| 346. | Andrew Albers | P | MIL | 18 | 10/6/1985 | 6-1 | 195 | L-L | College | | John Paul II High School (North Battleford,SK) | 1 |
| 347. | Jordan Chambless | P | CLE | 19 | 3/7/1985 | 6-1 | 205 | R-R | College | | Calallen High School (Corpus Christi,TX) | 7 |
| 350. | David Patton | P | COL | 20 | 5/18/1984 | 6-3 | 175 | R-R | A+ | | Green River Community College | 33 |
| 351. | Kevin Ardoin | P | TEX | 21 | 8/6/1982 | 6-1 | 167 | R-R | AA | | University of Louisiana-Lafayette | 68 |
| 352. | J.P. Padron | 3B | PIT | 18 | 2/14/1986 | 6-1 | 220 | R-R | College | | Clear Creek High School (League City,TX) | 8 |
| 353. | Tyler Johnson | OF | ANA | 18 | 11/2/1985 | 6-2 | 218 | R-R | A | | Haskell High School (Haskell,OK) | 3 |
| 354. | Robert Mosebach | OF | MTL | 19 | 9/14/1984 | 6-4 | 195 | R-R | AA | | Hillsborough Community College | 58 |
| 355. | Brad Hayes | 3B | KC | 22 | 3/26/1982 | 6-0 | 180 | R-R | Rookie | | Arkansas State University | 29 |
| 360. | Mark Worrell | P | STL | 21 | 3/8/1983 | 6-1 | 190 | R-R | MLB | 2008-2008 | Florida International University | 98 |
| 364. | Bryan Triplett | SS | HOU | 22 | 4/16/1982 | 6-0 | 185 | R-R | A+ | | University of South Carolina | 116 |
| 366. | Sean Gallagher | P | CHC | 18 | 12/30/1985 | 6-1 | 210 | R-R | MLB | 2007-2008 | St. Thomas Aquinas High School (Fort Lauderdale,FL) | 19 |
| 368. | Jeff Gogal | P | FLA | 22 | 6/10/1982 | 6-2 | 195 | R-L | AA | | Montclair State University | 33 |
| 369. | Rod Allen | OF | NYY | 21 | 9/21/1982 | 6-2 | 200 | R-R | A+ | | Oklahoma State University | 174 |
| 370. | Kevin Frandsen | 2B | SF | 22 | 5/24/1982 | 6-0 | 175 | R-R | MLB | 2006-2007 | San Jose State University | 79 |