| 1 | 9 | June-Reg | John Danks | P | 18 | 6-2 | 190 | L | L | MLB | 2007-2009 | Round Rock (Round Rock,TX) | $2,100,000 |
| 2 | 46 | June-Reg | Vince Sinisi | 1B | 21 | 6-0 | 195 | L | L | AAA | | Rice University | $2,070,000 |
| 3 | 76 | June-Reg | John Hudgins | P | 21 | 6-2 | 195 | R | R | AAA | | Stanford University | $490,000 |
| 4 | 106 | June-Reg | Wes Littleton | P | 20 | 6-3 | 200 | R | R | MLB | 2006-2008 | Cal State Fullerton | $315,000 |
| 5 | 136 | June-Reg | Matt Lorenzo | P | 21 | 6-3 | 205 | L | R | AA | | Kent State University | $210,000 |
| 6 | 166 | June-Reg | Adam Bourassa | OF | 22 | 5-8 | 165 | L | L | AA | | Wake Forest University | $35,000 |
| 7 | 196 | June-Reg | Matt Farnum | P | 22 | 6-2 | 195 | R | R | AA | | Texas A&M University | $138,000 |
| 8 | 226 | June-Reg | Jeremy Cleveland | OF | 21 | 6-3 | 185 | R | R | AA | | University of North Carolina | $85,000 |
| 9 | 256 | June-Reg | Tim Cunningham | P | 22 | 6-3 | 195 | L | L | A | | Stanford University | $20,000 |
| 10 | 286 | June-Reg | Adam Fox | 3B | 21 | 5-11 | 195 | R | R | AAA | | Ohio University | $58,000 |
| 11 | 316 | June-Reg | Cody Clark | C | 21 | 6-2 | 215 | R | R | AAA | | Wichita State University | |
| 12 | 346 | June-Reg | Andrew Wishy | OF | 20 | 6-3 | 210 | L | R | A | | University of Arkansas | |
| 13 | 376 | June-Reg | Emerson Frostad | 3B | 20 | 6-1 | 210 | L | R | AAA | | Lewis-Clark State College | |
| 14 | 406 | June-Reg | Brian Mattoon | P | 22 | 6-3 | 200 | L | L | A+ | | Le Moyne College | |
| 15 | 436 | June-Reg | Chris Alexander | 1B | 22 | 6-5 | 225 | R | R | A- | | University of New Mexico | |
| 16 | 466 | June-Reg | Kevin Altman | P | 18 | 6-2 | 160 | R | R | A+ | | Rubidoux (Riverside,CA) | |
| 17 | 496 | June-Reg | Ian Kinsler | SS | 21 | 6-0 | 175 | R | R | MLB | 2006-2009 | University of Missouri | |
| 18 | 526 | June-Reg | Cain Byrd | P | 19 | 6-3 | 185 | R | R | A | | Southwood (Shreveport,LA) | |
| 19 | 556 | June-Reg | Bobby Bowman | P | 22 | 6-6 | 220 | R | R | A | | Jacksonville University | |
| 20 | 586 | June-Reg | Micah Furtado | 2B | 21 | 5-7 | 170 | L | R | AA | | Lewis-Clark State College | |
| 21 | 616 | June-Reg | Marc LaMacchia | P | 21 | 6-0 | 195 | R | R | AA | | Florida State University | |
| 22 | 646 | June-Reg | Dane Bubela | OF | 23 | 5-10 | 190 | L | R | A | | Rice University | |
| 23 | 676 | June-Reg | Jonathan Ramos | P | 18 | 6-3 | 175 | R | R | Rookie | | Tomas C. Ongay (Tomas C. Ongay,Bayamon,PR) | |
| 24 | 706 | June-Reg | Ben Rowe | P | 19 | 6-4 | 210 | R | R | College | | Oregon State University | |
| 25 | 736 | June-Reg | Justin Hatcher | C | 23 | 5-10 | 200 | R | R | AAA | | Texas Christian University | |
| 26 | 766 | June-Reg | Ian Gac | 1B | 17 | 6-3 | 210 | R | R | A+ | | Edmonds-Woodway (Edmonds,WA) | |
| 27 | 796 | June-Reg | Johnny Washington | SS | 19 | 5-11 | 165 | R | R | A+ | | Mt. San Jacinto College | |
| 28 | 826 | June-Reg | Brad Lincoln | P | 18 | 5-11 | 180 | L | R | AAA | | Brazoswood (Clute,TX) | |
| 29 | 856 | June-Reg | Chris Cordeiro | P | 21 | 6-4 | 195 | R | R | A+ | | UCLA | |
| 30 | 886 | June-Reg | Scott Feldman | P | 20 | 6-4 | 210 | R | R | MLB | 2005-2009 | College of San Mateo | |
| 31 | 916 | June-Reg | Rosalino Valenzuela | P | 19 | 6-2 | 165 | R | R | - | | Central Arizona College | |
| 32 | 946 | June-Reg | Colby Paxton | P | 21 | 6-2 | 208 | R | R | College | | Auburn University | |
| 33 | 976 | June-Reg | Scott Welch | SS | 23 | 6-0 | 185 | L | R | A- | | University of Minnesota | |
| 34 | 1006 | June-Reg | Sammy Hewitt | 3B | 22 | 6-3 | 205 | R | R | College | | University of North Carolina | |
| 35 | 1036** | June-Reg | Austin Faught | P | 21 | 6-0 | 180 | L | L | College | | University of Louisiana at Lafayette | |
| 36 | 1066 | June-Reg | Dwayne White | OF | 20 | 6-1 | 195 | L | L | A+ | | Cowley College | |
| 37 | 1096 | June-Reg | Loren Deans | OF | 17 | 6-3 | 190 | R | R | - | | Capistrano Valley (Mission Viejo,CA) | |
| 38 | 1126 | June-Reg | P.J. Sandoval | P | 19 | 6-1 | 194 | R | R | College | | Saddleback College | |
| 39 | 1156 | June-Reg | Josh Lansford | 3B | 18 | 6-2 | 220 | R | R | AA | | St. Francis (Mountain View,CA) | |
| 40 | 1186** | June-Reg | Matt Vogel | 2B | 19 | | | R | R | A- | | East Los Angeles College | |
| 41 | 1216 | June-Reg | Francisco Mora | P | 18 | | | R | R | - | | Eastlake (Chula Vista,CA) | |
| 42 | 1245 | June-Reg | Charles Hesseltine | P | 18 | | | L | L | Ind | | Francis T. Maloney (Meriden,CT) | |
| 43 | 1274 | June-Reg | Hunter Harrigan | C | 20 | 6-1 | 210 | R | R | AAA | | Cowley College | |
| 44 | 1302 | June-Reg | Curtis White | P | 22 | 5-11 | 180 | L | L | College | | University of Oklahoma | |