| Harry Agganis | Died of a pulmonary embolism ten days after suffering from Pneumonia. |
| Steve Bechler | Heatstroke combined with Ephedra |
| Walt Bond | Died of leukemia |
| Tiny Bonham | Died 18 days after his last start on August 28th after an appendectormy and stomach surgery. |
| Lyman Bostock | Was killed while in the backseat of a car after the estranged husband of the woman he was with shot him. Bostock had just met the woman. |
| Hal Carlson | Died in his hotal room of an internal hemorrhage. |
| Ray Chapman | Hit in the head by a pitch thrown by Carl Mays during a game. |
| Roberto Clemente | Plane Crash while delivering relief supplies to Nicaragua |
| Mike Coolbaugh | While coaching in the first base box, was hit with a batted ball |
| Tim Crews | Boating accident during spring training on an off-day along with Steve Olin |
| Mike Darr | Car crash while driving to spring training |
| Jake Daubert | Died after complications during an appendectormy after the 1924 season |
| Ed Delahanty | Was swept over Niagara Falls after being kicked off a train. He crossed the International bridge near Niagara Falls and then fell or jumped off the bridge. |
| Joe DeSa | Automotible accident in San Juan, Puerto Rico. |
| Neal Finn | Died during the season after surgery to repair an ulcer. |
| Danny Frisella | Dune Buggy accident |
| Tom Gastall | Was piloting a plane that crashed into Chesapeake Bay. |
| Marv Goodwin | Crashed his plane in a training exercise with the Army air force reserves |
| Josh Hancock | Crashed his car into a tow truck helping another car on the highway |
| Clyde Hatter | Reported to have had a heart attack |
| Willard Hershberger | Committed suicide during the 1940 season. |
| Herman Hill | Drowned during the 1970 off-season in Venezuela |
| Ken Hubbs | Plane crash |
| Joe Kennedy | Died of hypertensive heart disease in the middle of the night during the 2007 off-season |
| Darryl Kile | Died of a heart attack in a Chicago hotel room during a road series against the Cubs. |
| Len Koenecke | Was hit over the head and killed with a fire extinguisher during a fight on a plane he chartered. |
| Frank Leary | ? |
| Joe Leonard | Died of a ruptured appendix during the 1920 season |
| Walt Lerian | Hit by a runaway truck on the streets of Baltimore after the 1929 season. |
| Cory Lidle | Crashed his plane into a New York residential building with a flight instructor at the end of the 2006 season. |
| Austin McHenry | Died of a brain tumor |
| Mike Miley | Automobile Accident |
| Bob Moose | Killed in a car accident in Ohio on his 29th birthday after the season. |
| Thurman Munson | Died in a plane crash while he was practicing takeoffs and landings. |
| John Odom | Heroin overdose |
| Steve Olin | Boating accident during spring training on an off-day along with Tim Crews |
| Charlie Peete | Plane crash during off-season en route to playing winter league baseball. |
| Doc Powers | Crashed into a wall while chasing a foul ball and later died of complications from suergeries, two weeks later becoming the first MLB to suffer a fatal on-field injury. |
| Chico Ruiz | Car accident |
| Jimmy Sebring | Died of brighs disease after the 1909 season |
| Mike Sharperson | Car accident while playing for Las Vegas of the International League. |
| Dernell Stenson | Was murdered while playing in the Arizona Fall League in Chandler, Arizona. |
| Danny Thompson | Died of leukemia after the 1976 season |
| Dick Wantz | Died of an inoperable brain tumor during the 1965 season |
| Don Wilson | Carbon monoxide poisoning |
| Cliff Young | Truck crash in Texas |
