| 2 | 71 | June-Reg | Brandon Weeden | P | 18 | 6-4 | 190 | R | R | A+ | | Edmond Santa Fe (Edmond,OK) | |
| 4 | 126 | June-Reg | Alan Bomer | P | 22 | 6-3 | 200 | R | R | A- | | University of Texas | |
| 5 | 156 | June-Reg | Matt Carson | OF | 20 | 6-2 | 200 | R | R | MLB | 2009-2009 | Brigham Young University | |
| 6 | 186 | June-Reg | Brandon Harmsen | P | 20 | 6-3 | 200 | R | R | A+ | | Grand Rapids Community College | |
| 7 | 216 | June-Reg | Ross Michelsen | 1B | 18 | 6-4 | 190 | L | L | Rookie | | Lamar (Arlington,TX) | |
| 8 | 246 | June-Reg | Brad Halsey | P | 21 | 6-1 | 180 | L | L | MLB | 2004-2006 | University of Texas | |
| 9 | 276 | June-Reg | Eric Verbryke | OF | 20 | 6-2 | 220 | L | L | AA | | Cal State Northridge | |
| 10 | 306 | June-Reg | Gary Bell | P | 22 | 6-1 | 190 | L | L | A | | University of South Carolina | |
| 11 | 336 | June-Reg | Marcus McClanahan | CF | | | 0 | | | - | | University of Alabama | |
| 12 | 366 | June-Reg | Matt Mamula | IF | 22 | 6-2 | 200 | L | L | A- | | Point Loma Nazarene University | |
| 13 | 396 | June-Reg | Blake Blase | IF | 21 | 6-3 | 225 | L | R | A | | Jefferson College | |
| 14 | 426 | June-Reg | Ray Clark | P | 21 | 6-2 | 185 | R | R | A | | University of Texas | |
| 15 | 456 | June-Reg | Phillip Tribe | P | 22 | 6-5 | 210 | R | R | A- | | Rice University | |
| 16 | 486 | June-Reg | Jared Koutnik | IF | 22 | 6-3 | 190 | R | R | AA | | Michigan State University | |
| 17 | 516 | June-Reg | Gabe Lopez | IF | 22 | 5-8 | 170 | R | R | AAA | - | San Jose State University | |
| 18 | 546 | June-Reg | Luis Robles | C | 20 | 6-4 | 180 | R | R | A+ | | Riverside Community College | |
| 19 | 576 | June-Reg | Jon Sheaffer | OF | 22 | 6-1 | 185 | R | R | A- | | Arizona State University | |
| 20 | 606 | June-Reg | Ben King | P | 21 | 6-1 | 190 | L | L | A- | | University of Texas | |
| 21 | 636 | June-Reg | Hector Zamora | 3B | 20 | 6-1 | 210 | L | R | A+ | | San Jose State University | |
| 22 | 666 | June-Reg | Skyler Fulton | CF | 20 | 6-1 | 210 | B | R | - | | Skagit Valley College | |
| 23 | 696 | June-Reg | Eric Hacker | P | 19 | 6-1 | 210 | B | R | MLB | 2009-2009 | Duncanville (Duncanville,TX) | |
| 24 | 726 | June-Reg | Dane De la Rosa | P | 19 | 6-6 | 220 | R | R | A- | | Riverside Community College | |
| 25 | 756 | June-Reg | Josh Neitz | P | 22 | 6-1 | 180 | R | R | A- | | Saint Leo University | |
| 26 | 786 | June-Reg | Phillip Coke | P | 19 | 6-1 | 210 | L | L | MLB | 2008-2009 | San Joaquin Delta College | |
| 27 | 816 | June-Reg | Michael Knox | P | 18 | 6-4 | 195 | R | R | A+ | | Jesuit Prep (Plano,TX) | |
| 28 | 846 | June-Reg | Nathan Kopp | P | 22 | 6-0 | 205 | R | L | A- | | Wright State University | |
| 29 | 876 | June-Reg | Charlie Isaacson | P | 22 | 6-2 | 190 | R | R | AAA | | University of Arkansas | |
| 30 | 906 | June-Reg | Kyle Marlatt | P | 19 | 6-3 | 215 | R | R | College | | San Jacinto College | |
| 31 | 936 | June-Reg | Paul Thorp | P | 21 | 6-1 | 200 | R | R | AA | | Baylor University | |
| 32 | 966 | June-Reg | Justin Meccage | P | 21 | 6-5 | 220 | R | R | A- | | Oklahoma State University | |
| 33 | 996 | June-Reg | David Smith | P | 19 | 6-3 | 220 | L | L | A- | | Parkland College | |
| 34 | 1026 | June-Reg | Nathan Bowden | IF | 22 | 6-3 | 200 | R | R | A- | | University of North Alabama | |
| 35 | 1056 | June-Reg | Mike Brown | P | | | 0 | | | - | | Owasso (Owasso,OK) | |
| 36 | 1086 | June-Reg | Doug Boone | C | 23 | 6-1 | 200 | R | R | AA | | Ball State University | |
| 37 | 1116 | June-Reg | Richard Cowan | P | 19 | 6-2 | 200 | R | R | Rookie | | Navarro College | |
| 38 | 1146** | June-Reg | Justin Keadle | P | 19 | 6-2 | 211 | R | R | A- | | Cypress College | |
| 39 | 1176 | June-Reg | Randy Gattis | | 18 | 6-2 | 182 | R | R | College | | Mesquite (Mesquite,TX) | |
| 40 | 1206 | June-Reg | Joe Difranco | P | 23 | 6-1 | 180 | R | R | A | | St Thomas (FL) | |
| 41 | 1236 | June-Reg | Michael Miehls | C | | | 0 | | | - | | Tennessee Technological University | |
| 42 | 1266 | June-Reg | Matt Goodson | | 18 | 5-11 | 195 | | R | College | | Galveston College | |
| 43 | 1295 | June-Reg | Jason Maes | P | | | 0 | | | - | | Folsom (Folsom,TX) | |
| 44 | 1323 | June-Reg | Matt Brumit | P | 22 | 6-4 | 220 | R | R | A+ | | Youngstown State University | |
| 45 | 1350 | June-Reg | Matt Yost | | | | | | | College | | Elk City (Elk City,OK) | |
| 46 | 1377 | June-Reg | Jared Treadway | OF | 22 | 6-0 | 180 | R | R | A | - | Wooster (Wooster,OH) | |
| 47 | 1403 | June-Reg | Ryan Jennings | P | | | 0 | | | - | | James Monroe (Greenville,WV) | |
| 48 | 1429** | June-Reg | Bill Carnline | P | 18 | 6-3 | 190 | R | R | A+ | | New Caney (New Caney,TX) | |
| 49 | 1454 | June-Reg | Levi Dartt | P | | | 0 | | | - | | Denton (Denton,TX) | |
| 50 | 1478 | June-Reg | Arthur Christal | CF | | | 0 | | | College | | Ennis (Ennis,TX) | |