| 2 | 64 | June-Reg | Hunter Pence | OF | 21 | 6-4 | 210 | R | R | MLB | 2007-2009 | University of Texas-Arlington | $575,000 |
| 3 | 94 | June-Reg | Jordan Parraz | OF | 19 | 6-3 | 190 | R | R | AAA | | College of Southern Nevada | $400,000 |
| 4 | 124 | June-Reg | Lou Santangelo | C | 21 | 6-1 | 200 | R | R | AAA | | Clemson University | $260,000 |
| 5 | 154 | June-Reg | Mitch Einertson | 2B | 18 | 5-10 | 180 | R | R | AA | | Rancho Buena Vista (Vista,CA) | $170,000 |
| 6 | 184 | June-Reg | Ben Zobrist | 2B | 23 | 6-3 | 200 | B | R | MLB | 2006-2009 | Dallas Baptist University | $55,000 |
| 7 | 214 | June-Reg | Andrew Alvarado | P | 21 | 6-2 | 205 | R | R | A | | Chabot College | $100,000 |
| 8 | 244 | June-Reg | Evan Englebrook | P | 22 | 6-8 | 225 | R | R | AAA | | Shippensburg University of Pennsylvania | $35,000 |
| 9 | 274 | June-Reg | Troy Patton | P | 18 | 6-1 | 185 | B | L | MLB | 2007-2007 | Tomball (Tomball,TX) | $550,000 |
| 10 | 304 | June-Reg | Eric Cavers | C | 21 | 6-1 | 205 | R | R | A | | Franklin Pierce University | $52,000 |
| 11 | 334 | June-Reg | Jonny Ash | 2B | 21 | 5-9 | 180 | L | R | AAA | | Stanford University | |
| 12 | 364 | June-Reg | Bryan Triplett | SS | 22 | 6-0 | 185 | R | R | A+ | | University of South Carolina | |
| 13 | 394 | June-Reg | Chad Reineke | P | 22 | 6-6 | 210 | R | R | MLB | 2008-2009 | Miami University | |
| 14 | 424 | June-Reg | Ole Sheldon | 1B | 21 | 6-4 | 210 | R | R | AA | | University of Oklahoma | |
| 15 | 454 | June-Reg | Drew Sutton | OF | 21 | 6-3 | 185 | B | R | MLB | 2009-2009 | Baylor University | |
| 16 | 484 | June-Reg | Garrett Murdy | P | 21 | 6-4 | 215 | R | R | A | | Texas A&M University-Kingsville | |
| 17 | 514 | June-Reg | Beau Torbert | OF | 21 | 6-4 | 205 | R | R | AAA | | Faulkner State Community College | |
| 18 | 544 | June-Reg | Chris Clark | C | | | | | | College | | Eastern Kentucky University | |
| 19 | 574 | June-Reg | Jared Clark | P | 18 | 6-4 | 215 | R | R | Rookie | | Valencia (Valencia,CA) | |
| 20 | 604 | June-Reg | J.R. Towles | C | 20 | 6-2 | 190 | R | R | MLB | 2007-2009 | North Central Texas College | |
| 21 | 634 | June-Reg | Ryan Reed | OF | 20 | 6-4 | 210 | L | L | A+ | | Louisiana State University-Eunice | |
| 22 | 664 | June-Reg | Matt Brown | P | 21 | 6-5 | 235 | R | R | College | | University of California | |
| 23 | 694 | June-Reg | Jeff Wigdahl | P | 22 | 6-0 | 200 | L | L | AA | | St. Mary's University | |
| 24 | 724 | June-Reg | Brandon Averill | 3B | 22 | 6-4 | 200 | R | R | A- | | UCLA | |
| 25 | 754** | June-Reg | Andrew Darnell | OF | 17 | 6-1 | 215 | R | R | A | | Castro Valley (Castro Valley,CA) | |
| 26 | 784 | June-Reg | Jared Brite | P | 22 | 6-2 | 205 | R | R | College | | Kansas State University | |
| 27 | 814 | June-Reg | Casey Brown | P | 22 | 6-0 | 220 | R | R | A- | | University of Oklahoma | |
| 28 | 844 | June-Reg | Chris Sotro | P | 23 | 6-1 | 205 | R | R | Rookie | | Cal Poly Pomona | |
| 29 | 874 | June-Reg | Brad James | P | 20 | 6-2 | 200 | R | R | AA | | North Central Texas College | |
| 30 | 904 | June-Reg | Luke Barganier | OF | 21 | 6-1 | 185 | L | R | A | | Temple College | |
| 31 | 934 | June-Reg | Chris Uhle | SS | 21 | 5-10 | 180 | R | R | Rookie | | Eastern Illinois University | |
| 32 | 964 | June-Reg | Neil Sellers | 3B | 22 | 6-0 | 195 | R | R | AA | | Eastern Kentucky University | |
| 33 | 994 | June-Reg | James Cooper | OF | 22 | 6-3 | 185 | R | R | A- | | Grambling State University | |
| 34 | 1024** | June-Reg | Nick Cobler | P | 17 | 6-4 | 190 | L | L | - | | Strake Jesuit (Houston,TX) | |
| 35 | 1054 | June-Reg | Kyle Woodruff | P | 18 | 6-6 | 230 | R | R | A | | Leland (San Jose,CA) | |
| 36 | 1084 | June-Reg | Anthony DeWitt | P | 22 | 6-0 | 225 | R | R | A+ | | University of Southern Mississippi | |
| 37 | 1114 | June-Reg | Brad Chedister | P | | | | | | Rookie | | Louisiana Tech University | |
| 38 | 1144 | June-Reg | Brandon Todd | P | 19 | 6-2 | 205 | R | R | A | | Central Florida Community College | |
| 39 | 1174** | June-Reg | Zachary Williams | P | | | | | | - | | Lindsay (Lindsay,OK) | |
| 40 | 1204** | June-Reg | Dane Ponciano | C | | | | | | - | | Mount Miguel (Spring Valley,CA) | |
| 41 | 1234** | June-Reg | Casey McCleskey | OF | | | | | | - | | Burkburnett (Burkburnett,TX) | |
| 42 | 1263 | June-Reg | Josh Smith | P | 21 | 6-5 | 220 | R | R | - | | Riverside Community College | |
| 43 | 1292 | June-Reg | Tom Rafferty | OF | 19 | 6-1 | 175 | R | R | A+ | | Temple College | |
| 44 | 1321 | June-Reg | Vladimir Frias | SS | 17 | 6-2 | 170 | B | R | AAA | | Chipola College | |
| 45 | 1350** | June-Reg | Chris Siewert | SS | 19 | 6-0 | 200 | R | R | College | | College of Southern Nevada | |
| 46 | 1379 | June-Reg | Tony Adler | P | 24 | 6-3 | 196 | R | R | Rookie | | University of Texas-Dallas | |
| 47 | 1408 | June-Reg | Corey Bass | P | 19 | 6-3 | 210 | R | R | A+ | | Pearl River Community College | |
| 48 | 1436 | June-Reg | Eric Epperson | OF | | | | | | College | | Arlington Heights (Fort Worth,TX) | |
| 49 | 1464** | June-Reg | Matt Gardner | C | 19 | 6-2 | 230 | R | R | College | | Andrews (Andrews,TX) | |
| 50 | 1492** | June-Reg | Victor Ferrante | P | 19 | 6-3 | 225 | R | R | A+ | | Solano Community College | |