| 1 | 15 | June-Reg | Stephen Drew | SS | 21 | 6-1 | 195 | L | R | MLB | 2006-2009 | Florida State University | $4,000,000 |
| 2 | 56 | June-Reg | Jon Zeringue | OF | 21 | 6-2 | 215 | R | R | AA | | Louisiana State University | $630,000 |
| 3 | 86 | June-Reg | Garrett Mock | P | 21 | 6-4 | 215 | R | R | MLB | 2008-2009 | University of Houston | $440,000 |
| 4 | 116 | June-Reg | Ross Ohlendorf | P | 21 | 6-4 | 235 | R | R | MLB | 2007-2009 | Princeton University | $280,000 |
| 5 | 146 | June-Reg | Cesar Nicolas | 1B | 22 | 6-4 | 230 | R | R | AA | | Vanderbilt University | $60,000 |
| 6 | 176 | June-Reg | Brandon Burgess | OF | 21 | 6-3 | 210 | B | R | AA | | Sonoma State University | $140,000 |
| 7 | 206 | June-Reg | Koley Kolberg | P | 21 | 6-1 | 176 | R | R | A | | University of Arizona | $90,000 |
| 8 | 236** | June-Reg | Jimmy Shull | P | 20 | 6-2 | 185 | R | R | A+ | | Cal Poly | |
| 9 | 266 | June-Reg | A.J. Shappi | P | 21 | 6-2 | 200 | R | R | AAA | | University of California-Riverside | $65,000 |
| 10 | 296 | June-Reg | Steven Jackson | P | 22 | 6-5 | 215 | R | R | MLB | 2009-2009 | Clemson University | $15,000 |
| 11 | 326 | June-Reg | Darryl Lawhorn | OF | 21 | 6-2 | 180 | L | R | A+ | | East Carolina University | |
| 12 | 356 | June-Reg | Richard Mercado | C | 21 | 6-0 | 220 | R | R | AAA | | University of Arizona | |
| 13 | 386 | June-Reg | Antoan Richardson | OF | 20 | 5-8 | 165 | B | R | AA | | Vanderbilt University | |
| 14 | 416 | June-Reg | Lester Contreras | SS | 19 | 5-11 | 190 | R | R | A- | | St. Petersburg College | |
| 15 | 446 | June-Reg | Dan Pohlman | C | 22 | 6-2 | 212 | R | R | A+ | | Northwestern University | |
| 16 | 476 | June-Reg | Mark Reynolds | SS | 20 | 6-1 | 200 | R | R | MLB | 2007-2009 | University of Virginia | |
| 17 | 506 | June-Reg | Chris Carter | 1B-OF | 21 | 6-0 | 225 | L | L | MLB | 2008-2009 | Stanford University | |
| 18 | 536 | June-Reg | Vince Davis | P | 21 | 6-6 | 245 | R | L | Ind | | Southern University | |
| 19 | 566 | June-Reg | Derek Bruce | SS | 21 | 6-1 | 174 | R | R | A+ | | Lewis-Clark State College | |
| 20 | 596 | June-Reg | Edwin Roman | OF | 19 | 5-10 | 215 | B | R | A- | | Princeton (Princeton,IN) | |
| 21 | 626 | June-Reg | Chris Thompson | P | 22 | 6-3 | 195 | R | R | AAA | | University of Mississippi | |
| 22 | 656 | June-Reg | Luis Lajara | OF | 19 | 6-1 | 180 | L | L | A- | | | |
| 23 | 686 | June-Reg | Travis Gulick | OF | 21 | 6-3 | 215 | R | R | A | | Michigan State University | |
| 24 | 716 | June-Reg | Trey Hendricks | 1B | 21 | 6-4 | 210 | B | R | A | | Harvard University | |
| 25 | 746 | June-Reg | Todd Stein | P | 23 | 6-0 | 190 | L | L | A | | Illinois State University | |
| 26 | 776 | June-Reg | Erik Schindewolf | 2B | 22 | 5-11 | 180 | L | R | A+ | | Texas A&M University | |
| 27 | 806 | June-Reg | Garrett Bauer | P | 22 | 6-0 | 163 | R | L | A- | | Missouri Baptist University | |
| 28 | 836 | June-Reg | Ramon Downing | 2B | 20 | 5-10 | 187 | B | R | A+ | | Wabash Valley College | |
| 29 | 866 | June-Reg | Chris Bowen | P | | 6-5 | 195 | L | L | College | | University of Maryland | |
| 30 | 896 | June-Reg | Kevin Williams | OF | 22 | 6-0 | 175 | R | R | A- | | University of South Alabama | |
| 31 | 926 | June-Reg | Marcus Townsend | OF | 22 | 6-4 | 210 | R | R | Rookie | | Southern University | |
| 32 | 956 | June-Reg | Josh Buhagiar | OF | 23 | 6-1 | 180 | L | L | A | | Long Beach State University | |
| 33 | 986** | June-Reg | Joseph Campbell | 3B | | | | | | - | | Fremd (Palatine,IL) | |
| 34 | 1016** | June-Reg | David Hernandez | P | 19 | 6-3 | 215 | R | R | MLB | 2009-2009 | Cosumnes River College | $0 |
| 35 | 1046 | June-Reg | Jo Jo Batten | 2B | 19 | 5-10 | 175 | R | R | A+ | | Middle Georgia College | |
| 36 | 1076** | June-Reg | Craig Heyer | P | 18 | 6-3 | 195 | R | R | A+ | | Coronado (Scottsdale,AZ) | |
| 37 | 1106 | June-Reg | Billy Lockin | SS | 21 | 5-8 | 155 | R | R | A | | Loyola Marymount University | |
| 38 | 1136 | June-Reg | Lorenzo Church | P | 17 | 5-11 | 180 | R | R | A- | | Mission Bay (San Diego,CA) | |
| 39 | 1166 | June-Reg | Michael Jarman | P | 19 | 6-1 | 190 | L | L | A | | Edmond North (Edmond,OK) | |
| 40 | 1196** | June-Reg | Ulrich Snijders | C | 17 | 6-1 | 210 | R | R | A | | Trinity Christian Academy (Lake Worth,FL) | |
| 41 | 1226 | June-Reg | Frank Curreri | C | 21 | 6-4 | 215 | L | R | AAA | | University of Massachusetts | |
| 42 | 1255 | June-Reg | Brandon Pullen | P | 18 | 6-4 | 220 | L | L | A+ | | Idaho Falls (Idaho Falls,ID) | |
| 43 | 1284 | June-Reg | Brandon White | 3B | | | | | | - | | Surry Community College | |
| 44 | 1313 | June-Reg | Adam Howard | P | 20 | 6-4 | 200 | R | R | AAA | | Walters State Community College | |
| 45 | 1342 | June-Reg | Ryan McKibben | P | 18 | | | | | College | | Aliso Niguel (Aliso Viejo,CA) | |
| 46 | 1371 | June-Reg | Ryan Castellanos | 3B | 19 | 6-1 | 210 | R | R | College | | College of Southern Nevada | |
| 47 | 1400 | June-Reg | Eduardo Baeza | P | 19 | 6-0 | 180 | R | R | A+ | | Mission College | |
| 48 | 1429 | June-Reg | Ryan Mooradian | P | | | | | | - | | Essex County College | |
| 49 | 1457 | June-Reg | Carlos Soto | OF | | | | | | - | | Wabash Valley College | |
| 50 | 1485 | June-Reg | Kyler Newby | P | 19 | 6-4 | 225 | R | R | AA | | Mesa Community College | |