| 1 | 25 | June-Reg | Matt Cain | | P | 17 | 10/1/1984 | 6-3 | 180 | R | R | MLB | 2005-2008 | Houston High School (Germantown,TN) |
| 6 | 187 | June-Reg | Jesse English | | P | 17 | 9/13/1984 | 6-3 | 22 | L | L | A+ | | Rancho Buena Vista High School (Vista,CA) |
| 7 | 217 | June-Reg | Mike Musgrave | | P | 18 | 4/10/1984 | 6-2 | 185 | R | R | AA | | Ocala High School (Ocala,FL) |
| 10 | 307 | June-Reg | Glenn Woolard | | P | 21 | 4/18/1981 | 6-1 | 200 | R | R | AAA | | Kutztown University of Pennsylvania |
| 11 | 337 | June-Reg | Jake Wald | | 3B | 21 | 2/8/1981 | 6-2 | 180 | R | R | AAA | | George Washington University |
| 14 | 427 | June-Reg | Josh Habel | | P | 21 | 9/10/1980 | 6-1 | 185 | L | L | AA | | University of Northern Iowa |
| 15 | 457 | June-Reg | Matthew Dryer | | 3B | 22 | 11/12/1979 | 6-2 | 190 | R | R | AA | | University of Miami (Florida) |
| 17 | 517 | June-Reg | Luke Nelson | | P | 22 | 9/28/1979 | 6-2 | 180 | R | R | A- | | Southern Illinois University |
| 18 | 547 | June-Reg | Bryan Millikan | | P | 18 | 8/13/1983 | 6-5 | 190 | R | R | A | | Black Hills High School (Olympia,WA) |
| 19 | 577 | June-Reg | David Timm | | P | 18 | 9/28/1983 | 6-6 | 190 | L | L | AA | | Seminole Community College |
| 21 | 637 | June-Reg | Travis Ishikawa | | 1B | 18 | 9/24/1983 | 6-3 | 190 | L | L | MLB | 2006-2006 | Federal Way High School (Federal Way,WA) |
| 22 | 667 | June-Reg | Nelson Lopez | | P | 21 | 7/28/1980 | 6-2 | 205 | R | R | A | | Florida Atlantic University |
| 23 | 697** | June-Reg | Neil Walton | | H | 18 | 2/23/1984 | 6-5 | 180 | R | R | A+ | | Santa Cruz High School (Santa Cruz,CA) |
| 27 | 817 | June-Reg | Ryan McGovern | | P | 18 | 6/23/1984 | 6-1 | 185 | L | L | Rookie | | WJ Mouat SS (Abbotsford,Can) |
| 31 | 937 | June-Reg | Matt Palmer | | P | 23 | 3/21/1979 | 6-2 | 205 | R | R | AAA | | Southwest Missouri State University |
| 39 | 1177 | June-Reg | Anthony Moreno | | P | 18 | 5/4/1984 | 6-1 | 190 | R | R | AA | | South Mountain Community College |
| 42 | 1267 | June-Reg | Drew Jefferson | | P | 22 | 4/27/1980 | 5-9 | 185 | L | L | A- | | Southwest Missouri State University |
| 45 | 1351** | June-Reg | Matt Berezay | | OF | 18 | 11/15/1983 | 5-11 | 190 | B | R | AA | | Sierra Vista High School (Baldwin Park,CA) |
| 48 | 1430** | June-Reg | Dante Brinkley | | OF | 20 | 8/21/1981 | 5-10 | 170 | R | R | AAA | | Southwest Missouri State University |
| 49 | 1455** | June-Reg | Zach Borowiak | | SS | 21 | 5/18/1981 | 6-1 | 185 | R | R | AAA | | Southeast Missouri State University |
| 50 | 1479** | June-Reg | Robert Davis | | C | 18 | 12/31/1983 | 6-0 | 195 | R | R | A- | | Greenbrier High School (Evans,GA) |