Players Born in this City | Top | Major Leaguers | Drafted Players | Recently Active | Active Players | PRO Players |
| Player | Posit | Ht | Wt | B-T | BornDate | Place | HiLvl | Stat Years | MLB Years | Draft Information | High School | College(s) | Status | Current Org (Level) |
| Willie Aikens | 1B | 6-3 | 220 | L-R | 1954-10-14 | Seneca,South Carolina | MLB | 1974-1986 | 1977-1985 | 1975- 1- 2-CAL | Seneca (Seneca,SC) | South Carolina St | ||
| Colin Brady | P | 6-4 | 195 | R-R | 1996-- | Seneca,South Carolina | NCAA | 2015-2018 | - | Pendleton (Pendleton,SC) | Navy | |||
| Matt Davis | 1B | 5-11 | 170 | R-R | 1982-- | Seneca,South Carolina | NCAA | 2001-2004 | - | Seneca (Seneca,SC) | Wofford Col | |||
| Eddie Ferguson | C | 6-0 | 195 | R-R | 1980-07-20 | Seneca,South Carolina | NCAA | 2002-2002 | - | Seneca (Seneca,SC) | Alabama | |||
| Tim Fournier | P | 6-1 | 215 | R-R | 1988-03-25 | Seneca,South Carolina | NCAA | 2007-2009 | - | Walhalla (Walhalla,SC) | South Carolina-Upstate | |||
| Chris Hawkins | P | 6-4 | 200 | L-L | 1965-08-26 | Seneca,South Carolina | A- | 1987-1987 | - | 1987-15- 392-HOU | Anderson U., South Carolina-Upstate | |||
| Tristen Hudson | P-IF | 6-3 | 178 | B-R | 1999-07-03 | Seneca,South Carolina | NCAA | 2018-2018 | - | Seneca (Seneca,SC) | West Virginia U. | |||
| John Pollock | P | 5-11 | 170 | R-R | 1980-08-13 | Seneca,South Carolina | NCAA | 2000-2003 | - | Seneca (Seneca,SC) | The Citadel | |||
| Marv Rackley | OF | 5-10 | 170 | L-L | 1921-07-25 | Seneca,South Carolina | MLB | 1947-1950 | 1947-1950 | |||||
| Britt Reames | P | 5-11 | 175 | R-R | 1973-08-19 | Seneca,South Carolina | MLB | 1992-2006 | 2000-2006 | 1995-17- 463-SLN | Seneca (Seneca,SC) | The Citadel | ||
| Jay Reames | P | 6-1 | 205 | R-R | 1974-10-31 | Seneca,South Carolina | A+ | 1996-2003 | - | 1993-32- 907-MIL | Seneca (Seneca,SC) | |||
| Joe Reames | OF | 5-11 | 190 | R-R | 1979-09-26 | Seneca,South Carolina | A | 1999-2003 | - | Seneca (Seneca,SC) | Clemson U. |
