| 218. | Matthew Maniscalco | SS | TB | 22 | 2/18/1981 | 5-10 | 184 | R-R | AAA | | Mississippi State University | 121 |
| 219. | Ryan Marion | P | MIL | 18 | 9/23/1984 | 6-1 | 200 | R-R | A | | Glenn High School (Kernersville,NC) | 4 |
| 220. | Adam Trent | P | DET | 18 | 2/28/1985 | 6-5 | 180 | R-R | - | | Ooltewah High School (Ooltewah,TN) | 2 |
| 222. | Brandon Powell | 2B | KC | 22 | 8/15/1980 | 6-0 | 185 | L-R | AA | | Coastal Carolina University | 32 |
| 224. | Nathan Nery | P | BAL | 17 | 8/25/1985 | 6-4 | 212 | R-L | A- | | Moon Area High School (Coraopolis,PA) | 3 |
| 225. | Sergio Silva | P | PIT | 21 | 12/22/1981 | 6-4 | 205 | R-R | A | | University of the Pacific | 46 |
| 226. | Jeremy Cleveland | OF | TEX | 21 | 9/10/1981 | 6-3 | 185 | R-R | AA | | University of North Carolina | 125 |
| 227. | Darric Merrell | P | COL | 21 | 1/22/1982 | 6-4 | 210 | R-R | A+ | | California State University, Fullerton | 198 |
| 228. | Bo Ashabraner | P | CLE | 22 | 2/19/1981 | 6-7 | 230 | R-R | A | | Long Beach State University | 130 |
| 233. | Tanner Rogers | C | FLA | 18 | 1/11/1985 | 6-0 | 180 | R-R | AAA | | Columbine High School (Littleton,CO) | 7 |
| 237. | Daryl Thompson | P | MTL | 17 | 11/2/1985 | 6-1 | 170 | R-R | AAA | | La Plata High School (La Plata,MD) | 1 |
| 239. | Mike Collar | P | HOU | 21 | 10/16/1981 | 6-3 | 215 | R-R | A | | University of Maine-Orono | 58 |
| 241. | Lucas May | 3B | LA | 18 | 10/24/1984 | 6-0 | 190 | R-R | AA | | Parkway West High School (Ballwin,MO) | 5 |
| 243. | Tim Hutting | SS | SF | 21 | 10/29/1981 | 6-0 | 190 | R-R | AAA | | Long Beach State University | 131 |