| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-04-06 | Fri | BAL | AL | A | D | 1 | L | 2-4 | 9 | box - pbp - pit | L1 | 0-1 | 4 | 10 | 30 | 2:38 | 46,773 | Carl Pavano | Jake Arrieta (R) | Jake Arrieta | Carl Pavano | Jim Johnson | |
| 2012-04-07 | Sat | BAL | AL | A | N | 2 | L | 2-8 | 9 | box - pbp - pit | L2 | 0-2 | 5 | 14 | 29 | 2:37 | 31,532 | Francisco Liriano | Tommy Hunter (R) | Tommy Hunter | Francisco Liriano | None | |
| 2012-04-08 | Sun | BAL | AL | A | D | 3 | L | 1-3 | 9 | box - pbp - pit | L3 | 0-3 | 5 | 14 | 26 | 2:14 | 14,738 | Anthony Swarzak | Jason Hammel (R) | Jason Hammel | Anthony Swarzak | Jim Johnson | |
| 2012-04-09 | Mon | ANA | AL | H | D | 4 | L | 1-5 | 9 | box - pbp - pit | L4 | 0-4 | 5 | 14 | 29 | 2:50 | 39,414 | Nick Blackburn | CJ Wilson (L) | C.J. Wilson | Nick Blackburn | None | |
| 2012-04-11 | Wed | ANA | AL | H | N | 5 | W | 6-5 | 9 | box - pbp - pit | W1 | 1-4 | 5 | 13 | 28 | 2:47 | 31,413 | Carl Pavano | Jered Weaver (R) | Jeff Gray | Hisanori Takahashi | Matt Capps | |
| 2012-04-12 | Thu | ANA | AL | H | D | 6 | L | 10-9 | 9 | box - pbp - pit | L1 | 1-5 | 5 | 13 | 29 | 3:44 | 31,782 | Francisco Liriano | Dan Haren (R) | Jeff Gray | Rich Thompson | Matt Capps | |
| 2012-04-13 | Fri | TEX | AL | H | N | 7 | L | 1-4 | 9 | box - pbp - pit | L2 | 1-6 | 5 | 14 | 30 | 2:28 | 31,400 | Anthony Swarzak | Matt Harrison (L) | Matt Harrison | Anthony Swarzak | Alexi Ogando | |
| 2012-04-14 | Sat | TEX | AL | H | D | 8 | L | 2-6 | 9 | box - pbp - pit | L3 | 1-7 | 5 | 14 | 30 | 3:27 | 35,854 | Nick Blackburn | Yu Darvish (R) | Robbie Ross | Brian Duensing | None | |
| 2012-04-15 | Sun | TEX | AL | H | D | 9 | L | 3-4 | 9 | box - pbp - pit | L4 | 1-8 | 5 | 14 | 30 | 2:48 | 32,093 | Liam Hendriks | Neftali Feliz (R) | Robbie Ross | Glen Perkins | Joe Nathan | |
| 2012-04-16 | Mon | NYA | AL | A | N | 10 | W | 7-3 | 9 | box - pbp - pit | W1 | 2-8 | 5 | 13 | 30 | 3:04 | 40,218 | Carl Pavano | Freddy Garcia (R) | Carl Pavano | Freddy Garcia | None | |
| 2012-04-17 | Tue | NYA | AL | A | N | 11 | L | 3-8 | 9 | box - pbp - pit | L1 | 2-9 | 5 | 14 | 30 | 2:59 | 40,194 | Francisco Liriano | CC Sabathia (L) | CC Sabathia | Francisco Liriano | None | |
| 2012-04-18 | Wed | NYA | AL | A | N | 12 | W | 6-5 | 9 | box - pbp - pit | W1 | 3-9 | 5 | 14 | 29 | 3:27 | 36,831 | Jason Marquis | Hiroki Kuroda (R) | Jason Marquis | Hiroki Kuroda | Matt Capps | |
| 2012-04-19 | Thu | NYA | AL | A | N | 13 | L | 6-7 | 9 | box - pbp - pit | L1 | 3-10 | 5 | 14 | 29 | 3:13 | 40,327 | Anthony Swarzak | Phil Hughes (R) | Phil Hughes | Anthony Swarzak | Mariano Rivera | |
| 2012-04-20 | Fri | TBA | AL | A | N | 14 | W | 5-4 | 9 | box - pbp - pit | W1 | 4-10 | 5 | 13 | 28 | 3:09 | 18,763 | Liam Hendriks | Matt Moore (L) | Matt Maloney | Brandon Gomes | Matt Capps | |
| 2012-04-21 | Sat | TBA | AL | A | N | 15 | L | 1-4 | 9 | box - pbp - pit | L1 | 4-11 | 5 | 14 | 29 | 3:03 | 31,774 | Carl Pavano | James Shields (R) | James Shields | Carl Pavano | Fernando Rodney | |
| 2012-04-22 | Sun | TBA | AL | A | D | 16 | L | 2-6 | 9 | box - pbp - pit | L2 | 4-12 | 5 | 14 | 30 | 2:54 | 26,507 | Francisco Liriano | Jeff Niemann (R) | Jeff Niemann | Francisco Liriano | None | |
| 2012-04-23 | Mon | BOS | AL | H | N | 17 | L | 5-6 | 9 | box - pbp - pit | L3 | 4-13 | 5 | 14 | 30 | 3:12 | 32,351 | Jason Marquis | Jon Lester (L) | Daniel Bard | Matt Capps | Alfredo Aceves | |
| 2012-04-24 | Tue | BOS | AL | H | N | 18 | W | 2-11 | 9 | box - pbp - pit | W1 | 5-13 | 5 | 14 | 30 | 3:03 | 33,651 | Nick Blackburn | Josh Beckett (R) | Josh Beckett | Nick Blackburn | None | |
| 2012-04-25 | Wed | BOS | AL | H | N | 19 | L | 6-7 | 9 | box - pbp - pit | L1 | 5-14 | 5 | 14 | 30 | 3:32 | 32,254 | Liam Hendriks | Clay Buchholz (R) | Clay Buchholz | Liam Hendriks | Alfredo Aceves | |
| 2012-04-27 | Fri | KCA | AL | H | N | 20 | L | 6-7 | 9 | box - pbp - pit | L2 | 5-15 | 5 | 14 | 30 | 3:00 | 33,315 | Carl Pavano | Everett Teaford (L) | Jose Mijares | Brian Duensing | Jonathan Broxton | |
| 2012-04-29 | Sun | KCA | AL | H | D | 21 | W | 7-4 | 9 | box - pbp - pit | W1 | 6-15 | 5 | 14 | 30 | 3:02 | 34,201 | Jason Marquis | Bruce Chen (L) | Jason Marquis | Bruce Chen | None | |
| 2012-04-30 | Mon | ANA | AL | A | N | 22 | L | 3-4 | 9 | box - pbp - pit | L1 | 6-16 | 5 | 14 | 30 | 2:27 | 27,027 | Nick Blackburn | CJ Wilson (L) | C.J. Wilson | Nick Blackburn | Scott Downs | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-05-01 | Tue | ANA | AL | A | N | 23 | L | 0-4 | 9 | box - pbp - pit | L2 | 6-17 | 5 | 14 | 30 | 2:10 | 30,039 | Francisco Liriano | Jerome Williams (R) | Jerome Williams | Francisco Liriano | None | |
| 2012-05-02 | Wed | ANA | AL | A | N | 24 | L | 0-9 | 9 | box - pbp - pit | L3 | 6-18 | 5 | 14 | 30 | 2:28 | 27,288 | Liam Hendriks | Jered Weaver (R) | Jered Weaver | Liam Hendriks | None | |
| 2012-05-04 | Fri | SEA | AL | A | N | 25 | W | 3-2 | 9 | box - pbp - pit | W1 | 7-18 | 5 | 14 | 29 | 2:42 | 22,492 | Carl Pavano | Jason Vargas (L) | Carl Pavano | Tom Wilhelmsen | Matt Capps | |
| 2012-05-05 | Sat | SEA | AL | A | N | 26 | L | 0-7 | 9 | box - pbp - pit | L1 | 7-19 | 5 | 14 | 30 | 2:33 | 28,437 | Jason Marquis | Felix Hernandez (R) | Felix Hernandez | Jason Marquis | None | |
| 2012-05-06 | Sun | SEA | AL | A | D | 27 | L | 2-5 | 9 | box - pbp - pit | L2 | 7-20 | 5 | 14 | 30 | 2:30 | 23,913 | Nick Blackburn | Hector Noesi (R) | Hector Noesi | Nick Blackburn | None | |
| 2012-05-07 | Mon | ANA | AL | H | N | 28 | L | 3-8 | 9 | box - pbp - pit | L3 | 7-21 | 5 | 14 | 30 | 3:01 | 31,382 | Francisco Liriano | Jered Weaver (R) | Jered Weaver | Francisco Liriano | None | |
| 2012-05-08 | Tue | ANA | AL | H | N | 29 | W | 5-0 | 9 | box - pbp - pit | W1 | 8-21 | 5 | 13 | 29 | 2:37 | 30,776 | Scott Diamond | Dan Haren (R) | Scott Diamond | Dan Haren | None | |
| 2012-05-09 | Wed | ANA | AL | H | N | 30 | L | 2-6 | 9 | box - pbp - pit | L1 | 8-22 | 5 | 13 | 29 | 2:42 | 31,915 | Carl Pavano | Ervin Santana (R) | Ervin Santana | Carl Pavano | None | |
| 2012-05-10 | Thu | TOR | AL | H | N | 31 | L | 2-6 | 9 | box - pbp - pit | L2 | 8-23 | 5 | 13 | 29 | 2:45 | 31,438 | Jason Marquis | Henderson Alvarez (R) | Henderson Alvarez | Jason Marquis | None | |
| 2012-05-11 | Fri | TOR | AL | H | N | 32 | W | 7-6 | 9 | box - pbp - pit | W1 | 9-23 | 5 | 13 | 29 | 3:17 | 33,387 | Nick Blackburn | Kyle Drabek (R) | Nick Blackburn | Kyle Drabek | Matt Capps | |
| 2012-05-12 | Sat | TOR | AL | H | N | 33 | L | 1-2 | 9 | box - pbp - pit | L1 | 9-24 | 5 | 14 | 29 | 2:50 | 38,820 | P.J. Walters | Drew Hutchison (R) | Drew Hutchison | P.J. Walters | Casey Janssen | |
| 2012-05-13 | Sun | TOR | AL | H | D | 34 | W | 4-3 | 9 | box - pbp - pit | W1 | 10-24 | 5 | 14 | 29 | 2:59 | 36,889 | Scott Diamond | Ricky Romero (L) | Scott Diamond | Ricky Romero | Matt Capps | |
| 2012-05-14 | Mon | CLE | AL | H | N | 35 | L | 4-5 | 9 | box - pbp - pit | L1 | 10-25 | 5 | 14 | 30 | 2:43 | 32,313 | Carl Pavano | Jeanmar Gomez (R) | Joe Smith | Matt Capps | Chris Perez | |
| 2012-05-15 | Tue | CLE | AL | H | D | 36 | L | 0-5 | 9 | box - pbp - pit | L2 | 10-26 | 5 | 14 | 30 | 2:27 | 35,732 | Jason Marquis | Derek Lowe (R) | Derek Lowe | Jason Marquis | None | |
| 2012-05-16 | Wed | DET | AL | A | N | 37 | L | 11-7 | 9 | box - pbp - pit | L3 | 10-27 | 5 | 14 | 30 | 3:25 | 33,955 | Nick Blackburn | Rick Porcello (R) | Alex Burnett | Duane Below | None | |
| 2012-05-17 | Thu | DET | AL | A | D | 38 | W | 4-3 | 9 | box - pbp - pit | W1 | 11-27 | 5 | 14 | 30 | 2:36 | 37,840 | P.J. Walters | Doug Fister (R) | P.J. Walters | Doug Fister | Matt Capps | |
| 2012-05-18 | Fri | MIL | NL | A | N | 39 | L | 11-3 | 9 | box - pbp - pit | L1 | 11-28 | 5 | 14 | 30 | 3:35 | 32,421 | Scott Diamond | Marco Estrada (R) | Scott Diamond | Marco Estrada | None | |
| 2012-05-19 | Sat | MIL | NL | A | D | 40 | W | 5-4 | 11 | box - pbp - pit | W1 | 12-28 | 5 | 14 | 30 | 3:45 | 42,398 | Carl Pavano | Yovani Gallardo (R) | Jeff Gray | Manny Parra | Matt Capps | |
| 2012-05-20 | Sun | MIL | NL | A | D | 41 | W | 4-16 | 9 | box - pbp - pit | W2 | 13-28 | 5 | 14 | 30 | 3:25 | 33,064 | Jason Marquis | Zack Greinke (R) | Zack Greinke | Jason Marquis | None | |
| 2012-05-22 | Tue | CHA | AL | A | N | 42 | W | 9-2 | 9 | box - pbp - pit | W3 | 14-28 | 5 | 14 | 30 | 2:23 | 20,026 | P.J. Walters | Gavin Floyd (R) | P.J. Walters | Gavin Floyd | None | |
| 2012-05-23 | Wed | CHA | AL | A | N | 43 | L | 0-6 | 9 | box - pbp - pit | L1 | 14-29 | 5 | 14 | 30 | 2:28 | 20,064 | Scott Diamond | Chris Sale (L) | Chris Sale | Scott Diamond | None | |
| 2012-05-24 | Thu | CHA | AL | A | N | 44 | W | 8-11 | 9 | box - pbp - pit | W1 | 15-29 | 5 | 14 | 30 | 3:13 | 20,167 | Cole De Vries | Philip Humber (R) | Nate Jones | Cole De Vries | None | |
| 2012-05-25 | Fri | DET | AL | H | N | 45 | W | 6-10 | 9 | box - pbp - pit | W2 | 16-29 | 5 | 14 | 29 | 3:29 | 37,688 | Anthony Swarzak | Drew Smyly (L) | Drew Smyly | Anthony Swarzak | None | |
| 2012-05-26 | Sat | DET | AL | H | D | 46 | L | 3-6 | 9 | box - pbp - pit | L1 | 16-30 | 5 | 14 | 29 | 2:39 | 37,360 | Carl Pavano | Max Scherzer (R) | Max Scherzer | Carl Pavano | Jose Valverde | |
| 2012-05-27 | Sun | DET | AL | H | D | 47 | L | 3-4 | 9 | box - pbp - pit | L2 | 16-31 | 5 | 14 | 29 | 3:21 | 38,710 | P.J. Walters | Rick Porcello (R) | Brayan Villarreal | Matt Capps | Jose Valverde | |
| 2012-05-28 | Mon | OAK | AL | H | D | 48 | W | 5-4 | 9 | box - pbp - pit | W1 | 17-31 | 5 | 14 | 28 | 3:22 | 34,709 | Scott Diamond | Travis Blackley (L) | Alex Burnett | Ryan Cook | Matt Capps | |
| 2012-05-29 | Tue | OAK | AL | H | N | 49 | W | 3-2 | 9 | box - pbp - pit | W2 | 18-31 | 5 | 14 | 28 | 3:25 | 31,781 | Cole De Vries | Jarrod Parker (R) | Glen Perkins | Brian Fuentes | None | |
| 2012-05-29 | Tue | OAK | AL | H | N | 49 | W | 3-2 | 9 | box - pbp - pit | W3 | 18-31 | 5 | 14 | 28 | 3:25 | 31,781 | Cole De Vries | Kyle Parker (R) | Glen Perkins | Brian Fuentes | None | |
| 2012-05-30 | Wed | OAK | AL | H | D | 50 | W | 4-0 | 9 | box - pbp - pit | W4 | 19-31 | 5 | 14 | 29 | 2:16 | 35,103 | Francisco Liriano | Tyson Ross (R) | Francisco Liriano | Tyson Ross | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-06-01 | Fri | CLE | AL | A | N | 51 | L | 1-7 | 9 | box - pbp - pit | L1 | 19-32 | 5 | 14 | 29 | 2:32 | 19,904 | Carl Pavano | Derek Lowe (R) | Derek Lowe | Carl Pavano | None | |
| 2012-06-02 | Sat | CLE | AL | A | N | 52 | W | 7-4 | 9 | box - pbp - pit | W1 | 20-32 | 5 | 13 | 27 | 2:59 | 25,469 | P.J. Walters | Josh Tomlin (R) | Brian Duensing | Josh Tomlin | Matt Capps | |
| 2012-06-03 | Sun | CLE | AL | A | D | 53 | W | 6-3 | 9 | box - pbp - pit | W2 | 21-32 | 5 | 13 | 27 | 2:47 | 21,238 | Scott Diamond | Justin Masterson (R) | Scott Diamond | Justin Masterson | Matt Capps | |
| 2012-06-04 | Mon | KCA | AL | A | N | 54 | L | 10-7 | 9 | box - pbp - pit | L1 | 21-33 | 5 | 13 | 27 | 3:07 | 16,531 | Cole De Vries | Will Smith (L) | Cole De Vries | Will Smith | Matt Capps | |
| 2012-06-05 | Tue | KCA | AL | A | N | 55 | L | 0-1 | 9 | box - pbp - pit | L2 | 21-34 | 5 | 13 | 27 | 2:25 | 23,934 | Francisco Liriano | Bruce Chen (L) | Bruce Chen | Francisco Liriano | Jonathan Broxton | |
| 2012-06-06 | Wed | KCA | AL | A | N | 56 | W | 4-2 | 9 | box - pbp - pit | W1 | 22-34 | 5 | 13 | 27 | 3:04 | 18,386 | Nick Blackburn | Felipe Paulino (R) | Nick Blackburn | Luis Mendoza | Matt Capps | |
| 2012-06-08 | Fri | CHN | NL | H | N | 57 | W | 8-7 | 10 | box - pbp - pit | W2 | 23-34 | 5 | 13 | 27 | 3:37 | 38,014 | P.J. Walters | Travis Wood (L) | Matt Capps | Shawn Camp | None | |
| 2012-06-09 | Sat | CHN | NL | H | D | 58 | L | 11-3 | 9 | box - pbp - pit | L1 | 23-35 | 5 | 13 | 27 | 3:00 | 39,309 | Scott Diamond | Jeff Samardzija (R) | Scott Diamond | Jeff Samardzija | None | |
| 2012-06-10 | Sun | CHN | NL | H | D | 59 | L | 2-8 | 9 | box - pbp - pit | L2 | 23-36 | 5 | 13 | 27 | 2:54 | 37,526 | Francisco Liriano | Ryan Dempster (R) | Ryan Dempster | Francisco Liriano | None | |
| 2012-06-12 | Tue | PHI | NL | H | N | 60 | L | 11-7 | 9 | box - pbp - pit | L3 | 23-37 | 5 | 13 | 27 | 3:15 | 32,622 | Nick Blackburn | Kyle Kendrick (R) | Nick Blackburn | Kyle Kendrick | None | |
| 2012-06-13 | Wed | PHI | NL | H | N | 61 | L | 8-9 | 9 | box - pbp - pit | L4 | 23-38 | 5 | 13 | 27 | 3:05 | 32,581 | P.J. Walters | Cole Hamels (L) | Cole Hamels | P.J. Walters | Jonathan Papelbon | |
| 2012-06-14 | Thu | PHI | NL | H | N | 62 | L | 1-6 | 9 | box - pbp - pit | L5 | 23-39 | 5 | 13 | 27 | 2:38 | 32,205 | Scott Diamond | Joe Blanton (R) | Joe Blanton | Scott Diamond | None | |
| 2012-06-15 | Fri | MIL | NL | H | N | 63 | L | 3-5 | 9 | box - pbp - pit | L6 | 23-40 | 5 | 13 | 29 | 3:01 | 37,295 | Francisco Liriano | Yovani Gallardo (R) | Kameron Loe | Matt Capps | John Axford | |
| 2012-06-16 | Sat | MIL | NL | H | D | 64 | L | 2-6 | 9 | box - pbp - pit | L7 | 23-41 | 5 | 14 | 30 | 2:57 | 37,698 | Liam Hendriks | Mike Fiers (R) | Michael Fiers | Liam Hendriks | None | |
| 2012-06-17 | Sun | MIL | NL | H | D | 65 | W | 5-4 | 15 | box - pbp - pit | W1 | 24-41 | 5 | 14 | 29 | 4:50 | 39,206 | Nick Blackburn | Zack Greinke (R) | Anthony Swarzak | Tim Dillard | None | |
| 2012-06-19 | Tue | PIT | NL | A | N | 66 | L | 2-7 | 9 | box - pbp - pit | L1 | 24-42 | 5 | 14 | 29 | 3:10 | 19,936 | Scott Diamond | Kevin Correia (R) | Kevin Correia | Scott Diamond | None | |
| 2012-06-20 | Wed | PIT | NL | A | N | 67 | W | 2-1 | 9 | box - pbp - pit | W1 | 25-42 | 5 | 13 | 27 | 2:42 | 19,878 | Francisco Liriano | Erik Bedard (L) | Jared Burton | Jason Grilli | Glen Perkins | |
| 2012-06-21 | Thu | PIT | NL | A | N | 68 | L | 1-9 | 9 | box - pbp - pit | L1 | 25-43 | 5 | 13 | 27 | 2:29 | 21,563 | Liam Hendriks | James McDonald (R) | James McDonald | Liam Hendriks | None | |
| 2012-06-22 | Fri | CIN | NL | A | N | 69 | W | 5-4 | 9 | box - pbp - pit | W1 | 26-43 | 5 | 13 | 27 | 3:20 | 33,531 | Nick Blackburn | Homer Bailey (R) | Nick Blackburn | Homer Bailey | Glen Perkins | |
| 2012-06-23 | Sat | CIN | NL | A | D | 70 | L | 0-6 | 9 | box - pbp - pit | L1 | 26-44 | 5 | 13 | 27 | 2:40 | 41,750 | Brian Duensing | Johnny Cueto (R) | Johnny Cueto | Brian Duensing | None | |
| 2012-06-24 | Sun | CIN | NL | A | D | 71 | W | 4-3 | 9 | box - pbp - pit | W1 | 27-44 | 5 | 13 | 27 | 2:22 | 34,513 | Scott Diamond | Mike Leake (R) | Scott Diamond | Aroldis Chapman | Jared Burton | |
| 2012-06-25 | Mon | CHA | AL | H | N | 72 | W | 4-1 | 9 | box - pbp - pit | W2 | 28-44 | 5 | 13 | 27 | 3:01 | 35,659 | Francisco Liriano | Jake Peavy (R) | Francisco Liriano | Jake Peavy | Jared Burton | |
| 2012-06-26 | Tue | CHA | AL | H | N | 73 | L | 2-3 | 9 | box - pbp - pit | L1 | 28-45 | 5 | 13 | 27 | 2:41 | 35,102 | Liam Hendriks | Gavin Floyd (R) | Gavin Floyd | Liam Hendriks | Addison Reed | |
| 2012-06-27 | Wed | CHA | AL | H | D | 74 | W | 5-12 | 9 | box - pbp - pit | W1 | 29-45 | 5 | 13 | 27 | 2:48 | 36,539 | Nick Blackburn | Chris Sale (L) | Chris Sale | Nick Blackburn | None | |
| 2012-06-29 | Fri | KCA | AL | H | N | 75 | L | 3-4 | 9 | box - pbp - pit | L1 | 29-46 | 5 | 13 | 27 | 2:50 | 33,359 | Brian Duensing | Luis Mendoza (R) | Luis Mendoza | Brian Duensing | Jonathan Broxton | |
| 2012-06-30 | Sat | KCA | AL | H | D | 76 | W | 7-2 | 9 | box - pbp - pit | W1 | 31-46 | 5 | 13 | 27 | 2:45 | 37,694 | Scott Diamond | Jonathan Sanchez (L) | Scott Diamond | Jonathan Sanchez | None | |
| 2012-06-30 | Sat | KCA | AL | H | N | 77 | W | 5-1 | 9 | box - pbp - pit | W2 | 31-46 | 5 | 13 | 27 | 2:43 | 37,629 | Cole De Vries | Luke Hochevar (R) | Cole De Vries | Luke Hochevar | None | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-07-01 | Sun | KCA | AL | H | D | 78 | L | 10-8 | 9 | box - pbp - pit | L1 | 31-47 | 5 | 13 | 27 | 3:05 | 37,819 | Francisco Liriano | Bruce Chen (L) | Jeff Gray | Bruce Chen | None | |
| 2012-07-02 | Mon | DET | AL | A | N | 79 | W | 6-4 | 9 | box - pbp - pit | W1 | 32-47 | 5 | 13 | 28 | 3:25 | 37,406 | Liam Hendriks | Doug Fister (R) | Anthony Swarzak | Doug Fister | Glen Perkins | |
| 2012-07-03 | Tue | DET | AL | A | N | 80 | W | 8-6 | 9 | box - pbp - pit | W2 | 33-47 | 5 | 13 | 27 | 3:26 | 36,757 | Nick Blackburn | Duane Below (L) | Jeff Gray | Brayan Villarreal | Glen Perkins | |
| 2012-07-04 | Wed | DET | AL | A | N | 81 | L | 1-5 | 9 | box - pbp - pit | L1 | 33-48 | 5 | 13 | 28 | 2:33 | 41,023 | Brian Duensing | Justin Verlander (R) | Justin Verlander | Brian Duensing | None | |
| 2012-07-05 | Thu | DET | AL | A | D | 82 | L | 3-7 | 9 | box - pbp - pit | L2 | 33-49 | 5 | 13 | 28 | 2:59 | 33,350 | Scott Diamond | Rick Porcello (R) | Octavio Dotel | Alex Burnett | None | |
| 2012-07-06 | Fri | TEX | AL | A | N | 83 | W | 5-1 | 9 | box - pbp - pit | W1 | 34-49 | 5 | 13 | 28 | 2:58 | 47,240 | Francisco Liriano | Martin Perez (L) | Francisco Liriano | Martin Perez | None | |
| 2012-07-07 | Sat | TEX | AL | A | N | 84 | L | 3-4 | 10 | box - pbp - pit | L1 | 34-50 | 5 | 13 | 28 | 3:48 | 47,067 | Samuel Deduno | Derek Holland (L) | Joe Nathan | Kyle Waldrop | None | |
| 2012-07-08 | Sun | TEX | AL | A | N | 85 | L | 3-4 | 13 | box - pbp - pit | L2 | 34-51 | 5 | 13 | 29 | 4:32 | 43,268 | Cole De Vries | Roy Oswalt (R) | Scott Feldman | Alex Burnett | None | |
| 2012-07-13 | Fri | OAK | AL | H | N | 86 | L | 3-6 | 9 | box - pbp - pit | L3 | 34-52 | 5 | 13 | 29 | 2:44 | 33,230 | Francisco Liriano | AJ Griffin (R) | A.J. Griffin | Francisco Liriano | Ryan Cook | |
| 2012-07-14 | Sat | OAK | AL | H | N | 87 | L | 3-9 | 9 | box - pbp - pit | L4 | 34-53 | 5 | 13 | 29 | 2:57 | 39,084 | Cole De Vries | Tommy Milone (L) | Tom Milone | Cole De Vries | None | |
| 2012-07-15 | Sun | OAK | AL | H | D | 88 | L | 4-9 | 9 | box - pbp - pit | L5 | 34-54 | 5 | 13 | 29 | 3:14 | 36,853 | Brian Duensing | Jarrod Parker (R) | Jarrod Parker | Brian Duensing | None | |
| 2012-07-15 | Sun | OAK | AL | H | D | 88 | L | 4-9 | 9 | box - pbp - pit | L6 | 34-54 | 5 | 13 | 29 | 3:14 | 36,853 | Brian Duensing | Kyle Parker (R) | Jarrod Parker | Brian Duensing | None | |
| 2012-07-16 | Mon | BAL | AL | H | N | 89 | L | 19-7 | 9 | box - pbp - pit | L7 | 34-55 | 5 | 13 | 29 | 3:22 | 32,445 | Scott Diamond | Chris Tillman (R) | Scott Diamond | Chris Tillman | None | |
| 2012-07-17 | Tue | BAL | AL | H | N | 90 | W | 6-4 | 9 | box - pbp - pit | W1 | 35-55 | 5 | 13 | 29 | 3:43 | 32,202 | Samuel Deduno | Zack Britton (L) | Alex Burnett | Luis Ayala | Jared Burton | |
| 2012-07-18 | Wed | BAL | AL | H | N | 91 | L | 1-2 | 9 | box - pbp - pit | L1 | 35-56 | 5 | 13 | 29 | 2:46 | 33,195 | Francisco Liriano | Tommy Hunter (R) | Tommy Hunter | Francisco Liriano | Jim Johnson | |
| 2012-07-19 | Thu | BAL | AL | H | D | 92 | L | 3-4 | 9 | box - pbp - pit | L2 | 35-57 | 5 | 14 | 30 | 3:15 | 37,676 | Cole De Vries | Wei-Yin Chen (L) | Wei-Yin Chen | Alex Burnett | Jim Johnson | |
| 2012-07-20 | Fri | KCA | AL | A | N | 93 | W | 2-1 | 11 | box - pbp - pit | W1 | 36-57 | 5 | 13 | 29 | 3:23 | 25,719 | Nick Blackburn | Luke Hochevar (R) | Casey Fien | Jonathan Broxton | Glen Perkins | |
| 2012-07-21 | Sat | KCA | AL | A | N | 94 | L | 3-7 | 9 | box - pbp - pit | L1 | 36-58 | 5 | 14 | 30 | 3:02 | 26,747 | Scott Diamond | Luis Mendoza (R) | Luis Mendoza | Scott Diamond | Aaron Crow | |
| 2012-07-22 | Sun | KCA | AL | A | D | 95 | W | 7-5 | 9 | box - pbp - pit | W1 | 37-58 | 5 | 14 | 30 | 2:47 | 23,252 | Samuel Deduno | Jeremy Guthrie (R) | Samuel Deduno | Jeremy Guthrie | None | |
| 2012-07-23 | Mon | CHA | AL | A | N | 96 | L | 4-7 | 9 | box - pbp - pit | L1 | 37-59 | 5 | 14 | 30 | 2:48 | 37,788 | Francisco Liriano | Gavin Floyd (R) | Gavin Floyd | Francisco Liriano | Addison Reed | |
| 2012-07-24 | Tue | CHA | AL | A | N | 97 | W | 4-11 | 9 | box - pbp - pit | W1 | 38-59 | 5 | 14 | 29 | 3:08 | 34,715 | Cole De Vries | Jose Quintana (L) | Nate Jones | Casey Fien | None | |
| 2012-07-25 | Wed | CHA | AL | A | D | 98 | L | 2-8 | 9 | box - pbp - pit | L1 | 38-60 | 5 | 14 | 30 | 3:09 | 32,261 | Nick Blackburn | Jake Peavy (R) | Jake Peavy | Nick Blackburn | None | |
| 2012-07-27 | Fri | CLE | AL | H | N | 99 | W | 11-0 | 9 | box - pbp - pit | W1 | 39-60 | 5 | 14 | 28 | 2:25 | 37,820 | Scott Diamond | Josh Tomlin (R) | Scott Diamond | Josh Tomlin | None | |
| 2012-07-28 | Sat | CLE | AL | H | N | 100 | L | 12-5 | 9 | box - pbp - pit | L1 | 39-61 | 5 | 14 | 28 | 2:54 | 39,166 | Samuel Deduno | Justin Masterson (R) | Samuel Deduno | Justin Masterson | None | |
| 2012-07-29 | Sun | CLE | AL | H | D | 101 | W | 5-1 | 9 | box - pbp - pit | W1 | 40-61 | 5 | 14 | 28 | 2:28 | 34,720 | Brian Duensing | Ubaldo Jimenez (R) | Brian Duensing | Ubaldo Jimenez | None | |
| 2012-07-30 | Mon | CHA | AL | H | N | 102 | W | 7-6 | 9 | box - pbp - pit | W2 | 41-61 | 5 | 14 | 28 | 3:08 | 35,018 | Cole De Vries | Jose Quintana (L) | Glen Perkins | Brett Myers | None | |
| 2012-07-31 | Tue | CHA | AL | H | N | 103 | L | 3-4 | 9 | box - pbp - pit | L1 | 41-62 | 5 | 14 | 28 | 2:41 | 36,424 | Nick Blackburn | Francisco Liriano (L) | Matt Thornton | Jeff Gray | Addison Reed | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-08-01 | Wed | CHA | AL | H | D | 104 | L | 2-3 | 9 | box - pbp - pit | L2 | 41-63 | 5 | 14 | 28 | 2:49 | 34,823 | Scott Diamond | Jake Peavy (R) | Jake Peavy | Scott Diamond | Addison Reed | |
| 2012-08-02 | Thu | BOS | AL | A | N | 105 | W | 5-0 | 9 | box - pbp - pit | W1 | 42-63 | 5 | 14 | 28 | 2:35 | 37,191 | Samuel Deduno | Jon Lester (L) | Samuel Deduno | Jon Lester | Glen Perkins | |
| 2012-08-03 | Fri | BOS | AL | A | N | 106 | W | 6-5 | 10 | box - pbp - pit | W2 | 43-63 | 5 | 14 | 28 | 4:08 | 37,285 | Brian Duensing | Felix Doubront (L) | Jeff Gray | Vicente Padilla | Jared Burton | |
| 2012-08-04 | Sat | BOS | AL | A | N | 107 | W | 6-4 | 9 | box - pbp - pit | W3 | 44-63 | 5 | 14 | 28 | 3:22 | 37,914 | Cole De Vries | Clay Buchholz (R) | Alex Burnett | Alfredo Aceves | Jared Burton | |
| 2012-08-05 | Sun | BOS | AL | A | D | 108 | L | 4-6 | 9 | box - pbp - pit | L1 | 44-64 | 5 | 14 | 28 | 3:14 | 37,019 | Nick Blackburn | Franklin Morales (L) | Franklin Morales | Nick Blackburn | Alfredo Aceves | |
| 2012-08-06 | Mon | CLE | AL | A | N | 109 | L | 14-3 | 9 | box - pbp - pit | L2 | 44-65 | 5 | 14 | 28 | 3:01 | 18,775 | Scott Diamond | Zach McAllister (R) | Scott Diamond | Zach McAllister | None | |
| 2012-08-07 | Tue | CLE | AL | A | N | 110 | W | 7-5 | 9 | box - pbp - pit | W1 | 45-65 | 5 | 14 | 28 | 3:40 | 14,813 | Samuel Deduno | Corey Kluber (R) | Tyler Robertson | Chris Perez | Glen Perkins | |
| 2012-08-08 | Wed | CLE | AL | A | D | 111 | L | 2-6 | 9 | box - pbp - pit | L1 | 45-66 | 5 | 14 | 28 | 2:28 | 18,805 | Brian Duensing | Justin Masterson (R) | Justin Masterson | Brian Duensing | None | |
| 2012-08-10 | Fri | TBA | AL | H | N | 112 | W | 6-12 | 9 | box - pbp - pit | W1 | 46-66 | 5 | 14 | 28 | 3:06 | 38,108 | Cole De Vries | Jeremy Hellickson (R) | Jeremy Hellickson | Cole De Vries | None | |
| 2012-08-11 | Sat | TBA | AL | H | N | 113 | L | 2-4 | 9 | box - pbp - pit | L1 | 46-67 | 5 | 14 | 28 | 2:40 | 39,512 | Nick Blackburn | David Price (L) | David Price | Nick Blackburn | Fernando Rodney | |
| 2012-08-12 | Sun | TBA | AL | H | D | 114 | L | 3-7 | 10 | box - pbp - pit | L2 | 46-68 | 5 | 14 | 28 | 3:22 | 35,327 | Scott Diamond | James Shields (R) | Kyle Farnsworth | Alex Burnett | Fernando Rodney | |
| 2012-08-13 | Mon | DET | AL | H | N | 115 | W | 9-3 | 9 | box - pbp - pit | W1 | 47-68 | 5 | 14 | 28 | 3:05 | 34,366 | Samuel Deduno | Anibal Sanchez (R) | Samuel Deduno | Anibal Sanchez | None | |
| 2012-08-14 | Tue | DET | AL | H | N | 116 | L | 4-8 | 9 | box - pbp - pit | L1 | 47-69 | 5 | 14 | 29 | 2:54 | 37,544 | Brian Duensing | Doug Fister (R) | Doug Fister | Brian Duensing | None | |
| 2012-08-15 | Wed | DET | AL | H | D | 117 | L | 1-5 | 9 | box - pbp - pit | L2 | 47-70 | 5 | 14 | 29 | 3:08 | 37,118 | Cole De Vries | Max Scherzer (R) | Max Scherzer | Cole De Vries | None | |
| 2012-08-17 | Fri | SEA | AL | A | N | 118 | L | 3-5 | 9 | box - pbp - pit | L3 | 47-71 | 5 | 14 | 29 | 2:36 | 22,602 | Nick Blackburn | Hisashi Iwakuma (R) | Hisashi Iwakuma | Nick Blackburn | Tom Wilhelmsen | |
| 2012-08-18 | Sat | SEA | AL | A | N | 119 | L | 2-3 | 9 | box - pbp - pit | L4 | 47-72 | 5 | 14 | 29 | 3:23 | 21,154 | Scott Diamond | Jason Vargas (L) | Tom Wilhelmsen | Tyler Robertson | None | |
| 2012-08-19 | Sun | SEA | AL | A | D | 120 | L | 1-5 | 9 | box - pbp - pit | L5 | 47-73 | 5 | 14 | 29 | 3:07 | 22,635 | Samuel Deduno | Blake Beavan (R) | Blake Beavan | Samuel Deduno | Josh Kinney | |
| 2012-08-20 | Mon | OAK | AL | A | N | 121 | W | 7-2 | 9 | box - pbp - pit | W1 | 48-73 | 5 | 14 | 29 | 3:07 | 10,274 | Brian Duensing | Brandon McCarthy (R) | Brian Duensing | Brandon McCarthy | None | |
| 2012-08-21 | Tue | OAK | AL | A | N | 122 | L | 1-4 | 9 | box - pbp - pit | L1 | 48-74 | 5 | 14 | 29 | 2:32 | 13,116 | Cole De Vries | Brett Anderson (L) | Brett Anderson | Cole De Vries | Grant Balfour | |
| 2012-08-22 | Wed | OAK | AL | A | D | 123 | L | 1-5 | 9 | box - pbp - pit | L2 | 48-75 | 5 | 14 | 29 | 2:35 | 16,657 | Liam Hendriks | Tommy Milone (L) | Tom Milone | Liam Hendriks | None | |
| 2012-08-23 | Thu | TEX | AL | A | N | 124 | W | 6-10 | 9 | box - pbp - pit | W1 | 49-75 | 5 | 14 | 29 | 3:39 | 33,762 | Scott Diamond | Roy Oswalt (R) | Mike Adams | Jared Burton | Joe Nathan | |
| 2012-08-24 | Fri | TEX | AL | A | N | 125 | L | 0-8 | 9 | box - pbp - pit | L1 | 49-76 | 5 | 14 | 29 | 2:16 | 45,823 | Samuel Deduno | Matt Harrison (L) | Matt Harrison | Samuel Deduno | None | |
| 2012-08-25 | Sat | TEX | AL | A | D | 126 | L | 3-9 | 9 | box - pbp - pit | L2 | 49-77 | 5 | 14 | 29 | 3:07 | 44,215 | Brian Duensing | Ryan Dempster (R) | Ryan Dempster | Brian Duensing | None | |
| 2012-08-26 | Sun | TEX | AL | A | D | 127 | W | 6-5 | 9 | box - pbp - pit | W1 | 50-77 | 5 | 14 | 29 | 3:10 | 37,785 | Cole De Vries | Scott Feldman (R) | Cole De Vries | Scott Feldman | Glen Perkins | |
| 2012-08-27 | Mon | SEA | AL | H | N | 128 | L | 0-1 | 9 | box - pbp - pit | L1 | 50-78 | 5 | 14 | 29 | 2:10 | 31,883 | Liam Hendriks | Felix Hernandez (R) | Felix Hernandez | Liam Hendriks | None | |
| 2012-08-28 | Tue | SEA | AL | H | N | 129 | L | 2-5 | 9 | box - pbp - pit | L2 | 50-79 | 5 | 14 | 29 | 2:55 | 29,854 | Scott Diamond | Hisashi Iwakuma (R) | Hisashi Iwakuma | Scott Diamond | Tom Wilhelmsen | |
| 2012-08-29 | Wed | SEA | AL | H | N | 130 | W | 10-0 | 9 | box - pbp - pit | W1 | 51-79 | 5 | 14 | 29 | 2:49 | 29,281 | Samuel Deduno | Jason Vargas (L) | Samuel Deduno | Jason Vargas | None | |
| 2012-08-30 | Thu | SEA | AL | H | D | 131 | L | 4-5 | 9 | box - pbp - pit | L1 | 51-80 | 5 | 14 | 29 | 3:11 | 32,578 | Brian Duensing | Blake Beavan (R) | Blake Beavan | Brian Duensing | Tom Wilhelmsen | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-09-01 | Sat | KCA | AL | A | D | 132 | W | 3-1 | 9 | box - pbp - pit | W1 | 53-80 | 5 | 14 | 29 | 2:31 | 0 | Cole De Vries | Will Smith (L) | Cole De Vries | Will Smith | Glen Perkins | |
| 2012-09-01 | Sat | KCA | AL | A | N | 133 | W | 8-7 | 9 | box - pbp - pit | W2 | 53-80 | 5 | 14 | 29 | 3:07 | 23,189 | Liam Hendriks | Luke Hochevar (R) | Anthony Swarzak | Luke Hochevar | Glen Perkins | |
| 2012-09-02 | Sun | KCA | AL | A | D | 134 | L | 4-6 | 9 | box - pbp - pit | L1 | 53-81 | 5 | 14 | 29 | 2:55 | 23,641 | Esmerling Vasquez | Luis Mendoza (R) | Tim Collins | Esmerling Vasquez | Greg Holland | |
| 2012-09-03 | Mon | CHA | AL | A | N | 135 | L | 2-4 | 9 | box - pbp - pit | L2 | 53-82 | 5 | 14 | 29 | 3:00 | 21,676 | Samuel Deduno | Hector Santiago (L) | Hector Santiago | Samuel Deduno | Addison Reed | |
| 2012-09-04 | Tue | CHA | AL | A | N | 136 | L | 18-9 | 9 | box - pbp - pit | L3 | 53-83 | 5 | 14 | 29 | 3:24 | 15,698 | Scott Diamond | Jose Quintana (L) | Scott Diamond | Jose Quintana | None | |
| 2012-09-05 | Wed | CHA | AL | A | D | 137 | L | 2-6 | 9 | box - pbp - pit | L4 | 53-84 | 5 | 14 | 29 | 2:40 | 17,336 | P.J. Walters | Jake Peavy (R) | Jake Peavy | P.J. Walters | None | |
| 2012-09-07 | Fri | CLE | AL | H | N | 138 | L | 6-7 | 9 | box - pbp - pit | L5 | 53-85 | 5 | 14 | 29 | 3:21 | 30,111 | Liam Hendriks | Jeanmar Gomez (R) | David Huff | Tyler Robertson | Chris Perez | |
| 2012-09-08 | Sat | CLE | AL | H | N | 139 | W | 3-0 | 9 | box - pbp - pit | W1 | 54-85 | 5 | 14 | 29 | 2:58 | 33,698 | Cole De Vries | Zach McAllister (R) | Cole De Vries | Zach McAllister | Glen Perkins | |
| 2012-09-09 | Sun | CLE | AL | H | D | 140 | W | 8-7 | 9 | box - pbp - pit | W2 | 55-85 | 5 | 14 | 29 | 3:26 | 30,219 | Esmerling Vasquez | Corey Kluber (R) | Brian Duensing | Vinnie Pestano | None | |
| 2012-09-10 | Mon | CLE | AL | H | N | 141 | W | 7-2 | 9 | box - pbp - pit | W3 | 56-85 | 5 | 14 | 29 | 2:30 | 27,526 | Samuel Deduno | Justin Masterson (R) | Samuel Deduno | Justin Masterson | None | |
| 2012-09-11 | Tue | KCA | AL | H | N | 142 | L | 1-9 | 9 | box - pbp - pit | L1 | 56-86 | 5 | 14 | 29 | 2:56 | 28,993 | Scott Diamond | Will Smith (L) | Will Smith | Scott Diamond | None | |
| 2012-09-12 | Wed | KCA | AL | H | N | 143 | W | 5-10 | 9 | box - pbp - pit | W1 | 57-86 | 5 | 14 | 29 | 3:25 | 28,139 | P.J. Walters | Luke Hochevar (R) | Luke Hochevar | P.J. Walters | None | |
| 2012-09-13 | Thu | KCA | AL | H | N | 144 | W | 4-3 | 10 | box - pbp - pit | W2 | 58-86 | 5 | 14 | 29 | 3:13 | 28,669 | Liam Hendriks | Luis Mendoza (R) | Glen Perkins | Francisley Bueno | None | |
| 2012-09-14 | Fri | CHA | AL | H | N | 145 | L | 0-6 | 9 | box - pbp - pit | L1 | 58-87 | 5 | 14 | 29 | 2:48 | 30,729 | Esmerling Vasquez | Chris Sale (L) | Chris Sale | Esmerling Vasquez | None | |
| 2012-09-15 | Sat | CHA | AL | H | D | 146 | L | 3-5 | 9 | box - pbp - pit | L2 | 58-88 | 5 | 14 | 29 | 2:39 | 36,308 | Samuel Deduno | Francisco Liriano (L) | Francisco Liriano | Samuel Deduno | Matt Thornton | |
| 2012-09-16 | Sun | CHA | AL | H | D | 147 | L | 2-9 | 9 | box - pbp - pit | L3 | 58-89 | 5 | 14 | 29 | 2:55 | 31,722 | Scott Diamond | Jake Peavy (R) | Jake Peavy | Scott Diamond | None | |
| 2012-09-18 | Tue | CLE | AL | A | N | 148 | W | 6-5 | 12 | box - pbp - pit | W1 | 59-89 | 5 | 14 | 29 | 4:00 | 10,342 | P.J. Walters | David Huff (L) | Tyler Robertson | Scott Maine | Glen Perkins | |
| 2012-09-19 | Wed | CLE | AL | A | N | 149 | W | 6-4 | 9 | box - pbp - pit | W2 | 60-89 | 5 | 14 | 29 | 3:10 | 13,519 | Liam Hendriks | Zach McAllister (R) | Liam Hendriks | Zach McAllister | Glen Perkins | |
| 2012-09-20 | Thu | CLE | AL | A | D | 150 | L | 3-4 | 10 | box - pbp - pit | L1 | 60-90 | 5 | 14 | 29 | 3:09 | 12,331 | Esmerling Vasquez | Corey Kluber (R) | Esmil Rogers | Anthony Swarzak | None | |
| 2012-09-22 | Sat | DET | AL | A | D | 151 | L | 0-8 | 9 | box - pbp - pit | L2 | 60-91 | 5 | 14 | 29 | 2:23 | 40,586 | Samuel Deduno | Doug Fister (R) | Doug Fister | Samuel Deduno | None | |
| 2012-09-23 | Sun | DET | AL | A | D | 152 | L | 10-4 | 9 | box - pbp - pit | L3 | 61-92 | 5 | 14 | 29 | 3:05 | 40,438 | Scott Diamond | Max Scherzer (R) | Scott Diamond | Max Scherzer | None | |
| 2012-09-23 | Sun | DET | AL | A | N | 153 | W | 2-1 | 10 | box - pbp - pit | W1 | 61-92 | 5 | 14 | 29 | 3:07 | 39,839 | P.J. Walters | Drew Smyly (L) | Jared Burton | Jose Valverde | Glen Perkins | |
| 2012-09-24 | Mon | NYA | AL | H | N | 154 | L | 3-6 | 9 | box - pbp - pit | L1 | 61-93 | 5 | 14 | 29 | 2:46 | 33,720 | Liam Hendriks | Andy Pettitte (L) | Andy Pettitte | Liam Hendriks | None | |
| 2012-09-25 | Tue | NYA | AL | H | N | 155 | W | 5-4 | 9 | box - pbp - pit | W1 | 62-93 | 5 | 14 | 29 | 2:58 | 33,346 | Esmerling Vasquez | Phil Hughes (R) | Casey Fien | Phil Hughes | Glen Perkins | |
| 2012-09-26 | Wed | NYA | AL | H | D | 156 | L | 2-8 | 9 | box - pbp - pit | L1 | 62-94 | 5 | 14 | 29 | 2:54 | 33,251 | Samuel Deduno | CC Sabathia (L) | CC Sabathia | Brian Duensing | None | |
| 2012-09-28 | Fri | DET | AL | H | N | 157 | W | 4-2 | 9 | box - pbp - pit | W1 | 63-94 | 5 | 14 | 28 | 2:30 | 30,315 | Scott Diamond | Drew Smyly (L) | Jared Burton | Brayan Villarreal | Glen Perkins | |
| 2012-09-29 | Sat | DET | AL | H | D | 158 | L | 4-6 | 9 | box - pbp - pit | L1 | 63-95 | 5 | 14 | 29 | 3:23 | 32,839 | P.J. Walters | Justin Verlander (R) | Justin Verlander | P.J. Walters | Jose Valverde | |
| 2012-09-30 | Sun | DET | AL | H | D | 159 | L | 1-2 | 9 | box - pbp - pit | L2 | 63-96 | 5 | 14 | 29 | 2:43 | 32,554 | Liam Hendriks | Anibal Sanchez (R) | Phil Coke | Jared Burton | Jose Valverde | |
| Game Date | Day | Opp | Lg | H/A | D/N | G | W/L | Result | Inn | Boxscores | Strk | Record | Div-Rk | Lg-Rk | MLB-Rk | Time | Att | Ballpark | Starting Pitcher | Opposing Pitcher | Winning Pitcher | Losing Pitcher | Save Pitcher |
| 2012-10-01 | Mon | TOR | AL | A | N | 160 | L | 5-6 | 10 | box - pbp - pit | L3 | 63-97 | 5 | 14 | 30 | 3:14 | 12,359 | Esmerling Vasquez | Aaron Laffey (L) | Brandon Lyon | Brian Duensing | None | |
| 2012-10-02 | Tue | TOR | AL | A | N | 161 | L | 3-4 | 9 | box - pbp - pit | L4 | 63-98 | 5 | 14 | 30 | 2:33 | 13,930 | Anthony Swarzak | Chad Jenkins (R) | Chad Jenkins | Anthony Swarzak | Casey Janssen | |
| 2012-10-03 | Wed | TOR | AL | A | N | 162 | L | 1-2 | 9 | box - pbp - pit | L5 | 63-99 | 5 | 14 | 30 | 2:21 | 19,769 | Scott Diamond | Brandon Morrow (R) | Brandon Morrow | Scott Diamond | Brandon Lyon |
Team Splits | Top |
| Category | GP | W | L | Wpct | RF | RA | Diff |
| Season Total | 164 | 64 | 100 | .390 | 708 | 843 | -135 |
| Home Games | 83 | 31 | 52 | .373 | 373 | 428 | -55 |
| Away Games | 81 | 33 | 48 | .407 | 335 | 415 | -80 |
| Night Games | 107 | 47 | 60 | .439 | 497 | 532 | -35 |
| Day Games | 57 | 17 | 40 | .298 | 211 | 311 | -100 |
| March/April | 22 | 6 | 16 | .273 | 87 | 124 | -37 |
| May | 29 | 14 | 15 | .483 | 112 | 148 | -36 |
| June | 27 | 12 | 15 | .444 | 119 | 132 | -13 |
| July | 27 | 10 | 17 | .370 | 142 | 144 | -2 |
| August | 28 | 10 | 18 | .357 | 117 | 138 | -21 |
| Sept/Oct | 31 | 12 | 19 | .387 | 131 | 157 | -26 |
| 1-Run Games | 55 | 26 | 29 | .473 | 229 | 230 | -1 |
| Close Games (1-2-3 Runs) | 92 | 42 | 50 | .457 | 389 | 400 | -11 |
| Blowouts (7+ runs) | 20 | 7 | 13 | .350 | 134 | 141 | -7 |
| Extra Innings | 13 | 8 | 5 | .615 | 55 | 55 | 0 |
| Shutouts | 17 | 6 | 11 | .353 | 38 | 61 | -23 |
| vs LHSP | 51 | 22 | 29 | .431 | 221 | 260 | -39 |
| vs RHSP | 113 | 42 | 71 | .372 | 487 | 583 | -96 |
| vs Division | 72 | 33 | 39 | .458 | 354 | 362 | -8 |
| vs League | 146 | 57 | 89 | .390 | 623 | 735 | -112 |
| InterLeague | 18 | 7 | 11 | .389 | 85 | 108 | -23 |
