| Year | Rnd | Ovl | Phase | Player | Drafting Team | Pos | HiLvl | Played | Src | Drafted From | SF | State | AB | 2B | 3B | HR | RBI | SB | BAVG | W | L | ERA | SV | IP | SO | GS |
| 2000 | 1 | 26 | June-Reg | Corey Smith | Cleveland Indians | IF | AAA | 2000-2012 | H | Piscataway (Piscataway,NJ) | SF | NJ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 1 | 37 | June-Reg | Derek Thompson | Cleveland Indians | P | MLB | 2000-2005 | H | Land O'Lakes (Land O'Lakes,FL) | SF | FL | 4 | 0 | 0 | 0 | 0 | 0 | .000 | 0 | 0 | 3.50 | 0 | 18 | 13 | 3 |
| 2000 | 2 | 55 | June-Reg | Brian Tallet | Cleveland Indians | P | MLB | 1997-2012 | C | Louisiana State University | SF | LA | 5 | 0 | 0 | 0 | 0 | 0 | .000 | 16 | 25 | 4.79 | 0 | 460 | 337 | 36 |
| 2000 | 2 | 66 | June-Reg | Mark Folsom | Cleveland Indians | RF | A | 2000-2002 | H | Winter Garden (Winter Garden,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 3 | 96 | June-Reg | Sean Swedlow | Cleveland Indians | 1B | A | 2000-2002 | H | San Dimas (San Dimas,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 126 | June-Reg | Adam Cox | Cleveland Indians | P | A+ | 2000-2009 | C | Darton College | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 5 | 156 | June-Reg | Rashad Eldridge | Cleveland Indians | OF | AAA | 2000-2010 | H | First Presbyterian Day Sc (Macon,GA) | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 6 | 186 | June-Reg | Kyle Evans | Cleveland Indians | P | AAA | 1998-2005 | C | Baylor University | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 7 | 216 | June-Reg | Victor Kleine | Cleveland Indians | P | AAA | 2000-2007 | C | John A. Logan College | SF | IL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 8 | 246 | June-Reg | Joe Inglett | Cleveland Indians | IF | MLB | 2000-2011 | C | University of Nevada | SF | NV | 808 | 36 | 17 | 6 | 77 | 19 | .283 | 0 | 0 | 0.00 | 0 | 1 | 0 | 0 |
| 2000 | 9 | 276 | June-Reg | Scott Tolbert ** | Cleveland Indians | P | NCAA | 2002-2003 | H | Madison County (Danielsville,GA) | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 10 | 306 | June-Reg | Tom Canale | Cleveland Indians | P | A | 2000-2001 | C | California Lutheran University | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 11 | 336 | June-Reg | Scott Threinen | Cleveland Indians | 3B | A- | 2001-2003 | H | Kasson-Mantorville (Mantorville,MN) | SF | MN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 12 | 366 | June-Reg | Jason Colson ** | Cleveland Indians | P | A+ | 2001-2009 | C | Winthrop University | SF | SC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 13 | 396 | June-Reg | Jeff Haase | Cleveland Indians | C | A+ | 2000-2002 | C | Cleveland State University | SF | OH | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 14 | 426 | June-Reg | Ryan Church | Cleveland Indians | OF | MLB | 2000-2010 | C | University of Nevada | SF | NV | 1894 | 134 | 7 | 56 | 267 | 21 | .264 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 15 | 456 | June-Reg | Nate Janowicz | Cleveland Indians | OF | A+ | 2000-2002 | C | University of South Carolina | SF | SC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 16 | 486 | June-Reg | Luke Field | Cleveland Indians | P | AA | 2000-2002 | C | Arizona State University | SF | AZ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 17 | 516 | June-Reg | Brandon Matheny | Cleveland Indians | P | AAA | 2000-2003 | C | Emory and Henry College | SF | VA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 18 | 546 | June-Reg | Jeremy Rogelstad ** | Cleveland Indians | P | A- | 1998-2003 | C | San Jose State University | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 19 | 576 | June-Reg | Chad Cislak | Cleveland Indians | P | RK | 1999-2001 | C | UCLA | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 20 | 606 | June-Reg | Ryan Larson | Cleveland Indians | P | AAA | 2000-2004 | C | Sacramento City College | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 21 | 636 | June-Reg | Steven Fugarino | Cleveland Indians | P | A- | 1997-2000 | C | Iona College | SF | NY | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 22 | 666 | June-Reg | Vince Pietro | Cleveland Indians | 3B | A- | 1999-2000 | C | Creighton University | SF | NE | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 23 | 696 | June-Reg | Brandon Harmsen ** | Cleveland Indians | P | A+ | 2002-2007 | H | Jenison (Jenison,MI) | SF | MI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 24 | 726 | June-Reg | Chris Houser | Cleveland Indians | 3B | Ind | 1999-2001 | C | University of Texas | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 25 | 756 | June-Reg | Andy Helmer | Cleveland Indians | NCAA | 1998-2000 | C | Purdue University | SF | IN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 26 | 786 | June-Reg | Rodney Choy Foo ** | Cleveland Indians | ss | AA | 2001-2007 | H | Kailua (Kailua,HI) | SF | HI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 27 | 816 | June-Reg | Johri Litman | Cleveland Indians | P | A- | 2000-2002 | C | Yavapai College | SF | AZ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 28 | 846 | June-Reg | Jeff Opalewski | Cleveland Indians | NCAA | 2002-2004 | H | Heritage (Saginaw,MI) | SF | MI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 29 | 876 | June-Reg | Jon Van Every | Cleveland Indians | OF | MLB | 2001-2011 | C | Itawamba Community College | SF | MS | 47 | 1 | 1 | 2 | 9 | 0 | .255 | 0 | 0 | 10.80 | 0 | 2 | 1 | 0 |
| 2000 | 30 | 906 | June-Reg | Brian Wilson ** | Cleveland Indians | P | MLB | 2002-2012 | H | Londonderry (Londonderry,NH) | SF | NH | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 31 | 936 | June-Reg | Conor Jackson ** | Cleveland Indians | 1B | MLB | 2001-2013 | H | El Camino Real (Woodland Hills,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 32 | 966 | June-Reg | Scott Thomas ** | Cleveland Indians | C | AAA | 2006-2012 | C | Lake Michigan College | SF | MI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 33 | 996 | June-Reg | Ashley Dunlap | Cleveland Indians | - | C | Palomar College | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | ||
| 2000 | 34 | 1026 | June-Reg | Steve Fitch | Cleveland Indians | P | AA | 2000-2003 | C | Kutztown University | SF | PA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 35 | 1056 | June-Reg | Willie McKenzie | Cleveland Indians | NCAA | 2002-2003 | C | Walters State Community College | SF | TN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 36 | 1086 | June-Reg | Jonathan Schultz | Cleveland Indians | P | - | H | Appleton East (Appleton,WI) | SF | WI | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 37 | 1116 | June-Reg | Damon Katz | Cleveland Indians | 2B | A+ | 1997-2001 | C | Pepperdine University | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 38 | 1146 | June-Reg | Robert Sierer | Cleveland Indians | P | - | C | Bluffton College | SF | OH | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 39 | 1176 | June-Reg | Curtis Ledbetter ** | Cleveland Indians | A+ | 2003-2007 | H | Lawrence (Lawrence,KS) | SF | KS | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 40 | 1205 | June-Reg | Jon Hooker | Cleveland Indians | RK | 2000-2005 | C | University of Kentucky | SF | KY | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 41 | 1234 | June-Reg | Eric Crozier | Cleveland Indians | IF | MLB | 2000-2010 | C | Norfolk State University | SF | VA | 33 | 2 | 0 | 2 | 4 | 0 | .152 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 42 | 1263 | June-Reg | Silas Ah Sui ** | Cleveland Indians | 3b | - | C | College of The Siskiyous | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 43 | 1291 | June-Reg | Ron Colvard | Cleveland Indians | A- | 1999-2003 | C | The Citadel | SF | SC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 44 | 1318 | June-Reg | Joe Little ** | Cleveland Indians | P | A+ | 2001-2005 | H | Arvada (Arvada,CO) | SF | CO | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 45 | 1344 | June-Reg | Mark Carroll | Cleveland Indians | A+ | 2001-2006 | H | Arcadia (Arcadia,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 2000 | 46 | 1368 | June-Reg | Chris Appuhn | Cleveland Indians | NCAA | 2003-2004 | H | Millard North (Omaha,NE) | SF | NE | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |