| Player | Team(s) | Current Status | Play Years | Awards |
| Edwin Almonte | Erie | Retired | 1998-2009 | All-Star RP |
| Jose Bautista | Altoona | TOR 40m | 1998-2013 | All-Star 3B |
| Shelley Duncan | Trenton | TB Minors [AAA] | 1999-2013 | All-Star 1B |
| Mike Jacobs | Binghamton | Free Agent | 1999-2012 | MVP, All-Star C |
| Don Kelly | Erie | DET 40m | 2001-2013 | All-Star Utility |
| Jon Lester | Portland | BOS 40m | 2002-2013 | All-Star LHP, Pitcher of the Year |
| Torey Lovullo | Akron | Bench Coach - Boston Red Sox (2013) | 1987-1999 | Manager of the Year |
| Danny Matienzo | New Britain | Retired | 2000-2006 | All-Star Game MVP |
| Daniel Ortmeier | Norwich | Retired | 2002-2009 | All-Star OF |
| Dustin Pedroia | Portland | BOS 40m | 2002-2013 | All-Star 2B |
| Hanley Ramirez | Portland | LAD (DL-15) 40m | 2002-2013 | All-Star SS |
| Chris Roberson | Reading | Inactive | 2001-2012 | Rookie of the Year, All-Star OF |
| Alex Romero | New Britain | Inactive | 2002-2012 | All-Star OF |
| Randy Ruiz | Reading | CHW Minors | 1999-2012 | All-Star DH |
| Joel Zumaya | Erie | Inactive | 2002-2010 | All-Star RHP |