| 368. | Chad Orvella | P | TB | 22 | 10/1/1980 | 5-11 | 180 | R-R | MLB | 2005-2007 | North Carolina State University | 83 |
| 370. | Michael Brown | OF | DET | 22 | 11/25/1980 | 6-0 | 195 | R-R | College | | College of William and Mary | 16 |
| 373. | Ryan Coultas | SS | CHC | 21 | 4/24/1982 | 6-3 | 180 | R-R | AA | | University of California, Davis | 22 |
| 375. | Lee Land | P | PIT | 18 | 8/7/1984 | 6-2 | 220 | R-R | A- | | Riverside High School (Durham,NC) | 2 |
| 376. | Emerson Frostad | 3B | TEX | 20 | 1/13/1983 | 6-1 | 210 | L-R | AA | | Lewis-Clark State College | 79 |
| 377. | Matt Brinson | 1B | COL | 22 | 9/9/1980 | 6-5 | 225 | L-L | A- | | Mississippi State University | 122 |
| 378. | Steven Reinhold | 2B | CLE | 18 | 3/2/1985 | 5-8 | 175 | R-R | College | | Tuscola High School (Waynesville,NC) | 1 |
| 379. | Carlos Muniz | P | NYM | 22 | 3/12/1981 | 6-0 | 180 | R-R | MLB | 2007-2008 | Long Beach State University | 133 |
| 381. | Matt Gray | OF | CIN | 19 | 4/18/1984 | 6-2 | 205 | L-L | A | | Butler County Community College | 21 |
| 383. | Chris Pillsbury | P | FLA | 21 | 10/13/1981 | 6-3 | 190 | R-R | A | | Florida Atlantic University | 41 |
| 386. | Shawn Nottingham | P | SEA | 18 | 1/22/1985 | 6-0 | 180 | L-L | AAA | | Jackson High School (Jackson,OH) | 2 |
| 387. | Brad Ditter | 2B | MTL | 22 | 7/22/1980 | 6-0 | 180 | L-R | AA | | New Mexico State University | 48 |
| 389. | Jimmy Barthmaier | P | HOU | 19 | 1/6/1984 | 6-4 | 200 | R-R | AAA | | Roswell High School (Roswell,GA) | 9 |
| 391. | Derik Olvey | P | LA | 18 | 10/27/1984 | 6-3 | 210 | R-R | College | | Pelham High School (Pelham,AL) | 3 |
| 393. | Nick Conte | C | SF | 21 | 1/25/1982 | 5-10 | 175 | R-R | A | | St. Mary's College of California | 49 |
| 396. | Todd Buchanan | 1B | ARI | 22 | 9/16/1980 | 6-2 | 215 | L-L | A- | | Western Carolina University | 39 |