| 399. | Garrett Bussiere | C | MIL | 17 | 8/28/1985 | 6-3 | 178 | R-R | Rookie | | Northglenn High School (Northglenn,CO) | 4 |
| 401. | Steve Gendron | SS | SD | 21 | 11/25/1981 | 6-3 | 199 | R-R | AAA | | Mississippi State University | 123 |
| 404. | Brian Bock | C | BAL | 21 | 8/24/1981 | 6-0 | 205 | R-R | AAA | | University of Hawaii-Manoa | 73 |
| 405. | Jacob Cuffman | P | PIT | 18 | 3/3/1985 | 6-4 | 190 | R-R | A+ | | Butler High School (Butler,PA) | 3 |
| 410. | Jeremy Harper | P | TOR | 22 | 10/31/1980 | 6-2 | 190 | R-R | A+ | | Virginia Military Institute | 11 |
| 412. | Ricardo Nanita | OF | CHW | 22 | 6/12/1981 | 6-0 | 195 | L-L | AA | | Florida International University | 94 |
| 414. | Zach Borowiak | SS | BOS | 22 | 5/18/1981 | 6-1 | 185 | R-R | AAA | | Southeast Missouri State University | 19 |
| 416. | Tim Dorn | P | SEA | 20 | 12/30/1982 | 6-8 | 245 | R-R | A | | East Los Angeles Junior College | 39 |
| 423. | Sean Martin | P | SF | 23 | 3/27/1980 | 6-1 | 190 | R-R | A+ | | California State University, Fullerton | 200 |
| 425. | Ian Kennedy | P | STL | 18 | 12/19/1984 | 5-11 | 185 | R-R | MLB | 2007-2008 | La Quinta High School (Westminster,CA) | 14 |
| 427. | Steve Doetsch | OF | ATL | 19 | 12/2/1983 | 6-2 | 185 | R-R | A+ | | Indian River Community College | 147 |