| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-03-29 | Thu | CHA | AL | H | D | 1 | L | 7-14 | 9 | box - pbp - pit | L1 | 0-1 | 3 | 12 | 23 | 3:26 | 36,517 | Danny Duffy | James Shields (R) | James Shields | Danny Duffy | None | |
| 2018-03-31 | Sat | CHA | AL | H | N | 2 | L | 3-4 | 9 | box - pbp - pit | L2 | 0-2 | 4 | 14 | 28 | 2:54 | 17,564 | Ian Kennedy | Lucas Giolito (R) | Danny Farquhar | Brandon Maurer | Joakim Soria | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-04-02 | Mon | DET | AL | A | D | 3 | L | 1-6 | 9 | box - pbp - pit | L3 | 0-3 | 5 | 15 | 30 | 2:46 | 15,476 | Jason Hammel | Francisco Liriano (L) | Francisco Liriano | Jason Hammel | None | |
| 2018-04-03 | Tue | DET | AL | A | D | 4 | W | 1-0 | 9 | box - pbp - pit | W1 | 1-3 | 4 | 12 | 25 | 2:17 | 15,083 | Jake Junis | Matt Boyd (L) | Jake Junis | Matt Boyd | Kelvin Herrera | |
| 2018-04-06 | Fri | CLE | AL | A | D | 5 | L | 2-3 | 9 | box - pbp - pit | L1 | 1-4 | 5 | 14 | 28 | 2:41 | 34,720 | Danny Duffy | Carlos Carrasco (R) | Carlos Carrasco | Danny Duffy | Cody Allen | |
| 2018-04-07 | Sat | CLE | AL | A | D | 6 | W | 1-0 | 9 | box - pbp - pit | W1 | 2-4 | 5 | 14 | 24 | 2:29 | 17,362 | Ian Kennedy | Trevor Bauer (R) | Ian Kennedy | Trevor Bauer | Kelvin Herrera | |
| 2018-04-08 | Sun | CLE | AL | A | D | 7 | L | 1-3 | 9 | box - pbp - pit | L1 | 2-5 | 5 | 14 | 27 | 2:55 | 14,240 | Jason Hammel | Mike Clevinger (R) | Cody Allen | Brandon Maurer | None | |
| 2018-04-09 | Mon | SEA | AL | H | N | 8 | W | 10-0 | 9 | box - pbp - pit | W1 | 3-5 | 4 | 10 | 21 | 2:45 | 12,324 | Jake Junis | Marco Gonzales (L) | Jake Junis | Marco Gonzales | None | |
| 2018-04-10 | Tue | SEA | AL | H | N | 9 | L | 3-8 | 9 | box - pbp - pit | L1 | 3-6 | 4 | 12 | 22 | 2:58 | 14,850 | Eric Skoglund | Felix Hernandez (R) | Felix Hernandez | Eric Skoglund | None | |
| 2018-04-11 | Wed | SEA | AL | H | D | 10 | L | 2-4 | 9 | box - pbp - pit | L2 | 3-7 | 5 | 13 | 26 | 2:48 | 14,314 | Danny Duffy | James Paxton (L) | Nick Vincent | Justin Grimm | Edwin Diaz | |
| 2018-04-12 | Thu | ANA | AL | H | N | 11 | L | 1-7 | 9 | box - pbp - pit | L3 | 3-8 | 5 | 14 | 27 | 3:00 | 14,714 | Ian Kennedy | Nick Tropeano (R) | Nick Tropeano | Ian Kennedy | None | |
| 2018-04-13 | Fri | ANA | AL | H | N | 12 | L | 4-5 | 9 | box - pbp - pit | L4 | 3-9 | 5 | 14 | 28 | 3:24 | 15,011 | Jason Hammel | Andrew Heaney (L) | Blake Wood | Justin Grimm | Keynan Middleton | |
| 2018-04-14 | Sat | ANA | AL | H | N | 13 | L | 3-5 | 9 | box - pbp - pit | L5 | 3-10 | 5 | 14 | 28 | 3:03 | 15,876 | Jake Junis | Garrett Richards (R) | Garrett Richards | Jake Junis | Keynan Middleton | |
| 2018-04-17 | Tue | TOR | AL | A | D | 14 | L | 3-11 | 9 | box - pbp - pit | L6 | 3-12 | 5 | 15 | 29 | 2:56 | 0 | Eric Skoglund | Jaime Garcia (L) | Jaime Garcia | Eric Skoglund | None | |
| 2018-04-17 | Tue | TOR | AL | A | N | 15 | L | 4-5 | 10 | box - pbp - pit | L7 | 3-12 | 5 | 15 | 29 | 3:37 | 18,645 | Danny Duffy | Joe Biagini (R) | Tyler Clippard | Brian Flynn | None | |
| 2018-04-18 | Wed | TOR | AL | A | D | 16 | L | 5-15 | 9 | box - pbp - pit | L8 | 3-13 | 5 | 15 | 29 | 3:05 | 28,803 | Ian Kennedy | J.A. Happ (L) | J.A. Happ | Ian Kennedy | None | |
| 2018-04-20 | Fri | DET | AL | A | D | 17 | L | 2-3 | 10 | box - pbp - pit | L9 | 4-14 | 5 | 15 | 29 | 2:46 | 15,406 | Jason Hammel | Michael Fulmer (R) | Joe Jimenez | Brad Keller | None | |
| 2018-04-20 | Fri | DET | AL | A | N | 18 | W | 3-2 | 9 | box - pbp - pit | W1 | 4-14 | 5 | 15 | 29 | 2:34 | 17,194 | Jake Junis | Daniel Norris (L) | Jake Junis | Shane Greene | Kelvin Herrera | |
| 2018-04-21 | Sat | DET | AL | A | D | 19 | L | 4-12 | 9 | box - pbp - pit | L1 | 4-15 | 5 | 15 | 29 | 3:04 | 19,302 | Danny Duffy | Mike Fiers (R) | Michael Fiers | Danny Duffy | Warwick Saupold | |
| 2018-04-22 | Sun | DET | AL | A | D | 20 | W | 8-5 | 9 | box - pbp - pit | W1 | 5-15 | 4 | 14 | 27 | 3:09 | 19,034 | Eric Skoglund | Francisco Liriano (L) | Kevin McCarthy | Drew VerHagen | Kelvin Herrera | |
| 2018-04-24 | Tue | MIL | NL | H | N | 21 | L | 2-5 | 9 | box - pbp - pit | L1 | 5-16 | 5 | 15 | 29 | 2:59 | 16,555 | Ian Kennedy | Zach Davies (R) | Zach Davies | Ian Kennedy | None | |
| 2018-04-25 | Wed | MIL | NL | H | N | 22 | L | 2-6 | 9 | box - pbp - pit | L2 | 5-17 | 5 | 15 | 29 | 2:57 | 13,389 | Jason Hammel | Jhoulys Chacin (R) | Jhoulys Chacin | Jason Hammel | None | |
| 2018-04-26 | Thu | CHA | AL | H | N | 23 | L | 3-6 | 9 | box - pbp - pit | L3 | 5-18 | 5 | 15 | 29 | 3:08 | 18,315 | Jake Junis | Lucas Giolito (R) | Lucas Giolito | Jake Junis | Joakim Soria | |
| 2018-04-27 | Fri | CHA | AL | H | N | 24 | L | 4-7 | 11 | box - pbp - pit | L4 | 5-19 | 5 | 15 | 30 | 3:34 | 15,395 | Danny Duffy | Reynaldo Lopez (R) | Gregory Infante | Tim Hill | Joakim Soria | |
| 2018-04-28 | Sat | CHA | AL | H | D | 25 | L | 0-8 | 9 | box - pbp - pit | L5 | 6-20 | 5 | 15 | 29 | 2:49 | 16,971 | Trevor Oaks | Carson Fulmer (R) | Carson Fulmer | Trevor Oaks | None | |
| 2018-04-28 | Sat | CHA | AL | H | N | 26 | W | 5-2 | 9 | box - pbp - pit | W1 | 6-20 | 5 | 15 | 29 | 2:39 | 16,070 | Eric Skoglund | Dylan Covey (R) | Eric Skoglund | Dylan Covey | Kelvin Herrera | |
| 2018-04-29 | Sun | CHA | AL | H | D | 27 | W | 5-4 | 9 | box - pbp - pit | W2 | 7-20 | 5 | 15 | 29 | 3:19 | 23,892 | Ian Kennedy | Hector Santiago (L) | Kevin McCarthy | Bruce Rondon | Blaine Boyer | |
| 2018-04-30 | Mon | BOS | AL | A | N | 28 | L | 6-10 | 9 | box - pbp - pit | L1 | 7-21 | 5 | 15 | 29 | 3:13 | 31,314 | Jason Hammel | Eduardo Rodriguez (L) | Hector Velazquez | Jason Hammel | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-05-01 | Tue | BOS | AL | A | N | 29 | W | 7-6 | 13 | box - pbp - pit | W1 | 8-21 | 5 | 15 | 28 | 4:25 | 34,466 | Jake Junis | Chris Sale (L) | Kelvin Herrera | Brian Johnson | Brian Flynn | |
| 2018-05-02 | Wed | BOS | AL | A | D | 30 | L | 4-5 | 9 | box - pbp - pit | L1 | 8-22 | 5 | 15 | 28 | 2:45 | 32,267 | Danny Duffy | Drew Pomeranz (L) | Drew Pomeranz | Danny Duffy | Craig Kimbrel | |
| 2018-05-03 | Thu | DET | AL | H | D | 31 | W | 10-6 | 9 | box - pbp - pit | W1 | 9-22 | 5 | 14 | 28 | 3:07 | 28,866 | Eric Skoglund | Mike Fiers (R) | Kevin McCarthy | Chad Bell | None | |
| 2018-05-04 | Fri | DET | AL | H | N | 32 | W | 4-2 | 9 | box - pbp - pit | W2 | 10-22 | 4 | 13 | 27 | 2:49 | 24,648 | Ian Kennedy | Francisco Liriano (L) | Blaine Boyer | Daniel Stumpf | Kelvin Herrera | |
| 2018-05-05 | Sat | DET | AL | H | D | 33 | L | 2-3 | 9 | box - pbp - pit | L1 | 10-23 | 4 | 13 | 27 | 3:06 | 20,708 | Jason Hammel | Jordan Zimmermann (R) | Jordan Zimmermann | Jason Hammel | Shane Greene | |
| 2018-05-06 | Sun | DET | AL | H | D | 34 | W | 4-2 | 9 | box - pbp - pit | W1 | 11-23 | 4 | 13 | 27 | 2:16 | 18,424 | Jake Junis | Matt Boyd (L) | Jake Junis | Matt Boyd | Kelvin Herrera | |
| 2018-05-08 | Tue | BAL | AL | A | N | 35 | W | 15-7 | 9 | box - pbp - pit | W2 | 12-23 | 4 | 13 | 27 | 3:21 | 10,863 | Danny Duffy | Dylan Bundy (R) | Danny Duffy | Dylan Bundy | None | |
| 2018-05-09 | Wed | BAL | AL | A | N | 36 | L | 3-5 | 9 | box - pbp - pit | L1 | 12-24 | 4 | 13 | 27 | 2:45 | 14,375 | Eric Skoglund | Andrew Cashner (R) | Richard Bleier | Kevin McCarthy | Brad Brach | |
| 2018-05-10 | Thu | BAL | AL | A | N | 37 | L | 6-11 | 9 | box - pbp - pit | L2 | 12-25 | 4 | 13 | 27 | 2:57 | 17,842 | Ian Kennedy | Chris Tillman (R) | Miguel Castro | Ian Kennedy | None | |
| 2018-05-11 | Fri | CLE | AL | A | N | 38 | W | 10-9 | 9 | box - pbp - pit | W1 | 13-25 | 4 | 13 | 27 | 3:34 | 24,408 | Jason Hammel | Trevor Bauer (R) | Brad Keller | Andrew Miller | Kelvin Herrera | |
| 2018-05-12 | Sat | CLE | AL | A | N | 39 | L | 2-6 | 9 | box - pbp - pit | L1 | 13-26 | 4 | 13 | 27 | 2:31 | 24,587 | Jake Junis | Mike Clevinger (R) | Mike Clevinger | Jake Junis | None | |
| 2018-05-13 | Sun | CLE | AL | A | D | 40 | L | 2-11 | 9 | box - pbp - pit | L2 | 13-27 | 4 | 13 | 28 | 2:54 | 22,105 | Danny Duffy | Corey Kluber (R) | Corey Kluber | Danny Duffy | None | |
| 2018-05-14 | Mon | TBA | AL | H | N | 41 | L | 1-2 | 9 | box - pbp - pit | L3 | 13-28 | 4 | 13 | 29 | 2:33 | 14,174 | Eric Skoglund | Ryan Yarbrough (L) | Ryan Yarbrough | Eric Skoglund | Alex Colome | |
| 2018-05-15 | Tue | TBA | AL | H | N | 42 | L | 5-6 | 9 | box - pbp - pit | L4 | 13-29 | 4 | 14 | 29 | 2:53 | 21,500 | Ian Kennedy | Anthony Banda (L) | Jonny Venters | Kelvin Herrera | Alex Colome | |
| 2018-05-16 | Wed | TBA | AL | H | D | 43 | L | 3-5 | 9 | box - pbp - pit | L5 | 13-30 | 4 | 14 | 29 | 2:59 | 19,611 | Jason Hammel | Jake Faria (R) | Matt Andriese | Jason Hammel | Alex Colome | |
| 2018-05-18 | Fri | NYA | AL | H | N | 44 | W | 5-2 | 9 | box - pbp - pit | W1 | 14-30 | 4 | 14 | 29 | 2:46 | 26,433 | Jake Junis | CC Sabathia (L) | Jake Junis | CC Sabathia | Kelvin Herrera | |
| 2018-05-19 | Sat | NYA | AL | H | N | 45 | L | 3-8 | 9 | box - pbp - pit | L1 | 14-31 | 4 | 14 | 29 | 2:57 | 33,684 | Danny Duffy | Luis Severino (R) | Luis Severino | Danny Duffy | None | |
| 2018-05-20 | Sun | NYA | AL | H | D | 46 | L | 1-10 | 9 | box - pbp - pit | L2 | 14-32 | 4 | 14 | 29 | 2:31 | 24,121 | Eric Skoglund | Sonny Gray (R) | Sonny Gray | Eric Skoglund | None | |
| 2018-05-21 | Mon | SLN | NL | A | N | 47 | L | 0-6 | 9 | box - pbp - pit | L3 | 14-33 | 4 | 14 | 29 | 2:28 | 42,140 | Ian Kennedy | Miles Mikolas (R) | Miles Mikolas | Ian Kennedy | None | |
| 2018-05-22 | Tue | SLN | NL | A | N | 48 | W | 5-1 | 9 | box - pbp - pit | W1 | 15-33 | 4 | 14 | 29 | 2:53 | 39,545 | Jason Hammel | Luke Weaver (R) | Jason Hammel | Luke Weaver | None | |
| 2018-05-23 | Wed | SLN | NL | A | D | 49 | W | 5-2 | 10 | box - pbp - pit | W2 | 16-33 | 4 | 13 | 28 | 3:04 | 41,984 | Jake Junis | Michael Wacha (R) | Blaine Boyer | Bud Norris | Kelvin Herrera | |
| 2018-05-24 | Thu | TEX | AL | A | N | 50 | W | 8-2 | 9 | box - pbp - pit | W3 | 17-33 | 4 | 13 | 28 | 2:53 | 23,230 | Danny Duffy | Austin Bibens-Dirkx (R) | Danny Duffy | Austin Bibens-Dirkx | None | |
| 2018-05-25 | Fri | TEX | AL | A | N | 51 | L | 4-8 | 9 | box - pbp - pit | L1 | 17-34 | 4 | 14 | 29 | 3:07 | 35,105 | Eric Skoglund | Mike Minor (L) | Mike Minor | Eric Skoglund | Keone Kela | |
| 2018-05-26 | Sat | TEX | AL | A | D | 52 | L | 3-4 | 10 | box - pbp - pit | L2 | 17-35 | 4 | 14 | 29 | 2:59 | 29,644 | Ian Kennedy | Bartolo Colon (R) | Alex Claudio | Kevin McCarthy | None | |
| 2018-05-27 | Sun | TEX | AL | A | D | 53 | W | 5-3 | 9 | box - pbp - pit | W1 | 18-35 | 4 | 13 | 28 | 3:00 | 31,898 | Jason Hammel | Cole Hamels (L) | Jason Hammel | Cole Hamels | Kelvin Herrera | |
| 2018-05-28 | Mon | MIN | AL | H | N | 54 | L | 5-8 | 9 | box - pbp - pit | L1 | 18-36 | 4 | 13 | 28 | 3:13 | 18,572 | Jake Junis | Lance Lynn (R) | Lance Lynn | Jake Junis | Fernando Rodney | |
| 2018-05-29 | Tue | MIN | AL | H | N | 55 | W | 2-1 | 14 | box - pbp - pit | W1 | 19-36 | 4 | 13 | 27 | 4:12 | 20,533 | Danny Duffy | Kyle Gibson (R) | Scott Barlow | Taylor Rogers | None | |
| 2018-05-30 | Wed | MIN | AL | H | N | 56 | W | 11-8 | 9 | box - pbp - pit | W2 | 20-36 | 4 | 13 | 27 | 3:01 | 21,343 | Brad Keller | Fernando Romero (R) | Kevin McCarthy | Fernando Romero | Kelvin Herrera | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-06-01 | Fri | OAK | AL | H | N | 57 | L | 0-16 | 9 | box - pbp - pit | L1 | 20-37 | 4 | 13 | 27 | 2:49 | 23,413 | Ian Kennedy | Frankie Montas (R) | Frankie Montas | Ian Kennedy | None | |
| 2018-06-02 | Sat | OAK | AL | H | D | 58 | W | 5-4 | 9 | box - pbp - pit | W1 | 21-37 | 4 | 13 | 26 | 3:00 | 24,553 | Jason Hammel | Trevor Cahill (R) | Tim Hill | Yusmeiro Petit | Kelvin Herrera | |
| 2018-06-03 | Sun | OAK | AL | H | D | 59 | L | 1-5 | 9 | box - pbp - pit | L1 | 21-38 | 4 | 13 | 26 | 2:26 | 19,424 | Jake Junis | Daniel Gossett (R) | Lou Trivino | Jake Junis | None | |
| 2018-06-04 | Mon | ANA | AL | A | N | 60 | L | 6-9 | 9 | box - pbp - pit | L2 | 21-39 | 4 | 13 | 26 | 3:35 | 32,553 | Danny Duffy | Nick Tropeano (R) | Cam Bedrosian | Tim Hill | Blake Parker | |
| 2018-06-05 | Tue | ANA | AL | A | N | 61 | L | 0-1 | 9 | box - pbp - pit | L3 | 21-40 | 4 | 13 | 27 | 2:16 | 31,514 | Brad Keller | Andrew Heaney (L) | Andrew Heaney | Brad Keller | None | |
| 2018-06-06 | Wed | ANA | AL | A | N | 62 | L | 3-4 | 9 | box - pbp - pit | L4 | 21-41 | 5 | 14 | 29 | 3:11 | 36,512 | Ian Kennedy | Shohei Ohtani (R) | Cam Bedrosian | Scott Barlow | Blake Parker | |
| 2018-06-07 | Thu | OAK | AL | A | N | 63 | L | 1-4 | 9 | box - pbp - pit | L5 | 21-42 | 5 | 13 | 29 | 2:18 | 7,963 | Jason Hammel | Paul Blackburn (R) | Paul Blackburn | Jason Hammel | Blake Treinen | |
| 2018-06-08 | Fri | OAK | AL | A | N | 64 | L | 2-7 | 9 | box - pbp - pit | L6 | 21-43 | 5 | 14 | 29 | 2:32 | 10,132 | Jake Junis | Frankie Montas (R) | Frankie Montas | Jake Junis | Lou Trivino | |
| 2018-06-09 | Sat | OAK | AL | A | D | 65 | W | 2-0 | 9 | box - pbp - pit | W1 | 22-43 | 5 | 14 | 28 | 2:27 | 16,208 | Danny Duffy | Chris Bassitt (R) | Danny Duffy | Chris Bassitt | Kelvin Herrera | |
| 2018-06-10 | Sun | OAK | AL | A | D | 66 | L | 2-3 | 9 | box - pbp - pit | L1 | 22-44 | 5 | 14 | 29 | 2:25 | 15,548 | Brad Keller | Sean Manaea (L) | Blake Treinen | Jason Adam | None | |
| 2018-06-12 | Tue | CIN | NL | H | N | 67 | L | 1-5 | 10 | box - pbp - pit | L2 | 22-45 | 5 | 14 | 29 | 2:58 | 20,476 | Ian Kennedy | Sal Romano (R) | David Hernandez | Kevin McCarthy | None | |
| 2018-06-13 | Wed | CIN | NL | H | N | 68 | L | 0-7 | 9 | box - pbp - pit | L3 | 22-46 | 5 | 14 | 29 | 2:41 | 24,899 | Jason Hammel | Tyler Mahle (R) | Tyler Mahle | Jason Hammel | None | |
| 2018-06-15 | Fri | HOU | AL | H | N | 69 | L | 3-7 | 9 | box - pbp - pit | L4 | 22-47 | 5 | 14 | 29 | 2:49 | 27,603 | Jake Junis | Charlie Morton (R) | Charlie Morton | Jake Junis | None | |
| 2018-06-16 | Sat | HOU | AL | H | D | 70 | L | 2-10 | 9 | box - pbp - pit | L5 | 22-48 | 5 | 14 | 29 | 2:46 | 20,657 | Danny Duffy | Dallas Keuchel (L) | Dallas Keuchel | Danny Duffy | None | |
| 2018-06-17 | Sun | HOU | AL | H | D | 71 | L | 4-7 | 9 | box - pbp - pit | L6 | 22-49 | 5 | 14 | 29 | 2:46 | 22,326 | Brad Keller | Lance McCullers (R) | Tony Sipp | Brandon Maurer | Hector Rondon | |
| 2018-06-18 | Mon | TEX | AL | H | N | 72 | L | 3-6 | 9 | box - pbp - pit | L7 | 22-50 | 5 | 14 | 29 | 3:04 | 18,319 | Ian Kennedy | Bartolo Colon (R) | Bartolo Colon | Ian Kennedy | Keone Kela | |
| 2018-06-19 | Tue | TEX | AL | H | N | 73 | L | 1-4 | 9 | box - pbp - pit | L8 | 22-51 | 5 | 14 | 29 | 2:46 | 17,789 | Jason Hammel | Cole Hamels (L) | Cole Hamels | Jason Hammel | Keone Kela | |
| 2018-06-20 | Wed | TEX | AL | H | N | 74 | L | 2-3 | 9 | box - pbp - pit | L9 | 22-52 | 5 | 14 | 29 | 2:53 | 19,489 | Jake Junis | Austin Bibens-Dirkx (R) | Austin Bibens-Dirkx | Jake Junis | Jake Diekman | |
| 2018-06-22 | Fri | HOU | AL | A | N | 75 | W | 1-0 | 9 | box - pbp - pit | W1 | 23-52 | 5 | 14 | 29 | 3:09 | 39,357 | Danny Duffy | Dallas Keuchel (L) | Justin Grimm | Ken Giles | Tim Hill | |
| 2018-06-23 | Sat | HOU | AL | A | N | 76 | L | 3-4 | 12 | box - pbp - pit | L1 | 23-53 | 5 | 15 | 30 | 3:55 | 40,028 | Ian Kennedy | Lance McCullers (R) | Collin McHugh | Justin Grimm | None | |
| 2018-06-24 | Sun | HOU | AL | A | D | 77 | L | 3-11 | 9 | box - pbp - pit | L2 | 23-54 | 5 | 15 | 30 | 3:04 | 41,823 | Jason Hammel | Gerrit Cole (R) | Gerrit Cole | Jason Hammel | None | |
| 2018-06-25 | Mon | ANA | AL | H | D | 78 | W | 2-0 | 9 | box - pbp - pit | W1 | 24-54 | 5 | 14 | 29 | 2:44 | 19,535 | Brad Keller | Tyler Skaggs (L) | Brad Keller | Tyler Skaggs | Wily Peralta | |
| 2018-06-26 | Tue | MIL | NL | A | N | 79 | L | 1-5 | 9 | box - pbp - pit | L1 | 24-55 | 5 | 14 | 29 | 2:41 | 34,412 | Jake Junis | Freddy Peralta (R) | Freddy Peralta | Jake Junis | Josh Hader | |
| 2018-06-27 | Wed | MIL | NL | A | D | 80 | W | 5-4 | 9 | box - pbp - pit | W1 | 25-55 | 5 | 14 | 29 | 2:48 | 38,436 | Danny Duffy | Brent Suter (L) | Danny Duffy | Brent Suter | Wily Peralta | |
| 2018-06-29 | Fri | SEA | AL | A | N | 81 | L | 1-4 | 9 | box - pbp - pit | L1 | 25-56 | 5 | 14 | 29 | 2:26 | 25,558 | Ian Kennedy | Marco Gonzales (L) | Marco Gonzales | Ian Kennedy | None | |
| 2018-06-30 | Sat | SEA | AL | A | N | 82 | L | 4-6 | 9 | box - pbp - pit | L2 | 25-57 | 5 | 14 | 29 | 2:38 | 33,395 | Jason Hammel | Felix Hernandez (R) | Felix Hernandez | Jason Hammel | Edwin Diaz | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-07-01 | Sun | SEA | AL | A | D | 83 | L | 0-1 | 9 | box - pbp - pit | L3 | 25-58 | 5 | 14 | 29 | 2:00 | 38,344 | Brad Keller | James Paxton (L) | James Paxton | Brad Keller | Edwin Diaz | |
| 2018-07-02 | Mon | CLE | AL | H | N | 84 | L | 3-9 | 9 | box - pbp - pit | L4 | 25-59 | 5 | 14 | 29 | 2:44 | 18,285 | Jake Junis | Corey Kluber (R) | Corey Kluber | Jake Junis | None | |
| 2018-07-03 | Tue | CLE | AL | H | N | 85 | L | 4-6 | 9 | box - pbp - pit | L5 | 25-60 | 5 | 14 | 29 | 2:58 | 19,005 | Danny Duffy | Shane Bieber (R) | Shane Bieber | Danny Duffy | Cody Allen | |
| 2018-07-04 | Wed | CLE | AL | H | N | 86 | L | 2-3 | 9 | box - pbp - pit | L6 | 25-61 | 5 | 14 | 29 | 2:49 | 22,001 | Trevor Oaks | Trevor Bauer (R) | Trevor Bauer | Trevor Oaks | Cody Allen | |
| 2018-07-06 | Fri | BOS | AL | H | N | 87 | L | 5-10 | 9 | box - pbp - pit | L7 | 25-62 | 5 | 14 | 29 | 2:59 | 24,673 | Jason Hammel | Chris Sale (L) | Chris Sale | Jason Hammel | None | |
| 2018-07-07 | Sat | BOS | AL | H | N | 88 | L | 4-15 | 9 | box - pbp - pit | L8 | 25-63 | 5 | 14 | 29 | 4:03 | 30,347 | Brad Keller | David Price (L) | Heath Hembree | Jason Adam | None | |
| 2018-07-08 | Sun | BOS | AL | H | D | 89 | L | 4-7 | 9 | box - pbp - pit | L9 | 25-64 | 5 | 14 | 29 | 3:25 | 28,443 | Heath Fillmyer | Rick Porcello (R) | Rick Porcello | Heath Fillmyer | Craig Kimbrel | |
| 2018-07-09 | Mon | MIN | AL | A | N | 90 | L | 1-3 | 9 | box - pbp - pit | L10 | 25-65 | 5 | 14 | 29 | 3:03 | 20,199 | Danny Duffy | Jose Berrios (R) | Jose Berrios | Tim Hill | Fernando Rodney | |
| 2018-07-10 | Tue | MIN | AL | A | N | 91 | W | 9-4 | 9 | box - pbp - pit | W1 | 26-65 | 5 | 14 | 29 | 3:30 | 27,551 | Ian Kennedy | Aaron Slegers (R) | Brian Flynn | Aaron Slegers | None | |
| 2018-07-11 | Wed | MIN | AL | A | D | 92 | L | 5-8 | 9 | box - pbp - pit | L1 | 26-66 | 5 | 14 | 29 | 3:19 | 26,708 | Burch Smith | Lance Lynn (R) | Lance Lynn | Glenn Sparkman | None | |
| 2018-07-13 | Fri | CHA | AL | A | N | 93 | L | 6-9 | 9 | box - pbp - pit | L2 | 26-67 | 5 | 14 | 29 | 3:34 | 19,361 | Brad Keller | James Shields (R) | James Shields | Brad Keller | Joakim Soria | |
| 2018-07-14 | Sat | CHA | AL | A | D | 94 | W | 5-0 | 9 | box - pbp - pit | W1 | 27-67 | 5 | 14 | 29 | 2:47 | 20,159 | Danny Duffy | Reynaldo Lopez (R) | Danny Duffy | Reynaldo Lopez | None | |
| 2018-07-15 | Sun | CHA | AL | A | D | 95 | L | 1-10 | 9 | box - pbp - pit | L1 | 27-68 | 5 | 15 | 30 | 2:39 | 23,434 | Burch Smith | Lucas Giolito (R) | Lucas Giolito | Burch Smith | None | |
| 2018-07-20 | Fri | MIN | AL | H | N | 96 | W | 6-5 | 9 | box - pbp - pit | W1 | 28-68 | 5 | 14 | 29 | 3:08 | 27,719 | Danny Duffy | Kyle Gibson (R) | Danny Duffy | Kyle Gibson | Brandon Maurer | |
| 2018-07-21 | Sat | MIN | AL | H | N | 97 | W | 4-2 | 9 | box - pbp - pit | W2 | 29-68 | 5 | 14 | 29 | 3:11 | 22,159 | Jake Junis | Lance Lynn (R) | Brian Flynn | Lance Lynn | Wily Peralta | |
| 2018-07-22 | Sun | MIN | AL | H | D | 98 | W | 5-3 | 9 | box - pbp - pit | W3 | 30-68 | 5 | 14 | 29 | 2:35 | 18,107 | Brad Keller | Jake Odorizzi (R) | Brad Keller | Zach Duke | Wily Peralta | |
| 2018-07-23 | Mon | DET | AL | H | N | 99 | L | 4-5 | 9 | box - pbp - pit | L1 | 30-69 | 5 | 14 | 29 | 3:13 | 18,370 | Heath Fillmyer | Francisco Liriano (L) | Alex Wilson | Brandon Maurer | Shane Greene | |
| 2018-07-24 | Tue | DET | AL | H | N | 100 | W | 5-4 | 9 | box - pbp - pit | W1 | 31-69 | 5 | 14 | 29 | 2:43 | 25,957 | Burch Smith | Jordan Zimmermann (R) | Burch Smith | Jordan Zimmermann | Wily Peralta | |
| 2018-07-25 | Wed | DET | AL | H | D | 101 | L | 4-8 | 9 | box - pbp - pit | L1 | 31-70 | 5 | 14 | 29 | 2:50 | 17,382 | Danny Duffy | Matt Boyd (L) | Matt Boyd | Danny Duffy | None | |
| 2018-07-26 | Thu | NYA | AL | A | N | 102 | L | 2-7 | 9 | box - pbp - pit | L2 | 31-71 | 5 | 14 | 29 | 2:58 | 46,965 | Jake Junis | Sonny Gray (R) | Sonny Gray | Jake Junis | None | |
| 2018-07-28 | Sat | NYA | AL | A | D | 103 | W | 10-5 | 9 | box - pbp - pit | W1 | 32-72 | 5 | 14 | 29 | 3:06 | 46,571 | Brad Keller | Luis Severino (R) | Brad Keller | Luis Severino | None | |
| 2018-07-28 | Sat | NYA | AL | A | N | 104 | L | 4-5 | 9 | box - pbp - pit | L1 | 32-72 | 5 | 14 | 29 | 3:27 | 45,043 | Heath Fillmyer | CC Sabathia (L) | Dellin Betances | Brian Flynn | Aroldis Chapman | |
| 2018-07-29 | Sun | NYA | AL | A | D | 105 | L | 3-6 | 9 | box - pbp - pit | L2 | 32-73 | 5 | 14 | 29 | 2:51 | 46,192 | Burch Smith | J.A. Happ (L) | J.A. Happ | Burch Smith | Aroldis Chapman | |
| 2018-07-31 | Tue | CHA | AL | A | N | 106 | W | 4-2 | 9 | box - pbp - pit | W1 | 33-73 | 5 | 14 | 29 | 3:10 | 15,250 | Danny Duffy | James Shields (R) | Danny Duffy | James Shields | Wily Peralta | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-08-01 | Wed | CHA | AL | A | N | 107 | W | 10-5 | 9 | box - pbp - pit | W2 | 34-73 | 5 | 14 | 29 | 3:01 | 18,019 | Jake Junis | Dylan Covey (R) | Jake Junis | Dylan Covey | None | |
| 2018-08-02 | Thu | CHA | AL | A | D | 108 | L | 4-6 | 9 | box - pbp - pit | L1 | 34-74 | 5 | 14 | 29 | 2:52 | 19,682 | Brad Keller | Reynaldo Lopez (R) | Xavier Cedeno | Jason Adam | Luis Avilan | |
| 2018-08-03 | Fri | MIN | AL | A | N | 109 | L | 4-6 | 9 | box - pbp - pit | L2 | 34-75 | 5 | 14 | 29 | 3:21 | 22,236 | Heath Fillmyer | Jake Odorizzi (R) | Gabriel Moya | Brian Flynn | Fernando Rodney | |
| 2018-08-04 | Sat | MIN | AL | A | N | 110 | L | 2-8 | 9 | box - pbp - pit | L3 | 34-76 | 5 | 14 | 29 | 2:45 | 27,909 | Burch Smith | Jose Berrios (R) | Jose Berrios | Burch Smith | None | |
| 2018-08-05 | Sun | MIN | AL | A | D | 111 | L | 5-6 | 9 | box - pbp - pit | L4 | 34-77 | 5 | 14 | 29 | 2:53 | 25,390 | Danny Duffy | Ervin Santana (R) | Gabriel Moya | Danny Duffy | Fernando Rodney | |
| 2018-08-06 | Mon | CHN | NL | H | N | 112 | L | 1-3 | 9 | box - pbp - pit | L5 | 34-78 | 5 | 15 | 29 | 2:52 | 32,339 | Jake Junis | Cole Hamels (L) | Cole Hamels | Kevin McCarthy | Pedro Strop | |
| 2018-08-07 | Tue | CHN | NL | H | N | 113 | L | 0-5 | 9 | box - pbp - pit | L6 | 34-79 | 5 | 15 | 30 | 2:49 | 27,883 | Brad Keller | Mike Montgomery (L) | Mike Montgomery | Brad Keller | None | |
| 2018-08-08 | Wed | CHN | NL | H | N | 114 | W | 9-0 | 9 | box - pbp - pit | W1 | 35-79 | 5 | 14 | 29 | 2:31 | 24,294 | Heath Fillmyer | Jose Quintana (L) | Heath Fillmyer | Jose Quintana | None | |
| 2018-08-10 | Fri | SLN | NL | H | N | 115 | L | 0-7 | 9 | box - pbp - pit | L1 | 35-80 | 5 | 14 | 29 | 3:04 | 29,414 | Burch Smith | Austin Gomber (L) | Austin Gomber | Burch Smith | Daniel Poncedeleon | |
| 2018-08-11 | Sat | SLN | NL | H | N | 116 | L | 3-8 | 9 | box - pbp - pit | L2 | 35-81 | 5 | 14 | 29 | 2:56 | 38,427 | Danny Duffy | Jack Flaherty (R) | Jack Flaherty | Danny Duffy | Jordan Hicks | |
| 2018-08-12 | Sun | SLN | NL | H | D | 117 | L | 2-8 | 9 | box - pbp - pit | L3 | 35-82 | 5 | 14 | 29 | 3:04 | 23,409 | Jake Junis | Tyson Ross (R) | Tyson Ross | Jason Hammel | None | |
| 2018-08-13 | Mon | TOR | AL | H | N | 118 | W | 3-1 | 9 | box - pbp - pit | W1 | 36-82 | 5 | 14 | 29 | 2:42 | 14,721 | Brad Keller | Sean Reid-Foley (R) | Brad Keller | Sean Reid-Foley | Wily Peralta | |
| 2018-08-14 | Tue | TOR | AL | H | N | 119 | L | 5-6 | 9 | box - pbp - pit | L1 | 36-83 | 5 | 14 | 29 | 3:06 | 13,680 | Heath Fillmyer | Ryan Borucki (L) | Jake Petricka | Blaine Boyer | Ken Giles | |
| 2018-08-15 | Wed | TOR | AL | H | N | 120 | L | 5-6 | 9 | box - pbp - pit | L2 | 36-84 | 5 | 14 | 29 | 2:39 | 14,391 | Jorge Lopez | Marco Estrada (R) | Marco Estrada | Jorge Lopez | Ken Giles | |
| 2018-08-16 | Thu | TOR | AL | H | N | 121 | W | 6-2 | 9 | box - pbp - pit | W1 | 37-84 | 5 | 14 | 29 | 2:43 | 14,894 | Glenn Sparkman | Sam Gaviglio (R) | Brian Flynn | Sam Gaviglio | None | |
| 2018-08-17 | Fri | CHA | AL | A | N | 122 | L | 3-9 | 9 | box - pbp - pit | L1 | 37-85 | 5 | 14 | 29 | 2:57 | 24,556 | Jake Junis | James Shields (R) | James Shields | Tim Hill | None | |
| 2018-08-18 | Sat | CHA | AL | A | N | 123 | W | 3-1 | 9 | box - pbp - pit | W1 | 38-85 | 5 | 14 | 29 | 3:06 | 19,018 | Brad Keller | Dylan Covey (R) | Brad Keller | Dylan Covey | Wily Peralta | |
| 2018-08-19 | Sun | CHA | AL | A | D | 124 | L | 6-7 | 9 | box - pbp - pit | L1 | 38-86 | 5 | 14 | 29 | 3:11 | 22,033 | Heath Fillmyer | Reynaldo Lopez (R) | Hector Santiago | Brian Flynn | Jace Fry | |
| 2018-08-20 | Mon | TBA | AL | A | N | 125 | L | 0-1 | 9 | box - pbp - pit | L2 | 38-87 | 5 | 14 | 29 | 2:49 | 10,036 | Jorge Lopez | Hunter Wood (R) | Ryan Yarbrough | Jorge Lopez | Jose Alvarado | |
| 2018-08-21 | Tue | TBA | AL | A | N | 126 | L | 1-4 | 9 | box - pbp - pit | L3 | 38-88 | 5 | 14 | 29 | 3:03 | 9,402 | Glenn Sparkman | Blake Snell (L) | Blake Snell | Glenn Sparkman | Sergio Romo | |
| 2018-08-22 | Wed | TBA | AL | A | N | 127 | L | 3-6 | 9 | box - pbp - pit | L4 | 38-89 | 5 | 14 | 29 | 2:52 | 8,686 | Jake Junis | Ryne Stanek (R) | Yonny Chirinos | Jake Junis | Sergio Romo | |
| 2018-08-23 | Thu | TBA | AL | A | N | 128 | L | 3-4 | 9 | box - pbp - pit | L5 | 38-90 | 5 | 14 | 29 | 2:51 | 9,088 | Danny Duffy | Tyler Glasnow (R) | Sergio Romo | Brian Flynn | None | |
| 2018-08-24 | Fri | CLE | AL | H | N | 129 | W | 5-4 | 9 | box - pbp - pit | W1 | 39-90 | 5 | 14 | 29 | 2:55 | 19,304 | Brad Keller | Mike Clevinger (R) | Wily Peralta | Cody Allen | None | |
| 2018-08-25 | Sat | CLE | AL | H | N | 130 | W | 7-1 | 9 | box - pbp - pit | W2 | 40-90 | 5 | 14 | 29 | 2:45 | 16,894 | Heath Fillmyer | Corey Kluber (R) | Heath Fillmyer | Corey Kluber | None | |
| 2018-08-26 | Sun | CLE | AL | H | D | 131 | L | 5-12 | 9 | box - pbp - pit | L1 | 40-91 | 5 | 14 | 29 | 3:08 | 18,575 | Jorge Lopez | Shane Bieber (R) | Shane Bieber | Jorge Lopez | None | |
| 2018-08-28 | Tue | DET | AL | H | N | 132 | W | 6-2 | 9 | box - pbp - pit | W1 | 41-91 | 5 | 14 | 29 | 2:24 | 16,888 | Jake Junis | Matt Boyd (L) | Jake Junis | Matt Boyd | None | |
| 2018-08-29 | Wed | DET | AL | H | D | 133 | W | 9-2 | 9 | box - pbp - pit | W2 | 42-91 | 5 | 14 | 29 | 2:38 | 17,091 | Danny Duffy | Michael Fulmer (R) | Danny Duffy | Michael Fulmer | None | |
| 2018-08-31 | Fri | BAL | AL | H | N | 134 | W | 9-2 | 9 | box - pbp - pit | W3 | 43-91 | 5 | 14 | 29 | 2:39 | 15,394 | Brad Keller | Andrew Cashner (R) | Brad Keller | Andrew Cashner | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2018-09-01 | Sat | BAL | AL | H | N | 135 | W | 5-4 | 9 | box - pbp - pit | W4 | 44-91 | 5 | 14 | 29 | 2:56 | 15,358 | Heath Fillmyer | Dylan Bundy (R) | Jake Newberry | Mychal Givens | None | |
| 2018-09-02 | Sun | BAL | AL | H | D | 136 | W | 9-1 | 9 | box - pbp - pit | W5 | 45-91 | 5 | 14 | 29 | 2:48 | 18,463 | Jorge Lopez | David Hess (R) | Jorge Lopez | David Hess | None | |
| 2018-09-03 | Mon | CLE | AL | A | D | 137 | W | 5-1 | 9 | box - pbp - pit | W6 | 46-91 | 5 | 14 | 29 | 2:40 | 20,536 | Jake Junis | Adam Plutko (R) | Jake Junis | Adam Plutko | Tim Hill | |
| 2018-09-04 | Tue | CLE | AL | A | N | 138 | L | 3-9 | 9 | box - pbp - pit | L1 | 46-92 | 5 | 14 | 29 | 2:59 | 17,041 | Danny Duffy | Mike Clevinger (R) | Mike Clevinger | Danny Duffy | None | |
| 2018-09-05 | Wed | CLE | AL | A | D | 139 | L | 1-3 | 9 | box - pbp - pit | L2 | 46-93 | 5 | 14 | 29 | 2:31 | 18,435 | Brad Keller | Corey Kluber (R) | Corey Kluber | Brad Keller | Brad Hand | |
| 2018-09-07 | Fri | MIN | AL | A | N | 140 | L | 6-10 | 9 | box - pbp - pit | L3 | 46-94 | 5 | 14 | 29 | 3:36 | 19,944 | Heath Fillmyer | Stephen Gonsalves (L) | Trevor May | Glenn Sparkman | None | |
| 2018-09-08 | Sat | MIN | AL | A | N | 141 | W | 4-1 | 9 | box - pbp - pit | W1 | 47-94 | 5 | 14 | 29 | 2:42 | 25,814 | Jorge Lopez | Jose Berrios (R) | Jorge Lopez | Jose Berrios | Wily Peralta | |
| 2018-09-09 | Sun | MIN | AL | A | D | 142 | L | 1-3 | 9 | box - pbp - pit | L1 | 47-95 | 5 | 14 | 29 | 2:36 | 20,903 | Ian Kennedy | Chase De Jong (R) | Trevor Hildenberger | Jason Hammel | None | |
| 2018-09-10 | Mon | CHA | AL | H | N | 143 | W | 4-3 | 10 | box - pbp - pit | W1 | 48-95 | 5 | 14 | 29 | 2:51 | 17,809 | Jake Junis | Lucas Giolito (R) | Jake Newberry | Jeanmar Gomez | None | |
| 2018-09-11 | Tue | CHA | AL | H | N | 144 | W | 6-3 | 9 | box - pbp - pit | W2 | 49-95 | 5 | 14 | 29 | 2:55 | 17,613 | Brad Keller | Dylan Covey (R) | Brad Keller | Dylan Covey | Wily Peralta | |
| 2018-09-12 | Wed | CHA | AL | H | N | 145 | L | 2-4 | 12 | box - pbp - pit | L1 | 49-96 | 5 | 14 | 29 | 3:53 | 17,840 | Eric Skoglund | Carlos Rodon (L) | Juan Minaya | Burch Smith | Hector Santiago | |
| 2018-09-13 | Thu | MIN | AL | H | N | 146 | W | 6-4 | 9 | box - pbp - pit | W1 | 50-96 | 5 | 14 | 29 | 3:12 | 18,745 | Heath Fillmyer | Gabriel Moya (L) | Heath Fillmyer | Alan Busenitz | Wily Peralta | |
| 2018-09-14 | Fri | MIN | AL | H | N | 147 | W | 8-4 | 9 | box - pbp - pit | W2 | 51-96 | 5 | 14 | 29 | 3:15 | 18,389 | Jorge Lopez | Jose Berrios (R) | Jason Hammel | Trevor Hildenberger | None | |
| 2018-09-15 | Sat | MIN | AL | H | N | 148 | W | 10-3 | 9 | box - pbp - pit | W3 | 52-96 | 5 | 14 | 29 | 3:04 | 19,505 | Ian Kennedy | Chase De Jong (R) | Ian Kennedy | Chase De Jong | None | |
| 2018-09-16 | Sun | MIN | AL | H | D | 149 | L | 6-9 | 9 | box - pbp - pit | L1 | 52-97 | 5 | 14 | 29 | 3:24 | 20,286 | Jake Junis | Kyle Gibson (R) | Kyle Gibson | Jerry Vasto | None | |
| 2018-09-17 | Mon | PIT | NL | A | N | 150 | L | 6-7 | 9 | box - pbp - pit | L2 | 52-98 | 5 | 14 | 29 | 3:08 | 10,316 | Brad Keller | Joe Musgrove (R) | Edgar Santana | Ben Lively | None | |
| 2018-09-18 | Tue | PIT | NL | A | N | 151 | L | 1-2 | 11 | box - pbp - pit | L3 | 52-99 | 5 | 14 | 29 | 3:29 | 11,566 | Eric Skoglund | Jameson Taillon (R) | Kyle Crick | Burch Smith | None | |
| 2018-09-19 | Wed | PIT | NL | A | N | 152 | L | 1-2 | 9 | box - pbp - pit | L4 | 52-100 | 5 | 14 | 29 | 2:22 | 13,073 | Heath Fillmyer | Chris Archer (R) | Chris Archer | Heath Fillmyer | Felipe Vazquez | |
| 2018-09-20 | Thu | DET | AL | A | N | 153 | L | 8-11 | 9 | box - pbp - pit | L5 | 52-101 | 5 | 14 | 29 | 3:12 | 20,282 | Jorge Lopez | Matt Boyd (L) | Zac Reininger | Jorge Lopez | None | |
| 2018-09-21 | Fri | DET | AL | A | N | 154 | W | 4-3 | 9 | box - pbp - pit | W1 | 53-101 | 5 | 14 | 29 | 2:51 | 22,001 | Ian Kennedy | Francisco Liriano (L) | Ian Kennedy | Francisco Liriano | Wily Peralta | |
| 2018-09-22 | Sat | DET | AL | A | N | 155 | L | 4-5 | 9 | box - pbp - pit | L1 | 53-102 | 5 | 14 | 29 | 2:42 | 24,815 | Jake Junis | Jordan Zimmermann (R) | Joe Jimenez | Jason Hammel | Shane Greene | |
| 2018-09-23 | Sun | DET | AL | A | D | 156 | W | 3-2 | 9 | box - pbp - pit | W1 | 54-102 | 5 | 14 | 29 | 2:47 | 24,230 | Brad Keller | Daniel Norris (L) | Brad Keller | Drew VerHagen | Wily Peralta | |
| 2018-09-25 | Tue | CIN | NL | A | N | 157 | W | 4-3 | 9 | box - pbp - pit | W2 | 55-102 | 5 | 14 | 29 | 2:40 | 13,172 | Eric Skoglund | Matt Harvey (R) | Kevin McCarthy | Raisel Iglesias | Wily Peralta | |
| 2018-09-26 | Wed | CIN | NL | A | N | 158 | W | 6-1 | 9 | box - pbp - pit | W3 | 56-102 | 5 | 14 | 29 | 2:48 | 12,549 | Heath Fillmyer | Cody Reed (L) | Heath Fillmyer | Cody Reed | None | |
| 2018-09-27 | Thu | CLE | AL | H | N | 159 | W | 2-1 | 10 | box - pbp - pit | W4 | 57-102 | 5 | 14 | 29 | 3:08 | 19,262 | Glenn Sparkman | Josh Tomlin (R) | Jason Hammel | Neil Ramirez | None | |
| 2018-09-28 | Fri | CLE | AL | H | N | 160 | L | 6-14 | 9 | box - pbp - pit | L1 | 57-103 | 5 | 14 | 29 | 3:16 | 15,920 | Ian Kennedy | Mike Clevinger (R) | Mike Clevinger | Ian Kennedy | None | |
| 2018-09-29 | Sat | CLE | AL | H | N | 161 | W | 9-4 | 9 | box - pbp - pit | W1 | 58-103 | 5 | 14 | 29 | 3:07 | 23,324 | Jake Junis | Corey Kluber (R) | Jake Junis | Andrew Miller | None | |
| 2018-09-30 | Sun | CLE | AL | H | D | 162 | L | 1-2 | 9 | box - pbp - pit | L1 | 58-104 | 5 | 14 | 29 | 2:44 | 19,690 | Eric Skoglund | Carlos Carrasco (R) | Carlos Carrasco | Eric Skoglund | Trevor Bauer |
Team Splits | Top |
| Category | GP | W | L | Wpct | RF | RA | Diff |
| Season Total | 162 | 58 | 104 | .358 | 638 | 833 | -195 |
| Home Games | 81 | 32 | 49 | .395 | 333 | 424 | -91 |
| Away Games | 81 | 26 | 55 | .321 | 305 | 409 | -104 |
| Night Games | 107 | 39 | 68 | .364 | 437 | 540 | -103 |
| Day Games | 55 | 19 | 36 | .345 | 201 | 293 | -92 |
| March/April | 28 | 7 | 21 | .250 | 95 | 160 | -65 |
| May | 28 | 13 | 15 | .464 | 135 | 149 | -14 |
| June | 26 | 5 | 21 | .192 | 58 | 136 | -78 |
| July | 24 | 8 | 16 | .333 | 100 | 137 | -37 |
| August | 28 | 10 | 18 | .357 | 119 | 132 | -13 |
| Sept/Oct | 28 | 15 | 13 | .536 | 131 | 119 | +12 |
| 1-Run Games | 49 | 19 | 30 | .388 | 165 | 176 | -11 |
| Close Games (1-2-3 Runs) | 99 | 37 | 62 | .374 | 351 | 401 | -50 |
| Blowouts (7+ runs) | 23 | 7 | 16 | .304 | 114 | 198 | -84 |
| Extra Innings | 13 | 5 | 8 | .385 | 40 | 47 | -7 |
| Shutouts | 17 | 8 | 9 | .471 | 31 | 52 | -21 |
| vs LHSP | 49 | 19 | 30 | .388 | 182 | 236 | -54 |
| vs RHSP | 113 | 39 | 74 | .345 | 456 | 597 | -141 |
| vs Division | 76 | 36 | 40 | .474 | 338 | 384 | -46 |
| vs League | 142 | 52 | 90 | .366 | 584 | 746 | -162 |
| InterLeague | 20 | 6 | 14 | .300 | 54 | 87 | -33 |
