| 434. | Mike Pelfrey | P | TB | 18 | 1/14/1984 | 6-7 | 190 | R-R | MLB | 2006-2008 | Wichita Heights High School (Wichita,KS) | 3 |
| 436. | Matt Howerton | OF | BAL | 17 | 8/29/1984 | 5-11 | 170 | R-R | Rookie | | Riverdale High School (Fort Myers,FL) | 5 |
| 437. | Isaiah Wright | P | MTL | 18 | 7/21/1983 | 6-1 | 170 | R-R | A- | | Dover High School (Dover,DE) | 4 |
| 438. | Kila Kaaihue | 1B | KC | 18 | 3/29/1984 | 6-3 | 210 | L-R | AA | | Iolani High School (Honolulu,HI) | 3 |
| 439. | Justin Barnes | C | MIL | 19 | 8/21/1982 | 6-3 | 205 | R-R | AA | | Manatee Community College | 162 |
| 440. | Jesse Carlson | P | DET | 21 | 12/31/1980 | 6-1 | 160 | L-L | MLB | 2008-2008 | University of Connecticut | 56 |
| 446. | David Smith | OF | TOR | 21 | 1/12/1981 | 6-1 | 190 | R-R | AAA | | West Virginia State College | 17 |
| 450. | Adam Larson | P | CHW | 22 | 12/6/1979 | 6-3 | 230 | R-R | AAA | | Middle Tennessee State University | 41 |
| 451. | Eric Stults | P | LA | 22 | 12/9/1979 | 6-3 | 210 | L-L | MLB | 2006-2007 | Bethel High School (Bethel,IN) | 1 |
| 454. | Nathan Panther | OF | CLE | 20 | 7/12/1981 | 6-2 | 180 | L-L | AAA | | Muscatine Community College | 19 |
| 455. | John Lowen | C | ATL | 18 | 3/27/1984 | 6-2 | 225 | L-R | A | | Lassiter High School (Marietta,GA) | 4 |
| 457. | Matthew Dryer | 3B | SF | 22 | 11/12/1979 | 6-2 | 190 | R-R | AA | | University of Miami (Florida) | 179 |
| 458. | Chris Dunwell | P | OAK | 22 | 1/29/1980 | 6-1 | 200 | R-R | A+ | | San Diego State University | 150 |
| 460. | Gaby Sanchez | H | SEA | 18 | 9/2/1983 | 6-2 | 225 | R-R | AAA | | Brito Private High School (Miami,FL) | 2 |
| 462. | Daylon Monette | OF | STL | 21 | 4/8/1981 | 6-3 | 210 | B-R | A | | Oklahoma State University | 160 |