| 463. | John Hummel | P | PIT | 18 | 4/18/1984 | 6-5 | 210 | L-L | A- | | Schaumburg High School (Schaumburg,IL) | 5 |
| 464. | Michael Prochaska | P | TB | 22 | 5/23/1980 | 6-1 | 200 | L-L | AAA | | North Carolina State University | 78 |
| 467. | Brian Ellerson | IF | MTL | 22 | 9/18/1979 | 6-1 | 195 | R-R | A+ | | Montclair State University | 32 |
| 470. | Michael Smith | P | DET | 20 | 7/8/1981 | 6-5 | 205 | L-L | Rookie | | Valdosta State University | 28 |
| 474. | Tommy Duenas | C | ANA | 20 | 7/16/1981 | 5-11 | 200 | R-R | AAA | | Florida International University | 91 |
| 477. | Zac Clements | C | NYM | 22 | 4/17/1980 | 6-2 | 210 | R-R | AAA | | Christian Brothers High School (Christian Brothers) | |
| 478. | Peter Ciofrone | 2B | BOS | 18 | 9/28/1983 | 5-11 | 190 | L-R | AAA | | Smithtown High School (Nesconset,NY) | 3 |
| 481. | Sambu Ndungidi | OF | LA | 17 | 5/9/1985 | 6-3 | 200 | B-R | Rookie | | St. Georges High School (Pierrefonds,QC) | 1 |
| 482. | K.C. Jones | P | MIN | 18 | 6/30/1984 | 6-6 | 210 | R-R | Ind | | Eatonville High School (Eatonville,WA) | 1 |
| 483. | Jemel Spearman | SS | CHC | 21 | 12/27/1980 | 6-0 | 190 | R-R | AAA | | Georgia Southern University | 69 |
| 484. | Omar Casillas | C | CLE | 18 | 9/17/1983 | 6-1 | 170 | R-R | A | | Ana J candelas High School (Cidra,PR) | |
| 486. | Jared Koutnik | IF | NYY | 22 | 11/9/1979 | 6-3 | 190 | R-R | AA | | Michigan State University | 86 |
| 488. | Lloyd Turner | IF | OAK | 22 | 4/11/1980 | 6-1 | 180 | R-R | AAA | | Kennesaw State University | 16 |
| 492. | Brad Thompson | P | STL | 20 | 1/31/1982 | 6-1 | 190 | R-R | MLB | 2005-2008 | Dixie State College of Utah | 10 |