| 1941-12-11 | Johnny Mize | Traded by Cardinals to Giants for Johnny McCarthy, Bill Lohrman, Ken O'Dea and Cash. | 1B-OF | 6-2 | 215 | L | R | 1913-01-07 | Demorest,GA |
| MLB | 1936-1953 | 1936-1953 |
| 1941-12-11 | Johnny McCarthy | Traded by Giants with Bill Lohrman, Ken O'Dea and Cash to Cardinals for Johnny Mize. | 1B-OF | 6-1 | 185 | L | L | 1910-01-07 | Chicago,IL |
| MLB | 1934-1948 | 1934-1948 |
| 1941-12-11 | Ken O'Dea | Traded by Giants with Johnny McCarthy, Bill Lohrman and Cash to Cardinals for Johnny Mize. | C | 6-0 | 180 | L | R | 1913-03-16 | Lima,NY |
| MLB | 1935-1946 | 1935-1946 |
| 1941-12-11 | Bill Lohrman | Traded by Giants with Johnny McCarthy, Ken O'Dea and Cash to Cardinals for Johnny Mize. | P | 6-1 | 185 | R | R | 1913-05-22 | Brooklyn,NY |
| MLB | 1934-1944 | 1934-1944 |
| 1941-12-10 | Billy Werber | Purchased by Giants from Reds. | 3B-SS | 5-10 | 170 | R | R | 1908-06-20 | Berwyn,MD |
| MLB | 1930-1942 | 1930-1942 |
| 1941-12-10 | Morrie Arnovich | Purchased by Reds from Giants. | OF | 5-10 | 168 | R | R | 1910-11-16 | Superior,WI |
| MLB | 1936-1946 | 1936-1946 |
| 1941-12-10 | Jo-Jo Moore | Purchased by Reds from Giants. | OF | 5-11 | 155 | L | R | 1908-12-25 | Gause,TX |
| MLB | 1930-1941 | 1930-1941 |
| 1941-12-03 | Hank Leiber | Traded by Cubs to Giants for Bob Bowman. | OF-1B | 6-1 | 205 | R | R | 1911-01-17 | Phoenix,AZ |
| MLB | 1933-1942 | 1933-1942 |
| 1941-12-03 | Bob Bowman | Traded by Giants to Cubs for Hank Leiber. | P | 5-10 | 160 | R | R | 1910-10-03 | Keystone,WV |
| MLB | 1939-1942 | 1939-1942 |
| 1941-10-13 | Austin Knickerbocker | Selected by Giants from Phillies in the minor league draft. | OF | 5-11 | 185 | R | R | 1918-10-15 | Bangall,NY |
| MLB | 1947-1947 | 1947-1947 |
| 1941-09-25 | Gabby Hartnett | Released by Giants. | C-1B | 6-1 | 195 | R | R | 1900-12-20 | Woonsocket,RI |
| MLB | 1922-1941 | 1922-1941 |
| 1941-09-09 | Odell Hale | Purchased by Milwaukee (American Association) from Giants. | 2B-3B | 5-10 | 175 | R | R | 1908-08-10 | Hosston,LA |
| MLB | 1931-1941 | 1931-1941 |
| 1941-09-09 | Tom Sunkel | Traded by Cardinals to Giants for Jumbo Brown. | P | 6-1 | 190 | L | L | 1912-08-09 | Paris,IL |
| MLB | 1937-1944 | 1937-1944 |
| 1941-09-09 | Jumbo Brown | Traded by Giants to Cardinals for Tom Sunkel. | P | 6-4 | 295 | R | R | 1907-04-30 | Greene,RI |
| MLB | 1925-1941 | 1925-1941 |
| 1941-09-01 | Dave Koslo | Purchased by Giants from Milwaukee (American Association). | P | 5-11 | 180 | L | L | 1920-03-31 | Menasha,WI |
| MLB | 1941-1955 | 1941-1955 |
| 1941-08-07 | Connie Ryan | Purchased by Giants from Atlanta (Southern Association). | 2B-3B | 5-11 | 175 | R | R | 1920-02-27 | New Orleans,LA |
| MLB | 1942-1954 | 1942-1954 |
| 1941-07-22 | Babe Barna | Purchased by Giants from Minneapolis (American Association). | OF-1B | 6-2 | 210 | L | R | 1915-03-02 | Clarksburg,WV |
| MLB | 1937-1943 | 1937-1943 |
| 1941-07-21 | Frank Demaree | Claimed on waivers by Braves from Giants. | OF | 5-11 | 185 | R | R | 1910-06-10 | Winters,CA |
| MLB | 1932-1944 | 1932-1944 |
| 1941-06-19 | Odell Hale | Claimed on waivers by Giants from Red Sox. | 2B-3B | 5-10 | 175 | R | R | 1908-08-10 | Hosston,LA |
| MLB | 1931-1941 | 1931-1941 |
| 1941-05-15 | Dick Bartell | Signed as Free Agent by Giants. | SS-3B | 5-9 | 160 | R | R | 1907-11-22 | Chicago,IL |
| MLB | 1927-1946 | 1927-1946 |
| 1941-05-14 | Bill McGee | Traded by Cardinals to Giants for Paul Dean, Harry Gumbert and Cash. | P | 6-1 | 215 | R | R | 1909-11-16 | Batchtown,IL |
| MLB | 1935-1942 | 1935-1942 |
| 1941-05-14 | Paul Dean | Traded by Giants with Harry Gumbert and Cash to Cardinals for Bill McGee. | P | 6-0 | 175 | R | R | 1913-08-14 | Lucas,AR |
| MLB | 1934-1943 | 1934-1943 |
| 1941-05-14 | Harry Gumbert | Traded by Giants with Paul Dean and Cash to Cardinals for Bill McGee. | P | 6-2 | 185 | R | R | 1909-11-05 | Elizabeth,PA |
| MLB | 1935-1950 | 1935-1950 |
| 1941-05-12 | Al Piechota | Purchased by Giants from Braves. | P | 6-0 | 195 | R | R | 1914-01-19 | Chicago,IL |
| MLB | 1940-1941 | 1940-1941 |
| 1941-03-01 | George Myatt | Purchased by Cardinals from Giants. | 2B-3B | 5-11 | 167 | L | R | 1914-06-14 | Denver,CO |
| MLB | 1938-1947 | 1938-1947 |
| 1941-02-28 | Bob Seeds | Purchased by Phillies from Giants. | OF-1B | 6-0 | 180 | R | R | 1907-02-24 | Ringgold,TX |
| MLB | 1930-1940 | 1930-1940 |
| 1941-01-31 | Rene Monteagudo | Purchased by Giants from Senators. | P-OF | 5-7 | 165 | L | L | 1916-03-12 | Havana,CU |
| MLB | 1938-1945 | 1938-1945 |
| 1941-01-02 | Hy Vandenberg | Purchased by Cardinals from Giants. | P | 6-4 | 220 | R | R | 1906-03-17 | Abilene,KS |
| MLB | 1935-1945 | 1935-1945 |
| 1941-01-01 | Mickey Grasso | Signed as undrafted amateur Free Agent by Giants. | C | 6-0 | 195 | R | R | 1920-05-10 | Newark,NJ |
| MLB | 1946-1955 | 1946-1955 |
| 1941-01-01 | Marv Grissom | Signed as undrafted amateur Free Agent by Giants. | P | 6-3 | 195 | R | R | 1918-03-31 | Los Molinos,CA |
| MLB | 1946-1959 | 1946-1959 |
| 1941-01-01 | Bob Hooper | Signed as undrafted amateur Free Agent by Giants. | P | 5-11 | 195 | R | R | 1922-05-30 | Leamington,ON |
| MLB | 1950-1955 | 1950-1955 |
| 1941-01-01 | Buddy Kerr | Signed as undrafted amateur Free Agent by Giants. | SS-3B | 6-2 | 180 | R | R | 1922-11-06 | Astoria,NY |
| MLB | 1943-1951 | 1943-1951 |