| Year | Rnd | Ovl | Phase | Player | Drafting Team | Pos | HiLvl | Played | Src | Drafted From | SF | State | AB | 2B | 3B | HR | RBI | SB | BAVG | W | L | ERA | SV | IP | SO | GS |
| 1980 | 1 | 1 | June-Reg | Darryl Strawberry | New York Mets | OF | MLB | 1980-1999 | H | Crenshaw (Los Angeles,CA) | SF | CA | 5418 | 256 | 38 | 335 | 1000 | 221 | .259 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 2 | June-Reg | Garry Harris | Toronto Blue Jays | SS | AA | 1980-1983 | H | Hoover (San Diego,CA) | SF | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | |
| 1980 | 1 | 3 | June-Reg | Ken Dayley | Atlanta Braves | P | MLB | 1980-1993 | C | University of Portland | SF | OR | 81 | 0 | 0 | 0 | 2 | 0 | .210 | 33 | 45 | 3.64 | 39 | 574 | 406 | 33 |
| 1980 | 1 | 4 | June-Reg | Mike King | Oakland Athletics | P | AAA | 1980-1984 | C | Morningside College | SF | IA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 5 | June-Reg | Jeff Pyburn | San Diego Padres | OF | AAA | 1979-1982 | C | University of Georgia | SF | GA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 6 | June-Reg | Darnell Coles | Seattle Mariners | SS | MLB | 1980-1997 | H | Eisenhower (Rialto,CA) | SF | CA | 2891 | 142 | 14 | 75 | 368 | 20 | .245 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 7 | June-Reg | Jessie Reid | San Francisco Giants | 1B | MLB | 1980-1989 | H | Lynwood (Lynwood,CA) | SF | CA | 10 | 0 | 0 | 1 | 1 | 0 | .100 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 8 | June-Reg | Cecil Espy | Chicago White Sox | OF | MLB | 1980-1994 | H | Point Loma (San Diego,CA) | SF | CA | 1248 | 43 | 16 | 7 | 108 | 103 | .244 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 9 | June-Reg | Ross Jones | Los Angeles Dodgers | SS | MLB | 1980-1989 | C | University of Miami | SF | FL | 145 | 5 | 2 | 0 | 11 | 1 | .221 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 10 | June-Reg | Kelly Gruber | Cleveland Indians | SS | MLB | 1980-1997 | H | Westlake (Austin,TX) | SF | TX | 3159 | 148 | 24 | 117 | 443 | 80 | .259 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 11 | June-Reg | Don Schulze | Chicago Cubs | P | MLB | 1980-1993 | H | Lake Park (Roselle,IL) | SF | IL | 7 | 0 | 0 | 0 | 1 | 0 | .000 | 15 | 25 | 5.47 | 0 | 339 | 144 | 59 |
| 1980 | 1 | 12 | June-Reg | Jeff Reed | Minnesota Twins | C | MLB | 1980-2001 | H | Joliet West (Joliet,IL) | SF | IL | 3101 | 144 | 10 | 61 | 323 | 7 | .250 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 13 | June-Reg | Lebo Powell | Philadelphia Phillies | C | A | 1980-1982 | H | Pine Forest (Pensacola,FL) | SF | FL | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 14 | June-Reg | Tim Maki | Texas Rangers | P | A+ | 1980-1984 | H | Carroll (Fort Wayne,IN) | SF | IN | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 15 | June-Reg | Don Collins | St. Louis Cardinals | P | A+ | 1980-1983 | H | Ferguson (Newport News,VA) | SF | VA | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 16 | June-Reg | Frank Wills | Kansas City Royals | P | MLB | 1980-1991 | C | Tulane University | SF | LA | -- | -- | -- | -- | -- | -- | -- | 22 | 26 | 5.06 | 6 | 436 | 281 | 35 |
| 1980 | 1 | 17 | June-Reg | Dennis Rasmussen | California Angels | P | MLB | 1980-1995 | C | Creighton University | SF | NE | 259 | 8 | 0 | 0 | 14 | 0 | .193 | 91 | 77 | 4.15 | 0 | 1461 | 835 | 235 |
| 1980 | 1 | 18 | June-Reg | Glenn Wilson | Detroit Tigers | 3B | MLB | 1980-1993 | C | Sam Houston State University | SF | TX | 4151 | 209 | 26 | 98 | 521 | 27 | .265 | 0 | 0 | 0.00 | 0 | 1 | 1 | 0 |
| 1980 | 1 | 19 | June-Reg | Ron Robinson | Cincinnati Reds | P | MLB | 1980-1992 | H | Woodlake Union (Woodlake,CA) | SF | CA | 144 | 2 | 0 | 0 | 6 | 0 | .153 | 48 | 39 | 3.63 | 19 | 800 | 473 | 102 |
| 1980 | 1 | 20 | June-Reg | Rich Renteria | Pittsburgh Pirates | SS | MLB | 1980-1994 | H | South Gate (South Gate,CA) | SF | CA | 422 | 20 | 2 | 4 | 41 | 2 | .237 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 21 | June-Reg | Jim Acker | Atlanta Braves | P | MLB | 1980-1993 | C | University of Texas | SF | TX | 54 | 1 | 0 | 0 | 1 | 0 | .167 | 33 | 49 | 3.97 | 30 | 904 | 482 | 32 |
| 1980 | 1 | 22 | June-Reg | Terry Francona | Montreal Expos | OF | MLB | 1980-1990 | C | University of Arizona | SF | AZ | 1731 | 74 | 6 | 16 | 143 | 12 | .274 | 0 | 0 | 0.00 | 0 | 1 | 1 | 0 |
| 1980 | 1 | 23 | June-Reg | Billy Beane | New York Mets | P | MLB | 1980-1989 | H | Mount Carmel (San Diego,CA) | SF | CA | 301 | 14 | 0 | 3 | 29 | 5 | .219 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 24 | June-Reg | John Gibbons | New York Mets | OF | MLB | 1984-1990 | H | MacArthur (San Antonio,TX) | SF | TX | 50 | 4 | 0 | 1 | 2 | 0 | .220 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 25 | June-Reg | Dion James | Milwaukee Brewers | OF | MLB | 1980-1996 | H | McClatchy (Sacramento,CA) | SF | CA | 2708 | 142 | 21 | 32 | 266 | 43 | .288 | -- | -- | -- | -- | -- | -- | -- |
| 1980 | 1 | 26 | June-Reg | Jeff Williams | Baltimore Orioles | OF | AAA | 1980-1989 | H | Princeton (Cincinnati,OH) | SF | OH | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |