newcombe | Vern Bickford | Don Newcombe | | 160 | 147 | 13 |
| 1950-05-28 | vs BRO | 34 | W 4-1 | - | | 18,919 | Warren Spahn | Dan Bankhead | Warren Spahn | Dan Bankhead | | 164 | 148 | 16 |
| 1950-05-30 | vs NY1 | 35 | W 7-2 | - | | 0 | Johnny Sain | Monty Kennedy | Johnny Sain | Monty Kennedy | | 171 | 150 | 21 |
| 1950-05-30 | vs NY1 | 36 | L 3-10 | - | | 16,112 | Normie Roy | Larry Jansen | Larry Jansen | Normie Roy | | 174 | 160 | 14 |
| 1950-06-01 | @ PIT | 37 | W 14-2 | - | | 5,468 | Vern Bickford | Mel Queen | Vern Bickford | Mel Queen | | 188 | 162 | 26 |
| 1950-06-02 | @ PIT | 38 | L 4-5 | - | | 23,549 | Warren Spahn | Bill Macdonald | Bill Macdonald | Warren Spahn | | 192 | 167 | 25 |
| 1950-06-03 | @ PIT | 39 | W 10-6 | - | | 5,737 | Johnny Sain | Murry Dickson | Johnny Sain | Vic Lombardi | Bobby Hogue | 202 | 173 | 29 |
| 1950-06-04 | @ CIN | 40 | L 0-3 | - | | 0 | Johnny Antonelli | Ken Raffensberger | Ken Raffensberger | Johnny Antonelli | | 202 | 176 | 26 |
| 1950-06-04 | @ CIN | 41 | W 7-6 | - | | 11,043 | Bob Chipman | Herm Wehmeier | Bob Chipman | Herm Wehmeier | Bobby Hogue | 209 | 182 | 27 |
| 1950-06-06 | @ CIN | 42 | W 8-3 | - | | 2,152 | Vern Bickford | Ewell Blackwell | Vern Bickford | Ewell Blackwell | | 217 | 185 | 32 |
| 1950-06-07 | @ SLN | 43 | W 10-2 | - | | 13,413 | Warren Spahn | Gerry Staley | Warren Spahn | Gerry Staley | | 227 | 187 | 40 |
| 1950-06-08 | @ SLN | 44 | L 6-18 | - | | 11,417 | Johnny Sain | Harry Brecheen | Fred Martin | Johnny Sain | | 233 | 205 | 28 |
| 1950-06-09 | @ SLN | 45 | L 5-8 | - | | 11,582 | Bob Hall | Max Lanier | Max Lanier | Bob Hall | Gerry Staley | 238 | 213 | 25 |
| 1950-06-10 | @ CHN | 46 | L 10-13 | - | | 17,771 | Vern Bickford | Paul Minner | Doyle Lade | Bobby Hogue | Dutch Leonard | 248 | 226 | 22 |
| 1950-06-11 | @ CHN | 47 | L 4-5 | - | | 0 | Vern Bickford | Johnny Vander Meer | Johnny Schmitz | Vern Bickford | | 252 | 231 | 21 |
| 1950-06-11 | @ CHN | 48 | L 1-2 | - | | 36,835 | Warren Spahn | Bob Rush | Bob Rush | Warren Spahn | | 253 | 233 | 20 |
| 1950-06-13 | vs CIN | 49 | W 5-3 | - | | 9,446 | Bobby Hogue | Willie Ramsdell | Bob Chipman | Willie Ramsdell | | 258 | 236 | 22 |
| 1950-06-15 | vs CIN | 50 | W 5-3 | - | | 0 | Warren Spahn | Ken Raffensberger | Warren Spahn | Ken Raffensberger | | 263 | 239 | 24 |
| 1950-06-15 | vs CIN | 51 | W 6-5 | - | | 6,932 | Vern Bickford | Herm Wehmeier | Bobby Hogue | Frank Smith | | 269 | 244 | 25 |
| 1950-06-16 | vs PIT | 52 | W 6-5 | - | | 15,866 | Johnny Sain | Vern Law | Johnny Sain | Mel Queen | | 275 | 249 | 26 |
| 1950-06-17 | vs PIT | 53 | W 15-6 | - | | 6,272 | Ernie Johnson | Hank Borowy | Bobby Hogue | Hank Borowy | | 290 | 255 | 35 |
| 1950-06-18 | vs PIT | 54 | W 8-6 | - | | 0 | Vern Bickford | Frank Papish | Normie Roy | Murry Dickson | | 298 | 261 | 37 |
| 1950-06-18 | vs PIT | 55 | W 8-8 | - | | 22,817 | Dick Donovan | Cliff Chambers | | | | 306 | 269 | 37 |
| 1950-06-19 | vs PIT | 56 | L 0-1 | - | | 5,578 | Warren Spahn | Cliff Chambers | Cliff Chambers | Warren Spahn | | 306 | 270 | 36 |
| 1950-06-20 | vs CHN | 57 | L 3-4 | - | | 12,334 | Johnny Sain | Bob Rush | Bob Rush | Johnny Sain | | 309 | 274 | 35 |
| 1950-06-21 | vs CHN | 58 | L 0-3 | - | | 11,317 | Vern Bickford | Johnny Schmitz | Johnny Schmitz | Vern Bickford | | 309 | 277 | 32 |
| 1950-06-23 | vs SLN | 59 | W 4-3 | - | | 30,720 | Warren Spahn | Red Munger | Warren Spahn | Red Munger | | 313 | 280 | 33 |
| 1950-06-24 | vs SLN | 60 | L 6-7 | - | | 20,826 | Johnny Sain | Gerry Staley | Al Brazle | Bob Chipman | | 319 | 287 | 32 |
| 1950-06-25 | vs SLN | 61 | W 4-0 | - | | 17,434 | Vern Bickford | Fred Martin | Vern Bickford | Fred Martin | | 323 | 287 | 36 |
| 1950-06-27 | vs PHI | 62 | L 2-3 | - | | 13,361 | Warren Spahn | Curt Simmons | Curt Simmons | Warren Spahn | Jim Konstanty | 325 | 290 | 35 |
| 1950-06-28 | vs PHI | 63 | W 3-1 | - | | 18,724 | Johnny Sain | Russ Meyer | Johnny Sain | Russ Meyer | | 328 | 291 | 37 |
| 1950-06-29 | vs PHI | 64 | W 3-2 | - | | 13,980 | Vern Bickford | Ken Heintzelman | Vern Bickford | Ken Heintzelman | | 331 | 293 | 38 |
| 1950-06-30 | @ NY1 | 65 | W 8-4 | - | | 24,137 | Bob Hall | Monty Kennedy | Ernie Johnson | Sheldon Jones | Normie Roy | 339 | 297 | 42 |
| 1950-07-01 | @ NY1 | 66 | L 2-4 | - | | 12,090 | Warren Spahn | Clint Hartung | Clint Hartung | Warren Spahn | Larry Jansen | 341 | 301 | 40 |
| 1950-07-02 | @ NY1 | 67 | W 11-5 | - | | 0 | Johnny Sain | Dave Koslo | Johnny Sain | Dave Koslo | | 352 | 306 | 46 |
| 1950-07-02 | @ NY1 | 68 | W 6-3 | - | | 32,862 | Bob Chipman | Sheldon Jones | Bob Chipman | Sheldon Jones | | 358 | 309 | 49 |
| 1950-07-03 | @ PHI | 69 | W 3-1 | - | | 11,162 | Vern Bickford | Ken Heintzelman | Vern Bickford | Ken Heintzelman | | 361 | 310 | 51 |
| 1950-07-04 | @ PHI | 70 | L 5-14 | - | | 0 | Normie Roy | Robin Roberts | Robin Roberts | Normie Roy | | 366 | 324 | 42 |
| 1950-07-04 | @ PHI | 71 | W 12-9 | - | | 21,190 | Bob Hall | Ken Johnson | Bobby Hogue | Jim Konstanty | Warren Spahn | 378 | 333 | 45 |
| 1950-07-06 | @ BRO | 72 | L 3-8 | - | | 20,019 | Warren Spahn | Preacher Roe | Preacher Roe | Warren Spahn | | 381 | 341 | 40 |
| 1950-07-07 | vs NY1 | 73 | W 8-2 | - | | 26,178 | Johnny Sain | Larry Jansen | Johnny Sain | Larry Jansen | | 389 | 343 | 46 |
| 1950-07-08 | vs NY1 | 74 | W 4-2 | - | | 21,885 | Bob Chipman | Dave Koslo | Bob Chipman | Dave Koslo | | 393 | 345 | 48 |
| 1950-07-09 | vs NY1 | 75 | W 3-2 | - | | 14,662 | Vern Bickford | Jack Kramer | Vern Bickford | Sal Maglie | | 396 | 347 | 49 |
| 1950-07-13 | @ CIN | 76 | L 3-7 | - | | 14,198 | Johnny Sain | Herm Wehmeier | Herm Wehmeier | Johnny Sain | | 399 | 354 | 45 |
| 1950-07-14 | @ CIN | 77 | W 6-4 | - | | 3,032 | Warren Spahn | Ewell Blackwell | Warren Spahn | Ewell Blackwell | Bobby Hogue | 405 | 358 | 47 |
| 1950-07-15 | @ CIN | 78 | L 4-9 | - | | 4,218 | Bob Chipman | Willie Ramsdell | Willie Ramsdell | Bob Chipman | Herm Wehmeier | 409 | 367 | 42 |
| 1950-07-16 | @ PIT | 79 | W 9-5 | - | | 0 | Vern Bickford | Vern Law | Vern Bickford | Vern Law | | 418 | 372 | 46 |
| 1950-07-16 | @ PIT | 80 | L 5-6 | - | | 29,363 | Bob Hall | Mel Queen | Hank Borowy | Bobby Hogue | | 423 | 378 | 45 |
| 1950-07-17 | @ PIT | 81 | W 8-6 | - | | 21,450 | Johnny Sain | Bill Pierro | Ernie Johnson | Hank Borowy | Bobby Hogue | 431 | 384 | 47 |
| 1950-07-18 | @ PIT | 82 | W 11-3 | - | | 5,445 | Warren Spahn | Murry Dickson | Warren Spahn | Murry Dickson | | 442 | 387 | 55 |
| 1950-07-19 | @ CHN | 83 | L 3-11 | - | | 8,000 | Bob Chipman | Johnny Klippstein | Johnny Klippstein | Bob Chipman | | 445 | 398 | 47 |
| 1950-07-21 | @ CHN | 84 | L 3-4 | - | | 14,088 | Johnny Sain | Bob Rush | Johnny Schmitz | Johnny Sain | | 448 | 402 | 46 |
| 1950-07-22 | @ SLN | 85 | W 8-5 | - | | 9,510 | Vern Bickford | Gerry Staley | Vern Bickford | Gerry Staley | Bobby Hogue | 456 | 407 | 49 |
| 1950-07-22 | @ SLN | 86 | L 7-11 | - | | 21,756 | Warren Spahn | Howie Pollet | Howie Pollet | Warren Spahn | Gerry Staley | 463 | 418 | 45 |
| 1950-07-23 | @ SLN | 87 | L 4-8 | - | | 23,100 | Bob Chipman | Al Brazle | Al Brazle | Bob Chipman | Harry Brecheen | 467 | 426 | 41 |
| 1950-07-25 | vs PIT | 88 | W 7-2 | - | | 18,461 | Johnny Sain | Bill Pierro | Johnny Sain | Bill Pierro | | 474 | 428 | 46 |
| 1950-07-26 | vs PIT | 89 | L 4-8 | - | | 12,689 | Vern Bickford | Mel Queen | Mel Queen | Vern Bickford | Murry Dickson | 478 | 436 | 42 |
| 1950-07-27 | vs PIT | 90 | W 5-3 | - | | 8,302 | Warren Spahn | Cliff Chambers | Warren Spahn | Cliff Chambers | | 483 | 439 | 44 |
| 1950-07-28 | vs CIN | 91 | L 5-8 | - | | 13,505 | Bob Chipman | Ewell Blackwell | Ewell Blackwell | Bob Chipman | Frank Smith | 488 | 447 | 41 |
| 1950-07-29 | vs CIN | 92 | W 9-1 | - | | 6,394 | Johnny Sain | Herm Wehmeier | Johnny Sain | Herm Wehmeier | | 497 | 448 | 49 |
| 1950-07-30 | vs CIN | 93 | W 4-2 | - | | 0 | Vern Bickford | Ken Raffensberger | Vern Bickford | Ken Raffensberger | | 501 | 450 | 51 |
| 1950-07-30 | vs CIN | 94 | W 10-0 | - | | 16,562 | Johnny Antonelli | Howie Fox | Johnny Antonelli | Howie Fox | | 511 | 450 | 61 |
| 1950-07-31 | vs SLN | 95 | W 4-3 | - | | 16,104 | Warren Spahn | Max Lanier | Warren Spahn | Max Lanier | | 515 | 453 | 62 |
| 1950-08-01 | vs SLN | 96 | L 1-6 | - | | 14,522 | Bob Chipman | Cloyd Boyer | Cloyd Boyer | Bob Chipman | | 516 | 459 | 57 |
| 1950-08-02 | vs SLN | 97 | W 4-3 | - | | 21,365 | Johnny Sain | Harry Brecheen | Johnny Sain | Harry Brecheen | | 520 | 462 | 58 |
| 1950-08-03 | vs SLN | 98 | W 5-1 | - | | 19,325 | Vern Bickford | Al Brazle | Vern Bickford | Al Brazle | | 525 | 463 | 62 |
| 1950-08-04 | vs CHN | 99 | W 10-2 | - | | 16,910 | Warren Spahn | Bob Rush | Warren Spahn | Bob Rush | | 535 | 465 | 70 |
| 1950-08-05 | vs CHN | 100 | L 2-4 | - | | 8,246 | Bob Chipman | Paul Minner | Paul Minner | Bobby Hogue | | 537 | 469 | 68 |
| 1950-08-06 | vs CHN | 101 | W 5-2 | - | | 0 | Johnny Sain | Johnny Schmitz | Johnny Sain | Johnny Schmitz | | 542 | 471 | 71 |
| 1950-08-06 | vs CHN | 102 | L 1-9 | - | | 14,680 | Johnny Antonelli | Frank Hiller | Frank Hiller | Johnny Antonelli | | 543 | 480 | 63 |
| 1950-08-07 | vs NY1 | 103 | L 3-9 | - | | 11,916 | Vern Bickford | Monty Kennedy | Jack Kramer | Vern Bickford | | 546 | 489 | 57 |
| 1950-08-08 | vs NY1 | 104 | L 1-2 | - | | 15,471 | Warren Spahn | Sheldon Jones | Sheldon Jones | Warren Spahn | | 547 | 491 | 56 |
| 1950-08-09 | vs NY1 | 105 | W 3-2 | - | | 10,367 | Bob Chipman | Jim Hearn | Bob Chipman | Jim Hearn | | 550 | 493 | 57 |
| 1950-08-10 | vs BRO | 106 | L 3-4 | - | | 24,758 | Johnny Sain | Preacher Roe | Preacher Roe | Johnny Sain | Dan Bankhead | 553 | 497 | 56 |
| 1950-08-11 | vs BRO | 107 | W 7-0 | - | | 29,008 | Vern Bickford | Carl Erskine | Vern Bickford | Carl Erskine | | 560 | 497 | 63 |
| 1950-08-12 | vs BRO | 108 | W 10-2 | - | | 34,732 | Warren Spahn | Don Newcombe | Warren Spahn | Don Newcombe | | 570 | 499 | 71 |
| 1950-08-13 | vs BRO | 109 | L 2-8 | - | | 26,501 | Bob Chipman | Erv Palica | Erv Palica | Bob Chipman | | 572 | 507 | 65 |
| 1950-08-15 | @ PHI | 110 | L 1-9 | - | | 32,215 | Johnny Sain | Curt Simmons | Curt Simmons | Johnny Sain | Jim Konstanty | 573 | 516 | 57 |
| 1950-08-16 | @ PHI | 111 | L 1-5 | - | | 23,846 | Vern Bickford | Robin Roberts | Robin Roberts | Vern Bickford | | 574 | 521 | 53 |
| 1950-08-18 | @ BRO | 112 | L 3-8 | - | | 23,233 | Warren Spahn | Carl Erskine | Carl Erskine | Warren Spahn | Ralph Branca | 577 | 529 | 48 |
| 1950-08-21 | @ SLN | 113 | L 2-9 | - | | 13,104 | Johnny Sain | Harry Brecheen | Harry Brecheen | Johnny Sain | | 579 | 538 | 41 |
| 1950-08-22 | @ SLN | 114 | W 5-1 | - | | 14,215 | Vern Bickford | Cloyd Boyer | Vern Bickford | Cloyd Boyer | | 584 | 539 | 45 |
| 1950-08-23 | @ SLN | 115 | W 2-1 | - | | 12,789 | Warren Spahn | Gerry Staley | Warren Spahn | Gerry Staley | | 586 | 540 | 46 |
| 1950-08-24 | @ CHN | 116 | W 11-9 | - | | 0 | Max Surkont | Paul Minner | Max Surkont | Paul Minner | Bobby Hogue | 597 | 549 | 48 |
| 1950-08-24 | @ CHN | 117 | L 3-4 | - | | 23,083 | Mickey Haefner | Frank Hiller | Frank Hiller | Mickey Haefner | | 600 | 553 | 47 |
| 1950-08-25 | @ CHN | 118 | L 6-7 | - | | 6,535 | Johnny Sain | Johnny Vander Meer | Dutch Leonard | Warren Spahn | | 606 | 560 | 46 |
| 1950-08-26 | @ CHN | 119 | W 12-4 | - | | 17,072 | Vern Bickford | Johnny Schmitz | Vern Bickford | Johnny Schmitz | | 618 | 564 | 54 |
| 1950-08-27 | @ PIT | 120 | W 7-3 | - | | 0 | Warren Spahn | Bill Werle | Max Surkont | Bill Werle | | 625 | 567 | 58 |
| 1950-08-27 | @ PIT | 121 | W 4-1 | - | | 24,279 | Normie Roy | Mel Queen | Normie Roy | Mel Queen | | 629 | 568 | 61 |
| 1950-08-29 | @ CIN | 122 | W 4-0 | - | | 8,348 | Johnny Sain | Willie Ramsdell | Johnny Sain | Willie Ramsdell | | 633 | 568 | 65 |
| 1950-08-30 | @ CIN | 123 | W 9-4 | - | | 1,472 | Vern Bickford | Ken Raffensberger | Vern Bickford | Ken Raffensberger | | 642 | 572 | 70 |
| 1950-08-31 | @ BRO | 124 | L 3-19 | - | | 14,226 | Warren Spahn | Carl Erskine | Carl Erskine | Warren Spahn | | 645 | 591 | 54 |
| 1950-09-01 | vs PHI | 125 | L 3-7 | - | | 14,908 | Max Surkont | Bubba Church | Bubba Church | Max Surkont | | 648 | 598 | 50 |
| 1950-09-02 | vs PHI | 126 | L 0-2 | - | | 17,230 | Johnny Sain | Curt Simmons | Curt Simmons | Johnny Sain | | 648 | 600 | 48 |
| 1950-09-04 | vs BRO | 127 | W 11-4 | - | | 0 | Vern Bickford | Carl Erskine | Vern Bickford | Carl Erskine | | 659 | 604 | 55 |
| 1950-09-04 | vs BRO | 128 | W 3-2 | - | | 0 | Warren Spahn | Erv Palica | Warren Spahn | Ralph Branca | | 662 | 606 | 56 |
| 1950-09-06 | @ NY1 | 129 | L 1-3 | - | | 19,474 | Johnny Sain | Larry Jansen | Larry Jansen | Johnny Sain | | 663 | 609 | 54 |
| 1950-09-07 | @ NY1 | 130 | W 6-4 | - | | 8,849 | Vern Bickford | Jack Kramer | Vern Bickford | Dave Koslo | | 669 | 613 | 56 |
| 1950-09-08 | @ NY1 | 131 | W 4-3 | - | | 6,560 | Warren Spahn | Jim Hearn | Warren Spahn | Jim Hearn | | 673 | 616 | 57 |
| 1950-09-09 | @ PHI | 132 | L 6-7 | - | | 15,329 | Max Surkont | Curt Simmons | Jim Konstanty | Dave Cole | | 679 | 623 | 56 |
| 1950-09-10 | @ PHI | 133 | W 3-1 | - | | 14,684 | Johnny Sain | Bubba Church | Johnny Sain | Bubba Church | | 682 | 624 | 58 |
| 1950-09-12 | vs CHN | 134 | L 1-3 | - | | 3,392 | Vern Bickford | Bob Rush | Bob Rush | Vern Bickford | | 683 | 627 | 56 |
| 1950-09-13 | vs CHN | 135 | W 5-2 | - | | 4,280 | Warren Spahn | Paul Minner | Warren Spahn | Paul Minner | | 688 | 629 | 59 |
| 1950-09-14 | vs CHN | 136 | W 7-4 | - | | 1,489 | Johnny Sain | Frank Hiller | Johnny Sain | Frank Hiller | | 695 | 633 | 62 |
| 1950-09-15 | vs PIT | 137 | W 7-4 | - | | 9,168 | Max Surkont | Mel Queen | Max Surkont | Mel Queen | | 702 | 637 | 65 |
| 1950-09-16 | vs PIT | 138 | L 0-4 | - | | 4,606 | Vern Bickford | Cliff Chambers | Cliff Chambers | Vern Bickford | | 702 | 641 | 61 |
| 1950-09-17 | vs CIN | 139 | W 6-2 | - | | 0 | Warren Spahn | Kent Peterson | Warren Spahn | Kent Peterson | | 708 | 643 | 65 |
| 1950-09-17 | vs CIN | 140 | W 3-1 | - | | 9,626 | Johnny Antonelli | Frank Smith | Johnny Antonelli | Frank Smith | | 711 | 644 | 67 |
| 1950-09-19 | vs SLN | 141 | W 8-7 | - | | 7,233 | Johnny Sain | Harry Brecheen | Max Surkont | Al Brazle | | 719 | 651 | 68 |
| 1950-09-20 | vs SLN | 142 | L 0-1 | - | | 5,199 | Vern Bickford | Cloyd Boyer | Cloyd Boyer | Vern Bickford | | 719 | 652 | 67 |
| 1950-09-21 | vs SLN | 143 | W 5-0 | - | | 2,825 | Warren Spahn | Gerry Staley | Warren Spahn | Gerry Staley | | 724 | 652 | 72 |
| 1950-09-23 | vs NY1 | 144 | L 3-4 | - | | 4,690 | Johnny Sain | Larry Jansen | Larry Jansen | Johnny Sain | | 727 | 656 | 71 |
| 1950-09-24 | vs NY1 | 145 | L 4-12 | - | | 8,922 | Vern Bickford | Jim Hearn | Jim Hearn | Vern Bickford | | 731 | 668 | 63 |
| 1950-09-25 | vs PHI | 146 | L 4-12 | - | | 0 | Warren Spahn | Ken Heintzelman | Ken Heintzelman | Warren Spahn | | 735 | 680 | 55 |
| 1950-09-25 | vs PHI | 147 | W 5-3 | - | | 7,451 | Max Surkont | Russ Meyer | Max Surkont | Jim Konstanty | | 740 | 683 | 57 |
| 1950-09-26 | vs PHI | 148 | L 7-8 | - | | 1,987 | Vern Bickford | Bob Miller | Blix Donnelly | Bob Hall | | 747 | 691 | 56 |
| 1950-09-27 | @ BRO | 149 | L 6-9 | - | | 0 | Warren Spahn | Don Newcombe | Dan Bankhead | Bobby Hogue | | 753 | 700 | 53 |
| 1950-09-27 | @ BRO | 150 | W 4-2 | - | | 8,447 | Johnny Sain | Erv Palica | Johnny Sain | Erv Palica | Bobby Hogue | 757 | 702 | 55 |
| 1950-09-28 | @ BRO | 151 | L 5-6 | - | | 0 | Mickey Haefner | Carl Erskine | Carl Erskine | Mickey Haefner | Dan Bankhead | 762 | 708 | 54 |
| 1950-09-28 | @ BRO | 152 | W 8-4 | - | | 4,533 | Bob Chipman | Joe Hatten | Bob Chipman | Ralph Branca | | 770 | 712 | 58 |
| 1950-09-29 | @ BRO | 153 | L 5-7 | - | | 0 | Max Surkont | Preacher Roe | Dan Bankhead | Max Surkont | Don Newcombe | 775 | 719 | 56 |
| 1950-09-29 | @ BRO | 154 | L 6-7 | - | | 5,843 | Vern Bickford | Chris Van Cuyk | Carl Erskine | Vern Bickford | | 781 | 726 | 55 |
| 1950-09-30 | @ NY1 | 155 | L 3-5 | - | | 5,559 | Johnny Antonelli | Larry Jansen | Larry Jansen | Johnny Antonelli | | 784 | 731 | 53 |
| 1950-10-01 | @ NY1 | 156 | L 1-5 | - | | 9,446 | Warren Spahn | George Spencer | George Spencer | Warren Spahn | | 785 | 736 | 49 |