| Year | Rnd | Ovl | Phase | Player | Drafting Team | Pos | HiLvl | Played | Src | Drafted From | SF | State | AB | 2B | 3B | HR | RBI | SB | BAVG | W | L | ERA | SV | IP | SO | GS |
| 1981 | 1 | 1 | June-Reg | Mike Moore | Seattle Mariners | P | MLB | 1981-1995 | C | Oral Roberts University | SF | OK | 1 | 0 | 0 | 0 | 0 | 0 | .000 | 161 | 176 | 4.39 | 2 | 2832 | 1667 | 440 |
| 1981 | 1 | 2 | June-Reg | Joe Carter | Chicago Cubs | OF | MLB | 1981-1998 | C | Wichita State University | SF | KS | 8422 | 432 | 53 | 396 | 1445 | 231 | .259 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 3 | June-Reg | Dick Schofield | California Angels | SS | MLB | 1981-1996 | H | Sacred Heart-Griffin (Springfield,IL) | SF | IL | 4299 | 137 | 32 | 56 | 353 | 120 | .230 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 4 | June-Reg | Terry Blocker | New York Mets | OF | MLB | 1981-1989 | C | Tennessee State University | SF | TN | 244 | 5 | 2 | 2 | 11 | 2 | .205 | 0 | 0 | 0.00 | 0 | 1 | 0 | 0 |
| 1981 | 1 | 5 | June-Reg | Matt Williams | Toronto Blue Jays | P | MLB | 1981-1986 | C | Rice University | SF | TX | -- | -- | -- | -- | -- | -- | -- | 3 | 2 | 5.29 | 0 | 34 | 27 | 6 |
| 1981 | 1 | 6 | June-Reg | Kevin McReynolds | San Diego Padres | OF | MLB | 1982-1994 | C | University of Arkansas | SF | AR | 5423 | 284 | 35 | 211 | 807 | 93 | .265 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 7 | June-Reg | Daryl Boston | Chicago White Sox | P-OF | MLB | 1981-1996 | H | Woodward (Cincinnati,OH) | SF | OH | 2629 | 131 | 22 | 83 | 278 | 98 | .249 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 8 | June-Reg | Bob Meacham | St. Louis Cardinals | SS | MLB | 1981-1990 | C | San Diego State University | SF | CA | 1371 | 58 | 8 | 8 | 114 | 58 | .236 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 9 | June-Reg | Ron Darling | Texas Rangers | P | MLB | 1981-1995 | C | Yale University | SF | CT | 526 | 21 | 2 | 2 | 21 | 1 | .144 | 136 | 116 | 3.87 | 0 | 2360 | 1590 | 364 |
| 1981 | 1 | 10 | June-Reg | Mark Grant | San Francisco Giants | P | MLB | 1981-1995 | H | Catholic Academy (Joliet,IL) | SF | IL | 104 | 0 | 0 | 0 | 2 | 0 | .067 | 22 | 32 | 4.31 | 8 | 639 | 382 | 58 |
| 1981 | 1 | 11 | June-Reg | Mike Sodders | Minnesota Twins | 3B | AAA | 1981-1984 | C | Arizona State University | SF | AZ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 12 | June-Reg | Jay Roberts | Atlanta Braves | OF-P | A | 1981-1984 | H | Centralia (Centralia,WA) | SF | WA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 13 | June-Reg | George Alpert | Cleveland Indians | OF | A | 1981-1983 | H | Livingston (Livingston,NJ) | SF | NJ | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 14 | June-Reg | Jim Winn | Pittsburgh Pirates | P | MLB | 1981-1988 | C | John Brown University | SF | AR | 35 | 2 | 0 | 0 | 0 | 0 | .086 | 12 | 17 | 4.67 | 10 | 308 | 159 | 10 |
| 1981 | 1 | 15 | June-Reg | Tim Pyznarski | Oakland Athletics | 3B-OF | MLB | 1981-1989 | C | Eastern Illinois University | SF | IL | 42 | 1 | 0 | 0 | 0 | 2 | .238 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 16 | June-Reg | Vance Lovelace | Chicago Cubs | P | MLB | 1981-1998 | H | Hillsborough (Tampa,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | 0 | 0 | 5.79 | 0 | 5 | 2 | 0 |
| 1981 | 1 | 17 | June-Reg | Ricky Barlow | Detroit Tigers | P | AAA | 1981-1987 | H | Woodville (Woodville,TX) | SF | TX | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 18 | June-Reg | Darren Dilks | Montreal Expos | P | AAA | 1981-1984 | C | Oklahoma State University | SF | OK | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 19 | June-Reg | Steve Lyons | Boston Red Sox | SS-OF | MLB | 1981-1993 | C | Oregon State University | SF | OR | 2162 | 100 | 17 | 19 | 196 | 42 | .252 | 0 | 0 | 3.00 | 0 | 3 | 2 | 0 |
| 1981 | 1 | 20 | June-Reg | Johnny Abrego | Philadelphia Phillies | P | MLB | 1981-1987 | H | Mission San Jose (Fremont,CA) | SF | CA | 9 | 0 | 0 | 0 | 1 | 0 | .000 | 1 | 1 | 6.37 | 0 | 24 | 13 | 5 |
| 1981 | 1 | 21 | June-Reg | John Cerutti | Toronto Blue Jays | P | MLB | 1981-1995 | C | Amherst College | SF | MA | -- | -- | -- | -- | -- | -- | -- | 49 | 43 | 3.94 | 4 | 861 | 398 | 116 |
| 1981 | 1 | 22 | June-Reg | Dave Anderson | Los Angeles Dodgers | SS | MLB | 1981-1992 | C | University of Memphis | SF | TN | 2026 | 73 | 12 | 19 | 143 | 49 | .242 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 23 | June-Reg | Dave Leeper | Kansas City Royals | OF | MLB | 1980-1988 | C | USC | SF | CA | 40 | 0 | 0 | 0 | 4 | 0 | .075 | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 24 | June-Reg | Al Lachowicz | Texas Rangers | P | MLB | 1981-1986 | C | University of Pittsburgh | SF | PA | -- | -- | -- | -- | -- | -- | -- | 0 | 1 | 2.25 | 0 | 8 | 8 | 1 |
| 1981 | 1 | 25 | June-Reg | Kevin Burrell | Boston Red Sox | OF | AAA | 1981-1991 | H | Poway (Poway,CA) | SF | CA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1981 | 1 | 26 | June-Reg | Frank Castro | San Diego Padres | C | AA | 1981-1986 | C | University of Miami | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |