| 2001 | IL | AAA | Buffalo Bisons | S | R | Bisons | 1998-2020 | Buffalo,New York | NY | CLE | 91 | 51 | .641 | 1 | North | Eric Wedge | Dunn Tire Park | Lost in 1st Round (Wilkes-Barre) |
| 2001 | IL | AAA | Charlotte Knights | S | R | Knights | 1993-2020 | Charlotte,North Carolina | NC | CHA | 67 | 77 | .465 | 4 | South | Nick Leyva | Knights Stadium | dnq |
| 2001 | IL | AAA | Columbus Clippers | S | R | Clippers | 1977-2020 | Columbus,Ohio | OH | NYA | 67 | 76 | .469 | 2 | West | Trey Hillman | Cooper Stadium | dnq |
| 2001 | IL | AAA | Durham Bulls | S | R | Bulls | 2007-2020 | Durham,North Carolina | NC | TBA | 74 | 70 | .514 | 2 | South | Billy Evers | Durham Bulls Athletic Park | dnq |
| 2001 | IL | AAA | Indianapolis Indians | S | R | Indians | 1998-2020 | Indianapolis,Indiana | IN | MIL | 66 | 78 | .458 | 3 | West | Wendell Kim | Victory Field | dnq |
| 2001 | IL | AAA | Louisville RiverBats | S | R | RiverBats | 1998-2020 | Louisville,Kentucky | KY | CIN | 84 | 60 | .583 | 1 | West | Dave Miley | Louisville Slugger Field | Co-League Champions (Wilkes-Barre) |
| 2001 | IL | AAA | Norfolk Tides | S | R | Tides | 1993-2020 | Norfolk,Virginia | VA | NYN | 85 | 57 | .599 | 1 | South | John Gibbons | Harbor Park | Lost in 1st Round (Louisville) |
| 2001 | IL | AAA | Ottawa Lynx | S | R | Lynx | 1993-2007 | Ottawa,Ontario | ON | MON | 68 | 76 | .472 | 4 | North | Stan Hough | JetForm Park | dnq |
| 2001 | IL | AAA | Pawtucket Red Sox | S | R | Red Sox | 1977-2020 | Pawtucket,Rhode Island | RI | BOS | 60 | 82 | .423 | 5 | North | Gary Jones | McCoy Stadium | dnq |
| 2001 | IL | AAA | Richmond Braves | S | R | Braves | 1977-2008 | Richmond,Virginia | VA | ATL | 68 | 76 | .472 | 3 | South | Carlos Tosca | The Diamond | dnq |
| 2001 | IL | AAA | Rochester Red Wings | S | R | Red Wings | 1977-2020 | Rochester,New York | NY | BAL | 60 | 84 | .417 | 6 | North | Andy Etchebarren | Frontier Field | dnq |
| 2001 | IL | AAA | Scranton/Wilkes-Barre Red Barons | S | R | Red Barons | 1989-2020 | Scranton,Pennsylvania | PA | PHI | 78 | 65 | .545 | 2 | North | Marc Bombard | Lackawanna County Stadium | Co-League Champions (Louisville) |
| 2001 | IL | AAA | Syracuse SkyChiefs | S | R | SkyChiefs | 1977-2020 | Syracuse,New York | NY | TOR | 71 | 73 | .493 | 3 | North | Omar Malave | P&C Stadium | dnq |
| 2001 | IL | AAA | Toledo Mud Hens | S | R | Mud Hens | 1977-2020 | Toledo,Ohio | OH | DET | 65 | 79 | .451 | 4 | West | Bruce Fields | Ned Skeldon Stadium | dnq |
| 2001 | PCL | AAA | Calgary Cannons | S | R | Cannons | 1985-2002 | Calgary,Alberta | AB | MIA | 72 | 71 | .503 | 2 | North | Chris Chambliss | Foothills Stadium | dnq |
| 2001 | PCL | AAA | Colorado Springs Sky Sox | S | R | Sky Sox | 1988-2018 | Colorado Springs,Colorado | CO | COL | 62 | 79 | .440 | 4 | Central | Chris Cron | Sky Sox Stadium | dnq |
| 2001 | PCL | AAA | Edmonton Trappers | S | R | Trappers | 1981-2004 | Edmonton,Alberta | AB | MIN | 60 | 83 | .420 | 4 | North | John Russell | Telus Field | dnq |
| 2001 | PCL | AAA | Fresno Grizzlies | S | R | Grizzlies | 1998-2020 | Fresno,California | CA | SFN | 68 | 71 | .489 | 2 | South | Shane Turner | Pete Beiden Field | dnq |
| 2001 | PCL | AAA | Iowa Cubs | S | R | Cubs | 1998-2020 | Des Moines,Iowa | IA | CHN | 83 | 60 | .580 | 1 | Central | Bruce Kimm | Sec Taylor Stadium II | dnq |
| 2001 | PCL | AAA | Las Vegas Stars | S | R | Stars | 1983-2020 | Las Vegas,Nevada | NV | LAN | 68 | 76 | .472 | 3 | South | Rick Sofield | Cashman Field | dnq |
| 2001 | PCL | AAA | Memphis Redbirds | S | R | Redbirds | 1998-2020 | Memphis,Tennessee | TN | SLN | 62 | 81 | .434 | 4 | East | Gaylen Pitts | AutoZone Park | dnq |
| 2001 | PCL | AAA | Nashville Sounds | S | R | Sounds | 1998-2020 | Nashville,Tennessee | TN | PIT | 64 | 77 | .454 | 3 | East | Marty Brown | Herschel Greer Stadium | dnq |
| 2001 | PCL | AAA | New Orleans Zephyrs | S | R | Zephyrs | 1998-2019 | New Orleans,Louisiana | LA | HOU | 82 | 57 | .590 | 1 | East | Tony Pena | Zephyr Field | Co-League Champions (Tacoma) |
| 2001 | PCL | AAA | Oklahoma RedHawks | S | R | RedHawks | 1998-2008 | Oklahoma City,Oklahoma | OK | TEX | 74 | 69 | .517 | 2 | East | DeMarlo Hale | AT&T Bricktown Ballpark | dnq |
| 2001 | PCL | AAA | Omaha Royals | S | R | Royals | 1998-2020 | Omaha,Nebraska | NE | KCA | 70 | 74 | .486 | 3 | Central | John Mizerock | Johnny Rosenblatt Stadium | Lost in Semi-Finals (New Orleans) |
| 2001 | PCL | AAA | Portland Beavers | S | R | Beavers | 1978-2010 | Portland,Oregon | OR | SDN | 71 | 73 | .493 | 3 | North | Rick Sweet | PGE Park | dnq |
| 2001 | PCL | AAA | Sacramento River Cats | S | R | River Cats | 2000-2020 | Sacramento,California | CA | OAK | 75 | 69 | .521 | 1 | South | Bob Geren | Raley Field | Lost in Semi-Finals (Tacoma) |
| 2001 | PCL | AAA | Salt Lake Stingers | S | R | Stingers | 1977-2020 | Salt Lake City,Utah | UT | ANA | 79 | 64 | .552 | 2 | Central | Garry Templeton | Franklin Covey Field | dnq |
| 2001 | PCL | AAA | Tacoma Rainiers | S | R | Rainiers | 1977-2020 | Tacoma,Washington | WA | SEA | 85 | 59 | .590 | 1 | North | Dan Rohn | Cheney Stadium | Co-League Champions (New Orleans) |
| 2001 | PCL | AAA | Tucson Sidewinders | S | R | Sidewinders | 1977-2013 | Tucson,Arizona | AZ | ARI | 65 | 77 | .458 | 4 | South | Tom Spencer | Tucson Electric Park | dnq |
| 2001 | East | AA | Akron Aeros | S | R | Aeros | 1997-2020 | Akron,Ohio | OH | CLE | 68 | 74 | .479 | 3 | South | Chris Bando | Canal Park | dnq |
| 2001 | East | AA | Altoona Curve | S | R | Curve | 1999-2020 | Altoona,Pennsylvania | PA | PIT | 63 | 79 | .444 | 5 | South | Dale Sveum | Blair County Ballpark | dnq |
| 2001 | East | AA | Binghamton Mets | S | R | Mets | 1992-2020 | Binghamton,New York | NY | NYN | 73 | 68 | .518 | 4 | North | Howard Freiling | NYSEG Stadium | dnq |
| 2001 | East | AA | Bowie Baysox | S | R | Baysox | 1993-2020 | Bowie,Maryland | MD | BAL | 59 | 82 | .418 | 6 | South | Dave Machemer | Prince George's Stadium | dnq |
| 2001 | East | AA | Erie SeaWolves | S | R | SeaWolves | 1999-2020 | Erie,Pennsylvania | PA | DET | 84 | 58 | .592 | 1 | South | Luis Pujols | Jerry Uht Park | Lost in Semi-Finals |
| 2001 | East | AA | Harrisburg Senators | S | R | Senators | 1987-2020 | Harrisburg,Pennsylvania | PA | MON | 66 | 76 | .465 | 4 | South | Luis Dorante | Riverside Stadium | dnq |
| 2001 | East | AA | New Britain Rock Cats | S | R | Rock Cats | 1983-2015 | New Britain,Connecticut | CT | MIN | 87 | 55 | .613 | 1 | North | Stan Cliburn | New Britain Stadium | Co-League Champions |
| 2001 | East | AA | New Haven Ravens | S | R | Ravens | 1994-2003 | New Haven,Connecticut | CT | SLN | 47 | 95 | .331 | 6 | North | Danny Sheaffer | Yale Field | dnq |
| 2001 | East | AA | Norwich Navigators | S | R | Navigators | 1995-2005 | Norwich,Connecticut | CT | NYA | 83 | 59 | .585 | 2 | North | Stump Merrill | Senator Thomas J. Dodd Memorial Stadium | Lost in Semi-Finals |
| 2001 | East | AA | Portland Sea Dogs | S | R | Sea Dogs | 1994-2020 | Portland,Maine | ME | MIA | 77 | 65 | .542 | 3 | North | Rick Renteria | Hadlock Field | dnq |
| 2001 | East | AA | Reading Phillies | S | R | Phillies | 1977-2020 | Reading,Pennsylvania | PA | PHI | 77 | 65 | .542 | 2 | South | Gary Varsho | GPU Stadium | Co-League Champions |
| 2001 | East | AA | Trenton Thunder | S | R | Thunder | 1994-2020 | Trenton,New Jersey | NJ | BOS | 67 | 75 | .472 | 5 | North | Billy Gardner | Mercer County Waterfront Park | dnq |
| 2001 | Sou | AA | Birmingham Barons | S | R | Barons | 1981-2020 | Birmingham,Alabama | AL | CHA | 80 | 60 | .571 | 1 | West | Nick Capra | Hoover Metropolitan Stadium | Lost in Semi-Finals (Huntsville) |
| 2001 | Sou | AA | Carolina Mudcats | S | R | Mudcats | 1991-2011 | Zebulon,North Carolina | NC | COL | 62 | 76 | .449 | 3 | East | Ronnie Gideon | Five County Stadium | dnq |
| 2001 | Sou | AA | Chattanooga Lookouts | S | R | Lookouts | 1977-2020 | Chattanooga,Tennessee | TN | CIN | 72 | 67 | .518 | 2 | East | Phillip Wellman | BellSouth Park | Lost in Semi-Finals (Jacksonville) |
| 2001 | Sou | AA | Greenville Braves | S | R | Braves | 1984-2007 | Greenville,South Carolina | SC | ATL | 60 | 79 | .432 | 4 | East | Paul Runge | Greenville Municipal Stadium | dnq |
| 2001 | Sou | AA | Huntsville Stars | S | R | Stars | 1985-2014 | Huntsville,Alabama | AL | MIL | 75 | 63 | .543 | 3 | West | Ed Romero | Joe W. Davis Stadium | Co-League Champions (Jacksonville) |
| 2001 | Sou | AA | Jacksonville Suns | S | R | Suns | 1977-2020 | Jacksonville,Florida | FL | LAN | 83 | 56 | .597 | 1 | East | John Shoemaker | Sam W. Wolfson Baseball Park | Co-League Champions (Huntsville) |
| 2001 | Sou | AA | Mobile BayBears | S | R | BayBears | 1997-2019 | Mobile,Alabama | AL | SDN | 65 | 73 | .471 | 4 | West | Tracy Woodson | Hank Aaron Stadium | dnq |
| 2001 | Sou | AA | Orlando Rays | S | R | Rays | 1977-2003 | Orlando,Florida | FL | TBA | 59 | 81 | .421 | 5 | East | Mike Ramsey | Champion Stadium | dnq |
| 2001 | Sou | AA | Tennessee Smokies | S | R | Smokies | 2000-2020 | Knoxville,Tennessee | TN | TOR | 80 | 60 | .571 | 2 | West | Rocket Wheeler | Smokies Park | dnq |
| 2001 | Sou | AA | West Tennessee Diamond Jaxx | S | R | Diamond Jaxx | 1998-2010 | Jackson,Tennessee | TN | CHN | 59 | 80 | .424 | 5 | West | Dave Bialas | Pringles Park | dnq |
| 2001 | Tex | AA | Arkansas Travelers | S | R | Travelers | 1977-2020 | Little Rock,Arkansas | AR | ANA | 66 | 70 | .485 | 3 | East | Mike Brumley | Ray Winder Field | Co-League Champions (Round Rock) |
| 2001 | Tex | AA | El Paso Diablos | S | R | Diablos | 1977-2004 | El Paso,Texas | TX | ARI | 57 | 83 | .407 | 4 | West | Al Pedrique | Cohen Stadium | dnq |
| 2001 | Tex | AA | Midland RockHounds | S | R | RockHounds | 1977-2020 | Midland,Texas | TX | OAK | 71 | 69 | .507 | 2 | West | Tony DeFrancesco | Christensen Stadium | dnq |
| 2001 | Tex | AA | Round Rock Express | S | R | Express | 2000-2004 | Round Rock,Texas | TX | HOU | 86 | 54 | .614 | 1 | West | Jackie Moore | Dell Diamond | Co-League Champions (Arkansas) |
| 2001 | Tex | AA | San Antonio Missions | S | R | Missions | 1977-2018 | San Antonio,Texas | TX | SEA | 70 | 67 | .511 | 3 | West | Dave Brundage | Nelson W. Wolff Municipal Stadium | Lost in Semi-Finals (Round Rock) |
| 2001 | Tex | AA | Shreveport Swamp Dragons | S | R | Swamp Dragons | 1977-2002 | Shreveport,Louisiana | LA | SFN | 54 | 81 | .400 | 4 | East | Bill Russell | Fair Grounds Field | dnq |
| 2001 | Tex | AA | Tulsa Drillers | S | R | Drillers | 1977-2020 | Tulsa,Oklahoma | OK | TEX | 69 | 70 | .496 | 2 | East | Paul Carey | Drillers Stadium | dnq |
| 2001 | Tex | AA | Wichita Wranglers | S | R | Wranglers | 1987-2007 | Wichita,Kansas | KS | KCA | 79 | 58 | .577 | 1 | East | Keith Bodie | Lawrence-Dumont Stadium | Lost in Semi-Finals (Arkansas) |
| 2001 | Calif | A+ | Bakersfield Blaze | S | R | Blaze | 1978-2016 | Bakersfield,California | CA | TBA | 71 | 69 | .507 | 0 | Northern | Charlie Montoyo | Sam Lynn Ballpark | Lost in 2nd Round |
| 2001 | Calif | A+ | High Desert Mavericks | S | R | Mavericks | 1991-2016 | Victorville,California | CA | MIL | 71 | 69 | .507 | 3 | Southern | Frank Kremblas | Mavericks Stadium | Lost in Semi-Finals |
| 2001 | Calif | A+ | Lake Elsinore Storm | S | R | Storm | 1994-2020 | Lake Elsinore,California | CA | SDN | 91 | 49 | .650 | 1 | Southern | Craig Colbert | Lake Elsinore Diamond | Co-League Champions |
| 2001 | Calif | A+ | Lancaster JetHawks | S | R | JetHawks | 1996-2020 | Lancaster,California | CA | ARI | 61 | 79 | .436 | 5 | Southern | Scott Coolbaugh | Lancaster Municipal Stadium | dnq |
| 2001 | Calif | A+ | Modesto A's | S | R | A's | 1977-2020 | Modesto,California | CA | OAK | 55 | 85 | .393 | 5 | Northern | Greg Sparks | John Thurman Field | dnq |
| 2001 | Calif | A+ | Mudville Nine | S | R | Nine | 2000-2001 | Stockton,California | CA | CIN | 74 | 66 | .529 | 2 | Northern | Dave Oliver | Billy Hebert Field | Lost in Semi-Finals |
| 2001 | Calif | A+ | Rancho Cucamonga Quakes | S | R | Quakes | 1993-2020 | Rancho Cucamonga,California | CA | ANA | 63 | 77 | .450 | 4 | Southern | Tim Wallach | Rancho Cucamonga Epicenter | dnq |
| 2001 | Calif | A+ | San Bernardino Stampede | S | R | Stampede | 1987-2002 | San Bernardino,California | CA | SEA | 76 | 64 | .543 | 2 | Southern | Daren Brown | Arrowhead Credit Union Park | Lost in Semi-Finals |
| 2001 | Calif | A+ | San Jose Giants | S | R | Giants | 1979-2020 | San Jose,California | CA | SFN | 77 | 63 | .550 | 1 | Northern | Lenn Sakata | San Jose Municipal Stadium | Co-League Champions |
| 2001 | Calif | A+ | Visalia Oaks | S | R | Oaks | 1977-2020 | Visalia,California | CA | OAK | 61 | 79 | .436 | 4 | Northern | Juan Navarette | Recreation Park | dnq |
| 2001 | Caro | A+ | Frederick Keys | S | R | Keys | 1989-2020 | Frederick,Maryland | MD | BAL | 70 | 69 | .504 | 2 | Northern | Dave Cash | Harry Grove Stadium | Lost in Semi-Finals (Wilmington) |
| 2001 | Caro | A+ | Kinston Indians | S | R | Indians | 1978-2011 | Kinston,North Carolina | NC | CLE | 89 | 51 | .636 | 1 | Southern | Brad Komminsk | Grainger Stadium | Lost in Semi-Finals (Salem) |
| 2001 | Caro | A+ | Lynchburg Hillcats | S | R | Hillcats | 1977-2020 | Lynchburg,Virginia | VA | PIT | 58 | 79 | .423 | 4 | Northern | Curtis Wilkerson | Lynchburg City Stadium | dnq |
| 2001 | Caro | A+ | Myrtle Beach Pelicans | S | R | Pelicans | 1999-2020 | Myrtle Beach,South Carolina< | SC | ATL | 71 | 67 | .514 | 2 | Southern | Brian Snitker | BB&T Coastal Field | dnq |
| 2001 | Caro | A+ | Potomac Cannons | S | R | Cannons | 1999-2019 | Woodbridge,Virginia | VA | SLN | 66 | 74 | .471 | 3 | Northern | Joseph Cunningham | G. Richard Pfitzner Stadium | dnq |
| 2001 | Caro | A+ | Salem Avalanche | S | R | Avalanche | 1977-2020 | Salem,Virginia | VA | COL | 70 | 68 | .507 | 3 | Southern | Dave Collins | Salem Municipal Stadium | League Champions (Wilmington) |
| 2001 | Caro | A+ | Wilmington Blue Rocks | S | R | Blue Rocks | 1993-2020 | Wilmington,Delaware | DE | KCA | 78 | 62 | .557 | 1 | Northern | Jeff Garber | Daniel S. Frawley Stadium | Lost in Finals (Salem) |
| 2001 | Caro | A+ | Winston-Salem Warthogs | S | R | Warthogs | 1977-2020 | Winston-Salem,North Carolina< | NC | CHA | 54 | 86 | .386 | 4 | Southern | Wally Backman | Ernie Shore Field | dnq |
| 2001 | FSL | A+ | Brevard County Manatees | S | R | Manatees | 1994-2016 | Viera,Florida | FL | MIA | 80 | 55 | .593 | 1 | East | Dave Huppert | USSSA Space Coast Complex | Co-League Champions (Tampa) |
| 2001 | FSL | A+ | Charlotte Rangers | S | R | Rangers | 1987-2020 | Port Charlotte,Florida | FL | TEX | 67 | 70 | .489 | 5 | West | Darryl Kennedy | Charlotte County Stadium | Lost in Semi-Finals (Tampa) |
| 2001 | FSL | A+ | Clearwater Phillies | S | R | Phillies | 1985-2020 | Clearwater,Florida | FL | PHI | 68 | 69 | .496 | 3 | West | Ramon Aviles | Jack Russell Memorial Stadium | dnq |
| 2001 | FSL | A+ | Daytona Cubs | S | R | Cubs | 1977-2020 | Daytona Beach,Florida | FL | CHN | 68 | 68 | .500 | 3 | East | Dave Trembley | Jackie Robinson Ballpark | dnq |
| 2001 | FSL | A+ | Dunedin Blue Jays | S | R | Blue Jays | 1978-2020 | Dunedin,Florida | FL | TOR | 71 | 64 | .526 | 2 | West | Marty Pevey | Dunedin Stadium | dnq |
| 2001 | FSL | A+ | Fort Myers Miracle | S | R | Miracle | 1978-2020 | Fort Myers,Florida | FL | MIN | 68 | 69 | .496 | 4 | West | Jose Marzan | Hammond Stadium | dnq |
| 2001 | FSL | A+ | Jupiter Hammerheads | S | R | Hammerheads | 1998-2020 | Jupiter,Florida | FL | MON | 70 | 69 | .504 | 2 | East | Tim Leiper | Roger Dean Stadium | dnq |
| 2001 | FSL | A+ | Lakeland Tigers | S | R | Tigers | 1977-2020 | Lakeland,Florida | FL | DET | 67 | 69 | .493 | 4 | East | Kevin Bradshaw | Joker Marchant Stadium | dnq |
| 2001 | FSL | A+ | Sarasota Red Sox | S | R | Red Sox | 1989-2009 | Sarasota,Florida | FL | BOS | 54 | 83 | .394 | 6 | West | Ron Jackson | Ed Smith Stadium | dnq |
| 2001 | FSL | A+ | St. Lucie Mets | S | R | Mets | 1988-2020 | Port St. Lucie,Florida | FL | NYN | 63 | 76 | .453 | 6 | East | Ron Johnson | Thomas J. White Stadium | dnq |
| 2001 | FSL | A+ | Tampa Yankees | S | R | Yankees | 1977-2020 | Tampa,Florida | FL | NYA | 77 | 62 | .554 | 1 | West | Brian Butterfield | Legends Field | Co-League Champions (Brevard County) |
| 2001 | FSL | A+ | Vero Beach Dodgers | S | R | Dodgers | 1980-2008 | Vero Beach,Florida | FL | LAN | 67 | 66 | .504 | 5 | East | Bob Mariano | Holman Stadium | Lost in Semi-Finals (Brevary County) |
| 2001 | Midw | A | Beloit Snappers | S | R | Snappers | 1982-2020 | Beloit,Wisconsin | WI | MIL | 67 | 71 | .486 | 4 | Western | Don Money | Harry C. Pohlman Field | Lost in 1st Round (Kane County) |
| 2001 | Midw | A | Burlington Bees | S | R | Bees | 1977-2020 | Burlington,Iowa | IA | KCA | 55 | 79 | .410 | 7 | Western | Joe Szekely | Community Field | dnq |
| 2001 | Midw | A | Cedar Rapids Kernels | S | R | Kernels | 1977-2020 | Cedar Rapids,Iowa | IA | CAL | 60 | 77 | .438 | 5 | Western | Tyrone Boykin | Veterans Field | dnq |
| 2001 | Midw | A | Clinton LumberKings | S | R | LumberKings | 1977-2020 | Clinton,Iowa | IA | MON | 51 | 85 | .375 | 8 | Western | Steve Phillips | Riverview Stadium | dnq |
| 2001 | Midw | A | Dayton Dragons | S | R | Dragons | 2000-2020 | Dayton,Ohio | OH | CIN | 82 | 57 | .590 | 2 | Eastern | Donnie Scott | Fifth Third Field | Lost in Semi-Finals (South Bend) |
| 2001 | Midw | A | Fort Wayne Wizards | S | R | Wizards | 1993-2020 | Fort Wayne,Indiana | IN | SDN | 54 | 83 | .394 | 6 | Eastern | Tom Lawless, Donald Werner | Memorial Stadium | dnq |
| 2001 | Midw | A | Kane County Cougars | S | R | Cougars | 1991-2020 | Geneva,Illinois | IL | MIA | 88 | 50 | .638 | 1 | Western | Russ Morman | Elfstrom Stadium | Co-League Champions (South Bend) |
| 2001 | Midw | A | Lansing Lugnuts | S | R | Lugnuts | 1996-2020 | Lansing,Michigan | MI | CHN | 65 | 75 | .464 | 5 | Eastern | Julio Garcia | Oldsmobile Park | Lost in 1st Round (Dayton) |
| 2001 | Midw | A | Michigan Battle Cats | S | R | Battle Cats | 1995-2002 | Battle Creek,Michigan | MI | HOU | 82 | 55 | .599 | 1 | Eastern | John Massarelli | C.O. Brown Stadium | Lost in 1st Round (South Bend) |
| 2001 | Midw | A | Peoria Chiefs | S | R | Chiefs | 1983-2020 | Peoria,Illinois | IL | SLN | 57 | 81 | .413 | 6 | Western | Joe Hall | Pete Vonachen Stadium at Meinen Field | dnq |
| 2001 | Midw | A | Quad Cities River Bandits | S | R | River Bandits | 1977-2020 | Davenport,Iowa | IA | MIN | 80 | 57 | .584 | 3 | Western | Jeff Carter | John O'Donnell Stadium | Lost in 1st Round (Wisconsin) |
| 2001 | Midw | A | South Bend Silver Hawks | S | R | Silver Hawks | 1988-2020 | South Bend,Indiana | IN | ARI | 70 | 66 | .515 | 3 | Eastern | Steve Scarsone | Stanley Covelski Regional Stadium | Co-League Champions (Kane County) |
| 2001 | Midw | A | West Michigan Whitecaps | S | R | Whitecaps | 1994-2020 | Grand Rapids,Michigan | MI | DET | 65 | 72 | .474 | 4 | Eastern | Brent Gates | Fifth Third Ballpark | dnq |
| 2001 | Midw | A | Wisconsin Timber Rattlers | S | R | Timber Rattlers | 1995-2020 | Oshkosh,Wisconsin | WI | SEA | 84 | 52 | .618 | 2 | Western | Gary Thurman | Fox Cities Stadium | Lost in Semi-Finals (Kane County) |
| 2001 | SAL | A | Asheville Tourists | S | R | Tourists | 1980-2020 | Asheville,North Carolina | NC | COL | 68 | 71 | .489 | 5 | Southern | Joe Mikulik | McCormick Field | Co-League Champions (Lexington) |
| 2001 | SAL | A | Augusta GreenJackets | S | R | GreenJackets | 1988-2020 | Augusta,Georgia | GA | BOS | 74 | 65 | .532 | 3 | Southern | Mike Boulanger | Lake Olmstead Stadium | Lost in Semi-Finals (Asheville) |
| 2001 | SAL | A | Charleston (sc) Riverdogs | S | R | Riverdogs | 1980-2020 | Charleston,South Carolina | SC | TBA | 64 | 76 | .457 | 6 | Southern | Rolando Pino | Joseph P. Riley, Jr. Park | dnq |
| 2001 | SAL | A | Charleston (Wv) AlleyCats | S | R | AlleyCats | 1987-2004 | Charleston,West Virginia | WV | TOR | 51 | 87 | .370 | 8 | Northern | Buddy Biancalana | Walt Powell Park | dnq |
| 2001 | SAL | A | Columbia Bombers | S | R | Bombers | 1983-2020 | Columbia,South Carolina | SC | NYN | 62 | 73 | .459 | 7 | Southern | Ken Oberkfell | Capital City Stadium | dnq |
| 2001 | SAL | A | Columbus Red Stixx | S | R | Red Stixx | 1991-2008 | Columbus,Georgia | GA | CLE | 77 | 59 | .566 | 1 | Southern | Ted Kubiak | Golden Park | dnq |
| 2001 | SAL | A | Delmarva Shorebirds | S | R | Shorebirds | 1996-2020 | Salisbury,Maryland | MD | BAL | 61 | 79 | .436 | 6 | Northern | Joe Ferguson | Arthur W. Perdue Stadium | dnq |
| 2001 | SAL | A | Greensboro Bats | S | R | Bats | 1980-2020 | Greensboro,North Carolina | NC | NYA | 70 | 70 | .500 | 4 | Northern | Mitch Seoane | World War Memorial Stadium | dnq |
| 2001 | SAL | A | Hagerstown Suns | S | R | Suns | 1993-2020 | Hagerstown,Maryland | MD | SFN | 83 | 57 | .593 | 2 | Northern | Bill Hayes | Municipal Stadium | Lost in Semi-Finals (Lexington) |
| 2001 | SAL | A | Hickory Crawdads | S | R | Crawdads | 1993-2020 | Hickory,North Carolina | NC | PIT | 67 | 73 | .479 | 5 | Northern | Pete Mackanin | L. P. Frans Stadium | dnq |
| 2001 | SAL | A | Kannapolis Intimidators | S | R | Intimidators | 2001-2020 | Kannapolis,North Carolina | NC | CHA | 76 | 63 | .547 | 3 | Northern | Razor Shines | Fieldcrest Cannon Stadium | dnq |
| 2001 | SAL | A | Lakewood BlueClaws | S | R | BlueClaws | 2001-2020 | Lakewood,New Jersey | NJ | PHI | 60 | 79 | .432 | 7 | Northern | Greg Legg | FirstEnergy Park | dnq |
| 2001 | SAL | A | Lexington Legends | S | R | Legends | 2001-2020 | Lexington,Kentucky | KY | HOU | 92 | 48 | .657 | 1 | Northern | J.J. Cannon | Applebee's Park | Co-League Champions (Asheville) |
| 2001 | SAL | A | Macon Braves | S | R | Braves | 1980-2002 | Macon,Georgia | GA | ATL | 72 | 61 | .541 | 4 | Southern | Randy Ingle | Luther Williams Field | dnq |
| 2001 | SAL | A | Savannah Sand Gnats | S | R | Sand Gnats | 1984-2015 | Savannah,Georgia | GA | TEX | 54 | 82 | .397 | 8 | Southern | Bill Slack | Grayson Stadium | dnq |
| 2001 | SAL | A | Wilmington Waves | S | R | Waves | 2001-2001 | Wilmington,North Carolina | NC | LAN | 75 | 63 | .543 | 2 | Southern | Dino Ebel | Brooks Field | dnq |
| 2001 | NYPL | A- | Auburn Doubledays | S | R | Doubledays | 1977-2020 | Auburn,New York | NY | TOR | 32 | 42 | .432 | 5 | McNamara | Paul Elliott | Falcon Park II | dnq |
| 2001 | NYPL | A- | Batavia Muckdogs | S | R | Muckdogs | 1977-2020 | Batavia,New York | NY | PHI | 37 | 39 | .487 | 3 | McNamara | Frank Klebe | Dwyer Stadium | dnq |
| 2001 | NYPL | A- | Brooklyn Cyclones | S | R | Cyclones | 2001-2020 | Brooklyn,New York | NY | NYN | 52 | 24 | .684 | 1 | Stedler | Edgar Alfonzo | KeySpan Park | Co-League Champions (Williamsport) |
| 2001 | NYPL | A- | Hudson Valley Renegades | S | R | Renegades | 1994-2020 | Wappingers Falls,New York | NY | TBA | 39 | 37 | .513 | 4 | Stedler | David Howard | Dutchess Stadium | dnq |
| 2001 | NYPL | A- | Jamestown Jammers | S | R | Jammers | 1977-2014 | Jamestown,New York | NY | ATL | 39 | 36 | .520 | 2 | McNamara | Jim Saul | Russell Diethrick Park | Lost in Semi-Finals (Williamsport) |
| 2001 | NYPL | A- | Lowell Spinners | S | R | Spinners | 1996-2020 | Lowell,Massachusetts | MA | BOS | 33 | 43 | .434 | 6 | Stedler | Arnold Beyeler | Edward A. LeLacheur Park | dnq |
| 2001 | NYPL | A- | Mahoning Valley Scrappers | S | R | Scrappers | 1999-2020 | Niles,Ohio | OH | CLE | 26 | 49 | .347 | 7 | McNamara | Chris Bando | Cafaro Field | dnq |
| 2001 | NYPL | A- | New Jersey Cardinals | S | R | Cardinals | 1994-2005 | Augusta,New Jersey | NJ | SLN | 35 | 41 | .461 | 5 | Stedler | Brian Rupp | Skylands Park | dnq |
| 2001 | NYPL | A- | Oneonta Tigers | S | R | Tigers | 1977-2009 | Oneonta,New York | NY | DET | 37 | 37 | .500 | 4 | McNamara | Gary Green | Damaschke Field | dnq |
| 2001 | NYPL | A- | Pittsfield Astros | S | R | Astros | 1989-2001 | Pittsfield,Massachusetts | MA | HOU | 45 | 30 | .600 | 3 | Stedler | Ivan DeJesus | Wahconah Park | dnq |
| 2001 | NYPL | A- | Staten Island Yankees | S | R | Yankees | 1999-2020 | Staten Island,New York | NY | NYA | 48 | 28 | .632 | 2 | Stedler | David Jorn | Richmond County Bank Ballpark | Lost in Semi-Finals (Brooklyn) |
| 2001 | NYPL | A- | Utica Blue Sox | S | R | Blue Sox | 1977-2001 | Utica,New York | NY | MIA | 27 | 47 | .365 | 6 | McNamara | Kevin Boles | Donovan Stadium at Murnane Field | dnq |
| 2001 | NYPL | A- | Vermont Expos | S | R | Expos | 1994-2020 | Burlington,Vermont | VT | MON | 28 | 47 | .373 | 7 | Stedler | Steve Balboni | Centennial Field | dnq |
| 2001 | NYPL | A- | Williamsport Crosscutters | S | R | Crosscutters | 1994-2020 | Williamsport,Pennsylvania | PA | PIT | 48 | 26 | .649 | 1 | McNamara | Tony Beasley | Bowman Field | Co-League Champions (Brooklyn) |
| 2001 | Nwst | A- | Boise Hawks | S | R | Hawks | 1978-2020 | Boise,Idaho | ID | CHN | 52 | 23 | .693 | 1 | North | Steve McFarland | Memorial Stadium | Lost in Finals |
| 2001 | Nwst | A- | Eugene Emeralds | S | R | Emeralds | 1977-2020 | Eugene,Oregon | OR | SDN | 32 | 44 | .421 | 4 | South | Randy Whisler | Civic Stadium | dnq |
| 2001 | Nwst | A- | Everett Aqua Sox | S | R | Aqua Sox | 1984-2020 | Everett,Washington | WA | SEA | 36 | 39 | .480 | 3 | South | Terry Pollreisz | Everett Memorial Stadium | dnq |
| 2001 | Nwst | A- | Salem-Keizer Volcanoes | S | R | Volcanoes | 1997-2020 | Keizer,Oregon | OR | SFN | 51 | 25 | .671 | 1 | South | Fred Stanley | Volcanoes Stadium | League Champions |
| 2001 | Nwst | A- | Spokane Indians | S | R | Indians | 1983-2020 | Spokane,Washington | WA | KCA | 22 | 54 | .289 | 4 | North | Tom Poquette | Avista Stadium | dnq |
| 2001 | Nwst | A- | Tri-City Dust Devils | S | R | Dust Devils | 1983-2020 | Pasco,Washington | WA | COL | 39 | 36 | .520 | 2 | North | Stu Cole | Tri-City Stadium | dnq |
| 2001 | Nwst | A- | Vancouver Canadians | S | R | Canadians | 2000-2020 | Vancouver,British Columbia | BC | OAK | 37 | 39 | .487 | 2 | South | Webster Garrison | Nat Bailey Stadium | dnq |
| 2001 | Nwst | A- | Yakima Bears | S | R | Bears | 1990-2012 | Yakima,Washington | WA | ARI | 33 | 42 | .440 | 3 | North | Greg Lonigro | Yakima County Stadium | dnq |
| 2001 | App | Rk | Bluefield Orioles | S | R | Orioles | 1977-2020 | Bluefield,West Virginia | WV | BAL | 33 | 33 | .500 | 1 | North | Joe Almaraz | Bowen Field at Peters Park | League Champions |
| 2001 | App | Rk | Bristol White Sox | S | R | White Sox | 1977-2020 | Bristol,Virginia | VA | CHA | 39 | 26 | .600 | 2 | South | John Orton | Devault Memorial Stadium | dnq |
| 2001 | App | Rk | Burlington Indians | S | R | Indians | 1986-2020 | Burlington,North Carolina | NC | CLE | 31 | 37 | .456 | 2 | North | Rouglas Odor | Burlington Athletic Stadium | dnq |
| 2001 | App | Rk | Danville Braves | S | R | Braves | 1993-2020 | Danville,Virginia | VA | ATL | 30 | 38 | .441 | 4 | North | Ralph Henriquez | American Legion Field | dnq |
| 2001 | App | Rk | Elizabethton Twins | S | R | Twins | 1977-2020 | Elizabethton,Tennessee | TN | MIN | 41 | 22 | .651 | 1 | South | Rudy Hernandez | Joe O'Brien Field | Lost in Finals |
| 2001 | App | Rk | Johnson City Cardinals | S | R | Cardinals | 1977-2020 | Johnson City,Tennessee | TN | SLN | 31 | 35 | .470 | 4 | South | Chris Maloney | Howard Johnson Field | dnq |
| 2001 | App | Rk | Kingsport Mets | S | R | Mets | 1977-2020 | Kingsport,Tennessee | TN | NYN | 31 | 36 | .463 | 5 | South | Joey Cora | Hunter Wright Stadium | dnq |
| 2001 | App | Rk | Martinsville Astros | S | R | Astros | 1988-2003 | Martinsville,Virginia | VA | HOU | 31 | 37 | .456 | 3 | North | Jorge Orta | Hooker Field | dnq |
| 2001 | App | Rk | Princeton Devil Rays | S | R | Devil Rays | 1988-2020 | Princeton,West Virginia | WV | TBA | 28 | 39 | .418 | 5 | North | Edwin Rodriguez | H.P. Hunnicut Field | dnq |
| 2001 | App | Rk | Pulaski Rangers | S | R | Rangers | 1977-2020 | Pulaski,Virginia | VA | TEX | 38 | 30 | .559 | 3 | South | Bruce Crabbe | Calfee Park | dnq |
| 2001 | Ariz | Rk | Arizona Angels | S | R | | 1989-2020 | --- | AZ | ANA | 22 | 34 | .393 | 7 | - | Brian Harper | Tempe Diablo Stadium | dnq |
| 2001 | Ariz | Rk | Arizona Athletics | S | R | | 1988-2020 | --- | AZ | OAK | 35 | 21 | .625 | 1 | - | Ricky Nelson | Papago Park Sports Facility | League Champions |
| 2001 | Ariz | Rk | Arizona Brewers | S | R | | 1988-2020 | --- | AZ | MIL | 27 | 29 | .482 | 4 | - | Carlos Lezcano | Maryvale Baseball Park | dnq |
| 2001 | Ariz | Rk | Arizona Cubs | S | R | | 1997-2020 | --- | AZ | CHN | 26 | 30 | .464 | 5 | - | Carmelo Martinez | Fitch Park | dnq |
| 2001 | Ariz | Rk | Arizona Giants | S | R | | 1991-2020 | --- | AZ | SFN | 29 | 27 | .518 | 3 | - | Keith Comstock | Scottsdale Stadium | dnq |
| 2001 | Ariz | Rk | Arizona Mariners | S | R | | 1989-2020 | --- | AZ | SEA | 34 | 22 | .607 | 2 | - | Omer Munoz | Peoria Sports Complex | Lost in Finals |
| 2001 | GCL | Rk | Gulf Coast Braves | S | R | | 1977-2020 | --- | FL | ATL | 30 | 30 | .500 | 2 | Eastern | Rick Albert | Cracker Jack Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Dodgers | S | R | | 1983-2008 | --- | FL | LAN | 41 | 19 | .683 | 1 | Eastern | Juan Bustabad | Holman Stadium | Lost in Finals |
| 2001 | GCL | Rk | Gulf Coast Expos | S | R | | 1977-2004 | --- | FL | MON | 20 | 40 | .333 | 4 | Eastern | Dave Dangler | Roger Dean Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Marlins | S | R | | 1992-2020 | --- | FL | MIA | 29 | 31 | .483 | 3 | Eastern | Jon Deeble | USSSA Space Coast Complex | dnq |
| 2001 | GCL | Rk | Gulf Coast Orioles | S | R | | 1991-2020 | --- | FL | BAL | 22 | 34 | .393 | 5 | Western | Jesus Alfaro | Ed Smith Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Phillies | S | R | | 1984-2020 | --- | FL | PHI | 31 | 29 | .517 | 3 | Northern | Roly De Armas | Carpenter Complex | dnq |
| 2001 | GCL | Rk | Gulf Coast Pirates | S | R | | 1977-2020 | --- | FL | PIT | 22 | 34 | .393 | 6 | Western | Woody Huyke | Pirate City Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Rangers | S | R | | 1977-2002 | --- | FL | TEX | 24 | 35 | .407 | 4 | Western | Carlos Subero | Charlotte County Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Red Sox | S | R | | 1989-2020 | --- | FL | BOS | 37 | 22 | .627 | 1 | Western | John Sanders | City of Palms Park | Lost in Semi-Finals |
| 2001 | GCL | Rk | Gulf Coast Reds | S | R | | 1984-2009 | --- | FL | CIN | 36 | 22 | .621 | 2 | Western | Edgar Caceres | Ed Smith Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Royals | S | R | | 1977-2008 | --- | FL | KCA | 20 | 40 | .333 | 4 | Northern | Lino Diaz | Baseball City Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Tigers (East) | S | R | | 1995-2020 | --- | FL | DET | 34 | 26 | .567 | 2 | Northern | Howard Bushong | Joker Marchant Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Twins | S | R | | 1989-2020 | --- | FL | MIN | 32 | 26 | .552 | 3 | Western | Al Newman | Hammond Stadium | dnq |
| 2001 | GCL | Rk | Gulf Coast Yankees | S | R | | 1980-2020 | --- | FL | NYA | 35 | 25 | .583 | 1 | Northern | Derek Shelton | Yankee Complex | League Champions |
| 2001 | Pio | Rk | Billings Mustangs | S | R | Mustangs | 1977-2020 | Billings,Montana | MT | CIN | 46 | 29 | .613 | 2 | North | Rick Burleson | Cobb Field | League Champions (Provo) |
| 2001 | Pio | Rk | Casper Rockies | S | R | Rockies | 2001-2011 | Casper,Wyoming | WY | COL | 37 | 39 | .487 | 2 | South | P.J. Carey | Georte Tani Field | Lost in Semi-Finals (Provo) |
| 2001 | Pio | Rk | Great Falls Dodgers | S | R | Dodgers | 1977-2020 | Great Falls,Montana | MT | LAN | 37 | 39 | .487 | 3 | North | Dave Silvestri | Legion Field | dnq |
| 2001 | Pio | Rk | Idaho Falls Padres | S | R | Padres | 1977-2020 | Idaho Falls,Idaho | ID | SDN | 21 | 54 | .280 | 4 | South | Jake Molina | McDermott Field | dnq |
| 2001 | Pio | Rk | Medicine Hat Blue Jays | S | R | Blue Jays | 1977-2002 | Medicine Hat,Alberta | AB | TOR | 20 | 56 | .263 | 4 | North | Tom Bradley | Athletic Park | dnq |
| 2001 | Pio | Rk | Missoula Osprey | S | R | Osprey | 1999-2020 | Missoula,Montana | MT | ARI | 52 | 24 | .684 | 1 | North | Chip Hale | Lindborg-Cregg Field | Lost in Semi-Finals (Billings) |
| 2001 | Pio | Rk | Ogden Raptors | S | R | Raptors | 1994-2020 | Ogden,Utah | UT | MIL | 36 | 38 | .486 | 3 | South | Ed Sedar | Lindquist Field | dnq |
| 2001 | Pio | Rk | Provo Angels | S | R | Angels | 2001-2004 | Provo,Utah | UT | ANA | 53 | 23 | .697 | 1 | South | Tom Kotchman | Larry H. Miller Field at Miller Park | Lost in Finals (Billings) |
| 180 record(s) |