| North | ||||||||||||||
| Rk | Team | Affiliate | W | L | Pct | Gbl | RF | RA | Manager | Stadium | Attendance | Top Batter | Top Pitcher | Playoffs |
| 1 | Northwest Arkansas Naturals | KC | 73 | 64 | .533 | -- | 688 | 688 | Brian Poldberg | Arvest Ballpark | 310,613 | Anthony Seratelli (11) | Will Smith (2) | Lost in Semi-Finals |
| 2 | Arkansas Travelers | LAA | 68 | 69 | .496 | 5.0 | 611 | 567 | Bill Mosiello | Dickey-Stephens Park | 300,594 | Darwin Perez (19) | Matt Shoemaker (1) | Lost in Finals |
| 3 | Tulsa Drillers | COL | 68 | 72 | .486 | 6.5 | 666 | 694 | Duane Espy | ONEOK Field | 366,291 | Tim Wheeler (1) | Rob Scahill (4) | |
| 4 | Springfield Cardinals | STL | 62 | 78 | .443 | 12.5 | 740 | 809 | Ron Warner | Hammons Field | 337,166 | Matt Adams (6) | Mike Blazek (13) | |
| South | ||||||||||||||
| Rk | Team | Affiliate | W | L | Pct | Gbl | RF | RA | Manager | Stadium | Attendance | Top Batter | Top Pitcher | Playoffs |
| 1 | San Antonio Missions ** | SD | 94 | 46 | .671 | -- | 801 | 533 | Doug Dascenzo | Nelson W. Wolff Municipal | 294,176 | Jaff Decker (3) | Casey Kelly (7) | League Champions |
| 2 | Frisco RoughRiders | TEX | 79 | 61 | .564 | 15.0 | 693 | 647 | Steve Buechele | Dr. Pepper Ballpark | 509,331 | Tommy Mendonca (2) | Carlos Pimentel (10) | Lost in Semi-Finals |
| 3 | Midland RockHounds | OAK | 63 | 77 | .450 | 31.0 | 675 | 780 | Steve Scarsone | Citibank Ballpark | 308,810 | Mike Spina (7) | Shawn Haviland (8) | |
| 4 | Corpus Christi Hooks | HOU | 50 | 90 | .357 | 44.0 | 605 | 761 | Tom Lawless | Whataburger Field | 395,128 | T.J. Steele (32) | Ross Seaton (11) | |