| Year | Rnd | Ovl | Phase | Player | Drafting Team | Pos | HiLvl | Played | Src | Drafted From | SF | State | AB | 2B | 3B | HR | RBI | SB | BAVG | W | L | ERA | SV | IP | SO | GS |
| 2000 | 4 | 101 | June-Reg | Anthony Brewer | Florida Marlins | OF | A | 2000-2003 | H | Simeon (Chicago,IL) | SF | IL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 102 | June-Reg | Jason Miller | Minnesota Twins | P | MLB | 2000-2008 | H | Sarasota (Sarasota,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | 0 | 0 | 18.00 | 0 | 4 | 2 | 0 |
| 2000 | 4 | 103 | June-Reg | Todd Wellemeyer | Chicago Cubs | P | MLB | 2000-2011 | C | Bellarmine University | SF | KY | 101 | 0 | 0 | 0 | 6 | 0 | .139 | 25 | 24 | 4.57 | 3 | 492 | 381 | 54 |
| 2000 | 4 | 104 | June-Reg | David DeJesus | Kansas City Royals | OF | MLB | 1998-2013 | C | Rutgers University | SF | NJ | 4303 | 235 | 58 | 80 | 486 | 58 | .281 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 105 | June-Reg | Cliff Lee | Montreal Expos | P | MLB | 2000-2013 | C | University of Arkansas | SF | AR | 207 | 6 | 0 | 2 | 12 | 2 | .164 | 125 | 78 | 3.59 | 0 | 1853 | 1530 | 280 |
| 2000 | 4 | 106 | June-Reg | Zach Miner | Atlanta Braves | P | MLB | 2001-2013 | H | Palm Beach Gardens (Palm Beach Gardens,FL) | SF | FL | 7 | 1 | 0 | 0 | 0 | 0 | .143 | 25 | 20 | 4.24 | 1 | 357 | 217 | 35 |
| 2000 | 4 | 107 | June-Reg | Cory Vance | Colorado Rockies | P | MLB | 2000-2004 | C | Georgia Tech | SF | GA | 8 | 1 | 0 | 0 | 0 | 0 | .250 | 1 | 3 | 5.74 | 0 | 31 | 13 | 4 |
| 2000 | 4 | 108 | June-Reg | Mark Woodyard | Detroit Tigers | P | MLB | 2000-2007 | C | Bethune-Cookman University | SF | FL | -- | -- | -- | -- | -- | -- | -- | 0 | 0 | 1.50 | 0 | 6 | 3 | 0 |
| 2000 | 4 | 109 | June-Reg | Mewelde Moore | San Diego Padres | OF | RK | 2001-2003 | H | Belaire (Baton Rouge,LA) | SF | LA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 110 | June-Reg | Charlie Thames | Anaheim Angels | P | AA | 1998-2002 | C | University of Texas | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 111 | June-Reg | Eric Henderson | Milwaukee Brewers | P | A+ | 2000-2004 | C | University of North Carolina | SF | NC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 112 | June-Reg | Alvin Jones | Chicago White Sox | P | RK | 2000-2002 | H | Seguin (Seguin,TX) | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 113 | June-Reg | Yadier Molina | St. Louis Cardinals | C | MLB | 2001-2013 | H | Maestro Ladi (Vega Alta,PR) | SF | PR | 3179 | 159 | 2 | 71 | 412 | 28 | .277 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 114 | June-Reg | Jon Skaggs ** | Baltimore Orioles | P | AA | 1998-2006 | C | Rice University | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 115 | June-Reg | Danny Gonzalez | Philadelphia Phillies | SS | AAA | 2001-2012 | H | Florida Air Academy (Melbourne,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 116 | June-Reg | Sam Hays | Seattle Mariners | P | A- | 2001-2003 | H | Waco (Waco,TX) | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 117 | June-Reg | Koyie Hill | Los Angeles Dodgers | C | MLB | 1998-2013 | C | Wichita State University | SF | KS | 872 | 41 | 4 | 8 | 76 | 3 | .210 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 118 | June-Reg | Raul Tablado | Toronto Blue Jays | IF | AA | 2000-2007 | H | Southridge (Miami,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 119 | June-Reg | Patrick Boyd ** | Pittsburgh Pirates | OF | AA | 1998-2004 | C | Clemson University | SF | SC | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 120 | June-Reg | Kevin McGerry | Oakland Athletics | P | A+ | 1998-2001 | C | St. John's University | SF | NY | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 121 | June-Reg | Ryan Hannaman | San Francisco Giants | P | A+ | 2000-2004 | H | Murphy (Mobile,AL) | SF | AL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 122 | June-Reg | Brandon Mims | Boston Red Sox | P | A- | 2000-2002 | H | Prattville (Prattville,AL) | SF | AL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 123 | June-Reg | Marc Kaiser ** | Cincinnati Reds | P | AAA | 2001-2010 | H | Reno (Reno,NV) | SF | NV | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 124 | June-Reg | Laynce Nix | Texas Rangers | OF | MLB | 2000-2013 | H | Midland (Midland,TX) | SF | TX | 1787 | 106 | 11 | 67 | 242 | 8 | .245 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 125 | June-Reg | Brandon Wilson | New York Mets | C | A+ | 2000-2006 | H | Christian Life Academy (Baton Rouge,LA) | SF | LA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 126 | June-Reg | Adam Cox | Cleveland Indians | P | A+ | 2000-2009 | C | Darton College | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 127 | June-Reg | Eric Keefner ** | Houston Astros | 1B | RK | 2001-2004 | H | De La Salle (Chicago,IL) | SF | IL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 128 | June-Reg | Matt Smith | New York Yankees | P | MLB | 1998-2008 | C | Oklahoma State University | SF | OK | -- | -- | -- | -- | -- | -- | -- | 0 | 1 | 2.55 | 0 | 25 | 22 | 0 |
| 2000 | 4 | 129 | June-Reg | Josh Kroeger | Arizona Diamondbacks | OF | MLB | 2000-2012 | H | Scripps Ranch (San Diego,CA) | SF | CA | 54 | 3 | 0 | 0 | 2 | 0 | .167 | -- | -- | -- | -- | -- | -- | -- |
| 2000 | 4 | 130 | June-Reg | Brian Montalbo ** | Atlanta Braves | P | A | 2001-2005 | H | Dimond (Anchorage,AK) | SF | AK | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |