| 493. | Chris Demaria | P | PIT | 21 | 9/28/1980 | 6-3 | 210 | R-R | MLB | 2005-2006 | Long Beach State University | 123 |
| 494. | Bud Woodruff | C | TB | 19 | 9/23/1982 | 6-4 | 200 | R-R | A- | | Gulf Coast Community College | 139 |
| 498. | Jason Bartz | P | KC | 22 | 11/25/1979 | 6-2 | 205 | R-R | A | | University of South Florida | 74 |
| 499. | Adam Mannon | LF | MIL | 18 | 12/12/1983 | 6-3 | 200 | R-R | A | - | Hamilton High School (Chandler,AZ) | 1 |
| 500. | Rob Watson | IF | DET | 22 | 12/31/1979 | 5-10 | 180 | R-R | A+ | | Oklahoma State University | 161 |
| 505. | Rashad Smith | OF | SD | 22 | 1/20/1980 | 6-4 | 200 | L-R | A | | Lambuth University (Tenn.) | 9 |
| 506. | Randy Braun | OF | TOR | 18 | 4/19/1984 | 6-4 | 190 | L-L | Rookie | | Belton High School (Belton,MO) | 2 |
| 508. | Arian Alcala | 3B | BOS | 22 | 10/7/1979 | 6-2 | 205 | R-R | A | | St Thomas High School (St Thomas) | |
| 509. | Scott Mathieson | P | PHI | 18 | 2/27/1984 | 6-3 | 190 | R-R | MLB | 2006-2006 | Aldergrove High School (Aldergrove,BC) | 1 |
| 512. | Adam Hawes | P | MIN | 19 | 4/25/1983 | 6-3 | 180 | L-R | A+ | | St Theresa's Catholic High School (Victoria Harbour,Can) | |
| 513. | Forrest Beverly | P | CHC | 18 | 3/3/1984 | 6-4 | 207 | R-L | College | | Conway High School (Conway,SC) | 2 |
| 514. | Jeff Ostrander | P | CLE | 18 | 2/23/1984 | 6-0 | 180 | L-L | College | | Patrick Henry High School (Ashland,VA) | 2 |
| 515. | Brad David | P | ATL | 22 | 5/26/1980 | 6-0 | 190 | L-L | A+ | | Louisiana State University | 130 |
| 516. | Gabe Lopez | IF | NYY | 22 | 3/11/1980 | 5-8 | 170 | R-R | AAA | - | San Jose State University | 74 |
| 517. | Luke Nelson | P | SF | 22 | 9/28/1979 | 6-2 | 180 | R-R | A- | | Southern Illinois University | 105 |
| 518. | David Harriman | C | OAK | 21 | 10/15/1980 | 6-0 | 200 | R-R | A+ | | Armstrong Atlantic State University | 14 |
| 520. | Corey Harrington | IF | SEA | 22 | 5/6/1980 | 6-1 | 180 | R-R | A | | New Mexico State University | 45 |