| Rnd | Ovl | Phase | Player Name | $$ | Pos | Age | Born | Ht | Wt | B | T | High Level | MLB Years | Drafted From |
| 1 | 12 | June-Reg | Jay Bruce | $$ | of | 18 | 4/3/1987 | 6-3 | 195 | L | L | MLB | 2008-2008 | West Brook High School (Beaumont,TX) |
| 2 | 60 | June-Reg | Travis Wood | $$ | lhp | 18 | 2/6/1987 | 6-0 | 165 | R | L | AA | | Bryant High School (Bryant,AR) |
| 3 | 92 | June-Reg | Zac Ward | $$ | RHP | 21 | 1/14/1984 | 6-3 | 235 | R | R | A | | Gardner-Webb University |
| 4 | 122 | June-Reg | Sam LeCure | | rhp | 21 | 5/4/1984 | 6-1 | 190 | R | R | AA | | University of Texas |
| 5 | 152 | June-Reg | James Avery | | rhp | 21 | 6/10/1984 | 6-1 | 210 | R | R | AAA | | Niagara University |
| 6 | 182 | June-Reg | Jeff Stevens | | rhp | 21 | 9/5/1983 | 6-2 | 205 | R | R | AA | | Loyola Marymount University |
| 7 | 212 | June-Reg | Brandon Roberts | | OF | 20 | 11/9/1984 | 6-0 | 185 | L | R | Rookie | | Cal Poly |
| 8 | 242 | June-Reg | Michael Jones | | SS | 18 | 11/19/1986 | 6-3 | 180 | R | R | Rookie | | Wayne County High School (Jesup,GA) |
| 9 | 272 | June-Reg | Milton Loo | | 3b | 19 | 4/2/1986 | 6-1 | 185 | R | R | Rookie | | Yavapai College |
| 10 | 302 | June-Reg | Bo Lanier | | RHP | 22 | 11/20/1982 | 6-0 | 160 | R | R | A+ | | University of Georgia |
| 11 | 332 | June-Reg | Charles Fisher | | rhp | 22 | 2/22/1983 | 6-4 | 220 | R | R | A | | Lewis-Clark State College (Idaho) |
| 12 | 362 | June-Reg | Adam Rosales | | ss | 22 | 5/20/1983 | 6-2 | 195 | R | R | AAA | | Western Michigan University |
| 13 | 392 | June-Reg | Logan Ondrusek | | rhp | 20 | 2/13/1985 | 6-8 | 195 | R | R | AAA | | McLennan Community College |
| 14 | 422 | June-Reg | Michael Griffin | | 2B | 21 | 10/1/1983 | 5-9 | 200 | R | R | AAA | | Baylor University |
| 15 | 452 | June-Reg | Michael De Jesus | | 2B | 21 | 7/16/1983 | 5-9 | 180 | L | R | A+ | | Coastal Carolina University |
| 16 | 482 | June-Reg | Jason Vecchio | | rhp | 21 | 4/7/1984 | 5-11 | 195 | R | R | Rookie | | University of Texas-San Antonio |
| 17 | 512 | June-Reg | David Wilson | | LHP | 22 | 2/28/1983 | 5-11 | 160 | R | L | Rookie | | Lander University |
| 18 | 542 | June-Reg | Kevyn Feiner | | ss | 18 | 6/11/1987 | 6-0 | 170 | R | R | A | | Sun Prairie High School (Sun Prairie,WI) |
| 19 | 572 | June-Reg | Eric Eymann | | ss | 21 | 2/9/1984 | 6-3 | 185 | R | R | AA | | Kansas State University |
| 20 | 602 | June-Reg | Ben Mummy | | 1b | 20 | 8/14/1984 | 6-3 | 220 | R | R | Rookie | | University of Nevada |
| 21 | 632 | June-Reg | Ben Blumenthal | | C | 22 | 4/24/1983 | 6-2 | 210 | R | R | A+ | | Erskine College |
| 22 | 662 | June-Reg | Robbie Nickols | | lhp | 19 | 3/4/1986 | 6-5 | 215 | B | L | Rookie | | Pima Community College |
| 23 | 692 | June-Reg | James Morris | | lhp | 22 | 6/3/1983 | 6-8 | 255 | L | L | Rookie | | University of Illinois |
| 24 | 722** | June-Reg | Kyle Ginley | | RHP | 18 | 9/1/1986 | 6-2 | 225 | R | R | A+ | | St. Petersburg College |
| 25 | 752 | June-Reg | Taylor Johnson | | of | 21 | 7/25/1983 | 6-0 | 195 | L | L | Ind | | University of Washington |
| 26 | 782 | June-Reg | Matthew Salmon | | OF | 18 | 5/18/1987 | 6-4 | 190 | B | R | - | | South Aiken High School (Aiken,SC) |
| 27 | 812 | June-Reg | Kenny Smalley | | rhp | 17 | 7/25/1987 | 6-2 | 200 | R | R | - | | St. Charles High School (St. Charles,IL) |
| 28 | 842 | June-Reg | Henry-Judsen Smith | | rhp | 20 | 9/29/1984 | 6-3 | 200 | R | R | - | | Phoenix College |
| 29 | 872 | June-Reg | Russell Haltiwanger | | RHP | 21 | 4/21/1984 | 6-2 | 180 | R | R | A+ | | Newberry College |
| 30 | 902 | June-Reg | Mark Rodriguez | | c | 22 | 6/1/1983 | 6-0 | 200 | R | R | A- | | University of Texas-Pan American |
| 31 | 932 | June-Reg | Abe Woody | | rhp | 22 | 11/9/1982 | 5-11 | 215 | R | R | AAA | | Baylor University |
| 32 | 962 | June-Reg | Chris Denove | | C | 22 | 12/9/1982 | 6-1 | 195 | R | R | A | | UCLA |
| 33 | 992 | June-Reg | Leroy Hunt | | of | 17 | 11/28/1987 | 6-6 | 220 | R | R | - | | Linden High School (Linden,CA) |
| 34 | 1022 | June-Reg | Brandon Camardese | | LHP | 21 | 7/2/1983 | 6-2 | 205 | R | L | A+ | | University of Miami (Florida) |
| 35 | 1052 | June-Reg | Angel Colon | | 3b | 21 | 9/27/1983 | 6-4 | 210 | R | R | A | | Iowa Wesleyan College |
| 36 | 1082 | June-Reg | Lorenzo Douglas | | rhp | 18 | 5/1/1987 | 6-0 | 175 | R | R | - | | Sace High School (Garland,TX) |
| 37 | 1112 | June-Reg | Jacob Long | | C | | | 6-2 | 215 | R | R | A+ | | Modesto Junior College |
| 38 | 1142 | June-Reg | Kuyaunnis Miles | | of | 18 | 5/15/1987 | 6-2 | 185 | L | R | Rookie | | Russell County High School (Phenix City,AL) |
| 39 | 1172 | June-Reg | Edwin Quirarte | | rhp | 18 | 12/20/1986 | 6-2 | 180 | R | R | College | | Oxnard High School (Oxnard,CA) |
| 40 | 1201 | June-Reg | Angel Cabrera | | SS | 19 | 10/14/1985 | 6-0 | 179 | R | R | A | | Connors State College |
| 41 | 1230 | June-Reg | Justin Tordi | | ss | 21 | 4/9/1984 | 6-1 | 192 | R | R | AA | | University of Florida |
| 42 | 1259 | June-Reg | John Axford | | RHP | 22 | 4/1/1983 | 6-5 | 185 | R | R | AAA | | University of Notre Dame |
| 43 | 1288 | June-Reg | Clay Long | | rhp | 19 | 9/19/1985 | 6-1 | 170 | R | R | A- | | Chipola College |
| 44 | 1317 | June-Reg | Jason Erickson | | rhp | 18 | 2/3/1987 | 6-1 | 170 | R | R | College | | White River High School (Buckley,WA) |
| 45 | 1346 | June-Reg | Andre Lamontagne | | RHP | 19 | 3/24/1986 | 6-4 | 180 | S | R | College | | Righetti High School (Santa Maria,CA) |
| 46 | 1375 | June-Reg | J.W. Brown | | 1B | 20 | 6/24/1985 | 6-3 | 220 | L | R | - | | Howard College |
| 47 | 1404 | June-Reg | Matt Garrett | | of | 20 | 12/22/1984 | 6-4 | 195 | R | R | Ind | | Grand Rapids Community College |
| 48 | 1432 | June-Reg | Gary Pointer | | rhp | 18 | 6/12/1987 | 6-3 | 215 | R | R | - | | Marcus High School (Flower Mound,TX) |
| 49 | 1459 | June-Reg | Cody Allen | | of | 19 | 6/21/1986 | 5-7 | 160 | L | R | - | | Coleman High School (Coleman,MI) |
| 50 | 1486 | June-Reg | Jacob Christensen | | RF | 18 | 8/15/1986 | 6-1 | 205 | R | L | - | | Lockport Township High School (Lockport,IL) |
| |