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| 2002 | Frederick | Caro | A+ | 22 | 0 | 0 | 0 | 116 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .955 | -- | -- | -- | -- | -- | -- | 199 | 327 | 25 |
| 2003 | Bowie | East | AA | 23 | 0 | 0 | 0 | 114 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .968 | -- | -- | -- | -- | -- | -- | 226 | 317 | 18 |
| 2004 | Ottawa | IL | AAA | 24 | 0 | 0 | 0 | 135 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .964 | -- | -- | -- | -- | -- | -- | 252 | 330 | 22 |
| 2005 | Iowa | PCL | AAA | 25 | 0 | 0 | 0 | 63 | 41 | 3 | 0 | 0 | 0 | 1 | 0 | -- | -- | -- | .984 | .918 | 1.000 | -- | -- | -- | -- | 170 | 232 | 13 |
| 2006 | Iowa | PCL | AAA | 26 | 0 | 0 | 0 | 92 | 6 | 2 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .978 | 1.000 | .750 | -- | -- | -- | -- | 188 | 264 | 11 |
| 2007 | Iowa | PCL | AAA | 27 | 0 | 0 | 0 | 19 | 15 | 24 | 0 | 0 | 0 | 1 | 0 | -- | -- | -- | .988 | .968 | .978 | -- | -- | -- | -- | 69 | 135 | 4 |
| | Chi Cubs | NL | MLB | 27 | 0 | 0 | 0 | 62 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .976 | -- | .500 | -- | -- | -- | -- | 114 | 128 | 8 |
| 2008 | Chi Cubs | NL | MLB | 28 | 0 | 0 | 0 | 82 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .996 | -- | -- | -- | -- | -- | -- | 101 | 143 | 1 |
| 2009 | Chi Cubs | NL | MLB | 29 | 0 | 0 | 0 | 70 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .989 | .963 | -- | -- | -- | -- | -- | 138 | 226 | 7 |
| 2010 | SF Giants | NL | MLB | 30 | 0 | 0 | 0 | 16 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .965 | 1.000 | .917 | -- | -- | -- | -- | 28 | 44 | 3 |
| | Chi Cubs | NL | MLB | 30 | 0 | 0 | 0 | 33 | 13 | 4 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .969 | .909 | 1.000 | -- | -- | -- | -- | 72 | 90 | 6 |
| 2011 | Fresno | PCL | AAA | 31 | 0 | 0 | 0 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | 1.000 | -- | 1.000 | -- | -- | -- | -- | 14 | 16 | 0 |
| | SF Giants | NL | MLB | 31 | 0 | 0 | 0 | 23 | 8 | 37 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | .963 | 1.000 | .968 | -- | -- | -- | -- | 70 | 137 | 7 |
| 2012 | Lehigh Valley | IL | AAA | 32 | 0 | 0 | 0 | 7 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | -- | -- | -- | 1.000 | 1.000 | 1.000 | -- | -- | -- | -- | 30 | 29 | 0 |
| | Philadelphia | NL | MLB | 32 | 0 | 0 | 0 | 17 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | -- | -- | -- | .951 | .920 | -- | -- | -- | -- | -- | 33 | 48 | 5 |
Minor League Totals | 0 | 0 | 0 | 555 | 69 | 31 | 0 | 0 | 0 | 2 | 0 | -- | -- | -- | .969 | .940 | .972 | -- | -- | -- | -- | 1148 | 1650 | 93 |