| Rnd | Ovl | Phase | Player Name | $$ | Pos | Age | Born | Ht | Wt | B | T | High Level | MLB Years | Drafted From |
| 1 | 2 | June-Reg | Justin Verlander | $$ | P | 21 | 2/20/1983 | 6-5 | 200 | R | R | MLB | 2005-2008 | Old Dominion University |
| 2 | 43 | June-Reg | Eric Beattie | $$ | P | 21 | 4/2/1983 | 6-3 | 190 | R | R | A | | University of Tampa |
| 3 | 73 | June-Reg | Jeff Frazier | $$ | OF | 21 | 8/10/1982 | 6-3 | 195 | R | R | AA | | Rutgers University |
| 4 | 103 | June-Reg | Collin Mahoney | | P | 21 | 12/26/1982 | 6-3 | 235 | R | R | A | | Clemson University |
| 5 | 133 | June-Reg | Andrew Kown | | P | 21 | 10/7/1982 | 6-6 | 210 | R | R | AA | | Georgia Tech |
| 6 | 163 | June-Reg | Brent Dlugach | | SS | 21 | 3/3/1983 | 6-5 | 200 | R | R | AAA | | University of Memphis |
| 7 | 193 | June-Reg | Chris Carpenter | | P | | | | | | | - | | Bryan High School (Bryan,OH) |
| 8 | 223 | June-Reg | Luke French | | P | 18 | 9/13/1985 | 6-4 | 220 | L | L | AA | | Heritage High School (Littleton,CO) |
| 9 | 253 | June-Reg | Brandon Timm | | OF | 19 | 12/4/1984 | 6-3 | 215 | R | R | A+ | | Broken Arrow High School (Broken Arrow,OK) |
| 10 | 283 | June-Reg | Cory Middleton | | SS | 18 | 10/3/1985 | 6-1 | 185 | R | R | A | | Escambia High School (Pensacola,FL) |
| 11 | 313 | June-Reg | Josh Kauten | | P | 22 | 4/5/1982 | 6-3 | 200 | R | R | A+ | | Illinois State University |
| 12 | 343 | June-Reg | Cole Miller | | C | 19 | 10/20/1984 | 5-11 | 200 | R | R | Rookie | | College of The Siskiyous |
| 13 | 373 | June-Reg | Brooks Colvin | | 3B | 22 | 12/11/1981 | 5-10 | 170 | R | R | A | | Southwest Missouri State University |
| 14 | 403 | June-Reg | James Skelton | | C | 18 | 10/28/1985 | 5-11 | 165 | L | R | A+ | | West Covina High School (West Covina,CA) |
| 15 | 433 | June-Reg | Matt O'Brien | | P | 21 | 8/10/1982 | 6-3 | 215 | R | R | AAA | | Florida Atlantic University |
| 16 | 463 | June-Reg | Steve Young | | 2B | 22 | 4/9/1982 | 5-9 | 165 | B | R | A | | Princeton University |
| 17 | 493 | June-Reg | Dan Konecny | | P | 22 | 9/5/1981 | 6-4 | 210 | R | R | A | | Northwestern University |
| 18 | 523** | June-Reg | Chris Martin | | P | 18 | 6/2/1986 | 6-7 | 175 | R | R | - | | Arlington High School (Arlington,TX) |
| 19 | 553 | June-Reg | Tyler Jacobson | | P | 21 | 5/5/1983 | 6-2 | 205 | R | R | A- | | Central Arizona College |
| 20 | 583 | June-Reg | Ed Clelland | | P | 22 | 6/27/1982 | 6-0 | 165 | L | L | A+ | | Gonzaga University |
| 21 | 613 | June-Reg | Matthew Righter | | P | 22 | 8/7/1981 | 6-5 | 190 | R | R | AAA | | Johns Hopkins University |
| 22 | 643 | June-Reg | Thomas Royals | | P | | | | | | | - | | Pearl River Community College |
| 23 | 673 | June-Reg | Vince Berry | | OF | 20 | 9/1/1983 | 5-9 | 170 | R | R | Ind | | Triton College |
| 24 | 703 | June-Reg | Jordan Foster | | OF | 22 | 10/19/1981 | 6-1 | 205 | R | R | Ind | | Lamar University |
| 25 | 733 | June-Reg | Robbie Tulk | | P | 22 | 7/5/1981 | 5-11 | 180 | L | R | A- | | University of California, Davis |
| 26 | 763 | June-Reg | Thad McBurrows | | P | | | | | | | College | | Lake Wales High School (Lake Wales,FL) |
| 27 | 793 | June-Reg | Dominic Carmosino | | P | | | | | | | A- | | Oakland University |
| 28 | 823 | June-Reg | Brian Hensen | | P | 21 | 8/12/1982 | 6-4 | 170 | L | L | AA | | Elon University |
| 29 | 853 | June-Reg | Octavio Amezquita | | SS | 22 | 3/11/1982 | 6-0 | 165 | R | R | A+ | | University of the Pacific |
| 30 | 883 | June-Reg | Josh Lee | | 1B | 21 | 9/13/1982 | 6-4 | 220 | L | L | A | | McMurry University |
| 31 | 913 | June-Reg | Leonardo Grullon | | OF | 22 | 5/8/1982 | 6-3 | 210 | R | R | A- | | University of South Florida |
| 32 | 943 | June-Reg | Nate Bumstead | | P | 22 | 5/5/1982 | 6-2 | 215 | R | R | AA | | Louisiana State University |
| 33 | 973 | June-Reg | Kevin Brower | | P | 22 | 11/12/1981 | 5-11 | 190 | R | R | Ind | | University of North Carolina |
| 34 | 1003 | June-Reg | Dallas Trahern | | P | 18 | 11/29/1985 | 6-3 | 190 | R | R | AAA | | Owasso High School (Owasso,OK) |
| 35 | 1033 | June-Reg | Clay Britton | | OF | | | | | | | College | | Weatherford College |
| 36 | 1063** | June-Reg | Travis Debondt | | OF | 20 | 10/28/1983 | 6-4 | 190 | L | L | College | | Bakersfield Junior College |
| 37 | 1093 | June-Reg | Ramon Navarro | | SS | | | | | | | Ind | | Triton College |
| 38 | 1123 | June-Reg | Jamaal Peoples | | OF | | | | | | | - | | Philadelphia High School (Philadelphia,MS) |
| 39 | 1153 | June-Reg | Adrian Bowens | | SS | | | | | | | - | | Lumberton High School (Lumberton,MS) |
| 40 | 1183 | June-Reg | Kevin McAtee | | 1B | | | | | | | - | | Regis Jesuit High School (Aurora,CO) |
| 41 | 1213 | June-Reg | Bryan Sheffield | | OF | | | | | | | - | | Williston High School (Williston,FL) |
| 42 | 1242 | June-Reg | Trenton Lare | | P | | | | | | | College | | Coffeyville Community College |
| 43 | 1271 | June-Reg | Chris Schwinden | | P | 17 | 9/22/1986 | 6-3 | 190 | R | R | - | | Golden West High School (Visalia,CA) |
| 44 | 1300 | June-Reg | Tyler Fockler | | P | | | | | | | College | | Scotts Valley High School (Scotts Valley,CA) |
| 45 | 1329 | June-Reg | Lionel Roberts | | 1B | 22 | 6/24/1982 | 5-11 | 190 | R | R | Rookie | | John McDonogh High School (New Orleans,LA) |
| 46 | 1358 | June-Reg | Alec Sheppard | | P | 18 | 1/17/1986 | 6-3 | 190 | R | R | - | | Colorado Springs Christian School High School (Colorado Springs,CO) |
| 47 | 1387 | June-Reg | Rene Recio | | P | | | | | | | College | | Oral Roberts University |
| 48 | 1416 | June-Reg | Bernard Williams | | OF | | | | | | | College | | East Marion High School (Columbia,MS) |
| 49 | 1444 | June-Reg | Dominic De La Osa | | SS | 18 | 1/13/1986 | 5-11 | 205 | R | R | College | | Archbishop Carroll High School (Miami,FL) |
| 50 | 1472 | June-Reg | Maxwell Leon | | 2B | 20 | 6/28/1984 | 5-11 | 190 | B | R | AAA | | South Mountain Community College |
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