| 407. | Erik Fiedler | P | MTL | 23 | 11/27/1978 | 6-4 | 190 | R-R | A | | San Diego State University | 149 |
| 410. | Jason Graham | P | DET | 22 | 9/24/1979 | 6-3 | 190 | R-R | A | | University of Central Florida | 58 |
| 411. | Bernie Gonzalez | OF | COL | 22 | 5/10/1980 | 6-2 | 205 | R-R | A+ | | Florida International University | 90 |
| 413. | Travis Chick | P | FLA | 18 | 6/10/1984 | 6-3 | 220 | R-R | MLB | 2006-2006 | Whitehouse High School (Whitehouse,TX) | 3 |
| 414. | Ronnie Ray | P | ANA | 18 | 5/11/1984 | 6-3 | 190 | R-R | AA | | Pacific High School (Pacific,MO) | 1 |
| 416. | Mike Galloway | OF | TOR | 21 | 5/9/1981 | 6-2 | 210 | R-R | AAA | | University of Miami (Florida) | 178 |
| 417. | Jeff Brewer | P | NYM | 21 | 10/5/1980 | 6-3 | 200 | R-R | A | | University of British Columbia | 1 |
| 418. | John Priola | P | BOS | 22 | 9/30/1979 | 6-3 | 190 | R-R | A | | Faulkner University (Ala.) | 3 |
| 420. | Christian Madson | P | CHW | 18 | 9/23/1983 | 6-8 | 250 | R-R | College | | Bloomingdale High School (Valrico,FL) | 6 |
| 422. | Garrett Mock | P | MIN | 19 | 4/25/1983 | 6-4 | 215 | R-R | MLB | 2008-2008 | Grayson County Junior College | 17 |
| 424. | Michael Mitchell | P | CLE | 20 | 10/27/1981 | 6-2 | 185 | R-R | AAA | | St. Charles Community College | 1 |
| 425. | Michael Reiss | P | ATL | 19 | 7/30/1982 | 6-5 | 190 | R-R | Rookie | | Seminole Community College | 61 |
| 427. | Josh Habel | P | SF | 21 | 9/10/1980 | 6-1 | 185 | L-L | AA | | University of Northern Iowa | 13 |
| 431. | William Boening | P | HOU | 17 | 8/22/1984 | 6-5 | 210 | R-R | - | | Yoakum High School (Yoakum,TX) | 1 |